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Validation of prognostic scores for clinical outcomes in cirrhotic patients with acute variceal bleeding
Miguel Motola-Kuba*, Angélica Escobedo-Arzate*, Félix Tellez-Avila**, José Altamirano***, Nancy Aguilar-Olivos*, Alberto González-Angulo****, Felipe Zamarripa-Dorsey****, Misael Uribe*, Norberto C. Chávez-Tapia
,
Corresponding author
nchavez@medicasur.org.mx

Correspondence and reprint request:
* Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
** Endoscopy Department Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
*** Institut d’Investigacions Biomèdiques August-Pi-Sunyer (IDIBAPS) Hospital Clínic, University of Barcelona. Vall d’Hebron Institut de Recerca, Liver Unit- Internal Medicine Department. Hospital Vall d’Hebron, Barcelona, Spain
**** Gastroenterology Unit, Hospital Juárez de México, Mexico City, Mexico
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">Acute variceal bleeding is one of the most dreadful complications of cirrhosis and occurs in 20-50&#37; of patients&#46; Despite the improvements in prognosis in the past decade&#44; the mortality of patients with acute variceal bleeding remains high &#40;24&#37;&#41; in cirrhotic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0005">1</a></p><p id="p0010" class="elsevierStylePara elsevierViewall">The Child-Pugh score and its components&#44; bacterial infection&#44; and renal failure are important predictors of short-term mortality in patients with acute variceal bleeding&#46;<a class="elsevierStyleCrossRef" href="#bib0010">2</a> A recent report showed that a Model for End-stage Liver Disease &#40;MELD&#41;-based model&#44; including only objective variables&#44; accurately predicted mortality in cirrhotic patients with acute variceal bleeding&#46; MELD scores of &#8805; 19 predicted a mortality rate of &#8805; 20&#37;&#44; whereas scores of &#60; 11 predicted a mortality rate of &#60; 5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015">3</a></p><p id="p0015" class="elsevierStylePara elsevierViewall">There are other prognostic scores for assessing gastrointestinal bleeding&#44; such as the Glasgow-Blatchford score &#40;GBS&#41;&#44; Rockall score&#44; and AIMS65 score&#46; However&#44; most studies that have validated these scoring systems have focused on patients with nonvariceal gastrointestinal bleeding&#46;<a class="elsevierStyleCrossRef" href="#bib0020">4</a> These scores provide information about prognosis and help the clinician in medical decision-making&#46; The cornerstone of predictive scores for gastrointestinal bleeding is using simple clinical and analytical data accurately in the emergency room to stratify those patients with a high risk for mortality&#44; rebleeding&#44; and need for early interventions&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">The primary aim of this study was to compare the scores for the MELD&#44; MELD-Sodium&#44; Child-Pugh&#44; GBS&#44; Rockall&#44; and AIMS65 systems to predict in-hospital mortality in cirrhotic patients with acute variceal bleeding&#46; The secondary aim was to compare the accuracy of these scoring systems for predicting rebleeding&#46;</p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020">Materials and Methods</span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">Study cohort and data collection</span><p id="p0025" class="elsevierStylePara elsevierViewall">We retrospectively included all cirrhotic patients admitted to the emergency room with acute variceal bleeding from three tertiary hospitals in Mexico City&#44; Mexico&#46; The hospitals and timeframes of patient inclusion were&#58;<ul class="elsevierStyleList" id="l0005"><li class="elsevierStyleListItem" id="u0005"><span class="elsevierStyleLabel">&#8226;</span><p id="p0030" class="elsevierStylePara elsevierViewall">Medica Sur Clinic &#38; Foundation from January 2008 to December 2012&#46;</p></li><li class="elsevierStyleListItem" id="u0010"><span class="elsevierStyleLabel">&#8226;</span><p id="p0035" class="elsevierStylePara elsevierViewall">Instituto Nacional de Ciencias M&#233;dicas y Nutrici&#243;n Salvador Zubir&#225;n from January 2009 to December 2012&#46;</p></li><li class="elsevierStyleListItem" id="u0015"><span class="elsevierStyleLabel">&#8226;</span><p id="p0040" class="elsevierStylePara elsevierViewall">Hospital Ju&#225;rez de M&#233;xico from January 2007 to January 2008&#46;</p></li></ul></p><p id="p0045" class="elsevierStylePara elsevierViewall">All patients were older than 18 years&#46; The diagnosis of cirrhosis was based on previous clinical history&#44; liver biopsy&#44; and&#47;or unequivocal clinical data and compatible findings shown by imaging techniques&#46; Esophageal variceal bleeding was confirmed by emergency endoscopy according to the Baveno Consensus Workshop criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0025">5</a> The exclusion criteria were the presence of other causes of gastrointestinal bleeding &#40;e&#46;g&#46;&#44; peptic or esophageal ulcer&#44; vascular lesions&#44; gastrointestinal neoplasia&#41;&#44; hepatocellular carcinoma&#44; infection documented at entry or suspicion of infection during the first 24 h after hospital admission&#44; complete portal vein thrombosis&#44; variceal bleeding in noncirrhotic patients&#44; and incomplete data&#46;</p><p id="p0050" class="elsevierStylePara elsevierViewall">In all patients&#44; clinical and analytical data were collected&#46; Rescue therapies for rebleeding episodes &#40;e&#46;g&#46;&#44; repeat endoscopic treatment or transjugular intrahepatic portosystemic shunt &#91;TIPS&#93;&#41; and transfusion requirements were recorded&#46; Follow-up findings during the admission and until discharge or death were recorded&#46;</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030">Treatments</span><p id="p0055" class="elsevierStylePara elsevierViewall">All patients included in the study received antibiotic prophylaxis for 7 days&#46; An initial endoscopy was performed within the first 48 h after admission&#44; and endoscopic variceal ligation &#40;EVL&#41; was conducted in all cases&#46; A Sengstaken-Blakemore tube was placed as a bridge to a repeat endoscopy when indicated&#46; Vasoactive therapy was performed with octreotide or terlipressin and was started immediately after admission to the bleeding unit&#46; Use of vasoactive drugs was limited due to cost and lack of availability in some centers&#46;</p><p id="p0060" class="elsevierStylePara elsevierViewall">Secondary prophylaxis was initiated in surviving patients passing the 5-day period&#46; Oral propranolol was started at 40 mg&#47;day and subsequently increased until intolerance appeared or the heart rate decreased to &#60; 55 beats per minute or by &#8805; 25&#37; of the baseline heart rate&#46; All patients underwent EVL at 2 to 4-week intervals until variceal eradication was achieved&#46; In addition&#44; patients who were on pharmacological therapy before bleeding had EVL added to the prophylactic regimen&#46;</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0035">Definitions and scoring system calculations</span><p id="p0065" class="elsevierStylePara elsevierViewall">Acute gastrointestinal bleeding from a variceal source was considered&#44; if the initial endoscopy showed any of the signs of variceal hemorrhage according to the Baveno Consensus Workshop criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0025">5</a> Uncontrolled bleeding was defined as any bleeding from esophageal varices that persisted despite intensive endoscopic treatment &#40;i&#46;e&#46;&#44; &#62; 2 therapeutic endoscopy procedures&#41;&#44; balloon tamponade when indicated&#44; TIPS insertion&#44; or death&#46; Rebleeding was defined as a new hematemesis or melena resulting in any of the following&#58; hospital admission&#44; blood transfusion&#44; or 3 g drop in hemoglobin as defined in the Baveno Consensus Workshop criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0025">5</a> In-hospital rebleeding was defined as the presence of hematemesis or melena with signs of hemodynamic instability during hospitalization&#46; In-hospital mortality was defined as death resulting from any cause during the patient&#8217;s hospitalization&#46; The criteria for hemodynamic instability included systolic blood pressure &#60; 100 mmHg&#44; heart rate &#62; 100 bpm&#44; and&#47;or the presence of clinical signs of peripheral hypoperfusion&#46; The criteria for bacterial infection included&#58; fever &#62; 37&#46;5 &#176;C for &#62; 12 h&#59; spontaneous bacterial peritonitis&#59; ascitic fluid polymorphonuclear count &#8805; 250&#47;mm<a class="elsevierStyleCrossRef" href="#bib0015">3</a>&#59; positive blood culture&#59; urinary tract infection&#59; and&#47;or pneumonia on chest X-ray&#46; Other infections were diagnosed according to clinical&#44; radiological&#44; and bacteriologic data&#46;</p><p id="p0070" class="elsevierStylePara elsevierViewall">The scores for the MELD&#44; Child-Pugh&#44; GBS&#44; Rockall&#44; and AIMS65 were calculated in each patient based on their clinical and laboratory features at admission as described on <a class="elsevierStyleCrossRef" href="#t0005">table 1</a>&#46;</p><elsevierMultimedia ident="t0005"></elsevierMultimedia></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Statistical analysis</span><p id="p0075" class="elsevierStylePara elsevierViewall">Continuous variables were expressed as mean &#177; standard deviation&#44; and were compared using Student&#8217;s t test or the Mann-Whitney U test&#44; as appropriate&#44; depending on the normality of their distribution&#46; Differences between categorical variables were assessed by Fisher&#8217;s exact test or the &#967;<a class="elsevierStyleCrossRef" href="#bib0010">2</a> test with Yeat&#8217;s correction for continuity&#44; when necessary&#46; A p value of &#60; 0&#46;05 was considered significant&#46;</p><p id="p0080" class="elsevierStylePara elsevierViewall">The area under the receiver-operating characteristic curve &#40;AUROC&#41; was calculated for each scoring system for validation purposes and comparative analysis of the accuracy of each for predicting each clinical outcome&#46; Correlations between the different AUROC values for each outcome were performed using an estimated covariance matrix for nonparametric data to calculate the variability and to compare the differences between scoring systems&#46;<a class="elsevierStyleCrossRef" href="#bib0030">6</a> Calibration is how well the model tracks the outcome&#44; it was assessed using the Hosmer-Lemeshow Goodnessof-Fit test and P &#60; 0&#46;05 was considered as well-calibrated&#46;</p></span></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Results</span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Patients&#8217; features</span><p id="p0085" class="elsevierStylePara elsevierViewall">During the inclusion period&#44; 230 patients were enrolled and 70 were excluded&#46; One hundred sixty cirrhotic patients with variceal bleeding were finally included in the study cohort &#40;<a class="elsevierStyleCrossRef" href="#f0005">Figure 1</a>&#41;&#46; Sixty patients were from Hospital Ju&#225;rez de M&#233;xico&#44; 42 patients from Medica Sur Clinic &#38; Foundation&#44; and 58 patients from Instituto Nacional de Ciencias M&#233;dicas y Nutrici&#243;n&#46; The baseline demographic and clinical characteristics of patients at admission are shown in <a class="elsevierStyleCrossRef" href="#t0010">table 2</a>&#46;</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><elsevierMultimedia ident="t0010"></elsevierMultimedia><p id="p0090" class="elsevierStylePara elsevierViewall">The most frequent etiologies of cirrhosis were hepatitis C virus infection &#40;n &#61; 47&#41; and alcoholic liver disease &#40;n &#61; 47&#41;&#44; both representing 58&#46;7&#37; of all causes&#44; followed by cryptogenic cirrhosis &#40;n &#61; 30&#44; 18&#46;7&#37;&#41;&#46; Thirty-seven patients &#40;23&#37;&#41; showed renal impairment upon arrival at the hospital as shown by a serum creatinine concentration &#62; 1&#46;5 mg&#47;dL&#46; Overt hepatic encephalopathy &#40;grade &#62; 2&#41; was present in 66 patients &#40;41&#37;&#41;&#46; One hundred thirty-one patients &#40;82&#37;&#41; presented with melena at admission&#44; and 68 patients &#40;42&#37;&#41; had clinically detected ascites&#46; The overall mean in-hospital stay was 3&#46;4 &#177; 5&#46;4 days&#46;</p></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0055">Clinical outcomes</span><p id="p0095" class="elsevierStylePara elsevierViewall">Overall in-hospital mortality was 13&#37;&#46; All three centers showed comparable in-hospital mortality rates&#58; Hospital Ju&#225;rez de Mexico with 13&#37; mortality &#40;n &#61; 8&#41;&#44; Medica Sur Clinic &#38; Foundation with 14&#37; &#40;n &#61; 6&#41;&#44; and Instituto Nacional de Ciencias M&#233;dicas y Nutrici&#243;n with 12&#37; mortality &#40;n &#61; 7&#41; &#40;p &#61; 0&#46;947&#41;&#46; The presence of rebleeding during hospitalization was 12&#37;&#46; This rate did not differ between the participant centers&#58; Hospital Ju&#225;rez de M&#233;xico with 13&#37; &#40;n &#61; 8&#41;&#59; Medica Sur Clinic &#38; Foundation with 14&#37; &#40;n &#61; 6&#41;&#59; and Instituto Nacional de Ciencias M&#233;dicas y Nutrici&#243;n with 9&#37; &#40;n &#61; 5&#41; &#40;p &#61; 0&#46;62&#41;&#46;</p><p id="p0100" class="elsevierStylePara elsevierViewall">Eighty patients &#40;50&#37;&#41; were transfused&#46; The mean number of red blood cell packages used in each transfusion was 1&#46;4 &#177; 1&#46;9&#46; Vasoactive drugs were used in 49 patients &#40;30&#37;&#41; during hospitalization&#58; terlipressin in 27&#59; octreotide in 10&#59; norepinephrine in eight&#59; and vasopressin in four&#46; Ninety five percent of endoscopic procedures were done before 24 h &#40;mean time of 6 h&#41;&#46;</p></span><span id="s0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0060">Comparison of scoring systems for predicting outcomes</span><p id="p0105" class="elsevierStylePara elsevierViewall">AUROC analysis was performed to study the accuracy for prediction of in-hospital mortality for the liver-specific and gastrointestinal bleeding scoring systems &#40;<a class="elsevierStyleCrossRef" href="#t0015">Table 3</a>&#41;&#46; The higher AUROC values for predicting in-hospital mortality were those for MELD &#40;0&#46;828&#59; 95&#37; CI 0&#46;748-0&#46;909&#59; Hosmer-Lemeshow test P &#61; 0&#46;543&#41;&#44; and AIMS65 &#40;0&#46;817&#59; 95&#37; CI 0&#46;724-0&#46;909&#59; Hosmer-Lemeshow test P &#61; 0&#46;851&#41;&#46; The best cutoff values for predicting in-hospital mortality were MELD 13 points &#40;sensitivity 95&#46;2&#37;&#44; specificity 53&#46;2&#37;&#41;&#44; and AIMS65 &#8805; 1 point &#40;sensitivity 85&#46;7&#37;&#44; specificity 57&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#t0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="t0015"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia><p id="p0110" class="elsevierStylePara elsevierViewall">Finally&#44; we analyzed the accuracy of all scoring systems for predicting in-hospital rebleeding &#40;<a class="elsevierStyleCrossRef" href="#t0015">Table 3</a>&#41;&#46; The GBS has higher AUROC for predicting in-hospital rebleeding &#40;0&#46;756&#59; 95&#37; CI 0&#46;640-0&#46;827&#59; Hosmer-Lemeshow test P &#61; 0&#46;218&#41;&#44; followed by Rockall score &#40;0&#46;691&#59; 95&#37; CI 0&#46;580-0&#46;802&#59; Hosmer-Lemeshow test 0&#46;477&#41;&#46;</p><p id="p0115" class="elsevierStylePara elsevierViewall">We performed a sensitivity analysis comparing the group using the vasoactive drugs in order to evaluate if the result was similar if the patients received the adequate therapy&#46; Area under the curve was similar in all scores except for GBS which has to be carefully interpreted&#46;</p></span></span><span id="s0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Discussion</span><p id="p0120" class="elsevierStylePara elsevierViewall">One of the most difficult challenges for clinicians when treating patients with acute variceal bleeding is reducing the risk of mortality&#46; Most interventions to achieve this aim were applied systematically in all patients&#46; However&#44; risk classifications that could help the physician to predict the risk of death <span class="elsevierStyleItalic">a priori</span> and to prioritize clinical care for high-risk patients are underexplored&#46; The ability to detect high-risk patients will be useful for developing new strategies to reduce mortality and to identify those candidates suitable for salvage measures&#46;</p><p id="p0125" class="elsevierStylePara elsevierViewall">In this retrospective multicenter study&#44; we confirmed the utility of MELD for predicting short-term mortality in cirrhotic patients with acute variceal bleeding&#46;<a class="elsevierStyleCrossRef" href="#bib0015">3</a> Rather than trying to develop a new prognostic score&#44; we compared the current scoring systems to explore whether these validated systems&#44; developed for nonvariceal bleeding&#44; could help in the stratification of high-risk patients with variceal bleeding&#46; We found no differences in the accuracy between MELD and AIMS65 for predicting in-hospital mortality&#44; both of them with good calibration&#46; This is an interesting point given that the latter non-liver-specific score includes both data from other liver-specific scores &#40;e&#46;g&#46;&#44; serum albumin concentration and INR&#41; and other biologically significant variables &#40;e&#46;g&#46;&#44; mental status&#44; blood pressure&#44; and age&#41;&#44; which are not considered in the MELD and Child-Pugh scores&#46; AIMS65 is based on objective and well-validated variables and is easy to use in a clinical setting because specific calculations are not needed&#46; This approach has been previously tested<a class="elsevierStyleCrossRef" href="#bib0005">1</a> and that report found lower accuracy for the GBS and Rockall&#44; with AUROC values of 0&#46;527 and 0&#46;591&#44; respectively&#46; These differences underline the need for a more extensive external validation of this approach before its widespread clinical use&#46; One important difference regarding AIMS65 is the cut-off point &#8805; 1 instead of&#62; 2 reported on original studies&#46;</p><p id="p0130" class="elsevierStylePara elsevierViewall">Data about the accuracy of nonliver-specific scoring systems to predict in-hospital rebleeding in cirrhotic patients with acute variceal bleeding are limited&#46;<a class="elsevierStyleCrossRefs" href="#bib0035">7</a>&#8211;<a class="elsevierStyleCrossRef" href="#bib0045">9</a> We found no differences in the accuracy for the prediction of in-hospital rebleeding between the AIMS65 and Rockall scores with other liver-specific scoring systems&#46; Interestingly&#44; the GBS showed better predictive accuracy than the Child-Pugh score in a side-by-side comparison of their AUROC values &#40;<a class="elsevierStyleCrossRef" href="#f0010">Figure 2</a>&#41;&#46; Further studies are needed to clarify the best scoring system for this clinical outcome in cirrhotic patients with acute variceal bleeding&#46;</p><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0135" class="elsevierStylePara elsevierViewall">Finally&#44; in addition to the ability of liver-specific and nonliver-specific scores to predict mortality in patients with acute variceal bleeding&#44; critical care scoring systems have showed high accuracy for predicting in-hospital mortality in this setting&#46;<a class="elsevierStyleCrossRef" href="#bib0050">10</a> A comparative analysis with these critical care scores was beyond the objectives of the present study&#46; There is already a variety of scores to assess the mortality risk of cirrhotic patients with acute variceal bleeding&#46; We propose that the choice should be a rational selection based on the accuracy&#44; validity&#44; and the ease of use at the bedside&#46;</p><p id="p0140" class="elsevierStylePara elsevierViewall">We acknowledge that our study has limitations&#46; First&#44; it was a retrospective design&#44; and some data was not available or incomplete&#44; therefore information from Hospital Ju&#225;rez was included only for one year&#46; The second limitation is the lack of use of vasoactive drugs in all included patients because of the availability in the different centers&#44; hence&#44; the results cannot be extrapolated to patients receiving pharmacological standard of care&#46; Nevertheless&#44; we performed a sensitivity analysis and found this is not an important implication&#46; Third is the lack of full data for comparative analysis with critical care scoring systems&#46; This last point is interesting and deserves further investigation&#46; Lastly&#44; the accuracy is just enough only to predict in-hospital mortality&#44; more data is necessary for other outcomes&#46;</p><p id="p0145" class="elsevierStylePara elsevierViewall">Finally it is important bring the discussion about the significant outcomes in the management of variceal bleeding&#46; We decided to include in-hospital mortality&#44; and all scores show better performance for this outcome&#44; even nonvariceal scores&#46; Mortality is a complex and multifactorial outcome&#44; but must of other outcomes are designed for clinical trials and not for clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0055">11</a> We observe a lower performance of nonvariceal scores limitating their use in clinical trials&#46; However&#44; the recent validation of outcomes is a great advance for better trial design&#44; and the future discussion about consensus of hard outcomes will be seen in the future&#46;<a class="elsevierStyleCrossRef" href="#bib0060">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib0065">13</a></p><p id="p0150" class="elsevierStylePara elsevierViewall">In conclusion&#44; additionally to liver-specific scores&#44; gastrointestinal bleeding scoring systems are useful for predicting clinical outcomes of acute variceal bleeding&#46; The AIMS65 is particularly accurate for predicting in-hospital mortality in this setting&#46; Further prospective and multicentric studies are necessary to confirm our data&#46;</p></span><span id="s0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Abbreviations</span><p id="p0155" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0020"><span class="elsevierStyleLabel">&#8226;</span><p id="p0160" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">AUROC&#58;</span> area under the receiver operating characteristic curve&#46;</p></li><li class="elsevierStyleListItem" id="u0025"><span class="elsevierStyleLabel">&#8226;</span><p id="p0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">EVL&#58;</span> endoscopic variceal ligation&#46;</p></li><li class="elsevierStyleListItem" id="u0030"><span class="elsevierStyleLabel">&#8226;</span><p id="p0170" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">GBS&#58;</span> Glasgow-Blatchford score&#46;</p></li><li class="elsevierStyleListItem" id="u0035"><span class="elsevierStyleLabel">&#8226;</span><p id="p0175" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">MELD&#58;</span> Model for end stage liver disease&#46;</p></li><li class="elsevierStyleListItem" id="u0040"><span class="elsevierStyleLabel">&#8226;</span><p id="p0180" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">TIPS&#58;</span> transjugular intrahepatic portosystemic shunt&#46;</p></li></ul></p></span><span id="s0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Grants</span><p id="p0185" class="elsevierStylePara elsevierViewall">This research received no specific grant from any funding agency in the public&#44; commercial or not-for-profit sectors&#46;</p></span><span id="s0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Acknowledgments</span><p id="p0190" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p><p id="p0195" class="elsevierStylePara elsevierViewall">The study was performed in accordance with the declaration of Helsinki&#44; and was approved by the ethical committee at Medica Sur Clinic and Foundation&#46;</p><p id="p0200" class="elsevierStylePara elsevierViewall">NCT and MMK designed the protocol&#44; MMK&#44; AEA performed literature research and searched the clinical data&#44; FTA&#44; JA&#44; AGA and FZD collaborated to data collection&#44; NCT&#44; MMK and JA analyzed data&#44; and NCT&#44; JA&#44; MMK&#44; NAO and MU wrote&#44; reviewed and edited the anuscript&#46; NCT&#44; MMK&#44; AEA&#44; FTA&#44; JA&#44; AGA&#44; FZD&#44; NAO and MU read and approve the manuscript&#46;</p></span></span>"
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          "identificador" => "xres1207320"
          "titulo" => "Abstract"
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        1 => array:2 [
          "identificador" => "xpalclavsec1124366"
          "titulo" => "Keywords"
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        2 => array:2 [
          "identificador" => "s0005"
          "titulo" => "Introduction"
        ]
        3 => array:3 [
          "identificador" => "s0010"
          "titulo" => "Materials and Methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "s0015"
              "titulo" => "Study cohort and data collection"
            ]
            1 => array:2 [
              "identificador" => "s0020"
              "titulo" => "Treatments"
            ]
            2 => array:2 [
              "identificador" => "s0025"
              "titulo" => "Definitions and scoring system calculations"
            ]
            3 => array:2 [
              "identificador" => "s0030"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        4 => array:3 [
          "identificador" => "s0035"
          "titulo" => "Results"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "s0040"
              "titulo" => "Patients&#8217; features"
            ]
            1 => array:2 [
              "identificador" => "s0045"
              "titulo" => "Clinical outcomes"
            ]
            2 => array:2 [
              "identificador" => "s0050"
              "titulo" => "Comparison of scoring systems for predicting outcomes"
            ]
          ]
        ]
        5 => array:2 [
          "identificador" => "s0055"
          "titulo" => "Discussion"
        ]
        6 => array:2 [
          "identificador" => "s0060"
          "titulo" => "Abbreviations"
        ]
        7 => array:2 [
          "identificador" => "s0065"
          "titulo" => "Grants"
        ]
        8 => array:2 [
          "identificador" => "s0070"
          "titulo" => "Acknowledgments"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-01-18"
    "fechaAceptado" => "2016-04-27"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1124366"
          "palabras" => array:4 [
            0 => "Prognosis"
            1 => "Cirrhosis"
            2 => "Gastrointestinal hemorrhage"
            3 => "Mortality"
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    "resumen" => array:1 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abs0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Background&#46;</span> The Rockall&#44; Glasgow-Blatchford&#44; and AIMS65 are useful and validated scoring systems for predicting the outcomes of patients with nonvariceal gastrointestinal bleeding&#46; However&#44; there are no validated evidence for using them to predict outcomes on variceal bleeding&#46; The aim of this study was to evaluate and compare the prognostic accuracy of different nonvariceal bleeding scores with other liver-specific scoring systems in cirrhotic patients&#46; <span class="elsevierStyleBold">Material and methods&#46;</span> A retrospective multicenter study that included 160 cirrhotic patients with acute variceal bleeding&#46; The AUROC&#8217;s to predict in-hospital mortality&#44; and rebleeding&#44; were analyzed for each scoring system&#46;</p><p id="sp1030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#46;</span> Overall in-hospital mortality occurred in 13&#37; and in-hospital rebleeding in 12&#37; of patients&#46; The systems with the best AUROC value for predicting mortality were MELD &#40;0&#46;828&#59; 95&#37; CI 0&#46;748-0&#46;909&#41;&#44; and AIMS65 &#40;0&#46;817&#59; 95&#37; CI 0&#46;724-0&#46;909&#41;&#46; The best score systems for predicting rebleeding were Glasgow-Blatchford &#40;0&#46;756&#59; 95&#37; CI 0&#46;640-0&#46;827&#41;&#44; and Rockall &#40;0&#46;691&#59; 95&#37; CI 0&#46;580-0&#46;802&#41;&#46;</p><p id="sp0130" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions&#46;</span> In addition to liver-specific scores&#44; the AIMS65 score is accurate for predicting in-hospital mortality in cirrhotic patients with acute variceal bleeding&#46; Other scoring systems might be useful for predicting significant clinical outcomes in these patients&#46;</p></span>"
      ]
    ]
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          "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Flowchart of the enrolled patients in the study&#46;</p>"
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        "etiqueta" => "Figure 2"
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          "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">AUROC values&#46; A&#46; AUROC for mortality&#46; B&#46; AUROC for rebleeding&#46; P-value &#60; 0&#46;05 vs&#46; MELD-Na for mortality&#46; &#42;&#42; P-Value &#60; 0&#46;05 vs&#46; Child-Pugh Score for rebleeding&#46;</p>"
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          "leyenda" => "<p id="np0005" class="elsevierStyleSimplePara elsevierViewall">PCr&#58; plasmatic creatinine&#46; PB&#58; plasmatic bilirubin&#46; BUN&#58; blood urea nitrogen&#46; Hb&#58; hemoglobin&#46; SBP&#58; systolic blood pressure&#46; HR&#58; hearth rate&#46; HF&#58; hearth failure&#46; COPD&#58; chronic obstructive pulmonary disease&#46; DM&#58; diabetes mellitus&#46; CRF&#58; chronic renal failure&#46; P Alb&#58; plasmatic albumin&#46; GCS&#58; Glasgow coma score&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Score&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Calculation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">MELD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#46;957 &#215; ln &#40;PCr&#41; &#43; ln &#40;PB&#41; &#43; 1&#46;120 &#215; ln &#40;INR&#41; &#43; 0&#46;643&#41; &#215; 10 if hemodialysis in the last 2 weeks&#46;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">1</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; BUN &#40;mg&#47;dL&#41;&#58; 6&#46;5-7&#46;9 &#40;2 points&#41;&#44; 8&#46;0-9&#46;9 &#40;3 points&#41;&#44; 10-25 &#40;4 points&#41;&#44; &#62; 25 &#40;6 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Hb in men &#40;mg&#47;L&#41;&#58; 12-12&#46;9 &#40;1 point&#41;&#44; 10-11&#46;0 &#40;3 points&#41;&#44; &#60; 10 &#40;6 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Hb in women &#40;mg&#47;L&#41;&#58; 10-11&#46;9 &#40;1 point&#41;&#44; &#60; 10 &#40;6 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; SBP &#40;mmHg&#41;&#58; 100-109 &#40;1 point&#41;&#44; 90-99 &#40;2 points&#41;&#44; &#60; 90 &#40;3 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; HR &#62;100 &#40;1 point&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Presentation with melena &#40;1 point&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Presentation with syncope &#40;2 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Chronic HF failure &#40;2 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Previous HF &#40;2 points&#41;&#46;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">2</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rockall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Age&#58; &#60; 60 &#40;1 point&#41;&#44; 60-79 &#40;2 points&#41;&#44; &#62; 80 &#40;3 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; HR&#58; &#60; 100 &#40;1 point&#41;&#44; &#62; 100 &#40;2 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; SBP &#40;mmHg&#41;&#58; &#62; 100 &#40;1 point&#41;&#44; &#60; 100 &#40;3 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Previous comorbidity&#58; none &#40;1 point&#41;&#44; cardiac disease &#40;2 points&#41;&#44; COPD &#40;2 points&#41;&#44; DM &#40;2 points&#41;&#44;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CRF &#40;3 points&#41;&#44; cancer &#40;3 points&#41;&#44; cirrhosis &#40;3 points&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Endoscopic signs of recent bleeding&#58; no stigmata &#40;1 point&#41;&#44; fresh blood in stomach &#40;3 points&#41;&#46;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AIMS65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; P Alb &#40;mg&#47;dL&#41;&#58; &#60; 3&#46;0 &#40;1 point&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; INR &#62; 1&#46;5 s &#40;1 point&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; GCS&#58; &#60; 14 &#40;1 point&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; SBP&#58; &#60; 90 &#40;1 point&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Age &#62; 65 years &#40;1 point&#41;&#46;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2060805.png"
              ]
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          ]
          "notaPie" => array:4 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "1"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><span class="elsevierStyleItalic">Kamath PS</span>&#44; et al&#46; <span class="elsevierStyleItalic">A model to predict survival in patients with end-stage liver disease&#46;</span> Hepatology <span class="elsevierStyleItalic">2001&#59; 33&#58;464-70&#46;</span></p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "2"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010"><span class="elsevierStyleItalic">Blatchford O&#44; Murray WR&#44; Blatchford M&#46; A risk score to predict need for treatment for upper-gastrointestinal haemorrhage&#46;</span> Lancet <span class="elsevierStyleItalic">2000&#59; 356&#58; 1318-21&#46;</span></p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "3"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015"><span class="elsevierStyleItalic">Sanders DS&#44; Carter MJ&#44; Goodchap RJ&#44; Cross SS&#44; Gleeson DC&#44; Lobo AJ&#46; Prospective validation of the Rockall risk scoring system for upper GI hemorrhage in subgroups of patients with varices and peptic ulcers&#46;</span> Am J Gastroenterol <span class="elsevierStyleItalic">2002&#59; 97&#58; 630-5&#46;</span></p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "4"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020"><span class="elsevierStyleItalic">Saltzman JR&#44; Tabak YP&#44; Hyett BH&#44; Sun X&#44; Travis AC&#44; Johannes RS&#46; A simple risk score accurately predicts inhospital mortality&#44; length of stay&#44; and cost in acute upper GI bleeding&#46;</span> Gastrointestinal Endoscopy <span class="elsevierStyleItalic">2011&#59; 74&#58; 1215-24&#46;</span></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Scoring systems calculations&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "t0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="np0010" class="elsevierStyleSimplePara elsevierViewall">RBCT&#58; red blood cell transfusion&#46; Data are expressed as mean &#177; SD or n &#40;&#37;&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total &#40;n &#61; 160&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Survived &#40;n &#61; 139&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Died &#40;n &#61; 21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;53&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;61&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6390&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;1&#177;12&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;3&#177;12&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;4&#177;14&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;7678&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glasgow-Blatchford&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;8&#177;3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;4&#177;3&#46;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;5&#177;2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rockall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;7&#177;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;5&#177;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;6&#177;1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AIMS65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&#177;1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&#177;1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;7&#177;1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Child-Pugh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;2&#177;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;9&#177;1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;0&#177;2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MELD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;2&#177;6&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;1&#177;5&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;2&#177;6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melena&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131 &#40;81&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;35&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;71&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ascites&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;42&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">116 &#40;83&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;66&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0768&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Encephalopathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;41&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;16&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;80&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rebleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;11&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;61&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hospital stay &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;4&#177;5&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;5&#177;3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;7&#177;9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cancer history&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;6&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;5&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;19&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0396&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Systolic pressure &#40;mm&#47;Hg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">109&#177;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">111&#177;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#177;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diastolic pressure &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#177;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#177;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemoglobin &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;9&#177;2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;0&#177;2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;7&#177;2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6489&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinine &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;1 &#177;0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&#177;0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;76&#177;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Albumin &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;8&#177;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;8&#177;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;6&#177;0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0799&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">INR &#40;seconds&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&#177;0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;4&#177;0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7&#177;0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0324&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sodium &#40;mEq&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&#46;7&#177;5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&#46;4&#177;4&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&#46;4&#177;8&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Potassium &#40;mEq&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;3&#177;0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;2&#177;0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;7&#177;1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0119&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RBCT &#40;patients&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61 &#40;43&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;90&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RBCT &#40;units&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;4&#177;1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;5&#177;1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;6&#177;2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vasoactive drug use&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;28&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;21&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;76&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2060806.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Clinical and demographic characteristics for all patients and comparison between patients who survived and those who died&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "t0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Scale&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AUROC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">In-hospital mortality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MELD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;828&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;748-0&#46;909&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Child-Pugh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;760&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;645-0&#46;874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AIMS65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;817&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;724-0&#46;909&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glasgow-Blatchford&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;749&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;655-0&#46;842&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rockall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;721&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;616-0&#46;827&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">In-hospital rebleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MELD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;677&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;563-0&#46;792&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Child-Pugh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;581&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;451-0&#46;711&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">AIMS65&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;532-0&#46;795&nbsp;\t\t\t\t\t\t\n
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          "identificador" => "bs0010"
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                    0 => array:2 [
                      "titulo" => "The effectiveness of current acute variceal bleed treatments in unselected cirrhotic patients&#58; refining short-term prognosis and risk factors"
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                          "etal" => true
                          "autores" => array:8 [
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                            2 => "Manguso F&#46;"
                            3 => "Bennato R&#46;"
                            4 => "Bove A&#46;"
                            5 => "DeNucci C&#46;"
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                            7 => "Martino R&#46;"
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                      "titulo" => "Predicting early mortality after acute variceal hemorrhage based on classification and regression tree analysis"
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                            2 => "Altamirano J&#46;T&#46;"
                            3 => "Gonz&#225;lez A&#46;"
                            4 => "Saperas E&#46;"
                            5 => "Dot J&#46;"
                            6 => "Abu-Suboh M&#46;"
                            7 => "Armengol J&#46;R&#46;"
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                    0 => array:2 [
                      "doi" => "10.1016/j.cgh.2009.08.011"
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Article information
ISSN: 16652681
Original language: English
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