Evaluation of the hepatoprotective effect of Flourensia cernua against the damage induced ischemia-reperfusion in Wistar rats.
Evelyn L. García-Carmona1, Ramiro Tijerina-Márquez1, Liliana Torres-González1,2, Diana Moreno-Peña1, Diana R. Rodríguez-Rodríguez1, Paulina Espíndola-Vela1, Linda E. Muñoz-Espinosa1, Edelmiro Pérez-Rodríguez3, Homero Zapata-Chavira3, Paula Cordero-Pérez1
1 Liver Unit, Internal Medicine Department, University Hospital ''Dr. José Eleuterio González'', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León
2 Analytic Chemistry Department, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León
3 Organ and Tissue Transplant Service, Departament of General Surgery, University Hospital ''Dr. José Eleuterio González'', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León
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"apellidos" => "García-Carmona" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "Ramiro" "apellidos" => "Tijerina-Márquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 2 => array:3 [ "nombre" => "Liliana" "apellidos" => "Torres-González" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 3 => array:3 [ "nombre" => "Diana" "apellidos" => "Moreno-Peña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 4 => array:3 [ "nombre" => "Diana R." 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Levels of serum ALT and AST in different study groups. a) I/R at 24h after reperfusion, b) I/R at 2h after reperfusion. (Mean ± SD. **** <span class="elsevierStyleItalic">P˂0.0001</span>, *** <span class="elsevierStyleItalic">P˂0.001</span> vs. the I/R group; n=6 for each group). Sham (healthy control group), I/R (damage control group), EHFc + I/R (treatment group).<elsevierMultimedia ident="fig0002"></elsevierMultimedia></p><p id="para0012" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Figure 2.</span> Evaluation of oxidative stress in hepatic tissue. a)Malonaldehyde (MDA), b)Reduced glutathione (GSH), c)Superoxide dismutase(SOD). (Mean ± SD. ****<span class="elsevierStyleItalic">P˂0.0001</span>, ***<span class="elsevierStyleItalic">P˂0.001</span>, *<span class="elsevierStyleItalic">P˂0.05</span> vs. the I/R at 2h after reperfusion group; n=6 for each group). Sham (healthy control group), I/R (damage control group), EHFc + I/R (treatment group).</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Liver transplantation is the optimal treatment in patients with irreversible liver damage. The principal complication of a transplant is ischemia-reperfusion injury (I/R), which induces primary graft rejection. Treatment with plant extracts prior to I/R has decreased the severity of this injury due to their potential anti-inflammatory and antioxidant activity. A plant that presents potential antioxidant activity is <span class="elsevierStyleItalic">Flourensia cernua</span> (Fc). The objective was to evaluate the hepatoprotective effect of <span class="elsevierStyleItalic">Flourensia cernua</span> against the damage induced by ischemia-reperfusion in Wistar rats.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials an Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">42 mixed Wistar rats were sorted into 7 groups (n=6). Fc was administered (200 mg/kg/, p.o/5 days) followed by I/R clamping of the left portal triad producing 1hr of 70% ischemia and 2 or 24hrs of reperfusion. Biochemical and oxidative stress biomarkers, proinflammatory cytokine and gene expression were determined. Ethics Committee approval under HI17-00002 registry and PAICYT 152-CS-2022 financing. The research group declares no conflict of interest.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">The I/R groups with 2 (IR2hr) and 24 hour (IR24hr) reperfusion displayed significantly elevated ALT and AST concentrations vs. Sham (SH); only FcIR2hr significantly decreased these enzymes (Figure 1). The remaining biochemical parameters did not show any significant differences between the groups. IR2hr group induced a statistically significant alteration of oxidative stress biomarkers, Fc counteracted these effects, with a decrease of malondialdehyde(MDA) and an increase of reduced glutathione (GSH) and the superoxide dismutase(SOD) (Figure 2). The gene expression of NFκβ was increased in IR2hr group, the treatment with <span class="elsevierStyleItalic">F. cernua</span> counteracted this increase. TNF-α was significantly increased in the IR2hr group and decreased in the treatment group.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">I/R is a widely studied injury model, capable of inducing pathological changes in several spheres, not unlike the observed results in the present study; the hydroalcoholic extract of Fc displayed anti-inflammatory and antioxidant activity at 200mg/kg, it was not toxic and proved to be hepatoprotective against I/R.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials an Patients" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] "multimedia" => array:2 [ 0 => array:6 [ "identificador" => "fig0001" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr20.jpeg" "Alto" => 1079 "Ancho" => 1500 "Tamanyo" => 111096 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Unlabelled imag" "rol" => "short" ] ] ] 1 => array:6 [ "identificador" => "fig0002" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr21.jpeg" "Alto" => 356 "Ancho" => 1500 "Tamanyo" => 48669 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0002" "detalle" => "Unlabelled imag" "rol" => "short" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002114/v2_202404250742/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S2/v2_202404250742/S1665268124002114/v2_202404250742/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002114?idApp=UINPBA00004N" ]
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