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Letters to the editor
Reply to: Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease
Claudia P. Oliveira
Department of Gastroenterology, University of Sao Paulo Medical School, Brazil
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    "titulo" => "Reply to&#58; Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease"
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    "saludo" => "Dear Dr&#46; Panduro"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with great interest the comments of Chen&#44; Li&#44; Wu about our study entitled &#8220;Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease&#8221; published in Annals of Hepatology &#91;1&#93;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Concerning the researchers&#8217; notes&#44; we would like to clarify the following points&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0015" class="elsevierStylePara elsevierViewall">It is indeed interesting to know if the collagen type IV level is associated with the diagnosis of NAFLD&#44; but it was not the aim of our present work&#44; and that explains the absence of control group&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0020" class="elsevierStylePara elsevierViewall">Second&#44; we thank you for the opportunity to clarify the data regarding underlying diseases in the two groups &#40;significant fibrosis and advanced fibrosis&#41; of our study&#46; Of note&#44; they do not explain the differences in type IV collagen levels as hypothesized by Chen et al&#46; The observed frequencies of comorbidities are as it follows&#58; 76&#46;32&#37; of patients with significant fibrosis had diabetes&#44; 76&#46;32&#37; dyslipidemia&#44; 50&#37; hypertension and 76&#46;31&#37; obesity&#46; The group of NAFLD patients with advanced fibrosis had 72&#46;22&#37;&#44; 77&#46;78&#37;&#44; 55&#46;56&#37; and 38&#46;89&#37; of those complications respectively&#46; Therefore&#44; the only statistically different feature was obesity&#44; which was interestingly more frequent in the group with less fibrosis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3</span><p id="par0025" class="elsevierStylePara elsevierViewall">At last&#44; we appreciate the sagacious remark about the size of each group of fibrosis classification&#46; Necessarily&#44; the number of patients with significant fibrosis &#40;F2&#8211;F4&#41; has to be greater than the number of patients with advanced fibrosis &#40;F3&#8211;F4&#41; because one group encompasses the other&#46; We had 38 patients with significant fibrosis&#59; 20 were classified as F2 and 18 as advanced fibrosis&#46; To eliminate the doubt raised by Chen et al&#46;&#44; we calculated the mean type IV collagen level of each group&#44; 26&#46;81 for the F2 and 35&#46;91 for the F3&#8211;F4&#44; with a two-tailed T-test of 0&#46;02&#46;</p></li></ul></p><p id="par0030" class="elsevierStylePara elsevierViewall">We consider the researchers&#8217; notes are relevant&#46; Still&#44; we believe that they do not detract from the data already revised by the committee of the editorial board of Annals of Hepatology and published in this renowned journal&#46; Thank you for the opportunity to clarify possible doubts about our paper&#46;</p></span>"
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Article information
ISSN: 16652681
Original language: English
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