OP-3 HCV MICROELIMINATION PROGRAM IN HEMODIALYSIS PATIENTS: SUCCESS OF A MULTI-STAKEHOLDER PARTNERSHIP BASED ON A NATIONAL ERADICATION STRATEGY

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"identificador" => "aff0004" ] ] ] 6 => array:3 [ "nombre" => "Enrique Gabriel" "apellidos" => "Dorado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "4" "identificador" => "aff0004" ] ] ] 7 => array:3 [ "nombre" => "Ezequiel" "apellidos" => "Mauro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "2" "identificador" => "aff0002" ] ] ] 8 => array:3 [ "nombre" => "Marcelo Hugo" "apellidos" => "Puddu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "4" "identificador" => "aff0004" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Hepatology Section, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno “CEMIC”, Ciudad Autónoma de Buenos Aires, Argentina" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "National Coordination of Viral Hepatitis, Ministry of Health, Ciudad Autónoma de Buenos Aires, Argentina" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Pilar, Argentina" "etiqueta" => "3" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "Fresenius Medical Care, Ciudad Autónoma de Buenos Aires, Argentina" "etiqueta" => "4" "identificador" => "aff0004" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "Introduction and ObjectivesDirect-acting antivirals (DAAs) are highly effective in patients with chronic kidney disease in hemodialysis and chronic hepatitis C (HCV). The treatment of HCV in this population brings multiple benefits, including improved survival of the patient on dialysis and reduction of contagion in the dialysis room by achieving eradication. Our aim was to evaluate the effectiveness of DAA treatment in this population in routine clinical practice in Argentina using a multidisciplinary network of nephrologists and hepatologists, within the framework of the national micro-elimination strategy of the Viral Hepatitis Program of the Ministry of Health. Materials and MethodsIn this prospective multicenter cohort study, all patients on dialysis at Fresenius Argentina, were screened for anti-HCV. All HCV RNA- positive patients were offered treatment with Sofosbuvir/Velpatasvir (SOF/VEL) and Glecaprevir/Pibrentasvir (GP) according to national guidelines. FIB-4 and APRI scores, and liver stiffness (LSM) when available, were performed in all HCV RNA-positive patients before treatment. Those with F3-4 by LSM, FIB-4 >3.25 and/or APRI >1.5 were evaluated by a hepatologist. DAAs therapy was initiated in each dialysis unit under the supervision of hepatologists by telemedicine. ResultsA total of —10,144 patients from all hemodialysis units were evaluated between January 2018 and December 2022. A total of 323 (3.18%) were anti-HCV positive, of which 149/323 (46.13%) had detectable HCV RNA. Genotype 1 was the more prevalent (69%) and most patients had mild fibrosis (26% had F3-F4). By May 2023, 82 patients were evaluated 12 weeks after the end of treatment:76 achieved SVR (92,6%), 3 died, 1 stopped treatment due to intolerance, and 2 were lost to follow-up. ConclusionsA multi-stakeholder partnership model as a national micro-elimination strategy increased the treatment rates for HCV in dialysis units with acceptable effectiveness in this special population. This microelimination model is on the way to the WHO elimination program for 2030." 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Ezequiel Ridruejo1, Soledad Alonso1,2,3,4, Gustavo Laham1, Augusto Vallejos2, Marcelo Oscar Silva3, Marcelo Damian Ferder4, Enrique Gabriel Dorado4, Ezequiel Mauro2, Marcelo Hugo Puddu4

1 Hepatology Section, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno “CEMIC”, Ciudad Autónoma de Buenos Aires, Argentina

2 National Coordination of Viral Hepatitis, Ministry of Health, Ciudad Autónoma de Buenos Aires, Argentina

3 Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Pilar, Argentina

4 Fresenius Medical Care, Ciudad Autónoma de Buenos Aires, Argentina

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            "entidad" => "Hepatology Section&#44; Department of Medicine&#44; Centro de Educaci&#243;n M&#233;dica e Investigaciones Cl&#237;nicas Norberto Quirno &#8220;CEMIC&#8221;&#44; Ciudad Aut&#243;noma de Buenos Aires&#44; Argentina"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Direct-acting antivirals &#40;DAAs&#41; are highly effective in patients with chronic kidney disease in hemodialysis and chronic hepatitis C &#40;HCV&#41;&#46; The treatment of HCV in this population brings multiple benefits&#44; including improved survival of the patient on dialysis and reduction of contagion in the dialysis room by achieving eradication&#46; Our aim was to evaluate the effectiveness of DAA treatment in this population in routine clinical practice in Argentina using a multidisciplinary network of nephrologists and hepatologists&#44; within the framework of the national micro-elimination strategy of the Viral Hepatitis Program of the Ministry of Health&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">In this prospective multicenter cohort study&#44; all patients on dialysis at Fresenius Argentina&#44; were screened for anti-HCV&#46; All HCV RNA- positive patients were offered treatment with Sofosbuvir&#47;Velpatasvir &#40;SOF&#47;VEL&#41; and Glecaprevir&#47;Pibrentasvir &#40;GP&#41; according to national guidelines&#46; FIB-4 and APRI scores&#44; and liver stiffness &#40;LSM&#41; when available&#44; were performed in all HCV RNA-positive patients before treatment&#46; Those with F3-4 by LSM&#44; FIB-4 &#62;3&#46;25 and&#47;or APRI &#62;1&#46;5 were evaluated by a hepatologist&#46; DAAs therapy was initiated in each dialysis unit under the supervision of hepatologists by telemedicine&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">A total of &#8212;10&#44;144 patients from all hemodialysis units were evaluated between January 2018 and December 2022&#46; A total of 323 &#40;3&#46;18&#37;&#41; were anti-HCV positive&#44; of which 149&#47;323 &#40;46&#46;13&#37;&#41; had detectable HCV RNA&#46; Genotype 1 was the more prevalent &#40;69&#37;&#41; and most patients had mild fibrosis &#40;26&#37; had F3-F4&#41;&#46; By May 2023&#44; 82 patients were evaluated 12 weeks after the end of treatment&#58;76 achieved SVR &#40;92&#44;6&#37;&#41;&#44; 3 died&#44; 1 stopped treatment due to intolerance&#44; and 2 were lost to follow-up&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">A multi-stakeholder partnership model as a national micro-elimination strategy increased the treatment rates for HCV in dialysis units with acceptable effectiveness in this special population&#46; This microelimination model is on the way to the WHO elimination program for 2030&#46;</p></span>"
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