Letters to the editor
Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease
Read
688
Timeswas read the article
273
Total PDF
415
Total HTML
Share statistics
array:25 [ "pii" => "S1665268120302258" "issn" => "16652681" "doi" => "10.1016/j.aohep.2020.100300" "estado" => "S300" "fechaPublicacion" => "2021-05-01" "aid" => "100300" "copyright" => "Fundación Clínica Médica Sur, A.C." "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2021;22C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1665268121000181" "issn" => "16652681" "doi" => "10.1016/j.aohep.2021.100319" "estado" => "S300" "fechaPublicacion" => "2021-05-01" "aid" => "100319" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2021;22C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "Reply to: Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Claudia P. Oliveira" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Claudia P." "apellidos" => "Oliveira" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121000181?idApp=UINPBA00004N" "url" => "/16652681/000000220000000C/v3_202107300613/S1665268121000181/v3_202107300613/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1665268119322768" "issn" => "16652681" "doi" => "10.1016/j.aohep.2019.11.005" "estado" => "S300" "fechaPublicacion" => "2021-05-01" "aid" => "162" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Ann Hepatol. 2021;22C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 47 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 20 "PDF" => 18 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Tips for TIPS: A combined percutaneous and transjugular approach for intrahepatic portosystemic shunt placement after liver transplant" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1581 "Ancho" => 2833 "Tamanyo" => 775666 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Post-contrastographic sequences of liver MRI showing multiple hypodense focal lesions, more evident at the dome and the right lobe which show shrinking of the signal in DWI sequences; concomitant minimal dilatation of the intrahepatic bile ducts. (B) Section of hepatic specimen (1921<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>991; 20×) with evidence of hematologic extravasation, hepatocyte necrosis, focal dilation and congestion of sinusoids. (C) 6-Months after TIPS placement Doppler examination showing the patency of intrahepatic stent with high caval and portal velocity; no evidence of abdominal ascites.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ilaria Lenci, Benedetto Neri, Daniele Morosetti, Martina Milana, Giampiero Palmieri, Giuseppe Tisone, Antonio Orlacchio, Mario Angelico, Leonardo Baiocchi" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Ilaria" "apellidos" => "Lenci" ] 1 => array:2 [ "nombre" => "Benedetto" "apellidos" => "Neri" ] 2 => array:2 [ "nombre" => "Daniele" "apellidos" => "Morosetti" ] 3 => array:2 [ "nombre" => "Martina" "apellidos" => "Milana" ] 4 => array:2 [ "nombre" => "Giampiero" "apellidos" => "Palmieri" ] 5 => array:2 [ "nombre" => "Giuseppe" "apellidos" => "Tisone" ] 6 => array:2 [ "nombre" => "Antonio" "apellidos" => "Orlacchio" ] 7 => array:2 [ "nombre" => "Mario" "apellidos" => "Angelico" ] 8 => array:2 [ "nombre" => "Leonardo" "apellidos" => "Baiocchi" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119322768?idApp=UINPBA00004N" "url" => "/16652681/000000220000000C/v3_202107300613/S1665268119322768/v3_202107300613/en/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S1665268121000181" "issn" => "16652681" "doi" => "10.1016/j.aohep.2021.100319" "estado" => "S300" "fechaPublicacion" => "2021-05-01" "aid" => "100319" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Ann Hepatol. 2021;22C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "Reply to: Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Claudia P. Oliveira" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Claudia P." "apellidos" => "Oliveira" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121000181?idApp=UINPBA00004N" "url" => "/16652681/000000220000000C/v3_202107300613/S1665268121000181/v3_202107300613/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "autores" => array:3 [ 0 => array:3 [ "autoresLista" => "Chaoli Chen" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Chaoli" "apellidos" => "Chen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Laboratory Department, YiWu Central Hospital, Zhejiang 322000, China" "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "autoresLista" => "Xiaofei Li" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Xiaofei" "apellidos" => "Li" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Department of Infectious Diseases, YiWu Central Hospital, Zhejiang 322000, China" "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "autoresLista" => "Wu Guolin" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Wu" "apellidos" => "Guolin" "email" => array:1 [ 0 => "ganya96282@126.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Department of Orthopaedics and Traumatology, YiWu Central Hospita, Zhejiang 322000, China" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with considerable interest a diagnostic study entitled “<span class="elsevierStyleBold">Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease</span>” published in Annals of Hepatology [<a class="elsevierStyleCrossRef" href="#bib0005">1</a>]. In this study, the authors explored the value of five serological markers in the diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. This study utilized serological markers to determine the severity of liver fibrosis in NAFLD patients, which has important clinical guiding value. However, we would like to highlight the following issues.</p><p id="par0010" class="elsevierStylePara elsevierViewall">First, only 126 patients with NAFLD confirmed by biopsy were included in this study, which does not include healthy participants (i.e. the control group). In the absence of a control group, difficulties exist in distinguishing whether the collagen type IV (cIV) level tends to increase or decrease in NAFLD patients. For the purposes of providing further evidence for clinical practice, a preferable option would be to provide the information of a control group and then compare the cIV level differences between the control group and NAFLD patients.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Second, this study stated that “the <span class="elsevierStyleBold">prevalence of diabetes, dyslipidemia, arterial hypertension, and metabolic syndrome was 68.75%, 82.29%, 63.54% and 81.05%, respectively</span>”, and that most of the patients included in this study had underlying diseases. Yet, pursuant to the information provided in <span class="elsevierStyleBold">Table 1</span>, it cannot be determined whether there is any difference in baseline characteristics between the two groups (patients with significant fibrosis and patients with advanced fibrosis). A reasonable hypothesis is that patients with advanced fibrosis suffer more underlying diseases than patients with significant fibrosis, resulting in a higher level of cIV in patients with advanced fibrosis. Hence, providing the baseline characteristics of the two groups is essential.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Third, although 126 NAFLD patients were included in this study, this study did not describe the specific number of cases in the two groups (patients with significant fibrosis and patients with advanced fibrosis), which could be a significant error. Another reasonable assumption is that the number of patients with advanced fibrosis was notably less than that of patients with significant fibrosis. The huge difference in sample size leads to significant differences in cIV levels between the two groups. Thus, we strongly recommend that the authors provide the specific number of patients in the two groups.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Declaration of funding interests</span><p id="par0025" class="elsevierStylePara elsevierViewall">None.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Declaration of funding interests" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-12-04" "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "[1]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.T. Stefano" 1 => "L.V. Guedes" 2 => "A.A.A. de Souza" 3 => "D.S. Vanni" 4 => "V.A.F. Alves" 5 => "F.J. Carrilho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.aohep.2020.08.070" "Revista" => array:2 [ "tituloSerie" => "Ann Hepatol" "fecha" => "2020" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/000000220000000C/v3_202107300613/S1665268120302258/v3_202107300613/en/main.assets" "Apartado" => array:4 [ "identificador" => "82754" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/16652681/000000220000000C/v3_202107300613/S1665268120302258/v3_202107300613/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268120302258?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 14 | 0 | 14 |
| 2024 September | 16 | 5 | 21 |
| 2024 August | 20 | 5 | 25 |
| 2024 July | 23 | 5 | 28 |
| 2024 June | 11 | 1 | 12 |
| 2024 May | 9 | 3 | 12 |
| 2024 April | 9 | 4 | 13 |
| 2024 March | 22 | 2 | 24 |
| 2024 February | 12 | 5 | 17 |
| 2024 January | 7 | 3 | 10 |
| 2023 December | 6 | 2 | 8 |
| 2023 November | 10 | 3 | 13 |
| 2023 October | 19 | 5 | 24 |
| 2023 September | 2 | 1 | 3 |
| 2023 August | 8 | 6 | 14 |
| 2023 July | 4 | 5 | 9 |
| 2023 June | 3 | 0 | 3 |
| 2023 May | 7 | 1 | 8 |
| 2023 April | 5 | 1 | 6 |
| 2023 March | 6 | 2 | 8 |
| 2023 February | 4 | 2 | 6 |
| 2023 January | 10 | 7 | 17 |
| 2022 December | 9 | 11 | 20 |
| 2022 November | 10 | 10 | 20 |
| 2022 October | 11 | 9 | 20 |
| 2022 September | 10 | 5 | 15 |
| 2022 August | 6 | 4 | 10 |
| 2022 July | 9 | 9 | 18 |
| 2022 June | 11 | 7 | 18 |
| 2022 May | 8 | 4 | 12 |
| 2022 April | 3 | 9 | 12 |
| 2022 March | 15 | 9 | 24 |
| 2022 February | 4 | 8 | 12 |
| 2022 January | 18 | 7 | 25 |
| 2021 December | 7 | 13 | 20 |
| 2021 November | 9 | 22 | 31 |
| 2021 October | 9 | 14 | 23 |
| 2021 September | 5 | 11 | 16 |
| 2021 August | 9 | 2 | 11 |
| 2021 July | 5 | 5 | 10 |
| 2021 June | 8 | 6 | 14 |
| 2021 May | 11 | 14 | 25 |
| 2021 April | 8 | 16 | 24 |
| 2021 March | 0 | 7 | 7 |
| 2021 February | 1 | 2 | 3 |
| 2021 January | 0 | 0 | 0 |
Show all
