was read the article
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Toro, Aldo Torre, Pedro Montes, Alvaro Urzúa, Esteban Gonzalez Ballerga, María Dolores Silveyra, Douglas Michelato, Javier Díaz, Mirta Peralta, Josefina Pages, Sandro Ruiz García, Isabel Gutierrez Lozano, Yuridia Macias, Daniel Cocozzella, Norberto Chavez-Tapia, Martín Tagle, Alejandra Dominguez, Adriana Varón, Emilia Vera Pozo, Fátima Higuera-de la Tijera, Carla Bustios, Damiá Conte, Nataly Escajadillo, Andrés J Gómez, Laura Tenorio, Mauricio Castillo Barradas, Maria Isabel Schinoni, Fernando Bessone, Fernando Contreras, Leyla Nazal, Abel Sanchez, Matías García, Julia Brutti, María Cecilia Cabrera, Godolfino Miranda-Zazueta, German Rojas, Maximo Cattaneo, Graciela Castro-Narro, Fernando Rubinstein, Marcelo O. Silva" "autores" => array:45 [ 0 => array:2 [ "nombre" => "Manuel" "apellidos" => "Mendizabal" ] 1 => array:2 [ "nombre" => "Ezequiel" "apellidos" => "Ridruejo" ] 2 => array:2 [ "nombre" => "Federico" "apellidos" => "Piñero" ] 3 => array:2 [ "nombre" => "Margarita" "apellidos" => "Anders" ] 4 => array:2 [ "nombre" => "Martín" "apellidos" => "Padilla" ] 5 => array:2 [ "nombre" => "Luis G." 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"apellidos" => "Silva" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121000788?idApp=UINPBA00004N" "url" => "/16652681/00000024000000S1/v3_202110260720/S1665268121000788/v3_202110260720/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1665268121000764" "issn" => "16652681" "doi" => "10.1016/j.aohep.2021.100377" "estado" => "S300" "fechaPublicacion" => "2021-09-01" "aid" => "100366.11" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "abs" "cita" => "Ann Hepatol. 2021;24 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "P-11 POTENTIALLY HEPATOTOXIC DRUGS ARE STILL BEING PRESCRIBED TO LIVER DISEASE PATIENTS UNDER TERTIARY CARE: IT IS TIME TO SAY ENOUGH" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rodrigo Dorelo, Samantha T.A. Barcelos, Magela Barros, Valeria Elustondo, Ysela Y.P. Pérez, Martin Oricchio, Nelson D.S. Uribe, Nelia Hernandez, Dvora Joveleviths, Mário R. Álvares-da-Silva" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Rodrigo" "apellidos" => "Dorelo" ] 1 => array:2 [ "nombre" => "Samantha T.A." "apellidos" => "Barcelos" ] 2 => array:2 [ "nombre" => "Magela" "apellidos" => "Barros" ] 3 => array:2 [ "nombre" => "Valeria" "apellidos" => "Elustondo" ] 4 => array:2 [ "nombre" => "Ysela Y.P." "apellidos" => "Pérez" ] 5 => array:2 [ "nombre" => "Martin" "apellidos" => "Oricchio" ] 6 => array:2 [ "nombre" => "Nelson D.S." "apellidos" => "Uribe" ] 7 => array:2 [ "nombre" => "Nelia" "apellidos" => "Hernandez" ] 8 => array:2 [ "nombre" => "Dvora" "apellidos" => "Joveleviths" ] 9 => array:2 [ "nombre" => "Mário R." "apellidos" => "Álvares-da-Silva" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121000764?idApp=UINPBA00004N" "url" => "/16652681/00000024000000S1/v3_202110260720/S1665268121000764/v3_202110260720/en/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "P-12 QUALITATIVE EVALUATION OF NATURAL PRODUCTS USED BY PATIENTS IN A BRAZILIAN HEPATOTOXICITY AMBULATORY" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Caio Medina Lopes, Andréia de Santana Souza, Ademir do Vale, Juceni Pereira David, Genario Santos, Vinicius Santos Nunes, Maria Isabel Schinoni, Raymundo Paraná" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Caio Medina" "apellidos" => "Lopes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001_100366_12" ] ] ] 1 => array:3 [ "nombre" => "Andréia de Santana" "apellidos" => "Souza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001_100366_12" ] ] ] 2 => array:3 [ "nombre" => "Ademir" "apellidos" => "do Vale" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001_100366_12" ] ] ] 3 => array:3 [ "nombre" => "Juceni Pereira" "apellidos" => "David" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001_100366_12" ] ] ] 4 => array:3 [ "nombre" => "Genario" "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002_100366_12" ] ] ] 5 => array:3 [ "nombre" => "Vinicius Santos" "apellidos" => "Nunes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0003_100366_12" ] ] ] 6 => array:3 [ "nombre" => "Maria Isabel" "apellidos" => "Schinoni" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0004_100366_12" ] ] ] 7 => array:3 [ "nombre" => "Raymundo" "apellidos" => "Paraná" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002_100366_12" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Faculty of Pharmacy, Federal University of Bahia, Salvador, Brazil" "etiqueta" => "1" "identificador" => "aff0001_100366_12" ] 1 => array:3 [ "entidad" => "Faculty of Medicine, Federal University of Bahia, Salvador, Brazil" "etiqueta" => "2" "identificador" => "aff0002_100366_12" ] 2 => array:3 [ "entidad" => "University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil" "etiqueta" => "3" "identificador" => "aff0003_100366_12" ] 3 => array:3 [ "entidad" => "Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil" "etiqueta" => "4" "identificador" => "aff0004_100366_12" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001_100366_12" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001_100366_12">Introduction</span><p id="spara001_100366_12" class="elsevierStyleSimplePara elsevierViewall">Drug-induced liver injury (DILI) can be caused by more than 900 drugs, toxins, and herbs, making it a major problem of clinical importance. The use of food supplements and/or herbal products has become increasingly common in the daily lives of the population worldwide. Natural products can be used for a variety of therapeutic purposes, such as treating gastrointestinal disorders and relieving menopausal symptoms.</p></span> <span id="abss0002_100366_12" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002_100366_12">Aim</span><p id="spara002_100366_12" class="elsevierStyleSimplePara elsevierViewall">To evaluate the hepatotoxic activity of extracts of herbal medicines and dietary supplements used by patients with suspected DILI at a hepatotoxicity ambulatory.</p></span> <span id="abss0003_100366_12" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003_100366_12">Methods</span><p id="spara003_100366_12" class="elsevierStyleSimplePara elsevierViewall">This is an experimental study and was carried out through chemical screening of plant species and dietary supplements for the determination of phytochemical classes. The samples were obtained of patients had DILI suspect, in ambulatorial care of a University Hospital. The experiments were made at Pharmacognosy laboratory.</p></span> <span id="abss0004_100366_12" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004_100366_12">Results</span><p id="spara004_100366_12" class="elsevierStyleSimplePara elsevierViewall">18 samples were received from January 2019 to March 2020. Of these samples, 10 were leaves or stems, and 08 were herbal products or food supplements, with 02 samples being excluded due to contamination. Of the 10 (55%) samples that went to the analysis process, the presence of groups of chemical compounds from secondary plant metabolism was found, where 07 (36%) showed positive results for the presence of triterpenes and steroids. Of these 07 samples, 02 (11%) showed positive results for the presence of alkaloids.</p></span> <span id="abss0005_100366_12" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005_100366_12">Conclusion</span><p id="spara005_100366_12" class="elsevierStyleSimplePara elsevierViewall">There is a profile of liver damage caused by medicinal plants and the compounds present in them, which are mostly: alkaloids, triterpenes, steroids and anthraquinones. After conducting qualitative tests, triterpenes and steroids were identified in most samples (70%), in addition the presence of alkaloids (28%), suggesting that these can be responsible for the cases of DILI, but more robust studies on these samples are needed to identify chemical structure species.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abss0001_100366_12" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abss0002_100366_12" "titulo" => "Aim" ] 2 => array:2 [ "identificador" => "abss0003_100366_12" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abss0004_100366_12" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abss0005_100366_12" "titulo" => "Conclusion" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000024000000S1/v3_202110260720/S1665268121000776/v3_202110260720/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000024000000S1/v3_202110260720/S1665268121000776/v3_202110260720/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121000776?idApp=UINPBA00004N" ]
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