Letters to the editor
Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit
Shishi Ying
Emergecy Department, YiWu Central Hospital, Zhejiang 322000, China
Xiaofei Li
Corresponding author
Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China
Read
761
Timeswas read the article
270
Total PDF
491
Total HTML
Share statistics
array:25 [ "pii" => "S1665268120302210" "issn" => "16652681" "doi" => "10.1016/j.aohep.2020.100296" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "100296" "copyright" => "Fundación Clínica Médica Sur, A.C." "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2021;21C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1665268121000077" "issn" => "16652681" "doi" => "10.1016/j.aohep.2021.100308" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "100308" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2021;21C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit" "tienePdf" => "en" "tieneTextoCompleto" => "en" "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Aldo Torre" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Aldo" "apellidos" => "Torre" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121000077?idApp=UINPBA00004N" "url" => "/16652681/000000210000000C/v1_202102250957/S1665268121000077/v1_202102250957/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1665268119322136" "issn" => "16652681" "doi" => "10.1016/j.aohep.2019.06.012" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "107" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Ann Hepatol. 2021;21C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 104 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 32 "PDF" => 54 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Liver transplantation in acute liver failure due to Hepatitis B. Two clinical cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 882 "Ancho" => 1493 "Tamanyo" => 62096 ] ] "descripcion" => array:1 [ "en" => "<p id="spar3035" class="elsevierStyleSimplePara elsevierViewall">HBV viral load from baseline to week 24.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rocío Sedano, Lorena Castro, Mauricio Venegas, Julio Miranda, Carmen Hurtado, Jaime Poniachik, Javier Brahm" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Rocío" "apellidos" => "Sedano" ] 1 => array:2 [ "nombre" => "Lorena" "apellidos" => "Castro" ] 2 => array:2 [ "nombre" => "Mauricio" "apellidos" => "Venegas" ] 3 => array:2 [ "nombre" => "Julio" "apellidos" => "Miranda" ] 4 => array:2 [ "nombre" => "Carmen" "apellidos" => "Hurtado" ] 5 => array:2 [ "nombre" => "Jaime" "apellidos" => "Poniachik" ] 6 => array:2 [ "nombre" => "Javier" "apellidos" => "Brahm" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119322136?idApp=UINPBA00004N" "url" => "/16652681/000000210000000C/v1_202102250957/S1665268119322136/v1_202102250957/en/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S1665268121000077" "issn" => "16652681" "doi" => "10.1016/j.aohep.2021.100308" "estado" => "S300" "fechaPublicacion" => "2021-03-01" "aid" => "100308" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2021;21C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit" "tienePdf" => "en" "tieneTextoCompleto" => "en" "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Aldo Torre" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Aldo" "apellidos" => "Torre" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121000077?idApp=UINPBA00004N" "url" => "/16652681/000000210000000C/v1_202102250957/S1665268121000077/v1_202102250957/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "Shishi Ying" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Shishi" "apellidos" => "Ying" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Emergecy Department, YiWu Central Hospital, Zhejiang 322000, China" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "autoresLista" => "Xiaofei Li" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Xiaofei" "apellidos" => "Li" "email" => array:1 [ 0 => "icqwc46@163.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with great interest the article by Guerrero et al. [<a class="elsevierStyleCrossRef" href="#bib0005">1</a>] mainly explored the important risk factors of mortality in patients with acute on chronic liver failure (ACLF) admitted to the intensive care unit. The results of this retrospective cohort study revealed that renal and brain failure could be used to predict 28-day and 90-day mortality. The results of this study are attention-grabbing, but we would like to point out the following issues.</p><p id="par0010" class="elsevierStylePara elsevierViewall">First of all, it should be emphasized that obesity is a disease characterized by chronic low-grade inflammatory [<a class="elsevierStyleCrossRefs" href="#bib0010">2–4</a>], which has been confirmed as a risk factor for numerous diseases, including ACLF [<a class="elsevierStyleCrossRef" href="#bib0025">5</a>]. A study based on the United Network for Organ Sharing (UNOS) database involving 387,884 participants exhibited that obese patients had a higher incidence of adverse events than non-obese patients [<a class="elsevierStyleCrossRef" href="#bib0025">5</a>]. More interestingly, the conclusions of this study also demonstrated that obese ACLF patients had a higher incidence of renal failure that non-obese ACLF patients [<a class="elsevierStyleCrossRef" href="#bib0025">5</a>]. However, obesity, as a crucial indicator commonly used in clinical practice, was not described in this study, which might be a limitation that cannot be ignored. Since there is a significant association between obesity and renal failure and prognosis in ACLF patients, how to confirm that renal failure is independently related to prognosis of CLF patients without controlling the confounding factor of obesity? In our opinion, it is essential to describe the body mass index (BMI) of the two groups (died or survived) and then adjust BMI as a confounding factor in Cox regression analysis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Second, the use of vasopressor, mechanical ventilation and glucocorticoid are important treatment strategies for ICU patients in clinical practice, which are associated with mortality [<a class="elsevierStyleCrossRefs" href="#bib0030">6–8</a>]. However, although vasopressin and mechanical ventilation were described (Table 1) in this study and glucocorticoids were not described, none of these factors were included in bivariate and multivariate cox regression analysis, which is a little confusing. Obviously, grade 3 patients had a higher rate of vasopressin use that grade 1/2 patients (97.6% versus 75.6%/ 48%, p = 0.001) (Table 1). Therefore, we think it would be better to describe why vasopressor use was not included in the subsequent multivariate regression analysis. Additionally, considering that mechanical ventilation also has an impact on mortality in clinical practice [<a class="elsevierStyleCrossRef" href="#bib0045">9</a>,<a class="elsevierStyleCrossRef" href="#bib0050">10</a>], although there is no significant difference between groups, we believe that mechanical ventilation should also be included in the regression analysis in order to obtain more accurate results.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Declaration of funding interests</span><p id="par0020" class="elsevierStylePara elsevierViewall">None.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Declaration of funding interests" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-11-03" "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "[1]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O. Méndez-Guerrero" 1 => "D.A. Calle-Rodas" 2 => "E. Cervantes-Alvarez" 3 => "E. Alatorre-Arenas" 4 => "J. Pérez-Escobar" 5 => "N. Navarro-Alvarez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.aohep.2020.09.014" "Revista" => array:2 [ "tituloSerie" => "Ann Hepatol" "fecha" => "2020" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "[2]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and obese-related chronic low-grade inflammation in promotion of colorectal cancer development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Pietrzyk" 1 => "A. Torres" 2 => "R. Maciejewski" 3 => "K. Torres" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.31557/APJCP.2021.22.1.301" "Revista" => array:6 [ "tituloSerie" => "Asian Pac J Cancer Prev" "fecha" => "2015" "volumen" => "16.10" "paginaInicial" => "4161" "paginaFinal" => "4168" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33507712" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "[3]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.A. Cooke" 1 => "R.M. Connaughton" 2 => "C.L. Lyons" 3 => "A.M. McMorrow" 4 => "H.M. Roche" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejphar.2016.04.021" "Revista" => array:6 [ "tituloSerie" => "Eur J Pharmacol" "fecha" => "2016" "volumen" => "785" "paginaInicial" => "207" "paginaFinal" => "214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27083551" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "[4]" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Cruz KJC, de Oliveira ARS, Morais JBS, Severo JS, Marreiro PhD DDN, Role of microRNAs on adipogenesis, chronic low-grade inflammation, and insulin resistance in obesity. Nutrition 35 (2017): 28-35." ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "[5]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Class III obesity is a risk factor for the development of acute-on-chronic liver failure in patients with decompensated cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Sundaram" 1 => "R. Jalan" 2 => "J.C. Ahn" 3 => "M.R. Charlton" 4 => "D.S. Goldberg" 5 => "C.J. Karvellas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2021.01.041" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2018" "volumen" => "69.3" "paginaInicial" => "617" "paginaFinal" => "625" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33548385" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "[6]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.G. Kowalski" 1 => "W.C. Ziai" 2 => "R.N. Rees" 3 => "J.K. Werner" 4 => "G. Kim" 5 => "H. Goodwin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/CCM.0000000000004892" "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2012" "volumen" => "40.9" "paginaInicial" => "2677" "paginaFinal" => "2684" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33595959" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "[7]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First intention high-frequency oscillatory and conventional mechanical ventilation in premature infants without antenatal glucocorticoid prophylaxis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Salvo" 1 => "L.J. Zimmermann" 2 => "A.W. Gavilanes" 3 => "I. Barberi" 4 => "A. Ricotti" 5 => "R. Abella" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/PCC.0000000000002661" "Revista" => array:6 [ "tituloSerie" => "Pediatr Crit Care Med" "fecha" => "2012" "volumen" => "13.1" "paginaInicial" => "72" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33443979" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "[8]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of patients with cirrhosis requiring mechanical ventilation in ICU" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Levesque" 1 => "F. Saliba" 2 => "P. Ichaï" 3 => "D. Samuel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2020.10.033" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2014" "volumen" => "60.3" "paginaInicial" => "570" "paginaFinal" => "578" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33188904" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "[9]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolution of mortality over time in patients receiving mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Esteban" 1 => "F. Frutos-Vivar" 2 => "A. Muriel" 3 => "N.D. Ferguson" 4 => "O. Peñuelas" 5 => "V. Abraira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201903-0673OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2013" "volumen" => "188.2" "paginaInicial" => "220" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31657946" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "[10]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Sud" 1 => "J.O. Friedrich" 2 => "N.K. Adhikari" 3 => "P. Taccone" 4 => "J. Mancebo" 5 => "F. Polli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "CmAj" "fecha" => "2014" "paginaInicial" => "E381" "paginaFinal" => "E390" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/000000210000000C/v1_202102250957/S1665268120302210/v1_202102250957/en/main.assets" "Apartado" => array:4 [ "identificador" => "82754" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/16652681/000000210000000C/v1_202102250957/S1665268120302210/v1_202102250957/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268120302210?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 0 | 2 |
| 2024 October | 5 | 2 | 7 |
| 2024 September | 10 | 1 | 11 |
| 2024 August | 10 | 3 | 13 |
| 2024 July | 11 | 7 | 18 |
| 2024 June | 6 | 1 | 7 |
| 2024 May | 5 | 2 | 7 |
| 2024 April | 10 | 2 | 12 |
| 2024 March | 15 | 5 | 20 |
| 2024 February | 9 | 7 | 16 |
| 2024 January | 8 | 4 | 12 |
| 2023 December | 6 | 4 | 10 |
| 2023 November | 4 | 2 | 6 |
| 2023 October | 14 | 3 | 17 |
| 2023 September | 3 | 1 | 4 |
| 2023 August | 5 | 4 | 9 |
| 2023 July | 6 | 10 | 16 |
| 2023 June | 18 | 1 | 19 |
| 2023 May | 25 | 6 | 31 |
| 2023 April | 28 | 0 | 28 |
| 2023 March | 30 | 2 | 32 |
| 2023 February | 11 | 7 | 18 |
| 2023 January | 9 | 7 | 16 |
| 2022 December | 13 | 11 | 24 |
| 2022 November | 8 | 12 | 20 |
| 2022 October | 13 | 5 | 18 |
| 2022 September | 17 | 9 | 26 |
| 2022 August | 9 | 10 | 19 |
| 2022 July | 10 | 7 | 17 |
| 2022 June | 11 | 8 | 19 |
| 2022 May | 7 | 12 | 19 |
| 2022 April | 5 | 7 | 12 |
| 2022 March | 14 | 7 | 21 |
| 2022 February | 6 | 4 | 10 |
| 2022 January | 13 | 6 | 19 |
| 2021 December | 11 | 8 | 19 |
| 2021 November | 10 | 6 | 16 |
| 2021 October | 6 | 13 | 19 |
| 2021 September | 5 | 5 | 10 |
| 2021 August | 8 | 4 | 12 |
| 2021 July | 10 | 7 | 17 |
| 2021 June | 5 | 8 | 13 |
| 2021 May | 6 | 9 | 15 |
| 2021 April | 28 | 11 | 39 |
| 2021 March | 24 | 14 | 38 |
| 2021 February | 2 | 5 | 7 |
| 2021 January | 0 | 1 | 1 |
Show all
