P- 18 ANASTROZOLE MAY NOT BE ASSOCIATED FATTY LIVER DISEASE AND HEPATIC FIBROSIS IN WOMEN WITH BREAST CANCER
Mateus Jorge1, Guilherme Grossi2, Mísia Joyner De Sousa1, Adriana Maria Lamego2, Carolina Martins3, Paulo Henrique Costa3, Fernanda Alves4, Julia Cunha1, Ananda Queiroz1, Laura Melo1, Victor Peçanha1, Maria Clara Mendes1, Luciana Costa1, Claudia Alves1
1 Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brasil
2 Instituto Alfa de Gastroenterologia, Hospital das Clínicas da Universidade Federal, Belo Horizonte, Brasil
3 Serviço de Oncologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brasil
4 Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brasil
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class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Nonalcoholic fatty liver disease (NAFLD) is highly prevalent among women undergoing androgen inhibitors therapy for breast cancer. As breast cancer survival increases, understanding the long-term impact of anastrozole therapy on NAFLD becomes crucial. This study aimed to assess the prevalence and severity of NAFLD in relation to anastrozole adjuvant therapy among breast cancer patients and to investigate the risk factors associated with the occurrence and progression of NAFLD.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study, recruiting women with breast cancer from an oncology outpatient clinic. Participants underwent abdominal ultrasound to detect liver steatosis and transient elastography for hepatic fibrosis evaluation. Two groups were formed: those not receiving hormone therapy and those exposed to anastrozole.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">91 patients (mean age 58±12 years) were included (71 in the no hormone therapy group and 20 in the anastrozole-exposed group). Follow-up period ranged from 1-315 months [median 25, interquartile range (IQR) 70]. Prevalent comorbidities were diabetes mellitus (27.5%), arterial hypertension (52.7%), dyslipidemia (26.4%), and obesity (47.7%). Exposure to anastrozole ranged from 1 to 60 months (mean 23 ± 15.8). Liver steatosis was detected in 50.5% of the patients, with no significant difference between groups (p = 0.652). Median liver stiffness was also similar (5.2kPa, IQR 2.2, p = 0.102), with 6.7% of patients showing liver stiffness 8kPa (p = 0.613) and 4.5% with measurements 12kPa (p = 0.217). Variables associated with fatty liver were diabetes mellitus (p = 0.018), arterial hypertension (p = 0.047), dyslipidemia (p = 0.021), body mass index (BMI) (p = 0.001), and follow- up time (p = 0.002). Liver stiffness 8kPa was associated with BMI (p = 0.033).</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Half of breast cancer patients present NAFLD, with approximately 7% presenting advanced fibrosis. Anastrozole therapy was not associated with NAFLD. Shared metabolic risk factors may play a role in NAFLD in women with breast cancer.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Methods" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003083/v2_202405310451/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S1/v2_202405310451/S1665268123003083/v2_202405310451/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003083?idApp=UINPBA00004N" ]
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