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      "titulo" => "P- 33 FREQUENCY, PROPHYLAXIS AND MANAGEMENT OF VARICEAL BLEEDING IN PATIENTS WITH LIVER CIRRHOSIS IN A RETROSPECTIVE MULTICENTER COHORT FROM SOUTH AMERICA"
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      "titulo" => "P-31 METHOTREXATE SEEMS NOT TO BE ASSOCIATED WITH LIVER FIBROSIS IN RHEUMATOID ARTHRITIS PATIENTS"
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    "titulo" => "P- 32 VALIDATION OF LILLE-4 VERSUS LILLE-7 TO PREDICT SHORT-TERM MORTALITY IN PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS"
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        "autoresLista" => "Claudia Leticia Dorantes, María de Fátima Higuera, Alfredo Servín, Gabriela Gutiérrez, Miguel Yael Carmona, Sandra Teutli, Ernesto Javier Medina, José Luis Pérez"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">It has been proposed to calculate the Lille score on day 4 &#40;Lille-4&#41;&#44; which supposedly has comparable accuracy to the Lille score calculated on day 7 &#40;Lille-7&#41; for alcoholic hepatitis &#40;AH&#41;&#46; However&#44; this finding has not been validated&#46; This study aimed to validate the use of Lille-4 in predicting response to steroid treatment in patients with severe AH in the Mexican population&#44; with the aim of reducing the risk of secondary complications associated with their use&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Observational&#44; prospective&#44; ambilective&#44; analytical&#44; cohort study from January 2010 to April 2023&#46; Clinical and biochemical variables were collected upon admission&#44; and Lille models were calculated to evaluate response and 28-day mortality&#46; Comparative analyses were performed based on survival versus mortality&#46; Sensitivity&#44; PPV&#44; NPV and accuracy of the models were calculated&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">A total of 327 patients were included&#44; 297 &#40;90&#46;8&#37;&#41; men&#46; The mean age was 43&#46;4&#177;9&#46;3 years&#44; and the 50th percentile for alcohol consumption was 320 g&#47;day &#40;5th-95th percentile&#58;100&#46;8-662&#41;&#46; At day 28&#44; 207 patients &#40;63&#46;3&#37;&#41; died&#46; Upon admission&#44; patients who died showed a significant difference compared to survivors in&#58; Maddrey&#40;90&#91;95&#37;CI&#58;81-99&#93;vs&#46;70&#91;95&#37;CI&#58;65-75&#93;&#59;p&#60;0&#46;0001&#41;&#44; ABIC&#40;8&#46;8&#177;1&#46;8vs&#46;8&#46;1&#177;1&#46;3&#59; p&#60;0&#46;0001&#41;&#44; MELD&#40;32&#177;8vs&#46;27&#177;4&#59;p&#60;0&#46;0001&#41;&#44; and MELD-Na&#40;33&#177;6vs&#46;30&#177;4&#59;p&#60;0&#46;0001&#41;&#46; The AUROC for Lille-7 was 0&#46;71&#91;0&#46;65-0&#46;77&#93;&#44; where a value &#62;0&#46;45 had a sensitivity &#40;S&#41; of 78&#37; and specificity &#40;E&#41; of 45&#37; for predicting early mortality&#46; Lille-4 had an AUROC of 0&#46;68&#91;0&#46;63-0&#46;74&#93;&#44; where a value &#62;0&#46;45 had an S&#61;81&#37; and E&#61;54&#37; &#40;Figure 1&#41;&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Lille-7 showed higher accuracy&#44; in predicting early mortality in severe AH&#46; Therefore&#44; the determination of total bilirubin should not be before day 7&#44; and steroid therapy should be provided to patients for up to 7 days to classify treatment response&#46;</p></span>"
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