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    "titulo" => "O-17 NUTRICIONAL AND PHYSICAL THERAPHY IMPROVES LIVER FRAILTY INDEX IN LISTED PATIENTS WITH CIRRHOSIS: RANDOMIZED CONTROLLED TRIAL. INTERIM ANALYSIS"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Frailty is independently associated with a lower survival in cirrhotic patients&#46; Liver Frailty Index &#40;LFI&#41; determine frailty in listed patients predicting survival&#46; This study aimed to evaluate the effect of a physical and nutritional therapy &#40;intervention group&#41; over LFI compared with a physical and nutritional counseling &#40;control group&#41;&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Patients were recruited and randomized to an intervention group or a control group&#46; Patients were followed for 12 weeks with evaluations every 4 weeks&#46; We compared LFI and LFI at different time points between both groups during the follow-up&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">46 patients were recruited&#44; 27 of them in control group and 19 of them in the intervention group&#46; 50&#37; were women and the most common etiologies were metabolic associated fatty liver disease &#40;37&#37;&#41; and alcoholic liver disease &#40;19&#46;6&#37;&#41;&#44; primary biliary cholangitis &#40;6&#46;52&#37;&#41;&#44; autoimmune hepatitis &#40;6&#46;52&#37;&#41; and hepatitis C virus &#40;2&#46;17&#37;&#41;&#46; The median &#40;IQR&#41; age was 60 years &#40;53-63 years&#41;&#44; MELD-Na 17 &#40;15-21&#41;&#44; creatinine 0&#46;75 mg&#47;dl &#40;0&#46;6-0&#46;8&#41; albumin 3&#46;1 g&#47;dl &#40;2&#46;9-3&#46;1&#41;&#44; INR 1&#46;54 &#40;1&#46;4-1&#46;75&#41; and bilirubin 2&#46;6 mg&#47;dl &#40;1&#46;4-1&#46;7&#41;&#46; Child-Pugh scores were A&#47;B&#47;C 13&#37;&#47;58&#46;7&#37;&#47;28&#46;3&#37; respectively&#46; No differences in baseline characteristics were found between the groups&#46; Notably&#44; there was a significant improvement in LFI &#40;median&#59; IQR&#41; in the intervention group &#40;Figure 1&#41; after 8 weeks LFI 3&#46;74 &#40;3&#46;37-3&#46;97&#41; with LFI -0&#46;86 vs&#46; control group LFI 4&#46;15 &#40;3&#46;94-4&#46;23&#41; with LFI -0&#46;02&#44; p&#61;0&#46;007&#41; and after 12 weeks &#40;intervention group 3&#46;73 &#40;3&#46;31-4&#46;11&#41; with LFI -0&#46;87 vs&#46; control group LFI 4&#46;14 &#40;4&#46;06-4&#46;50&#41; with LFI -0&#46;03&#44; p&#61;0&#46;023&#41;&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">In this interim analysis nutritional and physical therapy improves LFI&#46; This is the first randomized controlled trial with positive results in listed patients with cirrhosis&#46;</p></span>"
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