O-6 ENHANCED METABOLISM OF AROMATIC AMINO ACIDS AND LOW-DIVERSITY GUT MICROBIOTA: SIGNATURES OF HEPATIC ENCEPHALOPATHY IN DECOMPENSATED CIRRHOTIC PATIENTS FROM WESTERN MEXICO
Tonatiuh Abimael Baltazar-Díaz1, Luz Alicia González-Hernández2, Juan Manuel Aldana-Ledesma3, Donovan Cortina-Romero1, Marcela Peña-Rodríguez4, Alejandra Natali Vega-Magaña5, Sara Minia Zepeda-Morales6, Rocío Ivette López-Roa6, Susana Del Toro-Arreola1, Miriam Bueno-Topete1
1 Institute for Research in Chronic-Degenerative Diseases, University Center of Health Sciences, Guadalajara University, Guadalajara, México
2 VIH Unit, Civil Hospital of de Guadalajara Fray Antonio Alcalde, Guadalajara, México
3 Gastroenterology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico
4 Laboratory for the Diagnosis of Emerging and Reemerging Diseases, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico
5 Biomedical Sciences Research Institute, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico
6 Pharmaceutical Research and Development Laboratory, University Center of Exact Sciences and Engineering, University of Guadalajara, Guadalajara, Mexico
Read
457
Timeswas read the article
120
Total PDF
337
Total HTML
Share statistics
array:22 [ "pii" => "S1665268123001205" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101016" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "100904.112" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2023;28 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S1665268123001217" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101017" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "100904.113" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2023;28 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "O-7 LIVER TOXICITY OF TYROSINE KINASE INHIBITORS: A DESCRIPTIVE ANALYSIS FROM SLATINDILI NETWORK" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nelia Hernández, Fernando Bessone, Daniela Chiodi, Norberto Tamagnone, Inmaculada Medina-Caliz, María Isabel Lucena, Raúl Andrade" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Nelia" "apellidos" => "Hernández" ] 1 => array:2 [ "nombre" => "Fernando" "apellidos" => "Bessone" ] 2 => array:2 [ "nombre" => "Daniela" "apellidos" => "Chiodi" ] 3 => array:2 [ "nombre" => "Norberto" "apellidos" => "Tamagnone" ] 4 => array:2 [ "nombre" => "Inmaculada" "apellidos" => "Medina-Caliz" ] 5 => array:2 [ "nombre" => "María Isabel" "apellidos" => "Lucena" ] 6 => array:2 [ "nombre" => "Raúl" "apellidos" => "Andrade" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123001217?idApp=UINPBA00004N" "url" => "/16652681/00000028000000S1/v2_202308150516/S1665268123001217/v2_202308150516/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1665268123001199" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101015" "estado" => "S300" "fechaPublicacion" => "2023-03-01" "aid" => "100904.111" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2023;28 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "O-5 INTEGRATED ANALYSIS OF ARCHAEAL, FUNGAL AND PROTOZOAN GUT TRANSCRIPTOME IN METABOLIC ASSOCIATED FATTY LIVER DISEASE (MAFLD) IN ARGENTINA" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bárbara Suárez, María Florencia Mascardi, Flavia Noelia Mazzini, M. Ruda Vera, Sebastián Marciano, Paola Casciato, Adrián Narvaez, Leila Haddad, Margarita Anders, Federico Orozco, Ana Jesica Tamaroff, Frank Cook, John Gounarides, Susana Gutt, Adrián Gadano, Celia Mén dez García, Martin L. Marro, Alberto Penas Steinhardt, Julieta Trinks" "autores" => array:19 [ 0 => array:2 [ "nombre" => "Bárbara" "apellidos" => "Suárez" ] 1 => array:2 [ "nombre" => "María Florencia" "apellidos" => "Mascardi" ] 2 => array:2 [ "nombre" => "Flavia Noelia" "apellidos" => "Mazzini" ] 3 => array:2 [ "nombre" => "M. Ruda" "apellidos" => "Vera" ] 4 => array:2 [ "nombre" => "Sebastián" "apellidos" => "Marciano" ] 5 => array:2 [ "nombre" => "Paola" "apellidos" => "Casciato" ] 6 => array:2 [ "nombre" => "Adrián" "apellidos" => "Narvaez" ] 7 => array:2 [ "nombre" => "Leila" "apellidos" => "Haddad" ] 8 => array:2 [ "nombre" => "Margarita" "apellidos" => "Anders" ] 9 => array:2 [ "nombre" => "Federico" "apellidos" => "Orozco" ] 10 => array:2 [ "nombre" => "Ana Jesica" "apellidos" => "Tamaroff" ] 11 => array:2 [ "nombre" => "Frank" "apellidos" => "Cook" ] 12 => array:2 [ "nombre" => "John" "apellidos" => "Gounarides" ] 13 => array:2 [ "nombre" => "Susana" "apellidos" => "Gutt" ] 14 => array:2 [ "nombre" => "Adrián" "apellidos" => "Gadano" ] 15 => array:2 [ "nombre" => "Celia Mén" "apellidos" => "dez García" ] 16 => array:2 [ "nombre" => "Martin L." "apellidos" => "Marro" ] 17 => array:2 [ "nombre" => "Alberto Penas" "apellidos" => "Steinhardt" ] 18 => array:2 [ "nombre" => "Julieta" "apellidos" => "Trinks" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123001199?idApp=UINPBA00004N" "url" => "/16652681/00000028000000S1/v2_202308150516/S1665268123001199/v2_202308150516/en/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "O-6 ENHANCED METABOLISM OF AROMATIC AMINO ACIDS AND LOW-DIVERSITY GUT MICROBIOTA: SIGNATURES OF HEPATIC ENCEPHALOPATHY IN DECOMPENSATED CIRRHOTIC PATIENTS FROM WESTERN MEXICO" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Tonatiuh Abimael Baltazar-Díaz, Luz Alicia González-Hernández, Juan Manuel Aldana-Ledesma, Donovan Cortina-Romero, Marcela Peña-Rodríguez, Alejandra Natali Vega-Magaña, Sara Minia Zepeda-Morales, Rocío Ivette López-Roa, Susana Del Toro-Arreola, Miriam Bueno-Topete" "autores" => array:10 [ 0 => array:3 [ "nombre" => "Tonatiuh Abimael" "apellidos" => "Baltazar-Díaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "Luz Alicia" "apellidos" => "González-Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "nombre" => "Juan Manuel" "apellidos" => "Aldana-Ledesma" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0003" ] ] ] 3 => array:3 [ "nombre" => "Donovan" "apellidos" => "Cortina-Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 4 => array:3 [ "nombre" => "Marcela" "apellidos" => "Peña-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0004" ] ] ] 5 => array:3 [ "nombre" => "Alejandra Natali" "apellidos" => "Vega-Magaña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Sara Minia" "apellidos" => "Zepeda-Morales" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0006" ] ] ] 7 => array:3 [ "nombre" => "Rocío Ivette" "apellidos" => "López-Roa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0006" ] ] ] 8 => array:3 [ "nombre" => "Susana Del" "apellidos" => "Toro-Arreola" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 9 => array:3 [ "nombre" => "Miriam" "apellidos" => "Bueno-Topete" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Institute for Research in Chronic-Degenerative Diseases, University Center of Health Sciences, Guadalajara University, Guadalajara, México" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "VIH Unit, Civil Hospital of de Guadalajara Fray Antonio Alcalde, Guadalajara, México" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Gastroenterology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico" "etiqueta" => "3" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "Laboratory for the Diagnosis of Emerging and Reemerging Diseases, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico" "etiqueta" => "4" "identificador" => "aff0004" ] 4 => array:3 [ "entidad" => "Biomedical Sciences Research Institute, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico" "etiqueta" => "5" "identificador" => "aff0005" ] 5 => array:3 [ "entidad" => "Pharmaceutical Research and Development Laboratory, University Center of Exact Sciences and Engineering, University of Guadalajara, Guadalajara, Mexico" "etiqueta" => "6" "identificador" => "aff0006" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Alterations in the intestinal microbiota in decompensated cirrhosis are recognized as being critical in clinical evolution. The onset of hepatic encephalopathy (HE) worsens the prognosis. Metabolic functions related to intestinal microbiota, such as ammonia production and imbalance of amino acid biosynthesis, are believed to play a key role on the pathophysiology of HE. This study aimed to evaluate the composition and functions of the intestinal microbiota in patients with decompensated cirrhosis and HE.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Fecal samples from 31 decompensated cirrhotic patients (20 with HE, 11 without HE) and 18 age-balanced healthy controls (HC) were included. Microbial composition was characterized by 16S rRNA sequencing and analyzed using QIIME2. Metabolic pathways were inferred by PICRUSt2. SCFAs quantification was performed by gas chromatography (GC).</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Intestinal microbiota in HE group was characterized by a decreased α-diversity, compared to no-HE group (<span class="elsevierStyleItalic">p</span><0.01) and HC (<span class="elsevierStyleItalic">p</span><0.001); β-diversity was also different between HE vs. no-HE group (<span class="elsevierStyleItalic">p</span><0.05) and HE vs. HC (<span class="elsevierStyleItalic">p</span><0.001). Intestinal microbiota from HE was defined by the presence of taxa such as <span class="elsevierStyleItalic">Escherichia</span>/<span class="elsevierStyleItalic">Shigella</span>, Burkholderiales and Lactobacillales. Furthermore, no-HE was characterized by the presence of <span class="elsevierStyleItalic">Veilonella</span> and <span class="elsevierStyleItalic">Bacteroides</span>. Both groups were depleted of potential beneficial taxa, such as <span class="elsevierStyleItalic">Ruminococcus</span> or <span class="elsevierStyleItalic">Faecalibacterium</span>, which correlates with diminished levels of fecal SCFAs in these groups. Inferred metabolic pathways showed that HE group was characterized by an enhanced chorismate metabolism, which is a key precursor of aromatic amino acids, along with antibiotic resistance and ammonia-producing pathways. HE and no-HE group showed a significant increase in the metabolism of lipopolysaccharides.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">The intestinal microbiota of HE patients exhibit a lower diversity compared with no-HE and HC. It is dominated by <span class="elsevierStyleItalic">Escherichia/Shigella</span> and characterized by an enhanced metabolism of aromatic amino acids precursors and ammonia-producing pathways, which suggests its participation in the pathophysiology of HE. These results are described for the first time in western Mexico.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Methods" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000028000000S1/v2_202308150516/S1665268123001205/v2_202308150516/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000028000000S1/v2_202308150516/S1665268123001205/v2_202308150516/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123001205?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 0 | 2 |
| 2024 October | 8 | 2 | 10 |
| 2024 September | 4 | 2 | 6 |
| 2024 August | 10 | 4 | 14 |
| 2024 July | 7 | 4 | 11 |
| 2024 June | 6 | 4 | 10 |
| 2024 May | 6 | 4 | 10 |
| 2024 April | 9 | 4 | 13 |
| 2024 March | 12 | 7 | 19 |
| 2024 February | 4 | 4 | 8 |
| 2024 January | 5 | 7 | 12 |
| 2023 December | 4 | 5 | 9 |
| 2023 November | 6 | 7 | 13 |
| 2023 October | 11 | 17 | 28 |
| 2023 September | 7 | 4 | 11 |
| 2023 August | 3 | 2 | 5 |
| 2023 July | 3 | 8 | 11 |
| 2023 June | 12 | 7 | 19 |
| 2023 May | 19 | 18 | 37 |
| 2023 April | 199 | 10 | 209 |
Show all
