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Poor correlation between HOMA index and Triglycerides/HDL-C ratio as markers of insulin resistance in adult patients with MAFLD.
Irlanda A. Ramírez-Velázquez, Raúl Contreras-Omaña
Hepatic Disease And Toxicologic Research Center (CEIHET), Pachuca de Soto, Hgo, Mexico
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    "titulo" => "Poor correlation between HOMA index and Triglycerides/HDL-C ratio as markers of insulin resistance in adult patients with MAFLD."
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0006" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee&#46; The identity of the patients is protected&#46; Consentment was obtained&#46;</p><p id="para0007" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0008" class="elsevierStylePara elsevierViewall">None</p><p id="para0009" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0010" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;<elsevierMultimedia ident="fig0001"></elsevierMultimedia></p><p id="para0011" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Figure 1&#46;</span> Simple scatter plot with HOMA index line fit by TG-HDL ratio&#46;<elsevierMultimedia ident="fig0002"></elsevierMultimedia></p><p id="para0012" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Table 1&#46;</span> Correlation between HOMA and Triglycerides&#47;HDL-C ratio using Pearson&#180;s test&#46;</p></span>"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">In children&#44; studies have demonstrated that Triglycerides&#47;HDL-C ratio can be a good alternative to the HOMA index for measuring insulin resistance as a more accessible and widely available method in MAFLD&#46; However&#44; this has not been replicated in adults&#46; Our goal is to show the correlation that exists between the HOMA index and the Triglycerides &#40;TG&#41; to High-Density Lipoprotein &#40;HDL&#41; ratio as markers of insulin resistance in adult patients with fatty liver disease&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Descriptive and retrospective study&#46; It included 80 adult patients with MAFLD between July 2021 and May 2023&#46; Insulin resistance &#40;RI&#41; was defined as a HOMA index &#8805;2&#46;71 or a TG&#47;HDL-C ratio &#8805;1&#46;36 mmol&#47;L&#46; The results were analyzed using measures of central tendency&#44; dispersion&#44; and Pearson&#180;s test&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">80 patients were evaluated&#44; with 65&#37; of the sample corresponding to women&#44; with a mean age of 52&#46;5 years&#46; 64&#37; of patients &#40;n&#61;51&#41; with MAFLD showed insulin resistance measured by HOMA-IR&#44; while 57&#46;7&#37; &#40;n&#61;46&#41; had a Trigl&#47;HDL-C ratio &#8805;1&#46;36&#46; 8 patients who showed extreme data&#44; possibly due to laboratory measurement error&#44; were excluded&#46; When applying the Pearson&#180;s test&#44; a score of 0&#46;25 was obtained&#44; indicating a weak correlation between both markers &#40;Table 1 and Figure 1&#41;&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">In our study&#44; we found a low correlation between the HOMA index and the Triglycerides&#47;HDL-C ratio&#44; suggesting that the Triglycerides&#47;HDL-C ratio may not be a suitable marker for insulin resistance in adult patients with MAFLD&#46; Therefore&#44; we do not currently recommend its use in this patient population&#46;</p></span>"
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Article information
ISSN: 16652681
Original language: English
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