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array:22 [ "pii" => "S1665268123003113" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101208" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101187.21" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S1665268123003125" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101209" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101187.22" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "P-22 UNCOVERING INSIGHTS ON ACUTE VARICEAL HEMORRHAGE: A CROSS- COUNTRY SURVEY STUDY ON THE MANAGEMENT OF UPPER GASTROINTESTINAL BLEEDING IN LATIN AMERICA" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jesus Ruiz, Wagner Enrique Ramirez, Antonio Olivas, Luis Carlos Chávez, Erick Jasso, Josealberto S. Arenas, Thamy Leidy Beltré, Jose Carlos Jésus Ticona, Karla Avendaño, Venny Alberto Venegas, Carlos Alonzo, María Fernanda Vásquez, Juanita Pérez, Godolfino Miranda, Graciela Castro, Luis Eduardo Zamora" "autores" => array:16 [ 0 => array:2 [ "nombre" => "Jesus" "apellidos" => "Ruiz" ] 1 => array:2 [ "nombre" => "Wagner Enrique" "apellidos" => "Ramirez" ] 2 => array:2 [ "nombre" => "Antonio" "apellidos" => "Olivas" ] 3 => array:2 [ "nombre" => "Luis Carlos" "apellidos" => "Chávez" ] 4 => array:2 [ "nombre" => "Erick" "apellidos" => "Jasso" ] 5 => array:2 [ "nombre" => "Josealberto S." "apellidos" => "Arenas" ] 6 => array:2 [ "nombre" => "Thamy Leidy" "apellidos" => "Beltré" ] 7 => array:2 [ "nombre" => "Jose Carlos Jésus" "apellidos" => "Ticona" ] 8 => array:2 [ "nombre" => "Karla" "apellidos" => "Avendaño" ] 9 => array:2 [ "nombre" => "Venny Alberto" "apellidos" => "Venegas" ] 10 => array:2 [ "nombre" => "Carlos" "apellidos" => "Alonzo" ] 11 => array:2 [ "nombre" => "María Fernanda" "apellidos" => "Vásquez" ] 12 => array:2 [ "nombre" => "Juanita" "apellidos" => "Pérez" ] 13 => array:2 [ "nombre" => "Godolfino" "apellidos" => "Miranda" ] 14 => array:2 [ "nombre" => "Graciela" "apellidos" => "Castro" ] 15 => array:2 [ "nombre" => "Luis Eduardo" "apellidos" => "Zamora" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003125?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003125/v2_202405310451/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1665268123003101" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101207" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101187.20" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "P-20 OXIDATIVE STRESS MARKERS IN ALCOHOLIC LIVER DISEASE" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "GABRIELA GUTIÉRREZ, Abigail Hernandez, Zaira Medina, Marisela Hernandez, Moisés Martínez, José Luis Pérez, Fátima Higuera, Jacqueline Córdova" "autores" => array:8 [ 0 => array:2 [ "nombre" => "GABRIELA" "apellidos" => "GUTIÉRREZ" ] 1 => array:2 [ "nombre" => "Abigail" "apellidos" => "Hernandez" ] 2 => array:2 [ "nombre" => "Zaira" "apellidos" => "Medina" ] 3 => array:2 [ "nombre" => "Marisela" "apellidos" => "Hernandez" ] 4 => array:2 [ "nombre" => "Moisés" "apellidos" => "Martínez" ] 5 => array:2 [ "nombre" => "José Luis" "apellidos" => "Pérez" ] 6 => array:2 [ "nombre" => "Fátima" "apellidos" => "Higuera" ] 7 => array:2 [ "nombre" => "Jacqueline" "apellidos" => "Córdova" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003101?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003101/v2_202405310451/en/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "P-21 FIBROSIS DEVELOPMENT AND MALIGNANCIES ARE DELAYED BY PIRFENIDONE WHILE INCREASING SIRT1 NUCLEAR TRANSLOCATION AND HISTONE 3 DEACETYLATIONS IN A HEPATOCARCINOMA MODEL" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Hugo Christian Monroy, Scarlet Arceo, Araceli Guadalupe Cabral, Marina Galicia, Juan Armendariz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Hugo Christian" "apellidos" => "Monroy" ] 1 => array:2 [ "nombre" => "Scarlet" "apellidos" => "Arceo" ] 2 => array:2 [ "nombre" => "Araceli Guadalupe" "apellidos" => "Cabral" ] 3 => array:2 [ "nombre" => "Marina" "apellidos" => "Galicia" ] 4 => array:2 [ "nombre" => "Juan" "apellidos" => "Armendariz" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara, México" "identificador" => "aff0001" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Hepatocellular carcinoma (HCC) is the most common liver neoplasm worldwide. Pro-inflammatory and pro-fibrogenic processes are fundamental in tumor development. On the other hand, Pirfenidone (PFD) has anti-inflammatory and antifibrogenic properties useful to counteract hepatocarcinogenesis; however, effects of this drug on SIRT1, and epigenetic regulations in this type of damage are unknown. The aimed of this study is to evaluate PDF effects on SIRT1 translocation, and deacetylation of histone H3 lysines 9 and 14 (H3K9 and H3K14) in a HCC model.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Male Fischer-344 rats (n=18) were divided into three groups: CTL: control group, HCC: damage group, rats weekly administrated with diethylnitrosamine (DEN,50mg/kg/i.p.) and 2-aminofluorene (2AAF, 25mg/kg/p.o.) for 16 weeks. HCC/PFD group of rats administrated with DEN and 2AAF plus PFD (300mg/kg/day/p.o.). Tumor development and fibrosis markers were analyzed histologically. In addition, expression of SIRT1 deacetylase, p300 acetylase, H3 and H3K9 and H3K14 acetylated were analyzed by western blot.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Normal liver architecture is disturbed by dysplastic nodules formation surrounded by extracellular matrix and fibrosis, also an increase in cells with anaplasia and steatotic foci was observed in liver tissues of HCC group. PFD was effective in preventing these changes. Immunohistochemistry revealed an overexpression of GPC3 and -SMA in damage group, which correlates with malignant degeneration; these responses were also prevented by PFD. Finally, western blots evidenced an overexpression of SIRT1 in nuclear fraction of PFD group, triggering H3K9 and H3K14 deacetylation, in addition, a decrease in p300 acetylase expression in nuclear fractions was noted. Noteworthy, c-Myc was decreased.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">PFD reduces fibrotic and malignant patterns development. Likewise, PFD induces SIRT1 expression and nuclear translocation along with H3K9 and H3K14 deacetylation, compacting chromatin and possibly down expression of oncogenes. These results demonstrate the capability of PFD to regulate epigenetic hallmarks on histones.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Methods" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003113/v2_202405310451/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S1/v2_202405310451/S1665268123003113/v2_202405310451/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003113?idApp=UINPBA00004N" ]
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