P- 24 DISTRIBUTION OF HEPATITIS C GENOTYPES IN THE ARGENTINE POPULATION IN THE LAST TEN YEARS

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Lucca, Maribel Martinez Wassaf, Néstor Portela, Sergio Grutadauria, Fabián Fay" "autores" => array:10 [ 0 => array:3 [ "nombre" => "Javier Alejandro" "apellidos" => "Sfalcin" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "Alan" "apellidos" => "Gomez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "aff0001" ] ] ] 2 => array:3 [ "nombre" => "Tomás" "apellidos" => "Fernandez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "2" "identificador" => "aff0002" ] ] ] 3 => array:3 [ "nombre" => "Dolores" "apellidos" => "Gagey" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "3" "identificador" => "aff0003" ] ] ] 4 => array:3 [ "nombre" => "Pablo" "apellidos" => "Gornitz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "4" "identificador" => "aff0004" ] ] ] 5 => array:3 [ "nombre" => "Andrea" "apellidos" => "Lucca" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "5" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Maribel Martinez" "apellidos" => "Wassaf" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "6" "identificador" => "aff0006" ] ] ] 7 => array:3 [ "nombre" => "Néstor" "apellidos" => "Portela" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "6" "identificador" => "aff0006" ] ] ] 8 => array:3 [ "nombre" => "Sergio" "apellidos" => "Grutadauria" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "7" "identificador" => "aff0007" ] ] ] 9 => array:3 [ "nombre" => "Fabián" "apellidos" => "Fay" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "aff0001" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Molecular Biology Area, Cibic Laboratorios, Rosario, Argentina" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Molecular Biology Laboratory, Casa Hospital San Juan de Dios, Ramos Mejía, Buenos Aires, Argentina" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Virology Area, Laboratorio Fares Taie, Mar del Plata, Argentina" "etiqueta" => "3" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "President, Gornitz Laboratorios, Villa María, Argentina" "etiqueta" => "4" "identificador" => "aff0004" ] 4 => array:3 [ "entidad" => "Molecular Biology Area, Fundación para el Progreso de la Medicina, Córdoba, Argentina" "etiqueta" => "5" "identificador" => "aff0005" ] 5 => array:3 [ "entidad" => "Virology Area, LACE Laboratorios, Córdoba, Argentina" "etiqueta" => "6" "identificador" => "aff0006" ] 6 => array:3 [ "entidad" => "Virology, Central Laboratory, Sanatorio Allende, Córdoba, Argentina" "etiqueta" => "7" "identificador" => "aff0007" ] ] ] ] "textoCompleto" => "<elsevierMultimedia ident="fig0001"></elsevierMultimedia>Table: Distribution of HCV genotypes." "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "Introduction and ObjectivesHepatitis C virus (HCV) consists of 7 genotypes and multiple subtypes. With the introduction of pangenotypic direct-acting antivirals (DAAs), the utility of genotype as a prognostic factor for treatment tends to be less relevant. However, it is useful for those patients who require a second DAAs regimen. In Argentina, there are few reports on the prevalence of HCV genotypes, which indicate a varied and changing distribution in different cities. This study aimed to determine the frequency of HCV genotypes in different cities of Argentina in the last ten years. Materials and MethodsRetrospective cross-sectional study of HCV genotypes performed by sequencing the 5′ untranslated region of the viral genome in 1.178 samples assayed in the periods 2013-2017 and 2018-2023, taken in clinical analysis laboratories in different cities of Argentina: Rosario (RO, n=465), Villa María (VM, n=173), Mar del Plata (MDQ, N=111), Córdoba (COR, n=384) and Ramos Mejía (RM, n=45). Frequencies between periods were compared using Fisher's test. ResultsThe frequencies of each genotype are presented in the Table. There is a variation among cities that is maintained in both periods, with the exception of MDQ. An increase in the frequency of G3 is observed in the 2018-2023 period, although it was not statistically significant. ConclusionsThe present study updates the knowledge on the distribution of HCV genotypes in Argentina, showing a variation among cities. The frequency of G3a, at present the most difficult genotype to treat, could be rising. Surveillance studies with a larger number of samples would be necessary to confirm this hypothesis. VM frequencies confirm the existence of foci with high prevalence of certain genotypes in some cities, as previously reported. It is necessary to continue monitoring the circulation of HCV genotypes even after DAAs usage and their consequent impact on public health." 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Javier Alejandro Sfalcin1, Alan Gomez1, Tomás Fernandez2, Dolores Gagey3, Pablo Gornitz4, Andrea Lucca5, Maribel Martinez Wassaf6, Néstor Portela6, Sergio Grutadauria7, Fabián Fay1

1 Molecular Biology Area, Cibic Laboratorios, Rosario, Argentina

2 Molecular Biology Laboratory, Casa Hospital San Juan de Dios, Ramos Mejía, Buenos Aires, Argentina

3 Virology Area, Laboratorio Fares Taie, Mar del Plata, Argentina

4 President, Gornitz Laboratorios, Villa María, Argentina

5 Molecular Biology Area, Fundación para el Progreso de la Medicina, Córdoba, Argentina

6 Virology Area, LACE Laboratorios, Córdoba, Argentina

7 Virology, Central Laboratory, Sanatorio Allende, Córdoba, Argentina

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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Hepatitis C virus &#40;HCV&#41; consists of 7 genotypes and multiple subtypes&#46; With the introduction of pangenotypic direct-acting antivirals &#40;DAAs&#41;&#44; the utility of genotype as a prognostic factor for treatment tends to be less relevant&#46; However&#44; it is useful for those patients who require a second DAAs regimen&#46; In Argentina&#44; there are few reports on the prevalence of HCV genotypes&#44; which indicate a varied and changing distribution in different cities&#46; This study aimed to determine the frequency of HCV genotypes in different cities of Argentina in the last ten years&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Retrospective cross-sectional study of HCV genotypes performed by sequencing the 5&#8242; untranslated region of the viral genome in 1&#46;178 samples assayed in the periods 2013-2017 and 2018-2023&#44; taken in clinical analysis laboratories in different cities of Argentina&#58; Rosario &#40;RO&#44; n&#61;465&#41;&#44; Villa Mar&#237;a &#40;VM&#44; n&#61;173&#41;&#44; Mar del Plata &#40;MDQ&#44; N&#61;111&#41;&#44; C&#243;rdoba &#40;COR&#44; n&#61;384&#41; and Ramos Mej&#237;a &#40;RM&#44; n&#61;45&#41;&#46; Frequencies between periods were compared using Fisher&#39;s test&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">The frequencies of each genotype are presented in the Table&#46; There is a variation among cities that is maintained in both periods&#44; with the exception of MDQ&#46; An increase in the frequency of G3 is observed in the 2018-2023 period&#44; although it was not statistically significant&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">The present study updates the knowledge on the distribution of HCV genotypes in Argentina&#44; showing a variation among cities&#46; The frequency of G3a&#44; at present the most difficult genotype to treat&#44; could be rising&#46; Surveillance studies with a larger number of samples would be necessary to confirm this hypothesis&#46; VM frequencies confirm the existence of foci with high prevalence of certain genotypes in some cities&#44; as previously reported&#46; It is necessary to continue monitoring the circulation of HCV genotypes even after DAAs usage and their consequent impact on public health&#46;</p></span>"
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