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Letters to the Editor
New model predicting gastroesophageal varices and variceal hemorrhage in patients with chronic liver disease
Yongxin Chen, Xiaofei Li
Corresponding author
icqwc46@163.com

Corresponding author.
Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Recently&#44; we read with great interest the study by Ma JL et al&#46; <a class="elsevierStyleCrossRef" href="#bib0045">&#91;1&#93;</a> who mainly assessed a new model for predicting gastroesophageal varices &#40;GOV&#41; and variceal hemorrhage &#40;VH&#41; in patients with chronic liver diseases &#40;CLDs&#41;&#46; The new algorithm developed in this study is novel and provides evidence for the prediction of GOV and VH in CLDs patients&#46; The author&#39;s great efforts are praiseworthy&#44; but the following issues need to be carefully considered&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">First&#44; it needs to be emphasized that MELD score and Child&#8211;Pugh score are important indicators for evaluating the severity of liver function in CLDs patients&#44; which have been widely recognized worldwide <a class="elsevierStyleCrossRefs" href="#bib0050">&#91;2&#44;3&#93;</a>&#46; In addition&#44; the above two scores are also generally used in clinical practice&#46; However&#44; these two scores were not reported in this study&#46; Therefore&#44; we do not know the severity of liver function in CLDs patients included in this study&#46; Considering that the above two scores are evaluated according to the results of routine examinations in clinical practice&#44; it is necessary to describe the severity of patients included in this study&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Second&#44; previous studies have indicated that obesity is closely related to the progression of chronic viral hepatitis <a class="elsevierStyleCrossRef" href="#bib0060">&#91;4&#93;</a>&#46; Evidence from a cohort study in the UK suggested that approximately 17&#37; of cirrhosis is caused by excessive weight gain <a class="elsevierStyleCrossRef" href="#bib0065">&#91;5&#93;</a>&#46; In addition&#44; the prognosis of patients with obesity related cirrhosis is worse than that of non-obese patients <a class="elsevierStyleCrossRef" href="#bib0070">&#91;6&#93;</a>&#46; Accordingly&#44; the progression of cirrhosis increases the risk of GOV or VH in CLDs patients&#46; However&#44; body weight or body mass index&#44; two important indicators of nutritional status commonly used in clinical practice&#44; was not reported in this study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Third&#44; it is generally accepted that portal hypertension is an important factor leading to GOV and VH in CLDs patients&#46; Is hepatic venous pressure gradient &#40;HVPG&#41; different between GOV and No-GOV patients in this study <a class="elsevierStyleCrossRefs" href="#bib0075">&#91;7&#44;8&#93;</a>&#63; Is HVPG associated with GOV in CLDs patients&#63; Although this is a retrospective cohort study&#44; and it may be difficult to report HVPG values&#44; we believe that solving this issue will help clinicians better understand the conclusion of this study&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Declaration of funding interests</span><p id="par0025" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos