Evaluation of the ALBI, MELD, MELD-Na, MELD 3.0 score in patients with hepatocellular carcinoma treated with Yttrium-90 (90y)
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"apellidos" => "Velasquez-Palacios" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0004" ] ] ] 7 => array:3 [ "nombre" => "Juan S." "apellidos" => "García-Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 8 => array:3 [ "nombre" => "Miguel A.G." "apellidos" => "Mendoza-Meléndez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 9 => array:3 [ "nombre" => "Eira" "apellidos" => "Cerda-Reyes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Research Department Hospital Central Militar" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Hospital Central Militar Medical Oncology Section" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Hospital Central Militar Radiology Department" "etiqueta" => "3" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "Military Graduate School of Health" "etiqueta" => "4" "identificador" => "aff0004" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0006" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0007" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee. The identity of the patients is protected. Consentment was obtained.</p><p id="para0008" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0009" class="elsevierStylePara elsevierViewall">None</p><p id="para0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0011" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</p><p id="para0012" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Table 1.</span> Blood cytometry, Liver Functional Tests & cancer scales systems in patients with cancer and treatment transarterial radioembolization (TARE) with Yttrium-90.<elsevierMultimedia ident="fig0001"></elsevierMultimedia></p><p id="para0013" class="elsevierStylePara elsevierViewall">*** Outside clinical reference value // Paired Samples t Test (pre-post) *P<0.05 // AST- Aspartate transaminase, ALT- Alanine transaminase, ALP- Alkaline phosphatase, GGT- Gamma-glutamyltransferase, INR- International Normalized Ratio, PT-Prothrombin time // *BCL PRE A=1, B=6 y POST BCL A=1, B=4 y C=2//</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Hepatocellular carcinoma (HCC) occupies the third cause of mortality worldwide. 10% of patients receive curative therapy. There are loco-regional therapies to improve patient survival such as (TACE) and radioembolization with Yttrium-90. There are prognostic scales, such as ALBI, MELD, MELD-Na, MELD 3.0, to identify those who will respond better to treatment.</p><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">To evaluate the potential of the ALBI, MELD, MELD-Na, MELD 3.0 index as a predictor of mortality in patients who received treatment with Yttrium-90</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Patients with cirrhosis and HCC who were candidates for radiation embolization with Yttrium-90 were evaluated. The following scores ALBI, MELD, MELD-Na, MELD 3.0 were assessed before and after therapy.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">There were 7 patients, age 70±11.3 years, 60% women, all BCLC B and Child Pugh B, etiology of CH was 3 patients due to alcohol-associated liver disease, 2 patients due to MASLD and 2 cryptogenic, 4 patients had 2 sessions and 3 patients 1 session, complete response in 3 patients and 5 progressed. 3 patients died. The variables of leukocytes, hemoglobin, platelets, PT, INR, BT, AST, ALT, albumin, ALBI, MELD, MELD 3.0, MELD-Na, Child Pugh were compared without obtaining statistical significance (Table 1). The survival of the patients was 14.6 months. There were no complications or adverse effects with the Yttrium-90 treatment.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara005" class="elsevierStyleSimplePara elsevierViewall">ALBI, MELD, MELD 3.0, MELD-Na score do not predict mortality in patients treated with Yttrium-90. 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