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Letters to the editor
Non-invasive diagnosis of non-alcoholic fatty liver disease using an algorithm combining clinical indexes and ultrasonographic measures
Lingzhen Jin, Xiaofei Li
Corresponding author
icqwc46@163.com

Corresponding author.
Department of Infectious Diseases, Yiwu Central Hospital, Zhejiang 322000, China
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Puga et al&#46; recently published an intriguing study entitled &#8220;<span class="elsevierStyleBold">Non-invasive diagnosis of non-alcoholic fatty liver disease using an algorithm combining clinical indexes and ultrasonographic measures</span>&#8221; in Annals of Hepatology &#91;<a class="elsevierStyleCrossRef" href="#bib0005">1</a>&#93;&#46; The results of this cross-sectional study provided evidence for the clinical diagnosis of Non-Alcoholic Fatty Liver Disease &#40;NAFLD&#41;&#46; Although we fully agree with the conclusions of this study&#44; the association between body mass index &#40;BMI&#41; and NAFLD needs to be highlighted&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Defined as weight &#40;kg&#41;&#47;height &#40;m&#41;<span class="elsevierStyleSup">2</span>&#44; BMI &#91;<a class="elsevierStyleCrossRef" href="#bib0010">2</a>&#44;<a class="elsevierStyleCrossRef" href="#bib0015">3</a>&#93; is a crucial marker widely adopted in clinical practice to judge obesity &#40;BMI&#8239;&#8805;&#8239;30&#8239;kg&#47;m<span class="elsevierStyleSup">2</span>&#41; &#91;<a class="elsevierStyleCrossRef" href="#bib0020">4</a>&#93;&#46; Further&#44; considering that the indicators &#40;weight and height&#41; for calculating BMI can be easily obtained from medical record systems&#44; BMI is extensively applied in clinical decision-making&#44; including NAFLD&#46; A cohort study based on community population found that BMI is a significant factor in predicting the occurrence of NAFLD&#44; implying that clinicians could use BMI to judge the probability of NAFLD occurrence &#91;<a class="elsevierStyleCrossRef" href="#bib0025">5</a>&#93;&#46; Further evidence from Australia has similarly suggested that obese people have a higher incidence of NAFLD &#91;<a class="elsevierStyleCrossRef" href="#bib0030">6</a>&#93;&#46; The above evidence indicates that BMI or obesity is closely related to the occurrence of NAFLD&#46; As detailed in <span class="elsevierStyleBold">Table 1</span> of the study of Puga et al&#46; &#91;<a class="elsevierStyleCrossRef" href="#bib0005">1</a>&#93;&#44; patients with NAFLD have significantly higher BMI levels than those without NAFLD &#40;30&#46;96&#8239;&#177;&#8239;4&#46;71 versus 27&#46;81&#8239;&#177;&#8239;5&#46;26&#44; P&#8239;&#61;&#8239;0&#46;025&#41;&#46; Hence&#44; BMI could be a vital confounding factor in exploring whether clinical indices and hepatic ultrasound measurements can improve the diagnostic accuracy of NAFLD&#46; In our opinion&#44; performing subgroup analysis premised on the BMI value or conducting regression analysis to adjust BMI might help to obtain reliable conclusions&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Declaration of funding interests</span><p id="par0015" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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Article information
ISSN: 16652681
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos