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Incidence and Associated factors to development of hyponatremia in a cohort of ambulatory patients with compensated liver cirrhosis
Marlene López-Sánchez1, Juan O. Talavera2, Nayeli Ortiz-Olvera3, Rosalba Moreno Alcántar3, Segundo Moran Villota1
1 Laboratorio de Investigación en Gastro-Hepatología, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México
2 Dirección de Enseñanza e Investigación, Centro Médico ABC, Ciudad de México
3 Servicio de Gastroenterología, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0006" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee&#46; The identity of the patients is protected&#46; Consentment was obtained&#46;</p><p id="para0007" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0008" class="elsevierStylePara elsevierViewall">None</p><p id="para0009" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0010" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p><p id="para0011" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="utbl0001"></elsevierMultimedia></p><p id="para0012" class="elsevierStylePara elsevierViewall">&#8727; Fisher exact test&#46;</p><p id="para0013" class="elsevierStylePara elsevierViewall">Unadjusted risk&#58; RH-MELD I &#40;reference&#41;&#44; II &#40;RR&#58;3&#46;67&#44; CI 95&#37;&#58;0&#46;71-19&#46;01&#44; p&#61;0&#46;121&#41;&#44; III &#40;RR&#58;11&#46;53&#44; CI 95&#37;&#58; 2&#46;01-66&#46;13&#44; p&#61;0&#46;006&#41;&#46;</p></span>"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Hyponatremia is associated with ascites&#44; hepatic encephalopathy&#44; primary bacterial peritonitis&#44; and increased mortality&#46; However&#44; the information about incidence and factors associated with hyponatremia in ambulatory patients with compensated cirrhosis is scarce&#46; The aim of the study was to estimate the incidence and associated factors to the development of hypervolemic hyponatremia&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Ambulatory patients with compensated cirrhosis seen at Medical Center Siglo XXI were selected&#46; All variables included in Child-Pugh Index and in the MELD Score and the types of treatment diet were analyzed&#46; Hyponatremia was considered when serum concentration of sodium was &#60;135 mEq&#47;L in hypotonic state and water retention&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">The incidence of hyponatremia was 9&#46;6&#37; &#40;13&#47;135&#41;&#46; A prognostic risk index was identified based on fluid retention and the baseline MELD score &#40;RH-MELD Index&#41; &#40;Table 1&#41;&#46; A higher incidence of hyponatremia was observed in patients in category III &#91;RR&#58; 7&#46;96 &#40;95&#37;CI&#58; 1&#46;17-54&#46;06&#44; p&#61;0&#46;034&#41;&#93;&#44; when adjusting for diet&#59; patients with protein supplement consumption without a structured diet had a higher risk of hyponatremia &#91;RR&#58; 17&#46;72 &#40;95&#37;CI&#58; 3&#46;50-89&#46;52&#41;&#44; p&#61;0&#46;001&#41;&#93;&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">The results suggest that the incidence of dilutional hyponatremia in outpatients with cirrhosis is frequent&#59; mild alterations in water retention and liver function in the compensated phase represent an early indicator of its development&#44; which can be modified by the indicated diet&#46;</p></span>"
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Article information
ISSN: 16652681
Original language: English
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