P-45 EVALUATION OF THE ALBI SCORE IN PATIENTS WITH HEPATOCELLULAR CARCINOMA TREATED WITH YTTRIUM-90 (90Y)

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=> array:2 [ "nombre" => "Miguel Angel" "apellidos" => "Mendoza" ] 8 => array:2 [ "nombre" => "Eira" "apellidos" => "Cerda" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Investigation, Military Central Hospital, Mexico City, Mexico" "identificador" => "aff0001" ] ] ] ] "textoCompleto" => "<elsevierMultimedia ident="fig0001"></elsevierMultimedia>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "Introduction and ObjectivesHepatocellular carcinoma (HCC) is the third cause of mortality worldwide. 10% of patients receive therapy with curative intent. There are loco-regional therapies to improve patient survival, such as (TACE) and radioembolization with Yttrium-90. There are prognostic scales, such as ALBI, to identify who will have a positive response to the treatment. We aimed to evaluate the potential of the ALBI index for HCC as a predictor of mortality and associate it with survival or complications in patients who received treatment with Yttrium-90, correlating with Child Pugh, MELD and MELD-NA scores. Materials and Methods8 patients with cirrhosis and (HCC) were evaluated; 60% (4) women aged 50 ±12.5 years, Child Pugh 7 points, MELD 11, MELD-NA 11, MELD 3.0 12 and initial BCLC (B), received an average of 2 radioembolization sessions with (90Y) and ALBI was evaluated. Results3 patients had a complete response, one with intolerance to the (90Y) who required a second line of treatment. The other patients presented progression of the disease, therefore, palliative treatment and complications treating the CHC were applied. 3 patients died, who obtained an ALBI score of .08 ± 0.27 (grade 3), which could be correlated with patient survival. After Yttrium- 90, the following final values were measured Child Pugh (8.86 ±2.61), MELD (15.43±7.13), Leukocytes (6.7±1.5), Hemoglobin (12.85±1.66), Platelets (76.71±42.16), Bilirubin (4.16 ±4.58), Albumin (2.58 ±0.55) without any significant difference.The only difference was in MELD-Na (17.43 ± 6.90) which can be due to the progression and complications of the cirrhosis itself. (Table 1) ConclusionsThe ALBI, Child-Pugh and MELD NA scores in the prediction of mortality, survival and complications development during the disease in patients’ treatment with Yttrium-90 could be a prognostic factor. Studies with a larger group of patients are needed to correlate and obtain more significant results regarding the score of ALBI." 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Stefanny Cornejo, Yailin Fabiola Velazquez, Blanca Zapote, Itzia Verduzco, Erika Santiago, Salvador Amezquita, Juan Salvador Garcia, Miguel Angel Mendoza, Eira Cerda

Department of Investigation, Military Central Hospital, Mexico City, Mexico

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    "titulo" => "P-45 EVALUATION OF THE ALBI SCORE IN PATIENTS WITH HEPATOCELLULAR CARCINOMA TREATED WITH YTTRIUM-90 &#40;90Y&#41;"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Hepatocellular carcinoma &#40;HCC&#41; is the third cause of mortality worldwide&#46; 10&#37; of patients receive therapy with curative intent&#46; There are loco-regional therapies to improve patient survival&#44; such as &#40;TACE&#41; and radioembolization with Yttrium-90&#46; There are prognostic scales&#44; such as ALBI&#44; to identify who will have a positive response to the treatment&#46; We aimed to evaluate the potential of the ALBI index for HCC as a predictor of mortality and associate it with survival or complications in patients who received treatment with Yttrium-90&#44; correlating with Child Pugh&#44; MELD and MELD-NA scores&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">8 patients with cirrhosis and &#40;HCC&#41; were evaluated&#59; 60&#37; &#40;4&#41; women aged 50 &#177;12&#46;5 years&#44; Child Pugh 7 points&#44; MELD 11&#44; MELD-NA 11&#44; MELD 3&#46;0 12 and initial BCLC &#40;B&#41;&#44; received an average of 2 radioembolization sessions with &#40;90Y&#41; and ALBI was evaluated&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">3 patients had a complete response&#44; one with intolerance to the &#40;90Y&#41; who required a second line of treatment&#46; The other patients presented progression of the disease&#44; therefore&#44; palliative treatment and complications treating the CHC were applied&#46; 3 patients died&#44; who obtained an ALBI score of &#46;08 &#177; 0&#46;27 &#40;grade 3&#41;&#44; which could be correlated with patient survival&#46; After Yttrium- 90&#44; the following final values were measured Child Pugh &#40;8&#46;86 &#177;2&#46;61&#41;&#44; MELD &#40;15&#46;43&#177;7&#46;13&#41;&#44; Leukocytes &#40;6&#46;7&#177;1&#46;5&#41;&#44; Hemoglobin &#40;12&#46;85&#177;1&#46;66&#41;&#44; Platelets &#40;76&#46;71&#177;42&#46;16&#41;&#44; Bilirubin &#40;4&#46;16 &#177;4&#46;58&#41;&#44; Albumin &#40;2&#46;58 &#177;0&#46;55&#41; without any significant difference&#46;The only difference was in MELD-Na &#40;17&#46;43 &#177; 6&#46;90&#41; which can be due to the progression and complications of the cirrhosis itself&#46; &#40;Table 1&#41;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">The ALBI&#44; Child-Pugh and MELD NA scores in the prediction of mortality&#44; survival and complications development during the disease in patients&#8217; treatment with Yttrium-90 could be a prognostic factor&#46; Studies with a larger group of patients are needed to correlate and obtain more significant results regarding the score of ALBI&#46;</p></span>"
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