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BUN/creatinine ratio associated with mortality in patients with cirrhosis and acute kidney injury.
Diego F. Abendaño-Rivera1, Cristian Y Sánchez-Sánchez1, Karina Cazarin-Chávez1, Paloma M. Diego-Salazar1, Daniel Santana-Vargas2, María F. Higuera-De La Tijera1, José L. Pérez-Hernández1
1 Department of Gastroenterology and Hepatology General Hospital of Mexico “Dr. Eduardo Liceaga", Mexico City, Mexico
2 Research Department General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City, Mexico
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0006" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0007" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee&#46; The identity of the patients is protected&#46; Consentment was obtained&#46;</p><p id="para0008" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0009" class="elsevierStylePara elsevierViewall">None</p><p id="para0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0011" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;<elsevierMultimedia ident="fig0001"></elsevierMultimedia></p><p id="para0012" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Figure 1&#46;</span> IBC and AKI at 90 days associated with mortality&#46;</p></span>"
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        "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Cirrhosis is a prevalent disease worldwide&#44; with complications such as acute kidney injury &#40;AKI&#41; that increase the risk of fatal outcomes&#46; A high BUN&#47;creatinine ratio &#40;IBC&#41; has been associated with mortality in other diseases Therefore&#44; evaluating this index in patients with cirrhosis could predict mortality&#46; To determine whether a high BUN&#47;creatinine ratio is associated with mortality in patients with cirrhosis and AKI&#46;</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis was conducted on a cohort of cirrhotic patients with and without AKI&#44; calculating the IBC and assessing its association with mortality&#46;</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">A total of 201 patients with cirrhosis were included&#44; of whom 106 were male &#40;52&#46;73&#37;&#41;&#44; with a mean age of 55&#177;10&#46;4 years&#46; The distribution of Child Pugh scores was as follows&#58; A &#40;25&#44; 12&#46;43&#37;&#41;&#44; B &#40;70&#44; 34&#46;82&#37;&#41;&#44; and C &#40;106&#44; 52&#46;73&#37;&#41;&#59; the mean MELD-Na score was 21&#46;8&#177;9&#46;45&#46; The cumulative mortality rate at 28 days was 37 &#40;18&#46;4&#37;&#41; and at 90 days was 39 &#40;24&#46;4&#37;&#41;&#46; The model was not significant at 28 days but was significant at 90 days with a X2 value of 48&#46;18 &#40;2&#41; and p&#60;0&#46;001&#46;</p><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">At 90 days&#44; the model was significant with a x2 value of 49&#46;7 &#40;2&#41; and p&#60;0&#46;001&#44; with an OR &#40;IBC&#41; of 2&#46;78 &#40;1&#46;08-7&#46;11&#44; 95&#37; CI&#44; p&#61;0&#46;33&#41;&#44; and for AKI OR of 7&#46;97 &#40;2&#46;2-28&#46;8&#44; 95&#37; CI&#44; p&#61;0&#46;02&#41; &#40;Figure 1&#41;&#46; Considering either factor present&#44; the model was significant at 28 days with a X2 of 27&#46;75 &#40;1&#41; and p&#60;0&#46;001&#44; with an OR of 7&#46;2 &#40;3-17&#46;3&#44; p&#60;0&#46;001&#41;&#44; and at 90 days with a X2 of 35&#46;59 &#40;1&#41; and p&#60;0&#46;001&#44; with an OR of 6&#46;67 &#40;3&#46;23-13&#46;76&#44; p&#60;0&#46;001&#41;&#46;</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara005" class="elsevierStyleSimplePara elsevierViewall">The Cox proportional hazards model was used to compare factors associated with mortality separately for AKI &#40;present vs&#46; absent&#41; and IBC &#40;&#62;20 mg&#47;dl vs&#46; &#60;20 mg&#47;dl&#41; at 28 and 90 days&#44; as well as if both factors were present&#46; The model was considered significant if the p-value was less than 0&#46;5&#46; The study concluded that a higher IBC &#40;&#62;20 mg&#47;dl&#41; could predict mortality in patients with cirrhosis&#44; as the odds ratios at 28 and 90 days were significant&#46;</p></span>"
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Article information
ISSN: 16652681
Original language: English
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