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Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD)
Stefano Bellentani1,
Corresponding author
, Mariano Marino1
1 Azienda USL di Modena – Liver and Nutrition Centre – “Ramazzini” Hospital Carpi, Modena, Italy
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015"><span class="elsevierStyleBold">Definition of NAFLD</span></span><p id="p0005" class="elsevierStylePara elsevierViewall">The term NAFLD is used to describe a condition of fat accumulation in the liver in the absence of excessive alcohol consumption &#40;less than 20 g per day&#41; and any other specific causes of hepatic steatosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the majority of the cases NAFLD is of primary origin and its aetiology is not yet completely understood&#44; even if it is strictly related to the presence of insulin resistance&#44; and thus frequently occurs as the initial part of the metabolic syndrome &#40;MS&#41;&#44; and accompany obesity&#44; type 2 diabetes and dyslipidaemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Among the secondary causes of NAFLD there are relevant causes&#44; such as nutritional &#40;e&#46;g&#46; malnutrition&#44; rapid weight loss&#41;&#44; metabolic &#40;e&#46;g&#46; abetali-poproteinemia&#44; lipodystrophy&#41; and drug-induced &#40;e&#46;g&#46; glucocorticoids&#44; methotrexate&#44; chemotherapics&#44; tamox-ifene&#44; etc&#46;&#41;&#44; as well as other conditions &#40;e&#46;g&#46; jejunal diver-ticulitis with bacterial overgrowth&#44; inflammatory bowel disease&#44; occupational exposure&#41;&#46; In this review we are focusing our attention only to the epidemiology and natural history of primary NAFLD&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020"><span class="elsevierStyleBold">Prevalence of NAFLD</span></span><p id="p0010" class="elsevierStylePara elsevierViewall">NAFLD is now the most common liver disease in the United States and possibly worldwide&#46; Furthermore&#44; the number of affected patients is growing rapidly&#44; and the disease has reached epidemic proportions&#46; However&#44; the true prevalence of NAFLD and Nonalcoholic-Steatohep-atitis &#40;NASH&#41;&#44; and their natural history remains incompletely deuned&#46; Furthermore&#44; there are no data on the change in prevalence of NAFLD within a population over time&#44; and there are no data on incidence of NAFLD&#46; The reported prevalence of NAFLD varies according to the population studied&#44; and the diagnostic criteria used&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Usually population-based studies provide better estimates of the prevalence of NAFLD in the general population compared with autopsy studies&#44; hospital series or studies performed exclusively in obese populations&#44; but few such studies have been reported to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> However&#44; the diagnosis of NAFLD within the population studies are usually made by ultrasonography &#40;US&#41;&#44; that allows detecting moderate and severe steatosis with a fair sensitivity and specificity only when fat on liver biopsy exceeds 33&#37;&#46; More sensitive techniques&#44; including MR imaging and spectroscopy&#44; are hindered by expense and lack of feasibility in large populations&#46; The American Association for the Study of Liver Diseases &#40;AASLD&#41; set the limit for the diagnosis of NAFLD at fat accumulation in the liver of at least 5 to 10&#37; by weight&#46; Therefore&#44; liver biopsy is still considered as the gold standard&#44; but is limited by sampling and interpretation error besides its cost and not applicability in population-based studies for both ethical and practical reasons&#46;</p><p id="p0015" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#t0005"><span class="elsevierStyleItalic">Table I</span></a> summarizes the results of several studies on the prevalence of NAFLD&#47;NAS H&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> Proton MR spectro-scopy and <span class="elsevierStyleSup">1</span>H-MRS are considered the most accurate non-invasive methods for measuring liver fat&#44; but again unpractical and too expensive to be applied on a large scale&#46; Recently both the Dallas Heart Study &#40;a population-based cohort study performed in an ethnically diverse community in the USA&#41; and our Dionysos study &#40;a population-based cohort study performed in 2 community of Northern of Italy&#41; reported that 30&#37; of adult Americans and 25&#37; of adult Italians have NAFLD&#46; This indicates that over 70 million adult Americans and 15 million adult Italians suffer from NAFLD&#46; In that studies 79 and 55&#37; of patients with NAFLD had normal aminotransferase levels&#44; suggesting that studies using liver enzymes as a surrogate for NAFLD highly underestimate the prevalence of NAFLD&#46;</p><elsevierMultimedia ident="t0005"></elsevierMultimedia><p id="p0020" class="elsevierStylePara elsevierViewall">NAFLD has also reached epidemic proportions among populations typically considered at &#8216;&#8216;low risk&#8217;&#8217; for this liver condition&#44; with a prevalence in China and Japan of 15 and 14&#37;&#44; respectively&#44; among adults&#46; The clinical implications of this alarming prevalence of NAFLD are derived from the fact that this liver condition may progress to endstage liver disease and liver cancer&#46; The prevalence of NAFLD among children is unknown&#44; but some data indicate that 2&#46;6-9&#46;6&#37; of children have NAFLD&#44; increasing up to 38-53&#37; among obese children <a class="elsevierStyleCrossRef" href="#t0005"><span class="elsevierStyleItalic">&#40;Table I&#41;&#46;</span></a></p><p id="p0025" class="elsevierStylePara elsevierViewall">NAFLD is more frequent among obese subjects &#40;75&#37;&#41; compared to controls &#40;16&#37;&#41;&#44; and among patients with type 2 diabetes &#40;34-74&#37;&#41;&#44; whereas it is an almost universal finding in obese patients with type 2 diabetes&#46; The prevalence of NAFLD is also more prevalent in Hispanics and Asian-Indians than in white Americans or Black&#44; and it is normally increasing with age&#46; Recent data indicate a doubling of the prevalence in children&#58; from 2&#46;6&#37; a decade ago to 5&#37; today in normal-weight&#44; and 38&#37; or 48&#37; in obese and diabetic children respectively&#46; All these prevalences makes NAFLD the most common chronic liver disease in the Western societies&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025"><span class="elsevierStyleBold">Natural history&#44; mortality and incidence of NAFLD</span></span><p id="p0030" class="elsevierStylePara elsevierViewall">Data on natural history and mortality of NAFLD&#47; NASH are contradictory and the study available in the literature are not conclusive&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> NAFLD progresses slowly to NASH and cirrhosis or HCC over many years or decades&#44; therefore the natural history is difficult to measure in short-time interval&#46; Patients with simple&#44; bland steatosis seem to have a more benign prognosis&#46; For instance&#44; a Danish study by Dam-Larsen and co-workers<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> of a cohort of 109 predominantly morbidly obese subjects&#44; followed for nearly 17 years&#44; found the incidence of cirrhosis to be less than 1&#37;&#44; and during the follow-up the mortality of people with fatty liver did not differ from the general population mortality&#46; Conversely&#44; patients with cryptogenic cirrhosis due to NASH have a worse prognosis&#44; as demonstrated in some recent studies where 9-26&#37; of patients died within 4-10 years of follow-up&#44; with most causes of death related to end-stage liver disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">66</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a> Using a community-based sample&#44; Adams et al&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a> demonstrated a lower survival among persons with NAFLD compared to the general population&#46; In a different study&#44; Ekstedt et al&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">68</span></a> showed that persons with NAFLD&#44; in particular those with the subtype of NASH&#44; had a reduced survival when compared with a matched reference population&#46; Both these studies however may not necessarily reflect the general population&#46; In the Dionysos cohort&#44; after 8&#46;5 years of follow up&#44; we found that people with alcohol use or abuse remains still the main risk factor for progression of fatty liver to end-stage liver disease&#46;<span class="elsevierStyleSup">23&#44;69</span> The last study available&#44; published by Ong et al&#46;<span class="elsevierStyleSup">70</span> that used the NHANES III data-base&#44; showed that persons with NAFLD have a higher likelihood of dying of a liver-related complication compared to those without NAFLD or liver disease&#46; This risk was independent of obesity or the presence of diabetes mellitus&#44; the latter being associated with higher rates of liver-related deaths&#46; However&#44; a great limitation of this study is the use of elevated serum aminotransferases as a marker of NAFLD&#44; which underestimates the true prevalence of NAFLD of more than 50&#37;&#44; as already reported above&#46;</p><p id="p0035" class="elsevierStylePara elsevierViewall">Among the various causes of death in people with NAFLD&#44; cardiovascular disease and malignancy seems to be the most important causes as found by Ong et al&#46;&#44;<span class="elsevierStyleSup">70</span> but also by others previously published cohort studies&#46; For this reason&#44; NAFLD is now believed to be the hepatic manifestation of the metabolic syndrome&#44; and an independent predictor of cardiovascular morbidity and mortality&#46;</p><p id="p0040" class="elsevierStylePara elsevierViewall">Overall&#44; a diagnosis of NAFLD is associated with a shorter survival than expected for the general population of the same age and gender&#44; and the higher mortality is mainly due to cardiovascular disease &#40;CVD&#41;&#46; A strong association between elevated levels of serum liver enzymes and increased CVD risk has also been reported by numerous population-based studies&#44; such as the Hoorn Study&#44; the Framingham Heart Study and the Valpolicella Heart Diabetes Study&#44;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">71</span></a><span class="elsevierStyleSup">-</span><a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a> where mildly elevated levels of liver enzymes were independently associated with an increased CVD mortality rate in both sexes&#44; independently of traditional risk factors and components of the metabolic syndrome&#46;</p><p id="p0045" class="elsevierStylePara elsevierViewall">Long-term data that clearly show that NAFLD progress to end-stage liver disease are lacking&#44; even if some short-term data suggest that NAFLD underlies a substantial proportion of cases of cryptogenic cirrho-sis<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">74</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">75</span></a> of patients with cryptogenic cirrhosis&#44; 50-73&#37; are obese or suffer from diabetes&#46; Further&#44; the presence of NAFLD increases disease severity and progression in oth-erliver diseases including chronic hepatitis C infection&#44; alcoholic liver disease and hemochromatosis&#46;</p><p id="p0050" class="elsevierStylePara elsevierViewall">The incidence of NAFLD remains unknown because no prospective studies have been conducted&#46; The only data available are the one referring to the incidence of fatty liver &#40;FL&#41; in the Dionysos cohort&#44; where we found that FL regressed in nearly 1 of every 2 cases and had a substantially benign course&#44; and ethanol intake was the most important risk factor for FL remission and inci-dence&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">76</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">77</span></a> The incidence and remission rates of FL after 8&#46;5 years of follow up in the Dionysos cohort were 18&#46;5 and 55&#46;0 per 1&#44;000 person-years&#59; every increase of 20 g&#47; day of ethanol intake at baseline was associated with a 17&#37; increase in the rate of incident FL&#46;<span class="elsevierStyleSup">76</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030"><span class="elsevierStyleBold">Conclusions</span></span><p id="p0055" class="elsevierStylePara elsevierViewall">NAFLD has become a common diagnosis in clinical practice of several medical specialties&#44; and its prevalence in the general population is increasing together with obesity&#44; type 2 diabetes and the metabolic syndrome&#46; Bland steatosis remains stable for a number of years and will probably never progress in many cases&#46; On the contrary in those patients with NASH&#44; whose disease progresses to advanced fibrosis and cirrhosis&#44; most liver and hearth-related morbidity and mortality are observed&#46; Prospective studies with long-term follow-up are necessary to better define the natural history of NAFLD and its incidence both in the general populations and in speciuc groups&#46; Genetic studies are also necessary to determine to what extent the genetic background predisposes to NAFLD development and progression to advanced liver disease&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">The authors summarize and update the most recent knowledge in the field of prevalence&#44; natural history and incidence of Non Alcoholic Fatty Liver Disease &#40;NAFLD&#41; and Non Alcoholic Steatohepatitis &#40;NASH&#41;&#46; These novel diseases&#44; firstly recognized at the beginning of the second millennium&#44; arose suddenly to the attention of the clinicians&#44; because they are the hepatic expression of the &#8220;so-called&#8221; metabolic syndrome&#46; Due to the epidemic burden of obesity&#44; diabetes&#44; and metabolic diseases&#44; NAFLD and NASH will become soon probably the most common hepatic disease worldwide&#44; and they surely will keep busy our future young hepa-tologists&#46;</p></span>"
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        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">Author &#40;year&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Diagnostic method&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Country&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">NAFLD P &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">NASH P &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Nomura &#40;1988&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Population-based&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">El-Hassan &#40;1992&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Outpatients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&#44; CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Saudi Arabia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Tominaga &#40;1995&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Health evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">3 &#40;children&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Franzese &#40;1997&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Outpatients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">53 &#40;obese children&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Lonardo &#40;1997&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Outpatients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Araujo &#40;1998&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Outpatients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">33&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Bellentani &#40;2000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Population-based&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">16 &#40;Lean&#41;76 &#40;Obese&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Omagari &#40;2002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Outpatients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Bedogni &#40;2005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Population-based&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Fan &#40;2005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Population-based&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">China&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Jimba &#40;2005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Health evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Hamaguchi &#40;2005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Health evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Park &#40;2006&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Health evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Ultrasonography&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">South Korea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Browning &#40;2004&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Population-based&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">MR spectroscopy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Patt &#40;2003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Health evaluation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Aminotransferase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">14-21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Clark &#40;2003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Population-based&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Aminotransferases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">5&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Ruhl &#40;2003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Population-based&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Aminotransferases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">2&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Hultcrantz &#40;1986&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Hospital series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Sweden&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Lee &#40;1989&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Hospital series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Nonomura &#40;1992&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Hospital series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Byron &#40;1996&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Hospital series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Daniel &#40;1999&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Hospital series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Berasain &#40;2000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Hospital series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Spain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Hilden &#40;1977&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Autopsy series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Sweden&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Ground &#40;1982&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Autopsy series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Wanless &#40;1990&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Autopsy series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Canada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Schwimmer &#40;2006&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Autopsy series&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">9&#46;6 &#40;children&#41;38 &#40;obese&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Luyckx &#40;1998&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Bariatric surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Belgium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Silverman &#40;1990&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Bariatric surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Dixon &#40;2001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Bariatric surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Australia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Beymer &#40;2003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Bariatric surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="middle">Spaulding &#40;2003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Bariatric surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">Liver biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="middle">88&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="middle">56&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="middle">Mathurin &#40;2006&#41;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Prevalence &#40;&#61;P&#41; of Nonalcoholic Liver Disease &#40;NAFLD&#41; and Nonalcoholic Steatohepatitis &#40;NASH&#41; according to different type of studies&#46; ND&#61; not determined&#46; See reference from 12 to 44&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bs0005"
          "bibliografiaReferencia" => array:77 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic steatohepatitis&#46; Mayo Clinic experiences with a hitherto unnamed disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Ludwig J"
                            1 => "Viggiano T"
                            2 => "McGill D"
                            3 => "Ott B&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1980"
                        "volumen" => "55"
                        "paginaInicial" => "434"
                        "paginaFinal" => "438"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7382552"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic steatohepatitis&#58; an expanded clinical entity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Bacon B&#46;R&#46;"
                            1 => "Farahvash M&#46;J&#46;"
                            2 => "Janney C&#46;G&#46;"
                            3 => "Neuschwander-Tetri BA&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "1994"
                        "volumen" => "107"
                        "paginaInicial" => "1103"
                        "paginaFinal" => "1109"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7523217"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of chronic liver disease in the general population of northern Italy&#58; the Dionysos Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Bellentani S"
                            1 => "Tiribelli C"
                            2 => "Saccoccio G"
                            3 => "Sodde M"
                            4 => "Fratti N"
                            5 => "De Martin C"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "1994"
                        "volumen" => "20"
                        "paginaInicial" => "1442"
                        "paginaFinal" => "1449"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7982643"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease&#58; a spectrum of clinical and pathological severity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Matteoni C&#46;A&#46;"
                            1 => "Younossi Z&#46;M&#46;"
                            2 => "Gramlich T"
                            3 => "Boparai N"
                            4 => "Liu Y&#46;C&#46;"
                            5 => "McCullough AJ&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "1413"
                        "paginaFinal" => "1419"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10348825"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic steatohepatitis&#58; summary of an AASLD single topic conference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Neuschwander-Tetri B&#46;A&#46;"
                            1 => "Caldwell SH&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jhep.2003.50193"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2003"
                        "volumen" => "37"
                        "paginaInicial" => "1202"
                        "paginaFinal" => "1219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12717402"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Angulo P&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra011775"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2002"
                        "volumen" => "346"
                        "paginaInicial" => "1221"
                        "paginaFinal" => "1231"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11961152"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical features&#44; diagnosis and natural history of nonalcoholic fatty liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "McCullough AJ&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cld.2004.04.004"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Liver Dis"
                        "fecha" => "2004"
                        "volumen" => "8"
                        "numero" => "3"
                        "paginaInicial" => "521"
                        "paginaFinal" => "533"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15331061"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The metabolic syndrome as a predictor of nonalcoholic fatty liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Hamaguchi M"
                            1 => "Kojima T"
                            2 => "Takeda N"
                            3 => "Nakagawa T"
                            4 => "Taniguchi H"
                            5 => "Fujii K"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-143-10-200511150-00009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2005"
                        "volumen" => "143"
                        "paginaInicial" => "722"
                        "paginaFinal" => "728"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16287793"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Angulo P&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Gastroenterol Mex"
                        "fecha" => "2005"
                        "volumen" => "70"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "52"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17471859"
                            "web" => "Medline"
                          ]
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                ]
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            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
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                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease&#58; predisposing factors and the role of nutrition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Cave M"
                            1 => "Deaciuc I"
                            2 => "Mendez C"
                            3 => "Song Z"
                            4 => "Joshi-Barve S"
                            5 => "Barve S"
                            6 => "McClain C&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jnutbio.2006.12.006"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Nutr Biochem"
                        "fecha" => "2007"
                        "volumen" => "18"
                        "numero" => "3"
                        "paginaInicial" => "184"
                        "paginaFinal" => "195"
                        "link" => array:1 [
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                    0 => array:2 [
                      "titulo" => "The obesity epidemic and nonalcoholic fatty liver disease in children"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "Dunn W"
                            1 => "Schwimmer JB&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:8 [
                        "tituloSerie" => "Curr Gastroenterol Rep"
                        "fecha" => "2008"
                        "volumen" => "10"
                        "numero" => "1"
                        "paginaInicial" => "67"
                        "paginaFinal" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18417045"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0161642015003061"
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                          "autores" => array:2 [
                            0 => "Adams L&#46;A&#46;"
                            1 => "Lindor KD&#46;"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.annepidem.2007.05.013"
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                        "tituloSerie" => "Ann Epidemiol"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "numero" => "11"
                        "paginaInicial" => "863"
                        "paginaFinal" => "869"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17728149"
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                          ]
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                ]
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              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and natural history of NAFLD and NASH"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Ong J&#46;P&#46;"
                            1 => "Younossi ZM&#46;"
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                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.cld.2007.02.009"
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                        "tituloSerie" => "Clin Liver Dis"
                        "fecha" => "2007"
                        "volumen" => "11"
                        "numero" => "1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "16 vii&#46;"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17544968"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GI epidemiology&#58; nonalcoholic fatty liver disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Angulo P&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2036.2007.03246.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aliment Pharmacol Ther"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "numero" => "8"
                        "paginaInicial" => "883"
                        "paginaFinal" => "889"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17402991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of fatty liver in a general population of Okinawa&#44; Japan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Nomura H"
                            1 => "Kashiwagi S"
                            2 => "Hayashi J"
                            3 => "Kajiyama W"
                            4 => "Tani S"
                            5 => "Goto M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Jpn J Med"
                        "fecha" => "1988"
                        "volumen" => "27"
                        "paginaInicial" => "521"
                        "paginaFinal" => "528"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fatty infiltration of the liver&#58; analysis of prevalence&#44; radiological and clinical features and influence on patient management"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "Ibrahim E&#46;M&#46;"
                            2 => "al-Mulhim F&#46;A&#46;"
                            3 => "Nabhan A&#46;A&#46;"
                            4 => "Chammas MY&#46;"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1259/0007-1285-65-777-774"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Radiol"
                        "fecha" => "1992"
                        "volumen" => "65"
                        "numero" => "777"
                        "paginaInicial" => "774"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1393413"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of fatty liver in Japanese children and relationship to obesity&#46; An epidemiological ultrasonographic survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Tominaga K"
                            1 => "Kurata J&#46;H&#46;"
                            2 => "Chen Y&#46;K&#46;"
                            3 => "Fujimoto E"
                            4 => "Miyagawa S"
                            5 => "Abe I"
                            6 => "Kusano Y&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "1995"
                        "volumen" => "40"
                        "numero" => "9"
                        "paginaInicial" => "2002"
                        "paginaFinal" => "2009"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7555456"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Liver involvement in obese children&#46; Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "Franzese A"
                            1 => "Vajro P"
                            2 => "Argenziano A"
                            3 => "Puzziello A"
                            4 => "Iannucci M&#46;P&#46;"
                            5 => "Saviano M&#46;C&#46;"
                            6 => "Brunetti F"
                            7 => "Rubino A&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "1997"
                        "volumen" => "42"
                        "numero" => "7"
                        "paginaInicial" => "1428"
                        "paginaFinal" => "1432"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9246041"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The bright liver syndrome&#46; Prevalence and determinants of a &#8220;bright&#8221; liver echopattern"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Lonardo A"
                            1 => "Bellini M"
                            2 => "Tartoni P"
                            3 => "Tondelli E&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ital J Gastroenterol Hepatol"
                        "fecha" => "1997"
                        "volumen" => "29"
                        "numero" => "4"
                        "paginaInicial" => "351"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9476190"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Liver and biliary ultrasonography in diabetic and non-diabetic obese women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Araujo L&#46;M&#46;"
                            1 => "De Oliveira D&#46;A&#46;"
                            2 => "Nunes DS&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetes Metab"
                        "fecha" => "1998"
                        "volumen" => "24"
                        "numero" => "5"
                        "paginaInicial" => "458"
                        "paginaFinal" => "462"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9881246"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of and risk factors for hepatic steatosis in Northern Italy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Bellentani S"
                            1 => "Saccoccio G"
                            2 => "Masutti F"
                            3 => "Croce L&#46;S&#46;"
                            4 => "Brandi G"
                            5 => "Sasso F"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-132-2-200001180-00004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2000"
                        "volumen" => "132"
                        "paginaInicial" => "112"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10644271"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fatty liver in non-alcoholic non-overweight Japanase adults&#58; incidence and clinical characteristics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Omagari K"
                            1 => "Kadokawa Y"
                            2 => "Masuda J&#46;I&#46;"
                            3 => "Egawa I"
                            4 => "Sawa T"
                            5 => "Hazama H"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gastroenterol Hepatol"
                        "fecha" => "2002"
                        "volumen" => "17"
                        "paginaInicial" => "1098"
                        "paginaFinal" => "1105"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12201871"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of and risk factors for nonalcoholic fatty liver disease&#58; the Dionysos nutrition and liver study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Bedogni G"
                            1 => "Miglioli L"
                            2 => "Masutti F"
                            3 => "Tiribelli C"
                            4 => "Marchesini G"
                            5 => "Bellentani S&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.20734"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2005"
                        "volumen" => "42"
                        "paginaInicial" => "44"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15895401"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of and risk factors for fatty liver in a general population of Shanghai&#44; China"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Fan J&#46;G&#46;"
                            1 => "Zhu J"
                            2 => "Li X&#46;J&#46;"
                            3 => "Chen L"
                            4 => "Li L"
                            5 => "Dai F"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2005.02.042"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2005"
                        "volumen" => "43"
                        "paginaInicial" => "508"
                        "paginaFinal" => "514"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16006003"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Jimba S"
                            1 => "Nakagami T"
                            2 => "Takahashi M"
                            3 => "Wakamatsu T"
                            4 => "Hirota Y"
                            5 => "Iwamoto Y"
                            6 => "Wasada T&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1464-5491.2005.01582.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabet Med"
                        "fecha" => "2005"
                        "volumen" => "22"
                        "numero" => "9"
                        "paginaInicial" => "1141"
                        "paginaFinal" => "1145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16108839"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The metabolic syndrome as a predictor of nonalcoholic fatty liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:13 [
                            0 => "Hamaguchi M"
                            1 => "Kojima T"
                            2 => "Takeda N"
                            3 => "Nakagawa T"
                            4 => "Taniguchi H"
                            5 => "Fujii K"
                            6 => "Omatsu T"
                            7 => "Nakajima T"
                            8 => "Sarui H"
                            9 => "Shimazaki M"
                            10 => "Kato T"
                            11 => "Okuda J"
                            12 => "Ida K&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-143-10-200511150-00009"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2005"
                        "volumen" => "143"
                        "numero" => "10"
                        "paginaInicial" => "722"
                        "paginaFinal" => "728"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16287793"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and risk factors of nonalcoholic fatty liver disease among Korean adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:10 [
                            0 => "Park S&#46;H&#46;"
                            1 => "Jeon W&#46;K&#46;"
                            2 => "Kim S&#46;H&#46;"
                            3 => "Kim H&#46;J&#46;"
                            4 => "Park D&#46;I&#46;"
                            5 => "Cho Y&#46;K&#46;"
                            6 => "Sung I&#46;K&#46;"
                            7 => "Sohn C&#46;I&#46;"
                            8 => "Keum D&#46;K&#46;"
                            9 => "Kim BI&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1746.2005.04086.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Gastroenterol Hepatol"
                        "fecha" => "2006"
                        "volumen" => "21"
                        "numero" => "1 Pt 1"
                        "paginaInicial" => "138"
                        "paginaFinal" => "143"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16706825"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of hepatic steatosis in an urban population in the United States&#58; impact of ethnicity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Browning J&#46;D&#46;"
                            1 => "Szczepaniak L&#46;S&#46;"
                            2 => "Dobbins R"
                            3 => "Nuremberg P"
                            4 => "Horton J&#46;D&#46;"
                            5 => "Cohen J&#46;C&#46;"
                            6 => "Grundy S&#46;M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.20466"
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                        "tituloSerie" => "Hepatology"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "1387"
                        "paginaFinal" => "1395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15565570"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of transaminase abnormalities in asymptomatic&#44; healthy subjects participating in an executive health-screening program"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Patt C&#46;H&#46;"
                            1 => "Yoo H&#46;Y&#46;"
                            2 => "Dibadj K"
                            3 => "Flynn J"
                            4 => "Thuluvath PJ&#46;"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "numero" => "4"
                        "paginaInicial" => "797"
                        "paginaFinal" => "801"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12741474"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            29 => array:3 [
              "identificador" => "bib0150"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prevalence and etiology of elevated aminotransferase levels in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Clark J&#46;M&#46;"
                            1 => "Brancati F&#46;L&#46;"
                            2 => "Diehl AM&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.2003.07486.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "2003"
                        "volumen" => "98"
                        "numero" => "5"
                        "paginaInicial" => "960"
                        "paginaFinal" => "967"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12809815"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib0155"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Ruhl C&#46;E&#46;"
                            1 => "Everhart JE&#46;"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/gast.2003.50004"
                      "Revista" => array:7 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "numero" => "1"
                        "paginaInicial" => "71"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12512031"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Liver investigation in 149 asymptomatic patients with moderately elevated activities of serum aminotransferases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Hultcrantz R"
                            1 => "Glaumann H"
                            2 => "Lindberg G"
                            3 => "Nilsson LH&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Scand J Gastroenterol"
                        "fecha" => "1986"
                        "volumen" => "21"
                        "numero" => "1"
                        "paginaInicial" => "109"
                        "paginaFinal" => "113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3952445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic steatohepatitis&#58; a study of 49 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Lee RG&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Pathol"
                        "fecha" => "1989"
                        "volumen" => "20"
                        "paginaInicial" => "594"
                        "paginaFinal" => "598"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2656500"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinicopathologic study of alcohol-like liver disease in non-alcoholic steatohepatitis and fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Nonomura A"
                            1 => "Mizukami Y"
                            2 => "Unoura M"
                            3 => "Kobayashi K"
                            4 => "Takeda Y"
                            5 => "Takeda R&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterol Jpn"
                        "fecha" => "1992"
                        "volumen" => "27"
                        "paginaInicial" => "521"
                        "paginaFinal" => "528"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1526433"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical hepatology&#58; profile of an urban&#44; hospital-based practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Byron D"
                            1 => "Minuk GY&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.510240410"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "1996"
                        "volumen" => "24"
                        "numero" => "4"
                        "paginaInicial" => "813"
                        "paginaFinal" => "815"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8855181"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Daniel S"
                            1 => "Ben-Menachem T"
                            2 => "Vasudevan G"
                            3 => "Ma C&#46;K&#46;"
                            4 => "Blumenkehl M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.1999.01451.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1999"
                        "volumen" => "94"
                        "numero" => "10"
                        "paginaInicial" => "3010"
                        "paginaFinal" => "3014"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10520861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathological and virological findings in patients with persistent hypertransaminasaemia of unknown aetiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Berasain C"
                            1 => "Betes M"
                            2 => "Panizo A"
                            3 => "Ruiz J"
                            4 => "Herrero J&#46;I&#46;"
                            5 => "Civeira M&#46;P&#46;"
                            6 => "Prieto J&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/gut.47.3.429"
                      "Revista" => array:7 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2000"
                        "volumen" => "47"
                        "numero" => "3"
                        "paginaInicial" => "429"
                        "paginaFinal" => "435"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10940283"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Liver histology in a &#8220;normal&#8221; population&#8212;examinations of 503 consecutive fatal traffic casualties"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Hilden M"
                            1 => "Christoffersen P"
                            2 => "Juhl E"
                            3 => "Dalgaard JB&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Scand J Gastroenterol"
                        "fecha" => "1977"
                        "volumen" => "12"
                        "numero" => "5"
                        "paginaInicial" => "593"
                        "paginaFinal" => "597"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/918553"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Liver pathology in aircrew"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Ground KE&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviat Space Environ Med"
                        "fecha" => "1982"
                        "volumen" => "53"
                        "numero" => "1"
                        "paginaInicial" => "14"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7055484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fatty liver hepatitis &#40;steatohepatitis&#41; and obesity&#58; an autopsy study with analysis of risk factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Wanless I&#46;R&#46;"
                            1 => "Lentz JS&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "1990"
                        "volumen" => "12"
                        "numero" => "5"
                        "paginaInicial" => "1106"
                        "paginaFinal" => "1110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2227807"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of fatty liver in children and adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Schwimmer J"
                            1 => "Deutsch R"
                            2 => "Kahen T"
                            3 => "Lavine J&#46;E&#46;"
                            4 => "Stanley C"
                            5 => "Behling C&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2006-1212"
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2006"
                        "volumen" => "118"
                        "paginaInicial" => "1388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17015527"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Liver abnormalities in severely obese subjects&#58; effect of drastic weight loss after gastroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Luyckx F&#46;H&#46;"
                            1 => "Desaive C"
                            2 => "Thiry A"
                            3 => "Dewe W"
                            4 => "Scheen A&#46;J&#46;"
                            5 => "Gielen J&#46;E&#46;"
                            6 => "Lefebvre PJ&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Obes Relat Metab Disord"
                        "fecha" => "1998"
                        "volumen" => "22"
                        "numero" => "3"
                        "paginaInicial" => "222"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9539189"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Liver pathology in morbidly obese patients with and without diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "Silverman J&#46;F&#46;"
                            1 => "O&#8217;Brien K&#46;F&#46;"
                            2 => "Long S"
                            3 => "Leggett N"
                            4 => "Khazanie P&#46;G&#46;"
                            5 => "Pories W&#46;J&#46;"
                            6 => "Norris H&#46;T&#46;"
                            7 => "Caro JF&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "1990"
                        "volumen" => "85"
                        "numero" => "10"
                        "paginaInicial" => "1349"
                        "paginaFinal" => "1355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2220728"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease&#58; predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Dixon J&#46;B&#46;"
                            1 => "Bhathal P&#46;S&#46;"
                            2 => "O&#8217;Brien PE&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2001"
                        "volumen" => "121"
                        "numero" => "1"
                        "paginaInicial" => "91"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11438497"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Beymer C"
                            1 => "Kowdley K&#46;V&#46;"
                            2 => "Larson A"
                            3 => "Edmonson P"
                            4 => "Dellinger E&#46;P&#46;"
                            5 => "Flum DR&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archsurg.138.11.1240"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Surg"
                        "fecha" => "2003"
                        "volumen" => "138"
                        "numero" => "11"
                        "paginaInicial" => "1240"
                        "paginaFinal" => "1244"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14609874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of non-alcoholic steatohepatitis in morbidly obese subjects undergoing gastric bypass"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Spaulding L"
                            1 => "Trainer T"
                            2 => "Janiec D&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1381/096089203765887633"
                      "Revista" => array:7 [
                        "tituloSerie" => "Obes Surg"
                        "fecha" => "2003"
                        "volumen" => "13"
                        "numero" => "3"
                        "paginaInicial" => "347"
                        "paginaFinal" => "349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12841891"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
            ]
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              "identificador" => "bib0235"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The evolution of severe steatosis after bariatric surgery is related to insulin resistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:14 [
                            0 => "Mathurin P"
                            1 => "Gonzalez F"
                            2 => "Kerdraon O"
                            3 => "Leteurtre E"
                            4 => "Arnalsteen L"
                            5 => "Hollebecque A"
                            6 => "Louvet A"
                            7 => "Dharancy S"
                            8 => "Cocq P"
                            9 => "Jany T"
                            10 => "Boitard J"
                            11 => "Deltenre P"
                            12 => "Romon M"
                            13 => "Pattou F&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2006.02.024"
                      "Revista" => array:7 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2006"
                        "volumen" => "130"
                        "numero" => "6"
                        "paginaInicial" => "1617"
                        "paginaFinal" => "1624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16697725"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0240"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis in nonalcoholic steatohepatitis &#40;Letter&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Propst A"
                            1 => "Propst T"
                            2 => "Judmaier G"
                            3 => "Vogel W&#46;"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
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                        "numero" => "5"
                        "paginaInicial" => "1607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7729662"
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                      "titulo" => "The natural history of nonalcoholic fatty liver&#58; a follow-up study"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "Teli M&#46;R&#46;"
                            1 => "James O&#46;F&#46;W&#46;"
                            2 => "Burt A&#46;D&#46;"
                            3 => "Bennett M&#46;K&#46;"
                            4 => "CP Day&#46;"
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                    ]
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                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Hepatology"
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                        "paginaInicial" => "1714"
                        "paginaFinal" => "1719"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7489979"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-alcoholic steatohepatitis"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "Sheth S&#46;G&#46;"
                            1 => "Gordon F&#46;D&#46;"
                            2 => "Chopra S&#46;"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-126-2-199701150-00008"
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                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1997"
                        "volumen" => "126"
                        "paginaInicial" => "137"
                        "paginaFinal" => "145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9005748"
                            "web" => "Medline"
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              "identificador" => "bib0255"
              "etiqueta" => "51&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features and natural history of nonalcoholic steatosis syndromes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Falck-Ytter Y"
                            1 => "Younossi Z&#46;M&#46;"
                            2 => "Marchesini G"
                            3 => "McCullough AJ&#46;"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Liver Dis"
                        "fecha" => "2001"
                        "volumen" => "21"
                        "paginaInicial" => "17"
                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11296693"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0260"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The spectrum of liver disease in the general population&#58; lesson from the Dionysos study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Bellentani S"
                            1 => "Tiribelli C&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2001"
                        "volumen" => "35"
                        "paginaInicial" => "531"
                        "paginaFinal" => "537"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11682041"
                            "web" => "Medline"
                          ]
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                ]
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                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease&#58; a feature of the metabolic syndrome"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Marchesini G"
                            1 => "Brizi M"
                            2 => "Bianchi G"
                            3 => "Tomassetti S"
                            4 => "Bugianesi E"
                            5 => "Lenzi M"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/diabetes.50.8.1844"
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                        "tituloSerie" => "Diabetes"
                        "fecha" => "2001"
                        "volumen" => "50"
                        "paginaInicial" => "1844"
                        "paginaFinal" => "1850"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11473047"
                            "web" => "Medline"
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                  "contribucion" => array:1 [
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                      "titulo" => "Nonalcholic fatty liver disease"
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                          "autores" => array:2 [
                            0 => "Yu A&#46;S&#46;"
                            1 => "Keeffe EB&#46;"
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                        "tituloSerie" => "Rev Gastroenterol Disord"
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                        "volumen" => "2"
                        "numero" => "1"
                        "paginaInicial" => "11"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12122975"
                            "web" => "Medline"
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                      "titulo" => "Non-alcoholic fatty liver disease&#58; an overview"
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                          "autores" => array:3 [
                            0 => "Mulhall B&#46;P&#46;"
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                            2 => "Younossi ZM&#46;"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Gastroenterol Hepatol"
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                        "volumen" => "17"
                        "paginaInicial" => "1136"
                        "paginaFinal" => "1143"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12453271"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Expanding the natural history of nonalcoholic steatohepatitis&#58; from cryptogenic cirrhosis to hepatocellular carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Bugianesi E"
                            1 => "Leone N"
                            2 => "Vanni E"
                            3 => "Marchesini G"
                            4 => "Brunello F"
                            5 => "Carucci P"
                            6 => "Musso A"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
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                        "paginaInicial" => "134"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12105842"
                            "web" => "Medline"
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                      "titulo" => "Non-alcoholic steatohepatitis &#40;NASH&#41;&#58; where are we now and where are we going&#63;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                    0 => array:2 [
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                        "tituloSerie" => "Gut"
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                        "volumen" => "50"
                        "paginaInicial" => "585"
                        "paginaFinal" => "588"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11950797"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0290"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Defining nonalcoholic fatty liver disease&#58; implications for epidemiologic studies"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Clark J&#46;M&#46;"
                            1 => "Diehl AM&#46;"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/gast.2003.50032"
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                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "numero" => "1"
                        "paginaInicial" => "248"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12512048"
                            "web" => "Medline"
                          ]
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                      "titulo" => "The natural history of nonalcoholic fatty liver disease&#58; a clinical histopathological study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Harrison S&#46;A&#46;"
                            1 => "Torgerson S"
                            2 => "Hayashi PH&#46;"
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                      ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.2003.07659.x"
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                        "tituloSerie" => "Am J Gastroenterol"
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                        "volumen" => "98"
                        "paginaInicial" => "2042"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14499785"
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                          "autores" => array:2 [
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                      "Revista" => array:7 [
                        "tituloSerie" => "Aliment Pharmacol Ther"
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                        "numero" => "8"
                        "paginaInicial" => "977"
                        "paginaFinal" => "986"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12694079"
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                    0 => array:2 [
                      "titulo" => "Natural history of NAFLD&#58; remarkably benign in the absence of cirrhosis"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "Day CP&#46;"
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                        "tituloSerie" => "Gastroenterology"
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                        "paginaInicial" => "375"
                        "paginaFinal" => "378"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16012969"
                            "web" => "Medline"
                          ]
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            61 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The characteristics and natural history of Japanese patients with nonalcoholic fatty liver disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Hashimoto E"
                            1 => "Yatsuji S"
                            2 => "Kaneda H"
                            3 => "Yoshioka Y"
                            4 => "Taniai M"
                            5 => "Tokushige K"
                            6 => "Shiratori K&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Hepatol Res"
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                        "paginaInicial" => "72"
                        "paginaFinal" => "76"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16203174"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            62 => array:3 [
              "identificador" => "bib0315"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonalcoholic fatty liver disease&#58; an underrecognized cause of cryptogenic cirrhosis"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "Clark J&#46;M&#46;"
                            1 => "Dihel AM&#46;"
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                    0 => array:2 [
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                        "volumen" => "289"
                        "paginaInicial" => "3000"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12799409"
                            "web" => "Medline"
                          ]
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            63 => array:3 [
              "identificador" => "bib0320"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:12 [
                            0 => "Sanyal A&#46;J&#46;"
                            1 => "Banas C"
                            2 => "Sargeant C"
                            3 => "Luketic V&#46;A&#46;"
                            4 => "Sterling R&#46;K&#46;"
                            5 => "Stravitz R&#46;T&#46;"
                            6 => "Shiffman M&#46;L&#46;"
                            7 => "Heuman D"
                            8 => "Coterrell A"
                            9 => "Fisher R&#46;A&#46;"
                            10 => "Contos M&#46;J&#46;"
                            11 => "Mills AS&#46;"
                          ]
                        ]
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                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "Hepatology"
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                        "volumen" => "43"
                        "paginaInicial" => "682"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16502396"
                            "web" => "Medline"
                          ]
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                      "titulo" => "Long term prognosis of fatty liver&#58; risk of chronic liver disease and death"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "Dam-Larsen S"
                            1 => "Franzmann M"
                            2 => "Andersen I&#46;B&#46;"
                            3 => "Christoffersen P"
                            4 => "Jensen L&#46;B&#46;"
                            5 => "S&#248;rensen T&#46;I&#46;"
                            6 => "Becker U"
                            7 => "Bendtsen F&#46;"
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                        "paginaFinal" => "755"
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                          0 => array:2 [
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                            "web" => "Medline"
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                      "titulo" => "The natural history of nonalcoholic fatty liver disease&#58; a population based cohort study"
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                          "autores" => array:6 [
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                            2 => "St Sauver J"
                            3 => "Sanderson S&#46;O&#46;"
                            4 => "Lindor K&#46;D&#46;"
                            5 => "Feldstein A"
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                    0 => array:1 [
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                        "link" => array:1 [
                          0 => array:2 [
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                    ]
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                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
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                          ]
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                      "titulo" => "Long-term follow-up of patients with NAFLD and elevated liver enzymes"
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                          "etal" => true
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                            1 => "Franze&#8217;n L&#46;E&#46;"
                            2 => "Mathiesen U&#46;L&#46;"
                            3 => "Thorelius L"
                            4 => "Holmqvist M"
                            5 => "Bodemar G"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.21327"
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                        "paginaFinal" => "873"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
                          ]
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              "identificador" => "bib0345"
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                    0 => array:2 [
                      "titulo" => "The Fatty Liver index&#58; a simple and accurate predictor of hepatic steatosis in the general population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Bedogni G"
                            1 => "Bellentani S"
                            2 => "Miglioli L"
                            3 => "Masutti F"
                            4 => "Passalacqua M"
                            5 => "Castiglione A"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-230X-6-33"
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                        "tituloSerie" => "BMC Gastroenterol"
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                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                0 => array:2 [
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                          "etal" => false
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                        "paginaFinal" => "612"
                        "link" => array:1 [
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                          "autores" => array:6 [
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                            2 => "Nijpels G"
                            3 => "Stehouwer C&#46;D&#46;"
                            4 => "Bouter L&#46;M&#46;"
                            5 => "Heine R&#46;J&#46;"
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                      ]
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                        "paginaFinal" => "396"
                        "link" => array:1 [
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                      ]
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                  ]
                ]
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                    0 => array:2 [
                      "titulo" => "Aminotransferase levels and 20-year risk of metabolic syndrome&#44; diabetes&#44; and cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "Massaro J&#46;M&#46;"
                            2 => "Vasan R&#46;S&#46;"
                            3 => "D&#8217;Agostino RB S&#46;r&#46;"
                            4 => "Ellison R&#46;C&#46;"
                            5 => "Fox CS&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2008.09.018"
                      "Revista" => array:7 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2008"
                        "volumen" => "135"
                        "numero" => "6"
                        "paginaInicial" => "1935"
                        "paginaFinal" => "1944"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19010326"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The International Diabetes Federation definition of the metabolic syndrome independently predicts future cardiovascular events in Type 2 diabetic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1464-5491.2006.01940.x"
                      "Revista" => array:7 [
                        "tituloSerie" => "The Valpolicella Heart Diabetes Study&#46; Diabet Med"
                        "fecha" => "2006"
                        "volumen" => "23"
                        "numero" => "11"
                        "paginaInicial" => "1270"
                        "paginaFinal" => "1271"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
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                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0370"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Assessing the outcome of nonalcoholic steatohepatitis&#63; It&#8217;s time to get serious"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.21391"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2006"
                        "volumen" => "44"
                        "paginaInicial" => "802"
                        "paginaFinal" => "805"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
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                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Suspected Nonalcoholic Fatty Liver Disease and Mortality Risk in a Population-Based Cohort Study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [ …7]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Am J Gastroenterol"
                        "fecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0380"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and natural course of fatty liver in the general population&#58; the Dionysos study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [ …7]
                        ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.21827"
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                        "tituloSerie" => "Hepatology"
                        "fecha" => "2007"
                        "volumen" => "46"
                        "paginaInicial" => "1387"
                        "paginaFinal" => "1391"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Natural course of chronic HCV and HBV infection and role of alcohol in the general population&#58; the Dionysos Study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:10 [ …10]
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1572-0241.2008.01948.x"
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                        "volumen" => "103"
                        "numero" => "9"
                        "paginaInicial" => "2248"
                        "paginaFinal" => "2253"
                        "link" => array:1 [
                          0 => array:2 [ …2]
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ISSN: 16652681
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es en pt

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