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      "titulo" => "Hepatology at the Civil Hospital of Guadalajara, Fray Antonio Alcalde (HCGFAA) in the last 25 years and its international scientific productivity"
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          "autoresLista" => "Irene M. Mariscal-Martinez, Sonia Roman, Arturo Panduro"
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      "titulo" => "Observational Study of Biliary Duct stenosis in patients with Post-Liver Transplant"
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          "autoresLista" => "Raul Sosa-Martinez, Daniela A. Garcia-Alonso, Julian Vargas-Flores, Luis A. Waller-González, Mayra V. Ramos-Gomez"
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    "titulo" => "N-acetyl cysteine prevents alterations generated during experimental liver steatosis induced by a chronic consumption of alcohol plus a hypercaloric diet."
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        "autoresLista" => "Marina Galicia-Moreno, Katia B. Roa-Romero, Ángel O. Vázquez-Esqueda, Hugo C. Monroy-Ramírez, Rebeca Rosas-Campos, Ana S. Sandoval-Rodríguez, Juan Armendáriz-Borunda"
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            "nombre" => "Marina"
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          1 => array:2 [
            "nombre" => "Katia B."
            "apellidos" => "Roa-Romero"
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          2 => array:2 [
            "nombre" => "Ángel O."
            "apellidos" => "Vázquez-Esqueda"
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            "nombre" => "Hugo C."
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            "entidad" => "Instituto de Biología Molecular en Medicina y Terapia Génica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0006" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0007" class="elsevierStylePara elsevierViewall">The study was conducted according to the guidelines of the Institutional Animal Care and Use Committee of UPAE-Bioterio at CUCS&#44; University of Guadalajara &#40;CI-02920&#41;&#46;</p><p id="para0008" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0009" class="elsevierStylePara elsevierViewall">None</p><p id="para0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0011" class="elsevierStylePara elsevierViewall">This research was funded by Programa de Impulso a la Investigaci&#243;n-2021-II &#40;PIN-2021-II&#41; to M&#46; G&#46;-M</p></span>"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">&#58; Metabolic alterations and alcohol consumption are the most common etiological agents related to hepatic steatosis &#40;HS&#41; development&#46; There is little evidence that shows the effects generated by synergy of both etiologic agents&#46; N-acetyl cysteine &#40;NAC&#41; is a drug whose efficacy in the early stages of SH&#44; generated by a hypercaloric diet plus alcohol consumption&#44; is unknown&#46;</p><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">The aim of this work was to evaluate NAC effects on oxidative stress&#44; and metabolic alterations induced in HS experimentally induced by chronic ethanol consumption plus a hypercaloric diet&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">C57BL&#47;6J mice &#40;n&#61;4&#41; grouped into 1&#41; Control&#59; 2&#41; HF&#47;OH&#44; administrated with hypercaloric diet and ethanol&#59; 3&#41; HF&#47;OH&#43;NAC&#44; same treatments of group 2 plus NAC&#46; Serum markers of liver damage and anorexigenic and orexigenic adipokines were evaluated&#59; oxidative stress markers in liver samples were analyzed&#59; finally&#44; a H&#38;E stain was performed&#46; This project was conducted in accordance with the guidelines of the University of Guadalajara under the approval number of the bioethics&#44; research&#44; and ethics research committees CI-02920&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">NAC prevents weight gain and metabolic alterations generated by concomitant consumption of a hypercaloric diet and alcohol&#59; this drug improves changes in anorexigenic and orexigenic adipokines such as leptin&#44; ghrelin&#44; resistin&#44; GLP-1&#44; and modulates total&#44; HDL&#44; and LDL cholesterol levels&#46; On the other hand&#44; NAC reduces CYP2E1 and alcohol dehydrogenase expression&#44; as well as the oxidative environment induced by both etiological agents&#44; by avoiding an increase in malondialdehyde levels&#44; promoting Nrf2 transcription factor expression and superoxide dismutase&#59; also preventing an increase in the expression of Catalase&#46; Finally&#44; H&#38;E staining showed that NAC prevents the development of tissue alterations in the liver parenchyma generated by the consumption of a hypocaloric diet plus alcohol&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara005" class="elsevierStyleSimplePara elsevierViewall">In this work&#44; we demonstrate that NAC prevents metabolic alterations and oxidative damage related to early phases of HS induced by concomitant consumption of alcohol plus a hypercaloric diet&#46; These effects would slow down the development of more severe stages of this disease&#46;</p></span>"
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