P- 39 N-ACETYL CYSTEINE ATTENUATES ALTERATIONS GENERATED IN EXPERIMENTAL LIVER STEATOSIS INDUCED BY CHRONIC ALCOHOL CONSUMPTION PLUS A HYPERCALORIC DIET
Marina Galicia, Katia Berenice Roa, Angel Omar Vazquez, Hugo Christian Monroy, Rebeca Rosas, Ana Soledad Sandoval, Juan Armendariz
Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara, Jalisco, México
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Berenice" "apellidos" => "Roa" ] 2 => array:2 [ "nombre" => "Angel Omar" "apellidos" => "Vazquez" ] 3 => array:2 [ "nombre" => "Hugo Christian" "apellidos" => "Monroy" ] 4 => array:2 [ "nombre" => "Rebeca" "apellidos" => "Rosas" ] 5 => array:2 [ "nombre" => "Ana Soledad" "apellidos" => "Sandoval" ] 6 => array:2 [ "nombre" => "Juan" "apellidos" => "Armendariz" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara, Jalisco, México" "identificador" => "aff0001" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Metabolic disorders and alcohol consumption are the most common etiological agents in hepatic steatosis (HS). Metabolic alterations, oxidative stress, and inflammation are key mechanisms in the development of this disease. There is a few evidence that demonstrates the synergistic effects generated by both etiological agents. N-acetyl cysteine (NAC) is an antioxidant used clinically, whose efficacy in HS development induced by a hypercaloric diet plus alcohol consumption is unknown. This study aimed to evaluate NAC effects on oxidative stress, and metabolic alterations induced in HS generated by ethanol chronic consumption plus a hypercaloric diet in a mouse model.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Male mice (C57BL/6J, n=4) were divided into 3 groups. 1) Control, mice fed with a conventional diet and water ad libitum; 2) HF/OH, mice fed a hypercaloric diet, and 20% ethanol; 3) HF/OH+NAC, mice with the same treatments of HF/OH group, and NAC (300 mg/kg/day, p.o.). All treatments lasted 5 months. Serum biochemical markers were determined: AST, ALT, cholesterol, HDL, LDL, triglycerides, leptin, ghrelin, insulin, resistin, and GLP1; also, oxidative stress parameters such as MDA, and SOD, CAT and Nrf2 proteins expression were analyzed through colorimetric assays, and western blot. Finally, H&E staining was performed in liver samples.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">NAC prevents weight gain and metabolic alterations generated by concomitant consumption of a hypercaloric diet and alcohol; it also modulates changes in anorexigenic and orexigenic adipokines. On the other hand, NAC reduces the oxidative environment induced by both etiological agents and prevents tissue alterations in hepatic parenchyma.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">NAC ameliorates alterations in processes related to establishment of HS induced by ethanol chronic consumption plus a hypercaloric diet. Its pharmacodynamic mechanisms go beyond its antioxidant capacity.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Methods" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003290/v2_202405310451/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S1/v2_202405310451/S1665268123003290/v2_202405310451/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003290?idApp=UINPBA00004N" ]
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