Association of IFNL3 gene rs4803217 with spontaneous clearance of Hepatitis C virus in patients from West Mexico
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Cisneros-Rodríguez, Miguel E. Manuel Moreno-Miceli, Ana D. Cano-Contreras, Bertha R. De La Paz-Ibarra, Jessica C. Carrillo-Navarro, Judith A. Sánchez Hernández, José A. Franco-Rico" "autores" => array:7 [ 0 => array:2 [ "nombre" => "José A." "apellidos" => "Cisneros-Rodríguez" ] 1 => array:2 [ "nombre" => "Miguel E. Manuel" "apellidos" => "Moreno-Miceli" ] 2 => array:2 [ "nombre" => "Ana D." "apellidos" => "Cano-Contreras" ] 3 => array:2 [ "nombre" => "Bertha R." "apellidos" => "De La Paz-Ibarra" ] 4 => array:2 [ "nombre" => "Jessica C." "apellidos" => "Carrillo-Navarro" ] 5 => array:2 [ "nombre" => "Judith A." "apellidos" => "Sánchez Hernández" ] 6 => array:2 [ "nombre" => "José A." "apellidos" => "Franco-Rico" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124001868?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124001868/v2_202404250742/en/main.assets" ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Association of <span class="elsevierStyleItalic">IFNL3</span> gene rs4803217 with spontaneous clearance of Hepatitis C virus in patients from West Mexico" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Andrea Y. Ochoa-Cervantes, Luis A. Torres-Reyes, Arturo Panduro, Sonia Roman, Karina Gonzalez-Aldaco" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Andrea Y." "apellidos" => "Ochoa-Cervantes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 1 => array:3 [ "nombre" => "Luis A." "apellidos" => "Torres-Reyes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "nombre" => "Arturo" "apellidos" => "Panduro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 3 => array:3 [ "nombre" => "Sonia" "apellidos" => "Roman" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 4 => array:3 [ "nombre" => "Karina" "apellidos" => "Gonzalez-Aldaco" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departament of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Guadalajara, Jalisco, Mexico" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico" "etiqueta" => "2" "identificador" => "aff0002" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0006" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee. The identity of the patients is protected. Consentment was obtained.</p><p id="para0007" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0008" class="elsevierStylePara elsevierViewall">None</p><p id="para0009" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0010" class="elsevierStylePara elsevierViewall">Programa para el Desarrollo Profesional Docente supported this work to</p><p id="para0011" class="elsevierStylePara elsevierViewall">Gonzalez-Aldaco K, No. UDG-PTC-1422.IGF</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Cytokines are crucial in modulating immune responses and the outcome of hepatitis C virus (HCV) infection. Polymorphisms in the IL10 and IFNL3 genes have been associated with spontaneous clearance (SC) in populations worldwide. However, their effect on the Mexican population remains unknown. This study aimed to analyze the association of polymorphisms in the IL10 (rs1800871, rs1800872, and rs1800896) and IFNL3 (rs4803217) genes with SC in HCV patients from West Mexico.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">A total of 203 treatment-naïve, anti-HCV-positive patients were included in the study. Among them, 60 had undetectable viral load, and 143 had a detectable viral load. Genotyping was performed using Real-Time PCR. Biochemical and serological analyses were conducted. Comparative statistical analysis was performed using SPSSv24 software. Written informed consent was obtained from all participants. The Institutional Review Board approved this study.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">The CC genotype of the <span class="elsevierStyleItalic">IFNL3</span> rs4803217 gene was associated with SC (OR=2.046, p=0.026). In SC patients, the CC genotype increased total cholesterol (TChol) compared to AA+AC genotypes (209.76 vs. 176.86 mg/dL, p=0.061). The IL10 rs1800871, rs1800872, and rs1800896 polymorphisms were not associated with SC. In SC patients, the CC+CT genotypes of IL10 rs1800871 and CC+CA genotypes of IL10 rs1800872 were associated with higher TChol levels compared to the TT genotype (198.68 vs. 177.85 mg/dL, p=0.010) and the AA genotype (196.81 vs. 178.58 mg/dL, p=0.006), respectively. In chronic patients, the GG+GA genotypes of <span class="elsevierStyleItalic">IL10</span> rs1800896 were associated with high insulin levels compared to the AA genotype (17.22 vs. 12.04 IU/mL, p=0.021).</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">The CC genotype of the <span class="elsevierStyleItalic">IFNL3</span> rs4803217 gene was associated with SC in patients from West Mexico. <span class="elsevierStyleItalic">IL10</span> and <span class="elsevierStyleItalic">IFNL3</span> polymorphisms increased TChol in SC patients. These results suggest an interaction between metabolic and immune factors in the outcome of HCV infection.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Patients" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S2/v2_202404250742/S166526812400187X/v2_202404250742/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S2/v2_202404250742/S166526812400187X/v2_202404250742/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S166526812400187X?idApp=UINPBA00004N" ]
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