Treatment of chronic hepatitis C genotype 1 early responders with 36 week pegylated interferon and ribavirin therapy

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Each reference viral strain is identified by Gen-Bank accession number, species and country of origin, and respective genotype and subtype. New variants in swine and humans (A) are shown in boldface (B). Numbers at the nodes indicate bootstrap percentages over 1,000 replicates (only values > 70% are shown). The bar indicates genetic distance. Avian HEV is the outgroup." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María S. Munné, Nancy R. Altabert, Lucio O. Otegui M., Sara N. Vladimirsky, Rita Moreiro, María P. Espul, Carlos Espul, Abelardo Manzur, Sonia S. Soto, Leonardo S. Brajterman, Jorge E. González" "autores" => array:11 [ 0 => array:3 [ "preGrado" => "Ph.D." "nombre" => "María S." "apellidos" => "Munné" ] 1 => array:2 [ "nombre" => "Nancy R." "apellidos" => "Altabert" ] 2 => array:2 [ "nombre" => "Lucio O. Otegui" "apellidos" => "M." ] 3 => array:2 [ "nombre" => "Sara N." "apellidos" => "Vladimirsky" ] 4 => array:2 [ "nombre" => "Rita" "apellidos" => "Moreiro" ] 5 => array:2 [ "nombre" => "María P." "apellidos" => "Espul" ] 6 => array:2 [ "nombre" => "Carlos" "apellidos" => "Espul" ] 7 => array:2 [ "nombre" => "Abelardo" "apellidos" => "Manzur" ] 8 => array:2 [ "nombre" => "Sonia S." "apellidos" => "Soto" ] 9 => array:2 [ "nombre" => "Leonardo S." "apellidos" => "Brajterman" ] 10 => array:2 [ "nombre" => "Jorge E." "apellidos" => "González" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119312487?idApp=UINPBA00004N" "url" => "/16652681/0000001300000005/v1_201906141004/S1665268119312487/v1_201906141004/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "titulo" => "Treatment of chronic hepatitis C genotype 1 early responders with 36 week pegylated interferon and ribavirin therapy" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "503" "paginaFinal" => "509" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ajit Sood, Vandana Midha, Omesh Goyal" "autores" => array:3 [ 0 => array:5 [ "preGrado" => "M.D., D.M." "nombre" => "Ajit" "apellidos" => "Sood" "email" => array:1 [ 0 => "ajitsood10@sify.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Vandana" "apellidos" => "Midha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Omesh" "apellidos" => "Goyal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Dayanand Medical College and Hospital, Punjab, India" "etiqueta" => "*" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondence and reprint request:" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 438 "Ancho" => 1043 "Tamanyo" => 57247 ] ] "descripcion" => array:1 [ "en" => "Flow of patients in the study. cEVR: complete early virological response. SVR: sustained virological response." ] ] ] "textoCompleto" => "IntroductionStandard treatment regimen for patients with chronic hepatitis C (CHC) genotype 1 (G-1) infection includes pegylated interferon plus ribavirin (PEG-RBV) for 48 weeks.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> Although newer therapeutic options have been recently approved for the treatment of CHC,<a class="elsevierStyleCrossRef" href="#bib0010">2</a> their use is limited due to high cost, side-effects and availability. Even the PEG-RBV therapy is associated with significant cost and side effects. Therefore, efforts have been made to keep the total drug dosage to the minimal but without compromising the treatment efficacy. This can be achieved by either using a lower dose or by reducing the total duration of therapy. In a large randomized trial, Hadziyannis, et al.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> reported that the sustained virological response (SVR) rate in CHC G-1 patients was significantly higher in patients treated for 48 weeks as compared to 24 weeks. However, a retrospective analysis of this trial showed that among patients who achieve rapid virological response (RVR) at week 4, the SVR rate was 89-90% after 24 or 48 weeks of treatment.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> Later, few groups prospectively tested the efficacy of an abbreviated 24 weeks PEG-RBV therapy in CHC G-1 patients but found it to be effective in a selected sub-group of patients who have low viral load (LVL) and who achieve RVR at 4 weeks.<a class="elsevierStyleCrossRefs" href="#bib0020">4</a>–<a class="elsevierStyleCrossRef" href="#bib0035">7</a> In all other patients, 48 weeks therapy is still recommended. We hypothesized that in patients who achieve virological response at 12 weeks, giving an additional 24 weeks of therapy (i.e. total 36 weeks therapy) may be sufficient to achieve a similar SVR rate as with standard 48 week therapy. In this study, we aimed to compare the efficacy of 36 week PEG-RBV therapy with standard 48 week therapy in patients with CHC G 1 infection patients who achieve complete early virological response (cEVR). To the best of our knowledge, no study till date has evaluated the efficacy of 36 weeks therapy for genotype 1 patients.Material and MethodsThis prospective study included consecutive treatment naïve CHC genotype 1 patients who were treated with PEG-RBV therapy in the gastroenterology out-patient department in our institute between January 2006 and December 2013. Inclusion criteria were- age 18-65 years, hepatitis C virus (HCV) ribo-nucleic acid (RNA) positivity, genotype 1 and treatment naïve patients. Patients with compensated cirrhosis (Child-Pugh class A) were eligible for the study. Exclusion criteria wereco-infections with HBV or HIV viruses, history of previous antiviral or immuno-modulatory therapy, decompensated liver disease, active alcohol or drug abuse, major neuro-psychiatric illness, uncontrolled thyroid disorder or uncontrolled diabetes, autoimmune diseases, advanced cardio-pulmonary disease, renal failure, hemoglobin < 12 g/dL (females) or < 13 g/dL (males), platelet count < 90,000/mm<a class="elsevierStyleCrossRef" href="#bib0015">3</a> or neutrophil count < 1,500/mm<a class="elsevierStyleCrossRef" href="#bib0015">3</a> were not offered anti-viral treatment. Written informed consent was taken from the patients and the study was approved by Institutional Ethics Committee. The study was conducted according to the guidelines of the Declaration of Helsinki.A detailed history and clinical examination was undertaken. Baseline laboratory work-up included haemogram, liver and renal function tests, thyroid function tests, prothrombin time index (PTI), fasting blood sugar, α-feto protein and ultrasound abdomen. Increased alanine aminotransferase (ALT) was defined as ALT levels > 40 IU/L. Cirrhosis was diagnosed on the basis of clinical, laboratory, radiological, endoscopic and/or histological (Metavir grade F4) or transient elastography (TE) criteria. In the initial phase of the study, liver biopsy was performed in all patients, but later, it was replaced by TE after its availability beyond the year 2010 at our institute. TE was performed using Fibroscan (Echosens, Paris, France) and results were expressed as Kilo Pascals. TE measurement was considered valid if 10 measurements were obtained with a success rate of > 60% and an interquartile range < 30% of the median. TE value > 11.7 was taken as the cut-off for cirrhosis (≥ F4).<a class="elsevierStyleCrossRef" href="#bib0040">8</a> IL28B genotype testing (SNPs rs12979860 and rs8099917) was performed in all patients beyond the year 2011. The CC genotype was taken as the favorable genotype for rs12979860, while CT and TT were taken as unfavorable. For rs8099917, TT was favorable while the TG and GG were unfavorable genotypes.All the patients were tested for HBV and HIV co-infections. Work-up for autoimmune and metabolic diseases was done, where indicated. Anti-HCV antibody positivity was confirmed by ELISA (ELISCAN HCV; RFCL limited, Dehradun, India). HCV RNA was quantified by real time polymerase chain reaction technology (COBAS Taqman HCV TEST 2.0; Roche Diagnostics Corporation, Indiapolis, IN, USA). Low viral load was defined as HCV RNA < 400,000 IU/mL. HCV genotype was also determined in all patients.Patients were treated with pegylated interferon α2b (PEG-Intron, Schering Corp, Kenilworth, NJ, USA) (1.5 μg/kg per week) or pegylated interferon α2a (Pegasys, Hoffmann-LaRoche) (180 μg per week) subcutaneously plus ribavirin 800-1,200 mg/ day orally, according to body weight (< 65 kg, 800 mg/day; 65-85 kg, 1,000 mg/day; > 85 kg, 1,200 mg/ day).After 12 weeks of treatment, patients were assessed for the presence of EVR. Patients who achieved cEVR (defined as undetectable HCV RNA in serum at 12 weeks, regardless of the 4 week RNA level<a class="elsevierStyleCrossRef" href="#bib0005">1</a>,<a class="elsevierStyleCrossRef" href="#bib0045">9</a> were randomized into 2 groups- group A (48 weeks therapy) and group B (36 weeks therapy). Randomization was performed using sealed opaque envelopes. Patients who did not achieve cEVR were not included in this study. However, treatment was continued in these patients according to standard guidelines.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> Treatment was withdrawn if viral load did not decrease by at least 2 log10 IU/mL after 12 weeks of therapy.All patients were then followed for additional 24 weeks after the end of treatment to assess SVR. Treatment was considered to be ‘complete’ if the patient received > 80% dose of both the treatment drugs for > 80% of the recommended duration. Dose adjustments for adverse effects were made according to standard protocols. Antidepressants and growth factors (erythropoietin or granulocyte colony stimulating factor) were used based on clinical condition of the patient or laboratory abnormalities.<a class="elsevierStyleCrossRef" href="#bib0050">10</a>Treatment efficacy was assessed by HCV RNA monitoring at weeks 12, 24, 36 and 48 of treatment, and 24 weeks after the end of treatment. In addition, HCV RNA at 4 weeks for assessment of RVR was performed after the year 2007.Safety and tolerability were assessed with patientreported adverse events, physical examination and laboratory evaluation (hematology at 2 and 4 weeks, then every 4 weeks and whenever required; liver biochemistry every 4 weeks and thyroid-stimulating hormone levels every 12 weeks during treatment).Study outcome measures and endpointsThe primary outcome measure was an undetectable HCV RNA at 24 weeks of follow-up (SVR) after end of treatment. The secondary outcome measures were the proportion of patients who achieved end-of-treatment response (ETR).The primary endpoint of the study was completion of 24 weeks of follow up after completion of full recommended therapy (36 or 48 weeks). Secondary end-points were- premature withdrawal of treatment due to severe side effects, or patient being lost to follow up.Statistical analysisAll data were analyzed using SPSS v. 14.0 software package. Continuous data were expressed as median (range) and compared using student’s t-test. Categorical data were expressed as number/proportion of subjects with a specific feature, and compared using χ<a class="elsevierStyleCrossRef" href="#bib0010">2</a> test. Analysis was performed on an ‘intention-to-treat’ basis. Univariate analysis was performed to compare various host and viral factors predicting SVR in the two groups. A two-tailed p value of < 0.05 was required for statistical significance.ResultsA total of 166 patients with chronic hepatitis C genotype 1 infection were started on PEG-RBV combination treatment. After 12 weeks of treatment, all patients were assessed for the achievement of EVR. One hundred and twelve patients (67.5%) achieved cEVR, 42 (25.3%) achieved partial EVR, 8 (4.8%) did not achieve EVR, and 4 (2.4%) were lost to follow up. Of the 112 patients who achieved cEVR, 59 patients were randomized to group A (standard 48 weeks therapy), and 53 patients to group B (36 weeks therapy). Flow of patients in the study is shown in <a class="elsevierStyleCrossRef" href="#f0005">figure 1</a>.<elsevierMultimedia ident="f0005"></elsevierMultimedia>Baseline characteristics of the two groups were comparable (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>). Majority of the patients were males, with a median age of 38-40 years, and a median BMI of 23.6-25.9 kg/m<a class="elsevierStyleCrossRef" href="#bib0010">2</a>. Almost three-quarter of the patients had viral load ≥ 400,000 IU/mL. About 25% of the patients had presence of advanced fibrosis/cirrhosis. Of the patients tested for IL28B phenotype, about half had favorable phenotype.<elsevierMultimedia ident="t0005"></elsevierMultimedia>In group A, 55 out of 59 patients (93.2%) completed 48 weeks of therapy, 2 (3.4%) were lost to followup and treatment had to be stopped in 2 (3.4%) patients due to severe adverse events. In group B, 50 out of 53 patients (94.3%) completed 36 weeks of therapy, 2 (3.8%) were lost to follow-up and treatment had to be stopped in 1 (1.9%) patient due to severe adverse events.According to the intention-to-treat analysis, the end-of-treatment response was 93.2% (55/59) in group A and 94.3% (50/53) in group B (p = 1.0). The relapse rates in group A and B were 13.6% (8/ 59) and 9.4% (5/53) respectively. The SVR rate in group A was similar to than in group B [79.6% (47/ 59) and 84.9% (45/53) respectively; p = 0.622]. According to the per-protocol analysis, the SVR rate in group A and B were 85.5% (47/55) and 90% (45/50) respectively (p = 0.562)Post hoc analysis of patients was performed to assess the effect of RVR on SVR. In group A, HCV viral load estimation at 4 weeks was performed in 45 patients. Out of these 27 (60%) patients achieved RVR while 18 did not. Of the RVR positive patients, 92.5% (25/27) achieved SVR, while of the RVR negative patients, 72.2% (13/18) achieved SVR (p = 0.097). In group B, HCV viral load estimation at 4 weeks was performed in 39 patients. Out of these 22 (56.4%) patients had achieved RVR while 17 did not. Of the RVR positive patients, 100% (22/22) achieved SVR, while of the RVR negative patients, 70.6% (12/ 17) achieved SVR (p = 0.011). Only 13.1% (8/61) patients in group A and 7.3% (4/55) in group B had both low viral load and also achieved RVR.Univariate analysis including various factors like viral load (≤ or > 400,000 IU/mL), RVR (achieved/ not achieved), age (≤ or > 40 years), body mass index (≤ or > 27) and advanced fibrosis (present/absent) was performed to assess the influence of these factors on SVR in the two groups (<a class="elsevierStyleCrossRef" href="#t0010">Table 2</a>). However, the SVR rates in the two groups were found to be comparable in all patient sub-groups.<elsevierMultimedia ident="t0010"></elsevierMultimedia>Adverse event profile was similar to that reported with PEG-RBV treatment.<a class="elsevierStyleCrossRef" href="#bib0050">10</a>,<a class="elsevierStyleCrossRef" href="#bib0080">16</a> A vast majority of patients [93.2% (55/59) in group A and 88.7% (47/ 53) in group B; p = 0.513] reported adverse events during the study period. Important adverse events were:<ul class="elsevierStyleList" id="l0005"><li class="elsevierStyleListItem" id="u0005">•Fatigue: 88.1% (52/59) vs. 84.9% (45/53).</li><li class="elsevierStyleListItem" id="u0010">•Weight loss: 64.4% (38/59) vs. 60.1% (32/53).</li><li class="elsevierStyleListItem" id="u0015">•Anemia: 35.5% (21/59) vs. 35.8% (19/53).</li><li class="elsevierStyleListItem" id="u0020">•Depression: 25.4% (15/59) vs. 20.7% (11/53).</li><li class="elsevierStyleListItem" id="u0025">•Breathlessness: 22% (13/59) vs. 18.8% (10/53).</li><li class="elsevierStyleListItem" id="u0030">•Thyroid dysfunction: 13.6% (8/59) vs. 9.4% (5/ 53).</li><li class="elsevierStyleListItem" id="u0035">•Neutropenia: 11.8% (7/59) vs. 9.4% (5/53) and</li><li class="elsevierStyleListItem" id="u0040">•Thrombocytopenia: 8.5% (5/59) vs. 9.4% (5/53) in groups A and B respectively.</li></ul>Therapy had to be discontinued due to severe adverse events in 3.4% patients in group A and 1.9% patient in group B (p = 1.0). Ribavirin dose modification was required in 37.3% (22/59) and 35.8% (19/53) patients (p = 1.0); and PEG-IFN dose modification in 11.8% (7/59) and 11.3% (6/53) patients (p = 1.0) in group A and B respectively.DiscussionPatients with chronic hepatitis C genotype 1 virus infection have been traditionally treated with 48 weeks of PEG-RBV combination therapy, because of the ‘difficult to cure’ nature of this genotype. SVR rate with the standard 48 week therapy has varied from 37-52% in studies from western world,<a class="elsevierStyleCrossRef" href="#bib0020">4</a>,<a class="elsevierStyleCrossRefs" href="#bib0055">11</a>–<a class="elsevierStyleCrossRef" href="#bib0075">15</a> while we recently reported 57% SVR rate among CHC G-1 patients treated in ‘real-life’ setting in northern India.<a class="elsevierStyleCrossRef" href="#bib0080">16</a> Nowadays, the focus has been shifted to response guided therapy depending on on-treatment virological response rather than fixed duration treatment. Ours is the first study which compared the efficacy of a shorter 36 weeks PEG-RBV combination therapy with the standard 48 weeks therapy in genotype 1 patients who achieve cEVR, and found it to have equal efficacy irrespective of other host or virological factors like age, BMI, advanced fibrosis, viral load and RVR.Pegylated IFN and ribavirin therapy for CHC is associated with significant side-effects and high cost. Because of both of these factors, a large number of patients with CHC are either not able to initiate the therapy or have to stop the treatment prematurely. As a result, the goal for clinicians is to find the most effective therapy with the shortest treatment duration. The shorter regimen would definitely be more acceptable to the patients, with fewer side-effects and fewer withdrawals from therapy. Initial studies by Jensen, et al.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> and Zeuzem, et al.<a class="elsevierStyleCrossRef" href="#bib0085">17</a> reported that abbreviated therapy for 24 weeks is a reasonable option for CHC G-1 patients who have LVL (< 600,000 IU/mL) and achieve RVR. Later, in a study by Ferenci, et al.,<a class="elsevierStyleCrossRef" href="#bib0025">5</a> all patients with CHC G-1 who achieved RVR were treated for 24 weeks and a SVR rate of 78.8% was observed. However, the SVR rate was significantly lower in patients with HCV RNA > 800,000 IU/mL (66.7%) compared to those with < 400,000 IU/mL (81.3%). A limitation of this study was the lack of a control arm receiving standard treatment. In another multicenter randomized trial in Asian patients, Liu, et al.<a class="elsevierStyleCrossRef" href="#bib0030">6</a> reported that the SVR rates with 24 week therapy in G-1 patients were similar to that with 48 week therapy only in patients with HCV RNA level < 800,000 IU/mL and those achieving RVR. In a recent study, Lin, et al.<a class="elsevierStyleCrossRef" href="#bib0035">7</a> reported baseline HVL as an important predictor of relapse in G-1 patients receiving abbreviated therapy even if they achieved RVR. Thus, 24 weeks therapy in genotype 1 patients appears to be a good option but only in patients who have LVL and who achieve RVR. However, in real life practice, only a small fraction of patients will be fulfilling these criteria to qualify for 24 weeks therapy. In the study by Ferenci, et al.,<a class="elsevierStyleCrossRef" href="#bib0025">5</a> only 9.4% (52/552) of the patients had both LVL and achieved RVR. Similarly, in the present study, if we had followed these criteria, only 10% of our patients would have qualified for 24 weeks therapy. On the other hand, a greater percentage of CHC G-1 patients would benefit from abbreviated therapy of 36 weeks using our novel criteria (which is independent of the baseline viral load and RVR), as 34-64% patients are known to achieve cEVR in various trials.<a class="elsevierStyleCrossRef" href="#bib0090">18</a>Ours is the first study which has evaluated the usefulness of HCV RNA level after 12 weeks of PEG-RBV therapy as a criterion for abbreviated (36 weeks) therapy in CHC G-1 patients. Earlier data suggests the use of HCV RNA level after 12 weeks as a criterion for stoppage of treatment in CHC G-1 patients because of its high negative predictive value.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> In patients with less than 2 log10 IU/mL decrease in HCV RNA after 12 weeks, treatment should be stopped at week 12, as the SVR rate in these patients with standard treatment duration is less than 2%. In patients with delayed virological response (DVR) (defined as a more than 2 log10 decline in HCV RNA concentration but a detectable HCV RNA level at week 12 and an undetectable HCV RNA level at week 24),<a class="elsevierStyleCrossRef" href="#bib0010">2</a> treatment may be prolonged for 72 weeks.In the present study, we did not consider RVR as a criterion for offering a shorter duration (36 weeks) therapy to the patients. In post-hoc analysis, we found that although the SVR rates were lower in patients who did not achieve RVR compared to patients who did, these were not significantly different among the 2 treatment groups. Thus, the shorter duration therapy was as effective as the standard 48 weeks therapy in patients who achieve cEVR, irrespective of the RVR status.On the basis of RVR and EVR, we propose to classify the patient into 3 sub-groups. First sub-group of patients who achieve RVR and cEVR can be called ‘quick responders’. These patients had exceptionally good SVR rates (93-100%) regardless of the treatment duration (36 weeks or 48 weeks). Therefore, they should be treated for 36 weeks only, while a further sub-group of these patients having LVL should be treated for 24 weeks only, as supported by recent literature.<a class="elsevierStyleCrossRef" href="#bib0010">2</a>,<a class="elsevierStyleCrossRefs" href="#bib0020">4</a>–<a class="elsevierStyleCrossRef" href="#bib0035">7</a> The second sub-group of patients who do not achieve RVR but achieve cEVR can be called as ‘average responders’. The SVR rate in these patients was about 70%, regardless of the treatment duration (36 weeks or 48 weeks). Therefore, they are also eligible for abbreviated therapy, as prolongation of therapy beyond 36 weeks did not increase the SVR rate. Both these sub-groups have 25% reduction in treatment cost and duration, and also suffer from fewer adverse events. The third subgroup of patients who do not achieve RVR or cEVR but have DVR can be labeled as ‘slow responders’ and should be considered for prolonged therapy. However, we did not address this issue in our study.Our study has few limitations. First, the pattern of IL28B polymorphisms was determined only in about half of the patients, as its importance as a predictor of response to treatment emerged only recently, when this trial was already underway. So the effect of IL28B on SVR could not be determined. Whether the pattern of IL28B polymorphism would affect the response rate of shorter duration therapy needs to be explored in future studies. Second, the total sample size in our study was relatively small.To conclude, our study suggests that HCV genotype 1 patients who achieve cEVR can be successfully treated with PEG-RBV therapy of 36 weeks duration without compromising the efficacy. Important observation is that factors like viral load, RVR, age, BMI and advanced fibrosis do not influence the SVR rates as is the case with 24 weeks therapy. Therefore, a larger proportion of patients would be eligible for abbreviated therapy using our criterion. However, our results need to be confirmed in larger controlled trials.Abbreviations<ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0045">•ALT: alanine aminotransferase.</li><li class="elsevierStyleListItem" id="u0050">•cEVR: complete early virological response.</li><li class="elsevierStyleListItem" id="u0055">•CHC: chronic hepatitis C.</li><li class="elsevierStyleListItem" id="u0060">•ETR: end-of-treatment response.</li><li class="elsevierStyleListItem" id="u0065">•G-1: genotype 1.</li><li class="elsevierStyleListItem" id="u0070">•HCV: hepatitis C virus.</li><li class="elsevierStyleListItem" id="u0075">•LVL: low viral load.</li><li class="elsevierStyleListItem" id="u0080">•PEG-RBV: pegylated interferon plus ribavirin.</li><li class="elsevierStyleListItem" id="u0085">•PTI: prothrombin time index.</li><li class="elsevierStyleListItem" id="u0090">•RNA: ribo-nucleic acid.</li><li class="elsevierStyleListItem" id="u0095">•RVR: rapid virological response.</li><li class="elsevierStyleListItem" id="u0100">•SVR: sustained virological response.</li><li class="elsevierStyleListItem" id="u0105">•TE: transient elastography.</li></ul>AcknowledgementsWe acknowledge the help from Dr. Jaskaran Sethi in data collection, and Dr. Suresh K. Sharma in statistical analysis.Financial SupportDepartment of Gastroenterology, D.M.C. and Hospital, Ludhiana." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1206714" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abs0010" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1123913" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "s0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "s0010" "titulo" => "Material and Methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "s0015" "titulo" => "Study outcome measures and endpoints" ] 1 => array:2 [ "identificador" => "s0020" "titulo" => "Statistical analysis" ] ] ] 4 => array:2 [ "identificador" => "s0025" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "s0030" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "s0035" "titulo" => "Abbreviations" ] 7 => array:2 [ "identificador" => "s0040" "titulo" => "Acknowledgements" ] 8 => array:2 [ "identificador" => "s0045" "titulo" => "Financial Support" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-03-06" "fechaAceptado" => "2014-04-22" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1123913" "palabras" => array:4 [ 0 => "Early virological response" 1 => "Shorter therapy" 2 => "Sustained virological response" 3 => "Thirty-six weeks" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Introduction. Standard treatment for patients with chronic hepatitis C genotype 1 (CHC G-1) infection includes pegylated interferon plus ribavirin (PEG-RBV) for 48 weeks. Shorter treatment regimen would be more acceptable due to lower cost and fewer side-effects. We aimed to compare the efficacy of 36 week PEG-RBV therapy with standard 48 week therapy in CHC G-1 patients who achieve complete early virological response (cEVR).Material and methods. Consecutive treatment-naïve patients with CHC G-1 were treated with pegylated interferon a2b (1.5 μg/kg/week) or α2a (180 μg/week) and weight based ribavirin. Patients who achieved cEVR at 12 weeks [undetectable HCV RNA irrespective of RVR (rapid virological response)] were randomized into- group A (48 weeks therapy) and group B (36 weeks therapy). Primary end-point was achievement of sustained virological response (SVR) at 24 weeks of follow up.Results. Out of the total 166 patients started on treatment, 112 (69.3%) achieved cEVR, and were randomized into group A (n = 59) and group B (n = 53). Fifty-five (93.2%) patients in group A and 50 (94.3%) in group B completed therapy. The overall SVR rate in group A was 79.6% (47/59) and group B was 84.9% (45/53) (p = 0.622). SVR rates in the two groups were comparable in all patient sub-groups according to factors like viral load (≤ or > 400,000 IU/mL), RVR (achieved/not achieved), age (≤ or > 40 years), body mass index (≤ or > 27) and cirrhosis (present/absent).Conclusion. In CHC G-1 patients who achieve cEVR, 36 weeks PEG-RBV therapy is as effective as standard 48 weeks therapy, irrespective of other host or virological factors." ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 438 "Ancho" => 1043 "Tamanyo" => 57247 ] ] "descripcion" => array:1 [ "en" => "Flow of patients in the study. cEVR: complete early virological response. SVR: sustained virological response." ] ] 1 => array:7 [ "identificador" => "t0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Characteristics \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group A (48 week therapy) n = 59 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group B (36 week therapy) n = 53 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 (22-65)<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 (19-62)<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.632 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Males \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71.2% (42/59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">74% (39/53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.834 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.9 (15.1-33)<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.6 (14.7-29.4)<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.712 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Viral load ≥ 400,000 IU/mL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69.5% (41/59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">77.4% (41/53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.397 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Alcohol intake \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35.6% (21/59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.5% (22/53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.563 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Co-morbidities \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.9% (7/59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.4% (5/53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.766 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cirrhosis <a class="elsevierStyleCrossRef" href="#tblfn0010">†</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27.1% (16/59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.5% (13/53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.831 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Favorable IL28B genotype <a class="elsevierStyleCrossRef" href="#tblfn0015">‡</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.6% (10/21) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50% (11/22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2059569.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "Data are expressed as median (range) or percentage (number)." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "†" "nota" => "Based on radiology/liver biopsy/elastography." ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "‡" "nota" => "Data available in 21 and 22 patients in group A and B respectively. Favorable was CC genotype for rs12979860, and TT for rs8099917. BMI: body mass index." ] ] ] "descripcion" => array:1 [ "en" => "Baseline characteristics of patients." ] ] 2 => array:7 [ "identificador" => "t0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "Data are expressed as percentage (number)." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Factors \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group A (48 week therapy) n = 59 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group B (36 week therapy) n = 53 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤ 40 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.8 (31/37) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86.2 (25/29) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">> 40 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">72.7 (16/22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.3 (20/24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.484 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80.9 (34/42) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82.1 (32/39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">76.5 (13/17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.9 (13/14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.345 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤ 27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">87.5 (28/32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82.6 (24/29) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.724 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">> 27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70.4 (19/27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">87.5 (21/24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.182 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Advanced fibrosis/cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68.8 (11/16) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">76.9 (10/13) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.697 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.7 (36/43) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">87.5 (35/40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.724 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HCV viral load \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤ 400,000 IU/mL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88.9 (16/18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.3 (10/12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">> 400,000 IU/mL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75.6 (31/41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">85.4 (35/41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.404 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RVR<a class="elsevierStyleCrossRef" href="#tblfn0020">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Achieved \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.5 (25/27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 (22/22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.495 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not-achieved \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">72.2 (13/18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70.6 (12/17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2059570.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "*" "nota" => "RVR data was available in 45 and 39 patients in group A and B patients respectively. BMI: body mass index. HCV: hepatitis C virus. RVR: rapid virological response." ] ] ] "descripcion" => array:1 [ "en" => "Univariate analysis of various host and viral factors predicting sustained virological response." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0010" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis, management, and treatment of hepatitis C: an update" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "American Association for the Study of Liver Diseases" "etal" => false "autores" => array:4 [ 0 => "Ghany M.G." 1 => "Strader D.B." 2 => "Thomas D.L." 3 => "Seeff L.B." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.22759" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2009" "volumen" => "49" "paginaInicial" => "1335" "paginaFinal" => "1374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19330875" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EASL Clinical Practice Guidelines: Management of hepatitis C virus infection" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "European Association for the Study of the Liver" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2013.11.003" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2014" "volumen" => "60" "paginaInicial" => "392" "paginaFinal" => "420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24331294" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peginterferon alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Hadziyannis S.J." 1 => "Sette H. Jr" 2 => "Morgan T.R." 3 => "Balan V." 4 => "Diago M." 5 => "Marcellin P." 6 => "Ramadori G." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2004" "volumen" => "140" "paginaInicial" => "346" "paginaFinal" => "355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14996676" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Austrian Hepatitis Study Group" "etal" => true "autores" => array:7 [ 0 => "Ferenci P." 1 => "Laferl H." 2 => "Scherzer T.M." 3 => "Gschwantler M." 4 => "Maieron A." 5 => "Brunner H." 6 => "Stauber R." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.gastro.2008.04.015" "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "2008" "volumen" => "135" "paginaInicial" => "451" "paginaFinal" => "458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18503773" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Review article: the management of side effects during therapy for hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Aspinall R.J." 1 => "Pockros P.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2036.2004.02192.x" "Revista" => array:6 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2004" "volumen" => "20" "paginaInicial" => "917" "paginaFinal" => "929" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15521838" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peg-interferon alfa -2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Manns M." 1 => "McHutchinson J." 2 => "Gordon S.C." 3 => "Rustgi V.K." 4 => "Shiffman M." 5 => "Reindollar R." 6 => "Goodman Z.D." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0140-6736(01)06102-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2001" "volumen" => "358" "paginaInicial" => "958" "paginaFinal" => "965" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11583749" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy, tolerability and safety in the treatment of chronic hepatitis C with combination of PEG-Interferon-Ribavirin in daily practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Ridruejo E." 1 => "Adrover R." 2 => "Cocozzella D." 3 => "Fernández N." 4 => "Reggiardo M.V." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Hepatol" "fecha" => "2010" "volumen" => "9" "paginaInicial" => "46" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20308722" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatitis C treatment outcomes in Australian clinics" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Gidding H.F." 1 => "Law M.G." 2 => "Amin J." 3 => "Ostapowicz G." 4 => "Weltman M." 5 => "Macdonald G.A." 6 => "Sasadeusz J.J." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med J Aust" "fecha" => "2012" "volumen" => "196" "paginaInicial" => "633" "paginaFinal" => "637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22676878" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of chronic hepatitis C with pegylated interferon and ribavirin in treatment-naive patients in ‘true life’: a plea in favor of independent post marketing evaluations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Pariente A." 1 => "Lahmek P." 2 => "Duprat C." 3 => "Denis J." 4 => "Faroux R." 5 => "Renou C." 6 => "Nalet B." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "2010" "volumen" => "22" "paginaInicial" => "1297" "paginaFinal" => "1302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20964260" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Sood A, Midha V, Goyal O, Hissar S, Sharma SK, Khanna P. Treatment of Chronic Hepatitis C with Pegylated Interferon plus Ribavirin in treatment-naive ‘real-life’ patients in India. Indian J Gastroenterol 2014 Mar 12 [Epub a head of print]." ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Zeuzem S." 1 => "Buti M." 2 => "Ferenci P." 3 => "Sperl J." 4 => "Horsmans Y." 5 => "Cianciara J." 6 => "Ibranyi E." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2005.10.003" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2006" "volumen" => "44" "paginaInicial" => "97" "paginaFinal" => "103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16290907" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." 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Ajit Sood

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ajitsood10@sify.com

Correspondence and reprint request:

, Vandana Midha*, Omesh Goyal*

* Dayanand Medical College and Hospital, Punjab, India

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          "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Flow of patients in the study&#46; cEVR&#58; complete early virological response&#46; SVR&#58; sustained virological response&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">Standard treatment regimen for patients with chronic hepatitis C &#40;CHC&#41; genotype 1 &#40;G-1&#41; infection includes pegylated interferon plus ribavirin &#40;PEG-RBV&#41; for 48 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Although newer therapeutic options have been recently approved for the treatment of CHC&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> their use is limited due to high cost&#44; side-effects and availability&#46; Even the PEG-RBV therapy is associated with significant cost and side effects&#46; Therefore&#44; efforts have been made to keep the total drug dosage to the minimal but without compromising the treatment efficacy&#46; This can be achieved by either using a lower dose or by reducing the total duration of therapy&#46; In a large randomized trial&#44; Hadziyannis&#44; <span class="elsevierStyleItalic">et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> reported that the sustained virological response &#40;SVR&#41; rate in CHC G-1 patients was significantly higher in patients treated for 48 weeks as compared to 24 weeks&#46; However&#44; a retrospective analysis of this trial showed that among patients who achieve rapid virological response &#40;RVR&#41; at week 4&#44; the SVR rate was 89-90&#37; after 24 or 48 weeks of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Later&#44; few groups prospectively tested the efficacy of an abbreviated 24 weeks PEG-RBV therapy in CHC G-1 patients but found it to be effective in a selected sub-group of patients who have low viral load &#40;LVL&#41; and who achieve RVR at 4 weeks&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#8211;</span><a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In all other patients&#44; 48 weeks therapy is still recommended&#46; We hypothesized that in patients who achieve virological response at 12 weeks&#44; giving an additional 24 weeks of therapy &#40;i&#46;e&#46; total 36 weeks therapy&#41; may be sufficient to achieve a similar SVR rate as with standard 48 week therapy&#46; In this study&#44; we aimed to compare the efficacy of 36 week PEG-RBV therapy with standard 48 week therapy in patients with CHC G 1 infection patients who achieve complete early virological response &#40;cEVR&#41;&#46; To the best of our knowledge&#44; no study till date has evaluated the efficacy of 36 weeks therapy for genotype 1 patients&#46;</p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020">Material and Methods</span><p id="p0010" class="elsevierStylePara elsevierViewall">This prospective study included consecutive treatment na&#239;ve CHC genotype 1 patients who were treated with PEG-RBV therapy in the gastroenterology out-patient department in our institute between January 2006 and December 2013&#46; Inclusion criteria were- age 18-65 years&#44; hepatitis C virus &#40;HCV&#41; ribo-nucleic acid &#40;RNA&#41; positivity&#44; genotype 1 and treatment na&#239;ve patients&#46; Patients with compensated cirrhosis &#40;Child-Pugh class A&#41; were eligible for the study&#46; Exclusion criteria wereco-infections with HBV or HIV viruses&#44; history of previous antiviral or immuno-modulatory therapy&#44; decompensated liver disease&#44; active alcohol or drug abuse&#44; major neuro-psychiatric illness&#44; uncontrolled thyroid disorder or uncontrolled diabetes&#44; autoimmune diseases&#44; advanced cardio-pulmonary disease&#44; renal failure&#44; hemoglobin &#60; 12 g&#47;dL &#40;females&#41; or &#60; 13 g&#47;dL &#40;males&#41;&#44; platelet count &#60; 90&#44;000&#47;mm<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> or neutrophil count &#60; 1&#44;500&#47;mm<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> were not offered anti-viral treatment&#46; Written informed consent was taken from the patients and the study was approved by Institutional Ethics Committee&#46; The study was conducted according to the guidelines of the Declaration of Helsinki&#46;</p><p id="p0015" class="elsevierStylePara elsevierViewall">A detailed history and clinical examination was undertaken&#46; Baseline laboratory work-up included haemogram&#44; liver and renal function tests&#44; thyroid function tests&#44; prothrombin time index &#40;PTI&#41;&#44; fasting blood sugar&#44; &#945;-feto protein and ultrasound abdomen&#46; Increased alanine aminotransferase &#40;ALT&#41; was defined as ALT levels &#62; 40 IU&#47;L&#46; Cirrhosis was diagnosed on the basis of clinical&#44; laboratory&#44; radiological&#44; endoscopic and&#47;or histological &#40;Metavir grade F4&#41; or transient elastography &#40;TE&#41; criteria&#46; In the initial phase of the study&#44; liver biopsy was performed in all patients&#44; but later&#44; it was replaced by TE after its availability beyond the year 2010 at our institute&#46; TE was performed using Fibroscan &#40;Echosens&#44; Paris&#44; France&#41; and results were expressed as Kilo Pascals&#46; TE measurement was considered valid if 10 measurements were obtained with a success rate of &#62; 60&#37; and an interquartile range &#60; 30&#37; of the median&#46; TE value &#62; 11&#46;7 was taken as the cut-off for cirrhosis &#40;&#8805; F4&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> IL28B genotype testing &#40;SNPs rs12979860 and rs8099917&#41; was performed in all patients beyond the year 2011&#46; The CC genotype was taken as the favorable genotype for rs12979860&#44; while CT and TT were taken as unfavorable&#46; For rs8099917&#44; TT was favorable while the TG and GG were unfavorable genotypes&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">All the patients were tested for HBV and HIV co-infections&#46; Work-up for autoimmune and metabolic diseases was done&#44; where indicated&#46; Anti-HCV antibody positivity was confirmed by ELISA &#40;ELISCAN HCV&#59; RFCL limited&#44; Dehradun&#44; India&#41;&#46; HCV RNA was quantified by real time polymerase chain reaction technology &#40;COBAS Taqman HCV TEST 2&#46;0&#59; Roche Diagnostics Corporation&#44; Indiapolis&#44; IN&#44; USA&#41;&#46; Low viral load was defined as HCV RNA &#60; 400&#44;000 IU&#47;mL&#46; HCV genotype was also determined in all patients&#46;</p><p id="p0025" class="elsevierStylePara elsevierViewall">Patients were treated with pegylated interferon &#945;2b &#40;PEG-Intron&#44; Schering Corp&#44; Kenilworth&#44; NJ&#44; USA&#41; &#40;1&#46;5 <span class="elsevierStyleItalic">&#956;</span>g&#47;kg per week&#41; or pegylated interferon &#945;2a &#40;Pegasys&#44; Hoffmann-LaRoche&#41; &#40;180 <span class="elsevierStyleItalic">&#956;</span>g per week&#41; subcutaneously plus ribavirin 800-1&#44;200 mg&#47; day orally&#44; according to body weight &#40;&#60; 65 kg&#44; 800 mg&#47;day&#59; 65-85 kg&#44; 1&#44;000 mg&#47;day&#59; &#62; 85 kg&#44; 1&#44;200 mg&#47; day&#41;&#46;</p><p id="p0030" class="elsevierStylePara elsevierViewall">After 12 weeks of treatment&#44; patients were assessed for the presence of EVR&#46; Patients who achieved cEVR &#40;defined as undetectable HCV RNA in serum at 12 weeks&#44; regardless of the 4 week RNA level<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> were randomized into 2 groups- group A &#40;48 weeks therapy&#41; and group B &#40;36 weeks therapy&#41;&#46; Randomization was performed using sealed opaque envelopes&#46; Patients who did not achieve cEVR were not included in this study&#46; However&#44; treatment was continued in these patients according to standard guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Treatment was withdrawn if viral load did not decrease by at least 2 log<span class="elsevierStyleInf">10</span> IU&#47;mL after 12 weeks of therapy&#46;</p><p id="p0035" class="elsevierStylePara elsevierViewall">All patients were then followed for additional 24 weeks after the end of treatment to assess SVR&#46; Treatment was considered to be &#8216;complete&#8217; if the patient received &#62; 80&#37; dose of both the treatment drugs for &#62; 80&#37; of the recommended duration&#46; Dose adjustments for adverse effects were made according to standard protocols&#46; Antidepressants and growth factors &#40;erythropoietin or granulocyte colony stimulating factor&#41; were used based on clinical condition of the patient or laboratory abnormalities&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="p0040" class="elsevierStylePara elsevierViewall">Treatment efficacy was assessed by HCV RNA monitoring at weeks 12&#44; 24&#44; 36 and 48 of treatment&#44; and 24 weeks after the end of treatment&#46; In addition&#44; HCV RNA at 4 weeks for assessment of RVR was performed after the year 2007&#46;</p><p id="p0045" class="elsevierStylePara elsevierViewall">Safety and tolerability were assessed with patientreported adverse events&#44; physical examination and laboratory evaluation &#40;hematology at 2 and 4 weeks&#44; then every 4 weeks and whenever required&#59; liver biochemistry every 4 weeks and thyroid-stimulating hormone levels every 12 weeks during treatment&#41;&#46;</p><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">Study outcome measures and endpoints</span><p id="p0050" class="elsevierStylePara elsevierViewall">The primary outcome measure was an undetectable HCV RNA at 24 weeks of follow-up &#40;SVR&#41; after end of treatment&#46; The secondary outcome measures were the proportion of patients who achieved end-of-treatment response &#40;ETR&#41;&#46;</p><p id="p0055" class="elsevierStylePara elsevierViewall">The primary endpoint of the study was completion of 24 weeks of follow up after completion of full recommended therapy &#40;36 or 48 weeks&#41;&#46; Secondary end-points were- premature withdrawal of treatment due to severe side effects&#44; or patient being lost to follow up&#46;</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030">Statistical analysis</span><p id="p0060" class="elsevierStylePara elsevierViewall">All data were analyzed using SPSS v&#46; 14&#46;0 software package&#46; Continuous data were expressed as median &#40;range&#41; and compared using student&#8217;s t-test&#46; Categorical data were expressed as number&#47;proportion of subjects with a specific feature&#44; and compared using &#967;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> test&#46; Analysis was performed on an &#8216;intention-to-treat&#8217; basis&#46; Univariate analysis was performed to compare various host and viral factors predicting SVR in the two groups&#46; A two-tailed p value of &#60; 0&#46;05 was required for statistical significance&#46;</p></span></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0035">Results</span><p id="p0065" class="elsevierStylePara elsevierViewall">A total of 166 patients with chronic hepatitis C genotype 1 infection were started on PEG-RBV combination treatment&#46; After 12 weeks of treatment&#44; all patients were assessed for the achievement of EVR&#46; One hundred and twelve patients &#40;67&#46;5&#37;&#41; achieved cEVR&#44; 42 &#40;25&#46;3&#37;&#41; achieved partial EVR&#44; 8 &#40;4&#46;8&#37;&#41; did not achieve EVR&#44; and 4 &#40;2&#46;4&#37;&#41; were lost to follow up&#46; Of the 112 patients who achieved cEVR&#44; 59 patients were randomized to group A &#40;standard 48 weeks therapy&#41;&#44; and 53 patients to group B &#40;36 weeks therapy&#41;&#46; Flow of patients in the study is shown in <a class="elsevierStyleCrossRef" href="#f0005">figure 1</a>&#46;</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><p id="p0070" class="elsevierStylePara elsevierViewall">Baseline characteristics of the two groups were comparable &#40;<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>&#41;&#46; Majority of the patients were males&#44; with a median age of 38-40 years&#44; and a median BMI of 23&#46;6-25&#46;9 kg&#47;m<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Almost three-quarter of the patients had viral load &#8805; 400&#44;000 IU&#47;mL&#46; About 25&#37; of the patients had presence of advanced fibrosis&#47;cirrhosis&#46; Of the patients tested for IL28B phenotype&#44; about half had favorable phenotype&#46;</p><elsevierMultimedia ident="t0005"></elsevierMultimedia><p id="p0075" class="elsevierStylePara elsevierViewall">In group A&#44; 55 out of 59 patients &#40;93&#46;2&#37;&#41; completed 48 weeks of therapy&#44; 2 &#40;3&#46;4&#37;&#41; were lost to followup and treatment had to be stopped in 2 &#40;3&#46;4&#37;&#41; patients due to severe adverse events&#46; In group B&#44; 50 out of 53 patients &#40;94&#46;3&#37;&#41; completed 36 weeks of therapy&#44; 2 &#40;3&#46;8&#37;&#41; were lost to follow-up and treatment had to be stopped in 1 &#40;1&#46;9&#37;&#41; patient due to severe adverse events&#46;</p><p id="p0080" class="elsevierStylePara elsevierViewall">According to the intention-to-treat analysis&#44; the end-of-treatment response was 93&#46;2&#37; &#40;55&#47;59&#41; in group A and 94&#46;3&#37; &#40;50&#47;53&#41; in group B &#40;p &#61; 1&#46;0&#41;&#46; The relapse rates in group A and B were 13&#46;6&#37; &#40;8&#47; 59&#41; and 9&#46;4&#37; &#40;5&#47;53&#41; respectively&#46; The SVR rate in group A was similar to than in group B &#91;79&#46;6&#37; &#40;47&#47; 59&#41; and 84&#46;9&#37; &#40;45&#47;53&#41; respectively&#59; p &#61; 0&#46;622&#93;&#46; According to the per-protocol analysis&#44; the SVR rate in group A and B were 85&#46;5&#37; &#40;47&#47;55&#41; and 90&#37; &#40;45&#47;50&#41; respectively &#40;p &#61; 0&#46;562&#41;</p><p id="p0085" class="elsevierStylePara elsevierViewall">Post hoc analysis of patients was performed to assess the effect of RVR on SVR&#46; In group A&#44; HCV viral load estimation at 4 weeks was performed in 45 patients&#46; Out of these 27 &#40;60&#37;&#41; patients achieved RVR while 18 did not&#46; Of the RVR positive patients&#44; 92&#46;5&#37; &#40;25&#47;27&#41; achieved SVR&#44; while of the RVR negative patients&#44; 72&#46;2&#37; &#40;13&#47;18&#41; achieved SVR &#40;p &#61; 0&#46;097&#41;&#46; In group B&#44; HCV viral load estimation at 4 weeks was performed in 39 patients&#46; Out of these 22 &#40;56&#46;4&#37;&#41; patients had achieved RVR while 17 did not&#46; Of the RVR positive patients&#44; 100&#37; &#40;22&#47;22&#41; achieved SVR&#44; while of the RVR negative patients&#44; 70&#46;6&#37; &#40;12&#47; 17&#41; achieved SVR &#40;p &#61; 0&#46;011&#41;&#46; Only 13&#46;1&#37; &#40;8&#47;61&#41; patients in group A and 7&#46;3&#37; &#40;4&#47;55&#41; in group B had both low viral load and also achieved RVR&#46;</p><p id="p0090" class="elsevierStylePara elsevierViewall">Univariate analysis including various factors like viral load &#40;&#8804; or &#62; 400&#44;000 IU&#47;mL&#41;&#44; RVR &#40;achieved&#47; not achieved&#41;&#44; age &#40;&#8804; or &#62; 40 years&#41;&#44; body mass index &#40;&#8804; or &#62; 27&#41; and advanced fibrosis &#40;present&#47;absent&#41; was performed to assess the influence of these factors on SVR in the two groups &#40;<a class="elsevierStyleCrossRef" href="#t0010">Table 2</a>&#41;&#46; However&#44; the SVR rates in the two groups were found to be comparable in all patient sub-groups&#46;</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><p id="p0095" class="elsevierStylePara elsevierViewall">Adverse event profile was similar to that reported with PEG-RBV treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> A vast majority of patients &#91;93&#46;2&#37; &#40;55&#47;59&#41; in group A and 88&#46;7&#37; &#40;47&#47; 53&#41; in group B&#59; p &#61; 0&#46;513&#93; reported adverse events during the study period&#46; Important adverse events were&#58;<ul class="elsevierStyleList" id="l0005"><li class="elsevierStyleListItem" id="u0005"><span class="elsevierStyleLabel">&#8226;</span><p id="p0100" class="elsevierStylePara elsevierViewall">Fatigue&#58; 88&#46;1&#37; &#40;52&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 84&#46;9&#37; &#40;45&#47;53&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0010"><span class="elsevierStyleLabel">&#8226;</span><p id="p0105" class="elsevierStylePara elsevierViewall">Weight loss&#58; 64&#46;4&#37; &#40;38&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 60&#46;1&#37; &#40;32&#47;53&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0015"><span class="elsevierStyleLabel">&#8226;</span><p id="p0110" class="elsevierStylePara elsevierViewall">Anemia&#58; 35&#46;5&#37; &#40;21&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 35&#46;8&#37; &#40;19&#47;53&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0020"><span class="elsevierStyleLabel">&#8226;</span><p id="p0115" class="elsevierStylePara elsevierViewall">Depression&#58; 25&#46;4&#37; &#40;15&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 20&#46;7&#37; &#40;11&#47;53&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0025"><span class="elsevierStyleLabel">&#8226;</span><p id="p0120" class="elsevierStylePara elsevierViewall">Breathlessness&#58; 22&#37; &#40;13&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 18&#46;8&#37; &#40;10&#47;53&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0030"><span class="elsevierStyleLabel">&#8226;</span><p id="p0125" class="elsevierStylePara elsevierViewall">Thyroid dysfunction&#58; 13&#46;6&#37; &#40;8&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 9&#46;4&#37; &#40;5&#47; 53&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0035"><span class="elsevierStyleLabel">&#8226;</span><p id="p0130" class="elsevierStylePara elsevierViewall">Neutropenia&#58; 11&#46;8&#37; &#40;7&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 9&#46;4&#37; &#40;5&#47;53&#41; and</p></li><li class="elsevierStyleListItem" id="u0040"><span class="elsevierStyleLabel">&#8226;</span><p id="p0135" class="elsevierStylePara elsevierViewall">Thrombocytopenia&#58; 8&#46;5&#37; &#40;5&#47;59&#41; <span class="elsevierStyleItalic">vs&#46;</span> 9&#46;4&#37; &#40;5&#47;53&#41; in groups A and B respectively&#46;</p></li></ul></p><p id="p0140" class="elsevierStylePara elsevierViewall">Therapy had to be discontinued due to severe adverse events in 3&#46;4&#37; patients in group A and 1&#46;9&#37; patient in group B &#40;p &#61; 1&#46;0&#41;&#46; Ribavirin dose modification was required in 37&#46;3&#37; &#40;22&#47;59&#41; and 35&#46;8&#37; &#40;19&#47;53&#41; patients &#40;p &#61; 1&#46;0&#41;&#59; and PEG-IFN dose modification in 11&#46;8&#37; &#40;7&#47;59&#41; and 11&#46;3&#37; &#40;6&#47;53&#41; patients &#40;p &#61; 1&#46;0&#41; in group A and B respectively&#46;</p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Discussion</span><p id="p0145" class="elsevierStylePara elsevierViewall">Patients with chronic hepatitis C genotype 1 virus infection have been traditionally treated with 48 weeks of PEG-RBV combination therapy&#44; because of the &#8216;difficult to cure&#8217; nature of this genotype&#46; SVR rate with the standard 48 week therapy has varied from 37-52&#37; in studies from western world&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11</span></a><span class="elsevierStyleSup">&#8211;</span><a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> while we recently reported 57&#37; SVR rate among CHC G-1 patients treated in &#8216;real-life&#8217; setting in northern India&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Nowadays&#44; the focus has been shifted to response guided therapy depending on on-treatment virological response rather than fixed duration treatment&#46; Ours is the first study which compared the efficacy of a shorter 36 weeks PEG-RBV combination therapy with the standard 48 weeks therapy in genotype 1 patients who achieve cEVR&#44; and found it to have equal efficacy irrespective of other host or virological factors like age&#44; BMI&#44; advanced fibrosis&#44; viral load and RVR&#46;</p><p id="p0150" class="elsevierStylePara elsevierViewall">Pegylated IFN and ribavirin therapy for CHC is associated with significant side-effects and high cost&#46; Because of both of these factors&#44; a large number of patients with CHC are either not able to initiate the therapy or have to stop the treatment prematurely&#46; As a result&#44; the goal for clinicians is to find the most effective therapy with the shortest treatment duration&#46; The shorter regimen would definitely be more acceptable to the patients&#44; with fewer side-effects and fewer withdrawals from therapy&#46; Initial studies by Jensen&#44; <span class="elsevierStyleItalic">et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and Zeuzem&#44; <span class="elsevierStyleItalic">et</span> al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> reported that abbreviated therapy for 24 weeks is a reasonable option for CHC G-1 patients who have LVL &#40;&#60; 600&#44;000 IU&#47;mL&#41; and achieve RVR&#46; Later&#44; in a study by Ferenci&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> all patients with CHC G-1 who achieved RVR were treated for 24 weeks and a SVR rate of 78&#46;8&#37; was observed&#46; However&#44; the SVR rate was significantly lower in patients with HCV RNA &#62; 800&#44;000 IU&#47;mL &#40;66&#46;7&#37;&#41; compared to those with &#60; 400&#44;000 IU&#47;mL &#40;81&#46;3&#37;&#41;&#46; A limitation of this study was the lack of a control arm receiving standard treatment&#46; In another multicenter randomized trial in Asian patients&#44; Liu&#44; <span class="elsevierStyleItalic">et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> reported that the SVR rates with 24 week therapy in G-1 patients were similar to that with 48 week therapy only in patients with HCV RNA level &#60; 800&#44;000 IU&#47;mL and those achieving RVR&#46; In a recent study&#44; Lin&#44; <span class="elsevierStyleItalic">et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported baseline HVL as an important predictor of relapse in G-1 patients receiving abbreviated therapy even if they achieved RVR&#46; Thus&#44; 24 weeks therapy in genotype 1 patients appears to be a good option but only in patients who have LVL and who achieve RVR&#46; However&#44; in real life practice&#44; only a small fraction of patients will be fulfilling these criteria to qualify for 24 weeks therapy&#46; In the study by Ferenci&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> only 9&#46;4&#37; &#40;52&#47;552&#41; of the patients had both LVL and achieved RVR&#46; Similarly&#44; in the present study&#44; if we had followed these criteria&#44; only 10&#37; of our patients would have qualified for 24 weeks therapy&#46; On the other hand&#44; a greater percentage of CHC G-1 patients would benefit from abbreviated therapy of 36 weeks using our novel criteria &#40;which is independent of the baseline viral load and RVR&#41;&#44; as 34-64&#37; patients are known to achieve cEVR in various trials&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="p0155" class="elsevierStylePara elsevierViewall">Ours is the first study which has evaluated the usefulness of HCV RNA level after 12 weeks of PEG-RBV therapy as a criterion for abbreviated &#40;36 weeks&#41; therapy in CHC G-1 patients&#46; Earlier data suggests the use of HCV RNA level after 12 weeks as a criterion for stoppage of treatment in CHC G-1 patients because of its high negative predictive value&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In patients with less than 2 log<span class="elsevierStyleInf">10</span> IU&#47;mL decrease in HCV RNA after 12 weeks&#44; treatment should be stopped at week 12&#44; as the SVR rate in these patients with standard treatment duration is less than 2&#37;&#46; In patients with delayed virological response &#40;DVR&#41; &#40;defined as a more than 2 log<span class="elsevierStyleInf">10</span> decline in HCV RNA concentration but a detectable HCV RNA level at week 12 and an undetectable HCV RNA level at week 24&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> treatment may be prolonged for 72 weeks&#46;</p><p id="p0160" class="elsevierStylePara elsevierViewall">In the present study&#44; we did not consider RVR as a criterion for offering a shorter duration &#40;36 weeks&#41; therapy to the patients&#46; In post-hoc analysis&#44; we found that although the SVR rates were lower in patients who did not achieve RVR compared to patients who did&#44; these were not significantly different among the 2 treatment groups&#46; Thus&#44; the shorter duration therapy was as effective as the standard 48 weeks therapy in patients who achieve cEVR&#44; irrespective of the RVR status&#46;</p><p id="p0165" class="elsevierStylePara elsevierViewall">On the basis of RVR and EVR&#44; we propose to classify the patient into 3 sub-groups&#46; First sub-group of patients who achieve RVR and cEVR can be called &#8216;quick responders&#8217;&#46; These patients had exceptionally good SVR rates &#40;93-100&#37;&#41; regardless of the treatment duration &#40;36 weeks or 48 weeks&#41;&#46; Therefore&#44; they should be treated for 36 weeks only&#44; while a further sub-group of these patients having LVL should be treated for 24 weeks only&#44; as supported by recent literature&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#8211;</span><a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The second sub-group of patients who do not achieve RVR but achieve cEVR can be called as &#8216;average responders&#8217;&#46; The SVR rate in these patients was about 70&#37;&#44; regardless of the treatment duration &#40;36 weeks or 48 weeks&#41;&#46; Therefore&#44; they are also eligible for abbreviated therapy&#44; as prolongation of therapy beyond 36 weeks did not increase the SVR rate&#46; Both these sub-groups have 25&#37; reduction in treatment cost and duration&#44; and also suffer from fewer adverse events&#46; The third subgroup of patients who do not achieve RVR or cEVR but have DVR can be labeled as &#8216;slow responders&#8217; and should be considered for prolonged therapy&#46; However&#44; we did not address this issue in our study&#46;</p><p id="p0170" class="elsevierStylePara elsevierViewall">Our study has few limitations&#46; First&#44; the pattern of IL28B polymorphisms was determined only in about half of the patients&#44; as its importance as a predictor of response to treatment emerged only recently&#44; when this trial was already underway&#46; So the effect of IL28B on SVR could not be determined&#46; Whether the pattern of IL28B polymorphism would affect the response rate of shorter duration therapy needs to be explored in future studies&#46; Second&#44; the total sample size in our study was relatively small&#46;</p><p id="p0175" class="elsevierStylePara elsevierViewall">To conclude&#44; our study suggests that HCV genotype 1 patients who achieve cEVR can be successfully treated with PEG-RBV therapy of 36 weeks duration without compromising the efficacy&#46; Important observation is that factors like viral load&#44; RVR&#44; age&#44; BMI and advanced fibrosis do not influence the SVR rates as is the case with 24 weeks therapy&#46; Therefore&#44; a larger proportion of patients would be eligible for abbreviated therapy using our criterion&#46; However&#44; our results need to be confirmed in larger controlled trials&#46;</p></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Abbreviations</span><p id="p0180" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0045"><span class="elsevierStyleLabel">&#8226;</span><p id="p0185" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">ALT&#58;</span> alanine aminotransferase&#46;</p></li><li class="elsevierStyleListItem" id="u0050"><span class="elsevierStyleLabel">&#8226;</span><p id="p0190" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">cEVR&#58;</span> complete early virological response&#46;</p></li><li class="elsevierStyleListItem" id="u0055"><span class="elsevierStyleLabel">&#8226;</span><p id="p0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">CHC&#58;</span> chronic hepatitis C&#46;</p></li><li class="elsevierStyleListItem" id="u0060"><span class="elsevierStyleLabel">&#8226;</span><p id="p0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">ETR&#58;</span> end-of-treatment response&#46;</p></li><li class="elsevierStyleListItem" id="u0065"><span class="elsevierStyleLabel">&#8226;</span><p id="p0205" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">G-1&#58;</span> genotype 1&#46;</p></li><li class="elsevierStyleListItem" id="u0070"><span class="elsevierStyleLabel">&#8226;</span><p id="p0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HCV&#58;</span> hepatitis C virus&#46;</p></li><li class="elsevierStyleListItem" id="u0075"><span class="elsevierStyleLabel">&#8226;</span><p id="p0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">LVL&#58;</span> low viral load&#46;</p></li><li class="elsevierStyleListItem" id="u0080"><span class="elsevierStyleLabel">&#8226;</span><p id="p0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">PEG-RBV&#58;</span> pegylated interferon plus ribavirin&#46;</p></li><li class="elsevierStyleListItem" id="u0085"><span class="elsevierStyleLabel">&#8226;</span><p id="p0225" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">PTI&#58;</span> prothrombin time index&#46;</p></li><li class="elsevierStyleListItem" id="u0090"><span class="elsevierStyleLabel">&#8226;</span><p id="p0230" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">RNA&#58;</span> ribo-nucleic acid&#46;</p></li><li class="elsevierStyleListItem" id="u0095"><span class="elsevierStyleLabel">&#8226;</span><p id="p0235" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">RVR&#58;</span> rapid virological response&#46;</p></li><li class="elsevierStyleListItem" id="u0100"><span class="elsevierStyleLabel">&#8226;</span><p id="p0240" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SVR&#58;</span> sustained virological response&#46;</p></li><li class="elsevierStyleListItem" id="u0105"><span class="elsevierStyleLabel">&#8226;</span><p id="p0245" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">TE&#58;</span> transient elastography&#46;</p></li></ul></p></span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Acknowledgements</span><p id="p0250" class="elsevierStylePara elsevierViewall">We acknowledge the help from Dr&#46; Jaskaran Sethi in data collection&#44; and Dr&#46; Suresh K&#46; Sharma in statistical analysis&#46;</p></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0055">Financial Support</span><p id="p0255" class="elsevierStylePara elsevierViewall">Department of Gastroenterology&#44; D&#46;M&#46;C&#46; and Hospital&#44; Ludhiana&#46;</p></span></span>"
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          "identificador" => "xres1206714"
          "titulo" => "Abstract"
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              "identificador" => "abs0010"
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          "identificador" => "xpalclavsec1123913"
          "titulo" => "Keywords"
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          "titulo" => "Introduction"
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          "titulo" => "Material and Methods"
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              "titulo" => "Study outcome measures and endpoints"
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              "titulo" => "Statistical analysis"
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        4 => array:2 [
          "identificador" => "s0025"
          "titulo" => "Results"
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          "titulo" => "Discussion"
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        6 => array:2 [
          "identificador" => "s0035"
          "titulo" => "Abbreviations"
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        7 => array:2 [
          "identificador" => "s0040"
          "titulo" => "Acknowledgements"
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        8 => array:2 [
          "identificador" => "s0045"
          "titulo" => "Financial Support"
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        9 => array:1 [
          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-03-06"
    "fechaAceptado" => "2014-04-22"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1123913"
          "palabras" => array:4 [
            0 => "Early virological response"
            1 => "Shorter therapy"
            2 => "Sustained virological response"
            3 => "Thirty-six weeks"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abs0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introduction&#46;</span> Standard treatment for patients with chronic hepatitis C genotype 1 &#40;CHC G-1&#41; infection includes pegylated interferon plus ribavirin &#40;PEG-RBV&#41; for 48 weeks&#46; Shorter treatment regimen would be more acceptable due to lower cost and fewer side-effects&#46; We aimed to compare the efficacy of 36 week PEG-RBV therapy with standard 48 week therapy in CHC G-1 patients who achieve complete early virological response &#40;cEVR&#41;&#46;</p><p id="sp1020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material and methods&#46;</span> Consecutive treatment-na&#239;ve patients with CHC G-1 were treated with pegylated interferon a2b &#40;1&#46;5 &#956;g&#47;kg&#47;week&#41; or &#945;2a &#40;180 &#956;g&#47;week&#41; and weight based ribavirin&#46; Patients who achieved cEVR at 12 weeks &#91;undetectable HCV RNA irrespective of RVR &#40;rapid virological response&#41;&#93; were randomized into- group A &#40;48 weeks therapy&#41; and group B &#40;36 weeks therapy&#41;&#46; Primary end-point was achievement of sustained virological response &#40;SVR&#41; at 24 weeks of follow up&#46;</p><p id="sp3020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#46;</span> Out of the total 166 patients started on treatment&#44; 112 &#40;69&#46;3&#37;&#41; achieved cEVR&#44; and were randomized into group A &#40;n &#61; 59&#41; and group B &#40;n &#61; 53&#41;&#46; Fifty-five &#40;93&#46;2&#37;&#41; patients in group A and 50 &#40;94&#46;3&#37;&#41; in group B completed therapy&#46; The overall SVR rate in group A was 79&#46;6&#37; &#40;47&#47;59&#41; and group B was 84&#46;9&#37; &#40;45&#47;53&#41; &#40;p &#61; 0&#46;622&#41;&#46; SVR rates in the two groups were comparable in all patient sub-groups according to factors like viral load &#40;&#8804; or &#62; 400&#44;000 IU&#47;mL&#41;&#44; RVR &#40;achieved&#47;not achieved&#41;&#44; age &#40;&#8804; or &#62; 40 years&#41;&#44; body mass index &#40;&#8804; or &#62; 27&#41; and cirrhosis &#40;present&#47;absent&#41;&#46;</p><p id="sp5020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusion&#46;</span> In CHC G-1 patients who achieve cEVR&#44; 36 weeks PEG-RBV therapy is as effective as standard 48 weeks therapy&#44; irrespective of other host or virological factors&#46;</p></span>"
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          "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Flow of patients in the study&#46; cEVR&#58; complete early virological response&#46; SVR&#58; sustained virological response&#46;</p>"
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        "tipo" => "MULTIMEDIATABLA"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Characteristics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group A &#40;48 week therapy&#41; n &#61; 59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group B &#40;36 week therapy&#41; n &#61; 53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;22-65&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;19-62&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;632&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Males&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#46;2&#37; &#40;42&#47;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#37; &#40;39&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;834&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;9 &#40;15&#46;1-33&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;6 &#40;14&#46;7-29&#46;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;712&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Viral load &#8805; 400&#44;000 IU&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;5&#37; &#40;41&#47;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#46;4&#37; &#40;41&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;397&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alcohol intake&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;6&#37; &#40;21&#47;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#46;5&#37; &#40;22&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;563&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Co-morbidities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;9&#37; &#40;7&#47;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;4&#37; &#40;5&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;766&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cirrhosis <a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#8224;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;1&#37; &#40;16&#47;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;5&#37; &#40;13&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;831&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Favorable IL28B genotype <a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;6&#37; &#40;10&#47;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#37; &#40;11&#47;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            1 => array:3 [
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              "etiqueta" => "&#8225;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Data available in 21 and 22 patients in group A and B respectively&#46; Favorable was CC genotype for rs12979860&#44; and TT for rs8099917&#46; BMI&#58; body mass index&#46;</p>"
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          "leyenda" => "<p id="np0005" class="elsevierStyleSimplePara elsevierViewall">Data are expressed as percentage &#40;number&#41;&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Factors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group A &#40;48 week therapy&#41; n &#61; 59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Group B &#40;36 week therapy&#41; n &#61; 53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8804; 40 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;8 &#40;31&#47;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;2 &#40;25&#47;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 40 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;7 &#40;16&#47;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;3 &#40;20&#47;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;484&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#46;9 &#40;34&#47;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#46;1 &#40;32&#47;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;5 &#40;13&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;9 &#40;13&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;345&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8804; 27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#46;5 &#40;28&#47;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#46;6 &#40;24&#47;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;724&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#62; 27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#46;4 &#40;19&#47;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#46;5 &#40;21&#47;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;182&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Advanced fibrosis&#47;cirrhosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;8 &#40;11&#47;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;9 &#40;10&#47;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;697&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;7 &#40;36&#47;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#46;5 &#40;35&#47;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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              "identificador" => "bib0005"
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                    0 => array:2 [
                      "titulo" => "Diagnosis&#44; management&#44; and treatment of hepatitis C&#58; an update"
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                          "colaboracion" => "American Association for the Study of Liver Diseases"
                          "etal" => false
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                            0 => "Ghany M&#46;G&#46;"
                            1 => "Strader D&#46;B&#46;"
                            2 => "Thomas D&#46;L&#46;"
                            3 => "Seeff L&#46;B&#46;"
                          ]
                        ]
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                    0 => array:2 [
                      "doi" => "10.1002/hep.22759"
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                        "tituloSerie" => "Hepatology"
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                        "volumen" => "49"
                        "paginaInicial" => "1335"
                        "paginaFinal" => "1374"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19330875"
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                          ]
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                      ]
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              "identificador" => "bib0010"
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                    0 => array:2 [
                      "titulo" => "EASL Clinical Practice Guidelines&#58; Management of hepatitis C virus infection"
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                        0 => array:2 [
                          "colaboracion" => "European Association for the Study of the Liver"
                          "etal" => false
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                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2013.11.003"
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                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2014"
                        "volumen" => "60"
                        "paginaInicial" => "392"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24331294"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peginterferon alpha2a and ribavirin combination therapy in chronic hepatitis C&#58; a randomized study of treatment duration and ribavirin dose"
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                        0 => array:2 [
                          "etal" => true
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                            2 => "Morgan T&#46;R&#46;"
                            3 => "Balan V&#46;"
                            4 => "Diago M&#46;"
                            5 => "Marcellin P&#46;"
                            6 => "Ramadori G&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2004"
                        "volumen" => "140"
                        "paginaInicial" => "346"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14996676"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
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                            6 => "Ferenci P&#46;"
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                      "doi" => "10.1002/hep.21159"
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                        "link" => array:1 [
                          0 => array:2 [
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                          "colaboracion" => "Austrian Hepatitis Study Group"
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                        "paginaInicial" => "451"
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                        "link" => array:1 [
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                        "paginaFinal" => "1269"
                        "link" => array:1 [
                          0 => array:2 [
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                          0 => array:2 [
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                      "doi" => "10.1016/s0140-6736(01)06102-5"
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                        "paginaFinal" => "965"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11583749"
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                ]
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                      "titulo" => "Peginterferon alfa-2a plus ribavirin for chronic hepatitis virus infection"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Fried M&#46;W&#46;"
                            1 => "Shiffman M&#46;L&#46;"
                            2 => "Reddy K&#46;R&#46;"
                            3 => "Smith C&#46;"
                            4 => "Marinos G&#46;"
                            5 => "Gon&#231;ales F&#46;L&#46; Jr"
                            6 => "H&#228;ussinger D&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "N Eng J Med"
                        "fecha" => "2002"
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                        "paginaInicial" => "975"
                        "paginaFinal" => "982"
                      ]
                    ]
                  ]
                ]
              ]
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            12 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Efficacy&#44; tolerability and safety in the treatment of chronic hepatitis C with combination of PEG-Interferon-Ribavirin in daily practice"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Ridruejo E&#46;"
                            1 => "Adrover R&#46;"
                            2 => "Cocozzella D&#46;"
                            3 => "Fern&#225;ndez N&#46;"
                            4 => "Reggiardo M&#46;V&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Hepatol"
                        "fecha" => "2010"
                        "volumen" => "9"
                        "paginaInicial" => "46"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20308722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Hepatitis C treatment outcomes in Australian clinics"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Gidding H&#46;F&#46;"
                            1 => "Law M&#46;G&#46;"
                            2 => "Amin J&#46;"
                            3 => "Ostapowicz G&#46;"
                            4 => "Weltman M&#46;"
                            5 => "Macdonald G&#46;A&#46;"
                            6 => "Sasadeusz J&#46;J&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med J Aust"
                        "fecha" => "2012"
                        "volumen" => "196"
                        "paginaInicial" => "633"
                        "paginaFinal" => "637"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22676878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Treatment of chronic hepatitis C with pegylated interferon and ribavirin in treatment-naive patients in &#8216;true life&#8217;&#58; a plea in favor of independent post marketing evaluations"
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                        0 => array:2 [
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                          "autores" => array:7 [
                            0 => "Pariente A&#46;"
                            1 => "Lahmek P&#46;"
                            2 => "Duprat C&#46;"
                            3 => "Denis J&#46;"
                            4 => "Faroux R&#46;"
                            5 => "Renou C&#46;"
                            6 => "Nalet B&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Gastroenterol Hepatol"
                        "fecha" => "2010"
                        "volumen" => "22"
                        "paginaInicial" => "1297"
                        "paginaFinal" => "1302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20964260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:1 [
                  "referenciaCompleta" => "Sood A&#44; Midha V&#44; Goyal O&#44; Hissar S&#44; Sharma SK&#44; Khanna P&#46; Treatment of Chronic Hepatitis C with Pegylated Interferon plus Ribavirin in treatment-naive &#8216;real-life&#8217; patients in India&#46; <span class="elsevierStyleItalic">Indian J Gastroenterol</span> 2014 Mar 12 &#91;Epub a head of print&#93;&#46;"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Zeuzem S&#46;"
                            1 => "Buti M&#46;"
                            2 => "Ferenci P&#46;"
                            3 => "Sperl J&#46;"
                            4 => "Horsmans Y&#46;"
                            5 => "Cianciara J&#46;"
                            6 => "Ibranyi E&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2005.10.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2006"
                        "volumen" => "44"
                        "paginaInicial" => "97"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16290907"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors associated with rapid and early virologic response to peginterferon alfa-2a&#47;ribavirin treatment in HCV genotype 1 patients representative of the general chronic hepatitis C population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Rodriguez-Torres M&#46;"
                            1 => "Sulkowski M&#46;S&#46;"
                            2 => "Chung R&#46;T&#46;"
                            3 => "Hamzeh F&#46;M&#46;"
                            4 => "Jensen D&#46;M&#46;"
                          ]
                        ]
                      ]
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                      "doi" => "10.1111/j.1365-2893.2009.01157.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Viral Hepat"
                        "fecha" => "2010"
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                        "paginaInicial" => "139"
                        "paginaFinal" => "147"
                        "link" => array:1 [
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Article information

ISSN: 16652681
Original language: English

DOI:10.1016/S1665-2681(19)31249-9

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Year/Month	Html	Pdf	Total

2024 November	3	1	4
2024 October	22	4	26
2024 September	14	6	20
2024 August	16	3	19
2024 July	14	2	16
2024 June	21	8	29
2024 May	15	8	23
2024 April	7	5	12
2024 March	7	4	11
2024 February	9	3	12
2024 January	4	4	8
2023 December	5	4	9
2023 November	2	8	10
2023 October	19	5	24
2023 September	8	1	9
2023 August	11	4	15
2023 July	3	3	6
2023 June	13	6	19
2023 May	44	7	51
2023 April	15	0	15
2023 March	7	1	8
2023 February	13	8	21
2023 January	16	9	25
2022 December	7	7	14
2022 November	8	16	24
2022 October	6	11	17
2022 September	4	6	10
2022 August	8	8	16
2022 July	5	6	11
2022 June	6	5	11
2022 May	9	5	14
2022 April	5	14	19
2022 March	6	7	13
2022 February	5	4	9
2022 January	13	2	15
2021 December	6	8	14
2021 November	20	8	28
2021 October	46	7	53
2021 September	23	9	32
2021 August	5	6	11
2021 July	9	6	15
2021 June	5	7	12
2021 May	6	8	14
2021 April	49	19	68
2021 March	8	3	11
2021 February	2	8	10
2021 January	7	8	15
2020 December	4	7	11
2020 November	1	5	6
2020 October	5	7	12
2020 September	7	3	10
2020 August	4	8	12
2020 July	3	6	9
2020 June	2	5	7
2020 May	2	4	6
2020 April	2	2	4
2020 March	5	0	5
2020 February	3	2	5
2020 January	3	1	4
2019 December	3	5	8
2019 November	5	2	7
2019 October	1	2	3
2019 September	3	0	3
2019 August	1	0	1
2019 July	1	3	4
2019 June	3	3	6

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