P-13 IMPACT OF SPONTANEOUS BACTERIAL PERITONITIS ON THE OUTCOME OF PATIENTS WITH HEPATIC CIRRHOSIS
Sandra Teutli, Claudia Leticia Dorantes, Miguel Yael Carmona, Ernesto Javier Medina, Daniel Santana, Maria De Fátima Higuera, Jose Luis Perez
Gastroenterology and Hepatology, Hospital General de México "Dr. Eduardo Liceaga"., Ciudad de México, México
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AND ANTIBIOTIC RESISTANCE PATTERNS" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bruno Campos, Eliabe Silva, Guilherme Grossi Lopes, Guilherme De Oliveira, Joao Pedro Rocha, Júlia Cunha, Laura Normando, Laura Melo, Laura Carolina Menezes, Luciana Costa, Cláudia Alves" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Bruno" "apellidos" => "Campos" ] 1 => array:2 [ "nombre" => "Eliabe" "apellidos" => "Silva" ] 2 => array:2 [ "nombre" => "Guilherme Grossi" "apellidos" => "Lopes" ] 3 => array:2 [ "nombre" => "Guilherme" "apellidos" => "De Oliveira" ] 4 => array:2 [ "nombre" => "Joao Pedro" "apellidos" => "Rocha" ] 5 => array:2 [ "nombre" => "Júlia" "apellidos" => "Cunha" ] 6 => array:2 [ "nombre" => "Laura" "apellidos" => "Normando" ] 7 => array:2 [ "nombre" => "Laura" "apellidos" => "Melo" ] 8 => array:2 [ "nombre" => 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FAILURE (ACLF)" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ernesto Javier Medina-Avalos, Fátima Higuera-de la Tijera, Miguel Yael Carmona-Castillo, Sandra Teutli- Carrión, Claudia Leticia Dorantes-Nava, José Luis Pérez-Hernández, Daniel Santana-Vargas" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Ernesto Javier" "apellidos" => "Medina-Avalos" ] 1 => array:2 [ "nombre" => "Fátima" "apellidos" => "Higuera-de la Tijera" ] 2 => array:2 [ "nombre" => "Miguel Yael" "apellidos" => "Carmona-Castillo" ] 3 => array:2 [ "nombre" => "Sandra Teutli-" "apellidos" => "Carrión" ] 4 => array:2 [ "nombre" => "Claudia Leticia" "apellidos" => "Dorantes-Nava" ] 5 => array:2 [ "nombre" => "José Luis" "apellidos" => "Pérez-Hernández" ] 6 => array:2 [ "nombre" => "Daniel" "apellidos" => "Santana-Vargas" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003022?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003022/v2_202405310451/en/main.assets" ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "P-13 IMPACT OF SPONTANEOUS BACTERIAL PERITONITIS ON THE OUTCOME OF PATIENTS WITH HEPATIC CIRRHOSIS" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Sandra Teutli, Claudia Leticia Dorantes, Miguel Yael Carmona, Ernesto Javier Medina, Daniel Santana, Maria De Fátima Higuera, Jose Luis Perez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Sandra" "apellidos" => "Teutli" ] 1 => array:2 [ "nombre" => "Claudia Leticia" "apellidos" => "Dorantes" ] 2 => array:2 [ "nombre" => "Miguel Yael" "apellidos" => "Carmona" ] 3 => array:2 [ "nombre" => "Ernesto Javier" "apellidos" => "Medina" ] 4 => array:2 [ "nombre" => "Daniel" "apellidos" => "Santana" ] 5 => array:2 [ "nombre" => "Maria De Fátima" "apellidos" => "Higuera" ] 6 => array:2 [ "nombre" => "Jose Luis" "apellidos" => "Perez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Gastroenterology and Hepatology, Hospital General de México "Dr. Eduardo Liceaga"., Ciudad de México, México" "identificador" => "aff0001" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para9001" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="fig0001"></elsevierMultimedia></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Spontaneous bacterial peritonitis (SBP) increases mortality, making it relevant to evaluate factors that negatively impact the outcome of patients who develop SBP. This study aimed to evaluate SBP as a risk factor in the outcome of patients with cirrhosis.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">A retrospective and analytical study was conducted on patients with cirrhosis who developed SBP. The cause of cirrhosis, Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, and MELD-Na score were evaluated. They were classified into early responders (ER) (more than 25% decrease in polymorphonuclear cells on the second day of effective antibiotic treatment), development of renal injury (RI), acute-on-chronic liver failure (ACLF), and 28-day mortality. Statistical analysis included evaluating the mortality rate using the Kaplan-Meier curve, log-rank test, considering significance at p 0.05. RI, ACLF, and non-early responders were independently compared.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">A total of 79 patients were included, 40 males (50.63%). The most common etiology was alcohol-related in 39 cases (49.36%), and Child-Pugh class C was observed in 67 cases (84.81%). Cephalosporins were used in 66 cases (83.54%), and carbapenems in 13 cases (16.45%). There were 6 deaths among early responders and 29 deaths among non-early responders, with a mean survival of 25.76 days for early responders versus 9.78 days for non-early responders, p < 0.001 (fig1). There were 2 deaths without ACLF and 33 deaths with ACLF, with a mean survival of 26.93 days without ACLF versus 14.6 days with ACLF, p < 0.001. There were 3 deaths without renal injury and 32 deaths with RI, with a mean survival of 25.65 days without RI versus 16.17 days with RI, p < 0.001.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">SBP is associated with a high mortality rate. 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