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P-5 APACHE STUDY DESIGN TO EVALUATE THE EFFICACY AND SAFETY OF PLASMA EXCHANGE WITH HUMAN SERUM ALBUMIN 5% ON SHORT-TERM SURVIVAL IN PATIENTS WITH ACUTE-ON-CHRONIC LIVER FAILURE AT HIGH RISK OF HOSPITAL MORTALITY.
Nikolaos Pyrsopoulos1, Giovanni Perricone2, Jasmohan S. Bajaj3, Thierry Gustot4, Thomas Reiberger5, Mireia Torres6, Peter Nelson6, Javier Fernandez7, Apache Study Investigators 8
1 Division of Gastroenterology and Hepatology, Rutgers-New Jersey Medical School, New Jersey, Estados Unidos (EEUU)
2 Hepatology and Gastroenterology Unit, ASST GOM Niguarda, Milan, Italia
3 Division of Gastroenterology, Hepatology, and Nutrition, Richmond VA Medical Center and Virginia Commonwealth University, Richmond, Virginia, Estados Unidos (EEUU)
4 Department of Gastroenterology, Hepato-Pancreatology, HUB Erasme Hospital, Université Libre de Bruxelles, Brussels, Bélgica
5 Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
6 Clinical Operations, Scientific Innovation Office, Grifols, Barcelona, España
7 Liver Unit, EF Clif, EASL-CLIF Consortium and Grifols Chair, Hospital Clínic, IDIBAPS and CIBERehd, Barcelona, España
8 Apache Study Investigators, Barcelona, España
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Acute-on-chronic liver failure &#40;ACLF&#41; in cirrhotic patients is characterized by acute deterioration of liver function and severe organ injury with high short-term mortality&#46; Liver transplantation is the only treatment to improve survival&#46; A pilot study suggested that plasma exchange with human serum albumin 5&#37; &#40;PEA5&#37;&#41; as a replacement fluid is feasible and safe in ACLF patients and may improve organ function and survival&#46; This study aimed to assess PE-A5&#37; as a treatment for patients with ACLF in a pivotal study&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">A phase 3&#44; multicenter&#44; randomized &#40;1&#58;1&#41;&#44; controlled&#44; parallel-group&#44; open-label study &#40;APACHE&#41; compares standard medical treatment &#40;SMT&#41;&#8239;&#43;&#8239;PE-A5&#37; &#40;treatment arm&#41; to SMT alone &#40;control arm&#41;&#46; PE-A5&#37; is performed using Albutein 5&#37; &#40;Grifols&#41;&#46; Treatment schedule consists of two initial PE-A5&#37; sessions on consecutive days followed by every other day PE-A5&#37; &#40;min-max 4-9 PE-A5&#37;&#41;&#46; Patients receive IVIG &#40;200mg&#47;kg&#41; after every 2 PE-A5&#37; to prevent hypogammaglobulinemia-associated infections&#44; and FFP after each PE-A5&#37; to prevent coagulopathy&#46; Eligible patients are adult &#40;18-79 years old&#41;&#44; with ACLF-1b&#44; ACLF-2&#44; or ACLF-3a at admission or during hospitalization&#46; Main exclusion criteria are patients with ACLF-1a or ACLF-3b&#44; ACLF &#62;10 days before randomization&#44; septic shock requiring norepinephrine &#40;&#62;0&#46;3&#181;g&#47;kg&#47;min&#41; or a second vasopressor&#44; active infection&#44; and severe respiratory failure&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Target enrollment is 380 ACLF patients at high risk of hospital mortality&#46; The primary efficacy endpoint is the 90-day overall survival&#46; Secondary efficacy endpoints include 90-day transplant-free survival and 28-day overall survival&#46; Main exploratory endpoints include overall and transplant-free survival at days 28 and 90&#44; in-patient hospital and ICU stay&#44; incidence of organ failures and ACLF course&#46; Safety analyses include adverse events&#44; vital signs&#44; physical assessments&#44; and laboratory tests&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">APACHE will provide pivotal results on the efficacy and safety of PE-A5&#37; as a treatment to improve survival in ACLF &#40;NCT03702920&#59;EudraCT&#58;2016-001787-10&#41;&#46;</p></span>"
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ISSN: 16652681
Original language: English
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