Statistics

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      "titulo" => "Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD)"
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    "titulo" => "Non alcoholic fatty liver disease"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="p0005" class="elsevierStylePara elsevierViewall">Non alcoholic fatty liver disease &#40;NAFLD&#41; is highly prevalent in Western countries as well as in some Latin American countries such as Brazil&#44; Chile and Mexico&#46; In fact&#44; it has been estimated that the prevalence of NAFLD ranged from 17 to 33&#37; in the general population of Western countries&#46;</p><p id="p0010" class="elsevierStylePara elsevierViewall">Besides&#44; it has been identified some ethnic differences in the epidemiology of NAFLD&#46; For example&#44; the prevalence of steatosis in United States&#44; assessed by magnetic resonance spectroscopy&#44; was highest in Hispanics &#40;45&#37;&#41;&#44; followed by whites &#40;33&#37;&#41;&#44; and African Americans &#40;24&#37;&#41;&#46; Interestingly&#44; the genetic variants contributing to differences in hepatic fat content have been identified in a recent study carried-out in a genome-wide association scan of nonsynonymous sequence variations&#46; This investigation found an allele in PNPLA3 &#40;rs738409&#91;G&#93;&#44; encoding I148M&#41; that was strongly associated with increased hepatic fat levels and with hepatic inflammation&#46; The allele was most common in Hispanics&#44; the group most susceptible to NAFLD&#46; This information clearly emphasizes the importance of NAFLD in this population&#46;</p><p id="p0015" class="elsevierStylePara elsevierViewall">On the other hand&#44; currently NAFLD is a recognized as a condition that ranges from simple steatosis to steatohepatitis &#40;NASH&#41;&#46; NASH is a more severe form of NAFLD in which fatty infiltration of the liver is accompanied by necroinflammatory activity&#44; and is now recognized as one of the most common cause of chronic liver disease&#46; The occurrence of NASH is clinically important as approximately 15&#8211;25&#37; of these patients will progress to cirrhosis&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">In this supplement the epidemiology&#44; pathophysiology&#44; diagnosis&#44; treatment as well as other comor-bidities of NAFLD are carefully reviewed by some experimented researches in this field&#46;</p><p id="p0025" class="elsevierStylePara elsevierViewall">I am delighted to present the edition of the Symposium on Non-Alcoholic Fatty Liver Disease held at Medica Sur Clinic &#38; Foundation in Mexico City in October 3&#44; 2008&#46; I hope you will enjoy this thorough update of current knowledge in the field&#46;</p></span>"
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