Cefuroxime axetil-induced liver failure
Fuat Ekiz
, O¿uz Üsküdar, Zahide Şimşek, Ilhami Yüksel, Ömer Başar, Akif Altinbaş, Osman Yüksel
Corresponding author
Diskapi Yildirim Beyazit Educational and Research Hospital, Department of Gastroenterology, Ankara, Turkey
Read
9078
Timeswas read the article
590
Total PDF
8488
Total HTML
Share statistics
array:24 [ "pii" => "S166526811931645X" "issn" => "16652681" "doi" => "10.1016/S1665-2681(19)31645-X" "estado" => "S300" "fechaPublicacion" => "2010-07-01" "aid" => "71331" "copyright" => "Fundación Clínica Médica Sur, A.C." "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2010;9:306" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 310 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 255 "PDF" => 43 ] ] "itemSiguiente" => array:19 [ "pii" => "S1665268119316461" "issn" => "16652681" "doi" => "10.1016/S1665-2681(19)31646-1" "estado" => "S300" "fechaPublicacion" => "2010-07-01" "aid" => "71332" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "nws" "cita" => "Ann Hepatol. 2010;9:307-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 71 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 28 "PDF" => 33 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Early warning of liver disease in diabetics" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "307" "paginaFinal" => "309" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Pablo Arab, Carolina Ramírez, Marco Arrese" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Juan" "apellidos" => "Pablo Arab" ] 1 => array:2 [ "nombre" => "Carolina" "apellidos" => "Ramírez" ] 2 => array:2 [ "nombre" => "Marco" "apellidos" => "Arrese" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119316461?idApp=UINPBA00004N" "url" => "/16652681/0000000900000003/v1_201906230902/S1665268119316461/v1_201906230902/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1665268119316448" "issn" => "16652681" "doi" => "10.1016/S1665-2681(19)31644-8" "estado" => "S300" "fechaPublicacion" => "2010-07-01" "aid" => "71330" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2010;9:305" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 73 "formatos" => array:3 [ "EPUB" => 15 "HTML" => 27 "PDF" => 31 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "A rare case of recurrent prolonged hepatotoxicity due to ornidazole" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "305" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bariş Yilmaz, Fuat Ekiz, Ilhami Yüksel, Akif Altinbas, Murat Deveci, Osman Yüksel" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Bariş" "apellidos" => "Yilmaz" ] 1 => array:2 [ "nombre" => "Fuat" "apellidos" => "Ekiz" ] 2 => array:2 [ "nombre" => "Ilhami" "apellidos" => "Yüksel" ] 3 => array:2 [ "nombre" => "Akif" "apellidos" => "Altinbas" ] 4 => array:2 [ "nombre" => "Murat" "apellidos" => "Deveci" ] 5 => array:2 [ "nombre" => "Osman" "apellidos" => "Yüksel" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119316448?idApp=UINPBA00004N" "url" => "/16652681/0000000900000003/v1_201906230902/S1665268119316448/v1_201906230902/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Cefuroxime axetil-induced liver failure" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "306" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Fuat Ekiz, O¿uz Üsküdar, Zahide Şimşek, Ilhami Yüksel, Ömer Başar, Akif Altinbaş, Osman Yüksel" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Fuat" "apellidos" => "Ekiz" "email" => array:1 [ 0 => "dr_ekiz@yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "O¿uz" "apellidos" => "Üsküdar" ] 2 => array:2 [ "nombre" => "Zahide" "apellidos" => "Şimşek" ] 3 => array:2 [ "nombre" => "Ilhami" "apellidos" => "Yüksel" ] 4 => array:2 [ "nombre" => "Ömer" "apellidos" => "Başar" ] 5 => array:2 [ "nombre" => "Akif" "apellidos" => "Altinbaş" ] 6 => array:2 [ "nombre" => "Osman" "apellidos" => "Yüksel" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Diskapi Yildirim Beyazit Educational and Research Hospital, Department of Gastroenterology, Ankara, Turkey" "identificador" => "aff1" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence and reprint request:" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="p0005" class="elsevierStylePara elsevierViewall">Cefuroxime is a second-generation cephalosporin antibiotic. It is effective against susceptible bacteria causing infections of the middle ear, tonsillitis, throat infections, laryngitis, bronchitis, and pneumonia. It is also used in treating urinary tract infections, skin infections, and gonorrhea. It is a generally well tolerated antibiotic. Common adverse effects of cefuroxime axetil are diarrhea, nausea, vomiting, headaches/migraines, dizziness and abdominal pain.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In the literature, only two cases were reported that cefuroxime axetil associated cholestha-tic hepatitis and ischemic hepatitis.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> There have been no published reports of liver failure associated with cefuroxime axetil. Herein we presented a patient who developed liver failure associated with ce-furoxime axetil use.</p><p id="p0010" class="elsevierStylePara elsevierViewall">A 60-year-old female patient was admitted to our hospital with a four-day history of jaundice and vomiting. Her past medical history revealed an upper respiratory infection treated with a 10-day course of oral cefuroxime axetil 500 mg twice a day. The patient has completed the treatment four days prior to presentation. She denied alcohol use and was not taking any prescription or herbal medications. There was no history of sexually transmitted diseases. She had no relevant family and travel history. Physical examination was remarkable for scleral icterus and jaundice. Laboratory tests were performed, total bi-lirubin: 25, 6 mg/dL, conjugated bilirubin: 17, 9 mg/ dL, ALT: 1527 IU/mL, AST: 1348 IU/mL, ALP: 1006 IU/mL, and GGT: 381 IU/mL. On admission, international normalized ratio (INR) was normal but increased to 1.9 six days after admission and total bilirubin increased up to 30 mg/dL and conjugated bilirubin to 20 mg/dL, while AST and ALT levels normalized. Other biochemical tests were normal. Serological markers for acute viral hepatitis were negative for anti hepatitis A IgM, anti-hepatitis B core IgM, CMV, EBV, herpes simplex viruses and hepatitis B surface antigen. Hepatitis C and HIV antibodies were negative. HBV-DNA and HCV RNA were negative. Liver ultrasound was normal. Autoimmune hepatitis markers including antinuclear antibody and smooth muscle antibody were negative with normal serum immunoglobulin levels. MELD score increased to 26 and patient was discussed about liver transplantation. Ursodeoxycolic acid (UDCA) was initiated two weeks after initial presentation. Within seven weeks from admission, her symptoms didn’t resolve, the bilirubin levels and INR didn’t return to normal range. She was transferred to liver transplantation center. After ten weeks later from admittance the patient recovered and laboratory parameters returned to normal.</p><p id="p0015" class="elsevierStylePara elsevierViewall">There are only a few case reports implicating other cephalosporins as the cause of hepatotoxicity in adults.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Even though, cholestatic type toxicity and ischemic hepatitis were reported before, to our knowledge, our case is first presentation of liver failure with cefuroxime axetil. In conclusion, physicians should be aware of hepatotoxicity due to cefuroxime axetil since it is a widespread used anti-biotic.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-10-11" "fechaAceptado" => "2010-01-11" "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cefuroxime axetil: an updated review of its use in the management of bacterial infections" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Scott L.J." 1 => "Ormrod D." 2 => "Goa K.L." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/00003495-200161100-00008" "Revista" => array:6 [ "tituloSerie" => "Drugs" "fecha" => "2001" "volumen" => "61" "paginaInicial" => "1455" "paginaFinal" => "1500" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11558834" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cho-lestatic attack due to ampicillin and cross-reactivity to cefuroxime" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Köklü S." 1 => "Yüksel O." 2 => "Yolcu O.F." 3 => "Arhan M." 4 => "Altiparmak E." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1345/aph.1E025" "Revista" => array:7 [ "tituloSerie" => "Ann Pharmacother" "fecha" => "2004" "volumen" => "38" "numero" => "9" "paginaInicial" => "1539" "paginaFinal" => "1540" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15266040" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ischemic hepatitis associated with toxic epidermal necrolysis in a ci-rrhotic patient treated with cefuroxime" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Yossepowitch O." 1 => "Amir G." 2 => "Safadi R." 3 => "Lossos I." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur J Med Res" "fecha" => "1997" "volumen" => "2" "numero" => "4" "paginaInicial" => "182" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9110927" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A rare case of hepatitis associated with cefprozil therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Bilici A." 1 => "Karaduman M." 2 => "Cankir Z." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00365540600823235" "Revista" => array:6 [ "tituloSerie" => "Scand J Infect Dis" "fecha" => "2007" "volumen" => "39" "paginaInicial" => "190" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17366046" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/0000000900000003/v1_201906230902/S166526811931645X/v1_201906230902/en/main.assets" "Apartado" => array:4 [ "identificador" => "77940" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letter to Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/16652681/0000000900000003/v1_201906230902/S166526811931645X/v1_201906230902/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S166526811931645X?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 33 | 5 | 38 |
| 2024 October | 278 | 20 | 298 |
| 2024 September | 287 | 20 | 307 |
| 2024 August | 243 | 17 | 260 |
| 2024 July | 222 | 13 | 235 |
| 2024 June | 185 | 9 | 194 |
| 2024 May | 165 | 17 | 182 |
| 2024 April | 186 | 9 | 195 |
| 2024 March | 169 | 13 | 182 |
| 2024 February | 237 | 31 | 268 |
| 2024 January | 243 | 11 | 254 |
| 2023 December | 184 | 7 | 191 |
| 2023 November | 213 | 19 | 232 |
| 2023 October | 264 | 9 | 273 |
| 2023 September | 215 | 2 | 217 |
| 2023 August | 176 | 4 | 180 |
| 2023 July | 206 | 6 | 212 |
| 2023 June | 211 | 6 | 217 |
| 2023 May | 242 | 5 | 247 |
| 2023 April | 182 | 4 | 186 |
| 2023 March | 213 | 3 | 216 |
| 2023 February | 152 | 7 | 159 |
| 2023 January | 162 | 2 | 164 |
| 2022 December | 111 | 3 | 114 |
| 2022 November | 128 | 4 | 132 |
| 2022 October | 136 | 10 | 146 |
| 2022 September | 149 | 12 | 161 |
| 2022 August | 123 | 16 | 139 |
| 2022 July | 101 | 13 | 114 |
| 2022 June | 46 | 6 | 52 |
| 2022 May | 79 | 8 | 87 |
| 2022 April | 179 | 13 | 192 |
| 2022 March | 193 | 11 | 204 |
| 2022 February | 162 | 6 | 168 |
| 2022 January | 193 | 8 | 201 |
| 2021 December | 142 | 10 | 152 |
| 2021 November | 88 | 8 | 96 |
| 2021 October | 79 | 10 | 89 |
| 2021 September | 103 | 11 | 114 |
| 2021 August | 108 | 8 | 116 |
| 2021 July | 95 | 5 | 100 |
| 2021 June | 96 | 9 | 105 |
| 2021 May | 88 | 5 | 93 |
| 2021 April | 228 | 22 | 250 |
| 2021 March | 99 | 6 | 105 |
| 2021 February | 71 | 13 | 84 |
| 2021 January | 70 | 17 | 87 |
| 2020 December | 78 | 9 | 87 |
| 2020 November | 88 | 16 | 104 |
| 2020 October | 49 | 13 | 62 |
| 2020 September | 75 | 8 | 83 |
| 2020 August | 70 | 5 | 75 |
| 2020 July | 49 | 5 | 54 |
| 2020 June | 44 | 3 | 47 |
| 2020 May | 58 | 8 | 66 |
| 2020 April | 62 | 4 | 66 |
| 2020 March | 84 | 2 | 86 |
| 2020 February | 80 | 8 | 88 |
| 2020 January | 70 | 1 | 71 |
| 2019 December | 46 | 10 | 56 |
| 2019 November | 34 | 2 | 36 |
| 2019 October | 33 | 4 | 37 |
| 2019 September | 26 | 3 | 29 |
| 2019 August | 2 | 2 | 4 |
| 2019 July | 2 | 10 | 12 |
| 2019 June | 3 | 4 | 7 |
Show all
