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Letters to the Editor
Reply to: Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19)
Ivan López-Mendez
Corresponding author
yahvelopezmendez@gmail.com

Corresponding author.
, Graciela Castro-Narro
Transplants and Hepatology Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150 Toriello Guerra, Tlalpan, ZC 14050 Mexico City, Mexico
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In response to correspondence for Xiaofei Li&#44; we appreciate the interest in our work and we have the following answers to each commentary&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">First commentary&#58;</span></p><p id="par0015" class="elsevierStylePara elsevierViewall">Regarding to Fib4 cut-off point&#44; in our study&#44; we used cut- off point of &#62;3&#46;25&#44; which is validated in the Latin American population&#46; &#40;Ann Hepatol&#46; 2013 May&#8211;Jun&#59;12&#40;3&#41;&#58;416&#8211;24&#46; PMID&#58; 23619258&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Second commentary&#58;</span></p><p id="par0025" class="elsevierStylePara elsevierViewall">The OR reported in our study correspond to all patients &#40;diabetics and non-diabetics&#41;&#59; however&#44; as suggested&#44; we conduct a subgroup analysis with diabetic patients&#59; results showed that in diabetic patients with high levels of glucose &#40;&#62;100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; the risk of ICU admission still been higher compared to those diabetic patients with normal glucose levels&#46; It is important to consider that despite previous diabetes diagnosis&#44; an increase in glucose levels could be caused by systemic inflammatory response syndrome&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Third commentary&#58;</span></p><p id="par0035" class="elsevierStylePara elsevierViewall">Regarding obesity&#44; despite the high worldwide and Mexico prevalence&#44; our population is majorly overweight&#44; being 30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> the cut-off point for obesity in the Mexican population&#59; this distribution and sample size could explain the absence of significative statistical association with clinical outcomes&#46; Nevertheless&#44; the presence of obesity needs to be evaluated in the assessment of COVID-19 patients&#44; especially in those with other metabolic comorbidities&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">All the authors appreciate the author&#39;s time invested in our manuscript&#46; If you need further information&#44; please contact us&#46;</p></span>"
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Article information
ISSN: 16652681
Original language: English
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