O-2 CHARACTERIZATION OF SERUM LEVELS OF BILE ACIDS, EXTRACELLULAR VESICLES AND ITS CARGO IN ALCOHOL-ASSOCIATED LIVER DISEASE
Jorge Arnold1, Luis Antonio Díaz1, Francisco Idalsoaga1, María Ayala Valverde2, Gustavo Ayares1, Paula Rivera1, Nancy Solís1, Fidel Allende3, Sandra Solari3, Marco Arrese1, Juan Pablo Arab1,4
1 Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
2 Internal Medicine Service, El Pino Hospital. Critical Patient Unit, Dávila Clinic. Santiago, Chile
3 Departamento de Laboratorios Clínicos, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
4 Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Center, London, Ontario, Canada
Read
404
Timeswas read the article
94
Total PDF
310
Total HTML
Share statistics
array:22 [ "pii" => "S1665268123001175" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101013" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "100904.109" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2023;28 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S1665268123001187" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101014" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "100904.110" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2023;28 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "O-4 CLINICAL, HISTOLOGICAL AND SEROLOGICAL FEATURES OF AUTOIMMUNE-LIKE ACUTE LIVER INJURY AFTER SARS-COV-2 VACCINATION" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marlene Padilla Lopez, Natalia Sobenko, Lucrecia Garcia Olivera, Agustina Martinez Garmendia, Eduardo Mullen, Paola Casciato, Sebastian Marciano, Alejandra Villamil" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Marlene Padilla" "apellidos" => "Lopez" ] 1 => array:2 [ "nombre" => "Natalia" "apellidos" => "Sobenko" ] 2 => array:2 [ "nombre" => "Lucrecia Garcia" "apellidos" => "Olivera" ] 3 => array:2 [ "nombre" => "Agustina Martinez" "apellidos" => "Garmendia" ] 4 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Mullen" ] 5 => array:2 [ "nombre" => "Paola" "apellidos" => "Casciato" ] 6 => array:2 [ "nombre" => "Sebastian" "apellidos" => "Marciano" ] 7 => array:2 [ "nombre" => "Alejandra" "apellidos" => "Villamil" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123001187?idApp=UINPBA00004N" "url" => "/16652681/00000028000000S1/v2_202308150516/S1665268123001187/v2_202308150516/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1665268123001163" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101012" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "100904.108" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2023;28 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "O-1 ECONOMIC IMPACT OF LONG-TERM ALBUMIN INFUSIONS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS AND UNCOMPLICATED ASCITES FROM THE BRAZILIAN PUBLIC AND PRIVATE HEALTHCARE SYSTEMS PERSPECTIVES" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Terra, Elisabet Viayna, Laura Ayzin, Cristina Fuster, Susana Aceituno, Maria Soler, Claudio Tafla" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Carlos" "apellidos" => "Terra" ] 1 => array:2 [ "nombre" => "Elisabet" "apellidos" => "Viayna" ] 2 => array:2 [ "nombre" => "Laura" "apellidos" => "Ayzin" ] 3 => array:2 [ "nombre" => "Cristina" "apellidos" => "Fuster" ] 4 => array:2 [ "nombre" => "Susana" "apellidos" => "Aceituno" ] 5 => array:2 [ "nombre" => "Maria" "apellidos" => "Soler" ] 6 => array:2 [ "nombre" => "Claudio" "apellidos" => "Tafla" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123001163?idApp=UINPBA00004N" "url" => "/16652681/00000028000000S1/v2_202308150516/S1665268123001163/v2_202308150516/en/main.assets" ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "O-2 CHARACTERIZATION OF SERUM LEVELS OF BILE ACIDS, EXTRACELLULAR VESICLES AND ITS CARGO IN ALCOHOL-ASSOCIATED LIVER DISEASE" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Jorge Arnold, Luis Antonio Díaz, Francisco Idalsoaga, María Ayala Valverde, Gustavo Ayares, Paula Rivera, Nancy Solís, Fidel Allende, Sandra Solari, Marco Arrese, Juan Pablo Arab" "autores" => array:11 [ 0 => array:3 [ "nombre" => "Jorge" "apellidos" => "Arnold" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "Luis Antonio" "apellidos" => "Díaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 2 => array:3 [ "nombre" => "Francisco" "apellidos" => "Idalsoaga" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 3 => array:3 [ "nombre" => "María Ayala" "apellidos" => "Valverde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 4 => array:3 [ "nombre" => "Gustavo" "apellidos" => "Ayares" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 5 => array:3 [ "nombre" => "Paula" "apellidos" => "Rivera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 6 => array:3 [ "nombre" => "Nancy" "apellidos" => "Solís" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 7 => array:3 [ "nombre" => "Fidel" "apellidos" => "Allende" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0003" ] ] ] 8 => array:3 [ "nombre" => "Sandra" "apellidos" => "Solari" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0003" ] ] ] 9 => array:3 [ "nombre" => "Marco" "apellidos" => "Arrese" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 10 => array:3 [ "nombre" => "Juan Pablo" "apellidos" => "Arab" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0004" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Internal Medicine Service, El Pino Hospital. Critical Patient Unit, Dávila Clinic. Santiago, Chile" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Departamento de Laboratorios Clínicos, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile" "etiqueta" => "3" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Center, London, Ontario, Canada" "etiqueta" => "4" "identificador" => "aff0004" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Figure 1.</span><elsevierMultimedia ident="fig0001"></elsevierMultimedia></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Alcohol consumption is among the five main factors responsible for the burden of disease and mortality. It is associated with changes in serum bile acids, and in recent years, extracellular vesicles (EV´s) and their Cargo have shown special interest in various lines of research due to their role in intercellular communication. This study aimed to characterize the serum levels of bile acids, changes in their composition, extracellular vesicles and their cargo in alcohol-associated liver disease (ALD).</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort, years 2019-2021. They were divided into four groups; control group, alcohol-associated hepatitis (AH), alcohol-related cirrhosis, and alcohol use disorder (AUD). Measurement of serum bile acids and C4 was performed through Liquid Chromatography /Tandem Mass Spectrometry, serum measurement of FGF19 and the serum concentration of extracellular vesicles through NTA (nanoparticle tracking analysis) and their cargo of bile acids.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">A greater concentration of total bile acids was measured in the AUD group (1366.28 ng/ml) compared to the control group (552.42 ng/ml) (p = 0.003). The concentration of chenodeoxycholic acid is higher in the group of patients with AH (734.23 ng/ml) (p=0.04). The EV´s concentration is higher in the HA groups (1.292 E^11 ± 6.4E^10 particles/ml) and in AUD (9.9E^10+ 4.9E^ particles/ml) (p=0.005). It was possible to analyze the Cargo of BA in exosomes with proportional differences between the groups.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Serum bile acids, both in concentration and composition, are modified in patients with AUD and HA, respectively; both present a higher concentration of exosomes, which could be a hepato-specific, dynamic and potentially prognostic biomarker in subjects with ALD.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Methods" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0001" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr26.jpeg" "Alto" => 869 "Ancho" => 1667 "Tamanyo" => 90833 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Unlabelled imag" "rol" => "short" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000028000000S1/v2_202308150516/S1665268123001175/v2_202308150516/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000028000000S1/v2_202308150516/S1665268123001175/v2_202308150516/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123001175?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 0 | 3 |
| 2024 October | 10 | 8 | 18 |
| 2024 September | 21 | 15 | 36 |
| 2024 August | 23 | 13 | 36 |
| 2024 July | 22 | 9 | 31 |
| 2024 June | 23 | 4 | 27 |
| 2024 May | 14 | 0 | 14 |
| 2024 April | 14 | 4 | 18 |
| 2024 March | 14 | 5 | 19 |
| 2024 February | 18 | 2 | 20 |
| 2024 January | 19 | 6 | 25 |
| 2023 December | 3 | 3 | 6 |
| 2023 November | 13 | 3 | 16 |
| 2023 October | 74 | 9 | 83 |
| 2023 September | 16 | 3 | 19 |
| 2023 August | 12 | 7 | 19 |
| 2023 July | 5 | 1 | 6 |
| 2023 June | 3 | 1 | 4 |
| 2023 May | 3 | 1 | 4 |
Show all
