P-55 QUALITY OF LIFE IMPROVES IN PATIENTS WITH OR WITHOUT CIRRHOSIS AFTER HEPATITIS C CURE WITH DIRECT-ACTING ANTIVIRAL AGENTS
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0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "P-56 LOW ROLE OF NON-INVASIVE FIBROSIS ASSESSMENT USING FIB-4 AND APRI IN PATIENTS WITH AUTOIMMUNE HEPATITIS" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Aline Lamaison, Javier Troncoso, Pablo Villafranca, Marcel Bonilla, Maximo Cattaneo, Laura Carreño, Jaime Poniachik, Alvaro Urzúa" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Aline" "apellidos" => "Lamaison" ] 1 => array:2 [ "nombre" => "Javier" "apellidos" => "Troncoso" ] 2 => array:2 [ "nombre" => "Pablo" "apellidos" => "Villafranca" ] 3 => array:2 [ "nombre" => "Marcel" "apellidos" => "Bonilla" ] 4 => array:2 [ "nombre" => "Maximo" "apellidos" => "Cattaneo" ] 5 => array:2 [ "nombre" => "Laura" "apellidos" => "Carreño" ] 6 => array:2 [ "nombre" => "Jaime" "apellidos" => "Poniachik" ] 7 => array:2 [ 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class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001_100366_53">Background</span><p id="spara001_100366_53" class="elsevierStyleSimplePara elsevierViewall">The effect of the treatment of chronic hepatitis C (CHC) with direct-acting antiviral agents (DAAs) on health- related quality of life (HRQL) has been mostly evaluated in clinical trials, and infrequently in Latin-American patients.</p></span> <span id="abss0002_100366_53" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002_100366_53">Aims</span><p id="spara002_100366_53" class="elsevierStyleSimplePara elsevierViewall">To evaluate the effect of CHC treatment with DAAs on HRQL in patients who achieved sustained virological response (SVR) in a real-life setting.</p></span> <span id="abss0003_100366_53" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003_100366_53">Materials and Methods</span><p id="spara003_100366_53" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort study of consecutive adult patients with chronic hepatitis C who achieved SVR with DAAs from August/2017 to December/2018 at Hospital Italiano de Buenos Aires (Argentina). To evaluate HRQL, SF-12v2® Health Survey (SF-12v2) was administered before treatment, at its end, and 12-16 weeks after treatment ended (follow-up visit). QualityMetric-2009 General Population Sample was used as a reference to compare summary scores. The survey has two main summary domains: the physical component summary score (PCS) and the mental component summary score (MCS). Changes over time > 3 points are considered significant.</p></span> <span id="abss0004_100366_53" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004_100366_53">Results</span><p id="spara004_100366_53" class="elsevierStyleSimplePara elsevierViewall">A total of 159 patients were included, median age 59 (50- 69) years-old, 103 (65%) had cirrhosis [85 (83%) Child A; 18 (17%) Child B]. Most patients (80%) received daclatasvir plus sofosbuvir, with or without ribavirin. Median treatment duration was 12 (12-24) weeks. At baseline, both PCS and MCS were below the mean reference of the standard population and showed a significant and progressive improvement over time. The overall mean change on PCS from basal visit to follow-up visit was 4.33 points (95% CI: 2.93-5.73 points). The overall mean change on MCS from pre-treatment visit to follow-up visit was 4.89 points (95% CI: 2.75-6.53 points). In the subgroup of patients with cirrhosis, a significant improvement in both PCS and MCS was also observed. (Figure).</p></span> <span id="abss0005_100366_53" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005_100366_53">Conclusion</span><p id="spara005_100366_53" class="elsevierStyleSimplePara elsevierViewall">HRQL significantly improved in Latin-American patients with CHC who achieved SVR with DAAs, even in those with cirrhosis.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abss0001_100366_53" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abss0002_100366_53" "titulo" => "Aims" ] 2 => array:2 [ "identificador" => "abss0003_100366_53" "titulo" => "Materials and Methods" ] 3 => array:2 [ "identificador" => "abss0004_100366_53" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abss0005_100366_53" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0001_100366_53" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 846 "Ancho" => 1500 "Tamanyo" => 71762 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001_100366_53" "detalle" => "Unlabelled imag" "rol" => "short" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000024000000S1/v3_202110260720/S1665268121001186/v3_202110260720/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000024000000S1/v3_202110260720/S1665268121001186/v3_202110260720/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268121001186?idApp=UINPBA00004N" ]
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