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    "doi" => "10.1016/j.aohep.2023.101247"
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      "titulo" => "P-60 DIAGNOSTIC PERFORMANCE OF FIBROSCAN FOR LIVER DISEASE IN BOGOTA, COLOMBIA"
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          "autoresLista" => "Diana Del Pilar Torres, Benedicto Velasco, Jonathan Alexander Guezguan"
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              "nombre" => "Jonathan Alexander"
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      "titulo" => "P- 58 CLINICAL OUTCOMES OF PATIENTS WITH GRAFT REJECTION FOLLOWING TRANSPLANTATION FOR AUTOIMMUNE LIVER DISEASE AT A LIVER TRANSPLANT CENTER IN COLOMBIA"
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          "autoresLista" => "Ximena Morales, Cristina Torres, Carolina Salinas, Martín Garzón, Geovanny Hernández, Oscar Beltrán, Gilberto Mejia, Andrés Murcia, Jairo Rivera, Angie Gelves, Felipe Méndez, Adriana Varón"
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    "titulo" => "P- 59 ROLE OF MARESINA-1 ON THE KIDNEY AND LIVER MORPHOLOGY ON A MURINE MODEL OF TYPE I DIABETES MELLITUS INDUCED WITH STREPTOZOTOCIN"
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        "autoresLista" => "Pamela Carolina Morales, Jessica Pamela Zúñiga, Ramón Norambuena, Daniel González"
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            "nombre" => "Pamela Carolina"
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            "nombre" => "Jessica Pamela"
            "apellidos" => "Z&#250;&#241;iga"
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        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Basical Biomedical Science Department&#44; Department of Health Sciences&#44; University of Talca&#44; Talca&#44; Chile"
            "etiqueta" => "1"
            "identificador" => "aff0001"
          ]
          1 => array:3 [
            "entidad" => "Department of Natural Resources and Veterinary Medicine&#44; School of Veterinary Medicine&#46; Santo Tomas University&#44; Talca&#44; Chile"
            "etiqueta" => "2"
            "identificador" => "aff0002"
          ]
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Diabetes mellitus &#40;DM&#41; is a chronic metabolic disease characterized by elevated blood glucose levels&#46; DM1 manifests itself through hyperglycemia&#44; the main factor inducing numerous life-threatening complications and comorbidities&#46; DM has high morbidity and mortality associated with cardiovascular diseases&#44; nephropathy and dyslipidemias&#44; which are correlated with the deterioration of liver function&#46; Maresin-1 &#40;MaR1&#41;&#44; a specialized pro-resolving lipid mediators has recently been described&#46; MaR1 has a positive role in various inflammation-related pathologies particularly&#44; it has favorable effect on chronic liver disease&#46; This study aims to evaluate the effect of MaR1 administration on liver and kidney tissues in a murine model of DM1&#46; Our hypothesis is that treatment produces an improvement in liver and kidney morphology&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">male C57BL&#47;6 mice where induced DM1 by Spreptozotocin injection &#40;50mg&#47;Kg&#41; and MaR1 &#40;4ng&#47;g&#41; diary for 4 weeks&#46; Liver and Kidneys were processed for H&#38;E and Masson&#180;s Trichrome stain and morphological analyzed&#46; An immunohistochemical study was also carried out with the use of antibodies to fibronectin and -SMA&#46; The data was evaluated by Image J and Prism 9 software&#39;s&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Both in liver and kidney&#44; the MaR1 animal group recovers the cito-architecture and decreased the score of fibrosis in comparison with DM group&#44; resembling the control group&#46; In liver tissue a decrease of lipids deposit was observed in the MaR1&#44; concomitant with the architecture improvement&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Mar1 at 4 ng&#47;g generates a positive response in the liver and kidney morphology&#44; depleting the tissue damage observed in a DM1 murine model&#46; Deeper analysis should carry on for to enlarge this results and assay Mar1 as a potential therapeutic activity against one of the most prevalent diseases in the world&#44; the DM&#46;</p></span>"
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