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Terrabuio, Mario Guimaraes, Marcos Girala, Leonardo Lucca, Edgard Aguilera, Álvaro Urzúa, Marcia Samada, Kenia Valenzuela, Rodrigo Zapata" "autores" => array:26 [ 0 => array:2 [ "nombre" => "Victoria" "apellidos" => "Mainardi" ] 1 => array:2 [ "nombre" => "Josemaría" "apellidos" => "Menéndez" ] 2 => array:2 [ "nombre" => "Solange" "apellidos" => "Gerona" ] 3 => array:2 [ "nombre" => "Alejandra" "apellidos" => "Villamil" ] 4 => array:2 [ "nombre" => "Josefina" "apellidos" => "Pages" ] 5 => array:2 [ "nombre" => "Manuel" "apellidos" => "Mendizabal" ] 6 => array:2 [ "nombre" => "Sergio" "apellidos" => "López" ] 7 => array:2 [ "nombre" => "Adriana" "apellidos" => "Varon" ] 8 => array:2 [ "nombre" => "Alfeu" "apellidos" => "De Medeiros" ] 9 => array:2 [ "nombre" => "Jhon" "apellidos" => "Abad" ] 10 => array:2 [ "nombre" => "Juan Carlos" "apellidos" => "Restrepo" ] 11 => array:2 [ "nombre" => "Liana" "apellidos" => "Codes" ] 12 => array:2 [ "nombre" => "Paulo" "apellidos" => "Lisboa" ] 13 => array:2 [ "nombre" => "Norma Marlene" "apellidos" => "Perez" ] 14 => array:2 [ "nombre" => "Pablo" "apellidos" => "Coste" ] 15 => array:2 [ "nombre" => "Graciela" "apellidos" => "Castro-Narro" ] 16 => array:2 [ "nombre" => "Martin" "apellidos" => "Padilla" ] 17 => array:2 [ "nombre" => "Débora Raquel B." "apellidos" => "Terrabuio" ] 18 => array:2 [ "nombre" => "Mario" "apellidos" => "Guimaraes" ] 19 => array:2 [ "nombre" => "Marcos" "apellidos" => "Girala" ] 20 => array:2 [ "nombre" => "Leonardo" "apellidos" => "Lucca" ] 21 => array:2 [ "nombre" => "Edgard" "apellidos" => "Aguilera" ] 22 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Urzúa" ] 23 => array:2 [ "nombre" => "Marcia" "apellidos" => "Samada" ] 24 => array:2 [ "nombre" => "Kenia" "apellidos" => "Valenzuela" ] 25 => array:2 [ "nombre" => "Rodrigo" "apellidos" => "Zapata" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123002946?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123002946/v2_202405310451/en/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "P-5 APACHE STUDY DESIGN TO EVALUATE THE EFFICACY AND SAFETY OF PLASMA EXCHANGE WITH HUMAN SERUM ALBUMIN 5% ON SHORT-TERM SURVIVAL IN PATIENTS WITH ACUTE-ON-CHRONIC LIVER FAILURE AT HIGH RISK OF HOSPITAL MORTALITY." "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Nikolaos Pyrsopoulos, Giovanni Perricone, Jasmohan S. Bajaj, Thierry Gustot, Thomas Reiberger, Mireia Torres, Peter Nelson, Javier Fernandez" "autores" => array:9 [ 0 => array:3 [ "nombre" => "Nikolaos" "apellidos" => "Pyrsopoulos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "Giovanni" "apellidos" => "Perricone" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "nombre" => "Jasmohan S." "apellidos" => "Bajaj" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0003" ] ] ] 3 => array:3 [ "nombre" => "Thierry" "apellidos" => "Gustot" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0004" ] ] ] 4 => array:3 [ "nombre" => "Thomas" "apellidos" => "Reiberger" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Mireia" "apellidos" => "Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0006" ] ] ] 6 => array:3 [ "nombre" => "Peter" "apellidos" => "Nelson" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0006" ] ] ] 7 => array:3 [ "nombre" => "Javier" "apellidos" => "Fernandez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0007" ] ] ] 8 => array:2 [ "colaborador" => "Apache Study Investigators" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">8</span>" "identificador" => "aff0008" ] ] ] ] "afiliaciones" => array:8 [ 0 => array:3 [ "entidad" => "Division of Gastroenterology and Hepatology, Rutgers-New Jersey Medical School, New Jersey, Estados Unidos (EEUU)" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Hepatology and Gastroenterology Unit, ASST GOM Niguarda, Milan, Italia" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Division of Gastroenterology, Hepatology, and Nutrition, Richmond VA Medical Center and Virginia Commonwealth University, Richmond, Virginia, Estados Unidos (EEUU)" "etiqueta" => "3" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "Department of Gastroenterology, Hepato-Pancreatology, HUB Erasme Hospital, Université Libre de Bruxelles, Brussels, Bélgica" "etiqueta" => "4" "identificador" => "aff0004" ] 4 => array:3 [ "entidad" => "Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria" "etiqueta" => "5" "identificador" => "aff0005" ] 5 => array:3 [ "entidad" => "Clinical Operations, Scientific Innovation Office, Grifols, Barcelona, España" "etiqueta" => "6" "identificador" => "aff0006" ] 6 => array:3 [ "entidad" => "Liver Unit, EF Clif, EASL-CLIF Consortium and Grifols Chair, Hospital Clínic, IDIBAPS and CIBERehd, Barcelona, España" "etiqueta" => "7" "identificador" => "aff0007" ] 7 => array:3 [ "entidad" => "Apache Study Investigators, Barcelona, España" "etiqueta" => "8" "identificador" => "aff0008" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Acute-on-chronic liver failure (ACLF) in cirrhotic patients is characterized by acute deterioration of liver function and severe organ injury with high short-term mortality. Liver transplantation is the only treatment to improve survival. A pilot study suggested that plasma exchange with human serum albumin 5% (PEA5%) as a replacement fluid is feasible and safe in ACLF patients and may improve organ function and survival. This study aimed to assess PE-A5% as a treatment for patients with ACLF in a pivotal study.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">A phase 3, multicenter, randomized (1:1), controlled, parallel-group, open-label study (APACHE) compares standard medical treatment (SMT) + PE-A5% (treatment arm) to SMT alone (control arm). PE-A5% is performed using Albutein 5% (Grifols). Treatment schedule consists of two initial PE-A5% sessions on consecutive days followed by every other day PE-A5% (min-max 4-9 PE-A5%). Patients receive IVIG (200mg/kg) after every 2 PE-A5% to prevent hypogammaglobulinemia-associated infections, and FFP after each PE-A5% to prevent coagulopathy. Eligible patients are adult (18-79 years old), with ACLF-1b, ACLF-2, or ACLF-3a at admission or during hospitalization. Main exclusion criteria are patients with ACLF-1a or ACLF-3b, ACLF >10 days before randomization, septic shock requiring norepinephrine (>0.3µg/kg/min) or a second vasopressor, active infection, and severe respiratory failure.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Target enrollment is 380 ACLF patients at high risk of hospital mortality. The primary efficacy endpoint is the 90-day overall survival. Secondary efficacy endpoints include 90-day transplant-free survival and 28-day overall survival. Main exploratory endpoints include overall and transplant-free survival at days 28 and 90, in-patient hospital and ICU stay, incidence of organ failures and ACLF course. Safety analyses include adverse events, vital signs, physical assessments, and laboratory tests.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">APACHE will provide pivotal results on the efficacy and safety of PE-A5% as a treatment to improve survival in ACLF (NCT03702920;EudraCT:2016-001787-10).</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Methods" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123002958/v2_202405310451/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S1/v2_202405310451/S1665268123002958/v2_202405310451/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123002958?idApp=UINPBA00004N" ]
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