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Letters to the editor
Non-invasive diagnosis of non-alcoholic fatty liver disease using an algorithm combining clinical indexes and ultrasonographic measures
Monica C. Preciado-Pugaa, Yeniley Ruiz-Noab, Juana R. Garcia-Ramirezc, Benjamin Jordan-Perezd, Serafin Garnelo-Cabañasd, Maria L. Lazo de la Vega-Monroyb, Karen I. Gutierrez-Aguirrea, Lorena R. Ibarra-Reynosob,
Corresponding author
rey221280@gmail.com

Corresponding author.
a Department of Medicine and Nutrition, Health Sciences Division, University of Guanajuato, Leon, Campus, Boulevard Puente del Milenio 1001, Colonia Predio San Carlos, CP 37672, Leon, Gto, Mexico
b Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon, Campus, 20 de enero #929, Colonia Obregon, CP 37320, Leon, Gto, Mexico
c Department of Pathology, General Hospital Leon, Boulevard Puente Milenio 1001, Colonia Predio San Carlos, CP 37672, Leon, Gto, Mexico
d Department of Surgery, General Hospital Leon, Boulevard Puente Milenio1001, Colonia Predio San Carlos, CP 37672, Leon, Gto, Mexico
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We are thankful for the kind suggestion regarding the association of BMI and NAFLD&#46; The pathophysiology of NAFLD and its progression is induced by multiple factors&#44; including both genetic and environmental factors&#44; which interact individually&#46; Obesity seems to play a role in NAFLD&#44; because if the capacity of adipose tissue to store excess energy is diminished&#44; hepatocytes store the extra lipids&#44; mainly in the form of triglycerides &#91;<a class="elsevierStyleCrossRef" href="#bib0005">1</a>&#93;&#46; Because of this&#44; most of the clinical indices that have been proposed for the evaluation of NAFLD use both biochemical and clinical parameters&#44; among which adiposity measures are found&#46; Such is the case of the indices that we tested in our research&#44; where the Fatty Liver Index &#40;FLI&#41; includes the BMI in its formula &#91;<a class="elsevierStyleCrossRef" href="#bib0010">2</a>&#93;&#44; and the Lipid Accumulation Product &#40;LAP&#41; is an algorithm that includes waist circumference &#91;<a class="elsevierStyleCrossRef" href="#bib0015">3</a>&#93;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Therefore&#44; we consider that adiposity has been considered in an integral way in our results&#46; However&#44; considering the proposed observation&#44; we carried out a regression analysis adjusting by BMI&#44; which does not change the factors associated with the index of NAFLD activity &#40;adjusted R<span class="elsevierStyleSup">2</span>&#8239;&#61;&#8239;0&#46;075 and p-value&#8239;&#61;&#8239;0&#46;004&#41;&#46; This further analysis supports our results and confirms that the clinical measurements evaluated are a good predictor of NAFLD&#46;</p></span>"
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ISSN: 16652681
Original language: English
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