metricas
covid
Buscar en
Annals of Hepatology
Toda la web
Inicio Annals of Hepatology Extrahepatic disease in a cohort of HCV infected patients succesfully treated wi...
Journal Information

Statistics

Follow this link to access the full text of the article

Extrahepatic disease in a cohort of HCV infected patients succesfully treated with direct acting antivirals. One year follow up.
Clara C. Sánchez-Rodríguez1, Jorge H. Luna-Domínguez2
1 Department of Internal Medicine, Regional General Hospital 6, Madero City, Tamaulipas, México, Instituto Mexicano del Seguro Social (IMSS)
2 Postgraduate unit of dentistry, research unit, Universidad Autonoma de Tamaulipas, Tampico, Tamaulipas, Mexico
Read
150
Times
was read the article
59
Total PDF
91
Total HTML
Share statistics
 array:22 [
  "pii" => "S1665268124002096"
  "issn" => "16652681"
  "doi" => "10.1016/j.aohep.2024.101415"
  "estado" => "S300"
  "fechaPublicacion" => "2024-02-01"
  "aid" => "101292.28"
  "copyrightAnyo" => "2024"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "abs"
  "cita" => "Ann Hepatol. 2024;29 Supl 2:"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:17 [
    "pii" => "S1665268124002102"
    "issn" => "16652681"
    "doi" => "10.1016/j.aohep.2024.101416"
    "estado" => "S300"
    "fechaPublicacion" => "2024-02-01"
    "aid" => "101292.29"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "abs"
    "cita" => "Ann Hepatol. 2024;29 Supl 2:"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Evaluation of the hepatoprotective effect of an hydroalcoholic extract of <span class="elsevierStyleItalic">Jatropha dioica</span> against the damage induced by valproic acid in Wistar rats"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ramiro Tijerina-M&#225;rquez, Oscar H&#46; Mendoza-Hern&#225;ndez, C&#233;sar B&#46; Espinosa-Cant&#250;, Ver&#243;nica M Rivas-Galindo, Diana Moreno-Pe&#241;a, Liliana Torres-Gonz&#225;lez, Linda E&#46; Mu&#241;oz-Espinosa, Edelmiro P&#233;rez-Rodr&#237;guez, Idalia A&#46; Cura-Esquivel, Paula Cordero-P&#233;rez"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Ramiro"
              "apellidos" => "Tijerina-M&#225;rquez"
            ]
            1 => array:2 [
              "nombre" => "Oscar H&#46;"
              "apellidos" => "Mendoza-Hern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "C&#233;sar B&#46;"
              "apellidos" => "Espinosa-Cant&#250;"
            ]
            3 => array:2 [
              "nombre" => "Ver&#243;nica M"
              "apellidos" => "Rivas-Galindo"
            ]
            4 => array:2 [
              "nombre" => "Diana"
              "apellidos" => "Moreno-Pe&#241;a"
            ]
            5 => array:2 [
              "nombre" => "Liliana"
              "apellidos" => "Torres-Gonz&#225;lez"
            ]
            6 => array:2 [
              "nombre" => "Linda E&#46;"
              "apellidos" => "Mu&#241;oz-Espinosa"
            ]
            7 => array:2 [
              "nombre" => "Edelmiro"
              "apellidos" => "P&#233;rez-Rodr&#237;guez"
            ]
            8 => array:2 [
              "nombre" => "Idalia A&#46;"
              "apellidos" => "Cura-Esquivel"
            ]
            9 => array:2 [
              "nombre" => "Paula"
              "apellidos" => "Cordero-P&#233;rez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002102?idApp=UINPBA00004N"
    "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002102/v2_202404250742/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "S1665268124002084"
    "issn" => "16652681"
    "doi" => "10.1016/j.aohep.2024.101414"
    "estado" => "S300"
    "fechaPublicacion" => "2024-02-01"
    "aid" => "101292.27"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "abs"
    "cita" => "Ann Hepatol. 2024;29 Supl 2:"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "CLIF-C-ACLF scale to predict mortality in pediatric patients with acute-on-chronic liver failure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Diego R&#46; Arellano-S&#225;nchez, Elizabeth Hern&#225;ndez-Ch&#225;vez"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Diego R&#46;"
              "apellidos" => "Arellano-S&#225;nchez"
            ]
            1 => array:2 [
              "nombre" => "Elizabeth"
              "apellidos" => "Hern&#225;ndez-Ch&#225;vez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002084?idApp=UINPBA00004N"
    "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002084/v2_202404250742/en/main.assets"
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "Extrahepatic disease in a cohort of HCV infected patients succesfully treated with direct acting antivirals&#46; One year follow up&#46;"
    "tieneTextoCompleto" => true
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Clara C&#46; S&#225;nchez-Rodr&#237;guez, Jorge H&#46; Luna-Dom&#237;nguez"
        "autores" => array:2 [
          0 => array:3 [
            "nombre" => "Clara C&#46;"
            "apellidos" => "S&#225;nchez-Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0001"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jorge H&#46;"
            "apellidos" => "Luna-Dom&#237;nguez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "aff0002"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Department of Internal Medicine&#44; Regional General Hospital 6&#44; Madero City&#44; Tamaulipas&#44; M&#233;xico&#44; Instituto Mexicano del Seguro Social &#40;IMSS&#41;"
            "etiqueta" => "1"
            "identificador" => "aff0001"
          ]
          1 => array:3 [
            "entidad" => "Postgraduate unit of dentistry&#44; research unit&#44; Universidad Autonoma de Tamaulipas&#44; Tampico&#44; Tamaulipas&#44; Mexico"
            "etiqueta" => "2"
            "identificador" => "aff0002"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0006" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee&#46; The identity of the patients is protected&#46; Consentment was obtained&#46;</p><p id="para0007" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0008" class="elsevierStylePara elsevierViewall">None</p><p id="para0009" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0010" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">The hepatitis C virus &#40;HCV&#41; infects hepatocytes and B lymphocytes&#46; The ability to infect B lymphocytes has been linked to cryoglobulinemia&#44; cryoglobulinemia syndrome&#44; lymphomas&#44; and organ-specific and systemic autoimmune diseases &#40;AD&#41;&#46; Among the AD&#44; diabetes mellitus&#44; thyroiditis&#44; and Sj&#246;gren syndrome stand out as extrahepatic diseases &#40;EH&#41;&#46; The aim of a study was identify HCV-related EH&#44; during infection and one year after successfully direct-acting antiviral &#40;DAA&#41; treatment</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">We conducted a prospective study in a Regional Hospital of reference for the treatment of Hepatitis C&#44; from 14 hospital units in the Northeast of Mexico&#46; From June 15&#44; 2018&#44; to January 1&#44; 2023&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Of 364 patients with positive serology&#44; 153 had viremia&#44; and 127 received DAA&#44; with different schemes aligned to the guidelines of treatment of hepatitis C&#46; 50&#37; were women&#44; with a mean age of 54&#46; 80&#37; received regimens based on sofosbuvir&#46; 96&#46;8&#37; achieved a sustained viral response 12&#46; Before the treatment with DAA&#44; we identified nine hypothyroidisms&#44; eight cryoglobulinemic vasculitis&#44; one with anemia and thrombocytopenia autoimmune&#44; and 25 with diabetes&#46; At basal visit for treatment&#44; 17 hypothyroidisms&#44; eight prediabetes&#44; eight diabetes&#44; one lymphoma&#44; one monoclonal gammopathy of uncertain significance&#44; three rheumatoid arthritis&#44; and three hepatocellular carcinomas&#46; At one year of follow-up&#44; plus sixteen with diabetes mellitus&#44; three with hepatocarcinoma&#44; 6 with xerophthalmia&#44; and one with breast cancer&#44; increasing obesity&#44; and fatty liver were identified&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">EH is frequent and carries out morbidity&#44; especially proliferative disorders of B lymphocytes and AD as some can persist even after the treatment of HCV infection&#46; The intentional search for EH should be mandatory and&#44; once identified&#44; will be multidisciplinary follow-up&#44; for the timely identification of worsening or malignant transformation&#44; to offer timely diagnosis and treatment&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abss0001"
            "titulo" => "Introduction and Objectives"
          ]
          1 => array:2 [
            "identificador" => "abss0002"
            "titulo" => "Materials and Patients"
          ]
          2 => array:2 [
            "identificador" => "abss0003"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abss0004"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002096/v2_202404250742/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S2/v2_202404250742/S1665268124002096/v2_202404250742/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002096?idApp=UINPBA00004N"
]
Article information
ISSN: 16652681
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 1 0 1
2024 October 6 8 14
2024 September 15 16 31
2024 August 10 7 17
2024 July 9 3 12
2024 June 10 2 12
2024 May 9 4 13
2024 April 14 6 20
2024 March 17 13 30

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos