Noninvasive markers of hepatic fibrosis and their clinical application in coronary artery disease.
José A. Velarde-Ruiz Velasco1, José R. Barrientos-Avalos2, Jorge A. Martínez-Ortiz3, Francisco A. Félix-Téllez1, Neisser Morales-Victorino4, Claudia Vásquez-Veloza5, Diana K. Tapia-Calderon1
1 Department of Gastroenterology, Hospital Civil de Guadalajara, Fray Antonio Alcalde
2 Department of Endocrinology, Hospital Civil de Guadalajara, Fray Antonio Alcalde
3 Department of Internal medicine, Hospital Regional Lic. Adolfo López Mateos, ISSSTE
4 Department of Cardiology, Hospital Regional Lic. Adolfo López Mateos, ISSSTE
5 Department of Radiology, Hospital Regional Lic. Adolfo López Mateos, ISSSTE
Read
124
Timeswas read the article
59
Total PDF
65
Total HTML
Share statistics
array:22 [ "pii" => "S1665268124002564" "issn" => "16652681" "doi" => "10.1016/j.aohep.2024.101462" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101292.75" "copyrightAnyo" => "2024" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 2:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S1665268124002576" "issn" => "16652681" "doi" => "10.1016/j.aohep.2024.101463" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101292.76" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 2:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Correlation between steatosis and fibrosis in patients with metabolic syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Leonardo S. Juárez-Chavez, Ángel D. Santana-Vargas, María F. Higuera-de la Tijera, Silvia J. Lozada Calle, Ricardo García-Peniche, Christian Calderón-Mendoza, Carlos Barragán-Pasten, José L. Pérez-Hernández" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Leonardo S." "apellidos" => "Juárez-Chavez" ] 1 => array:2 [ "nombre" => "Ángel D." "apellidos" => "Santana-Vargas" ] 2 => array:2 [ "nombre" => "María F." "apellidos" => "Higuera-de la Tijera" ] 3 => array:2 [ "nombre" => "Silvia J." "apellidos" => "Lozada Calle" ] 4 => array:2 [ "nombre" => "Ricardo" "apellidos" => "García-Peniche" ] 5 => array:2 [ "nombre" => "Christian" "apellidos" => "Calderón-Mendoza" ] 6 => array:2 [ "nombre" => "Carlos" "apellidos" => "Barragán-Pasten" ] 7 => array:2 [ "nombre" => "José L." "apellidos" => "Pérez-Hernández" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002576?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002576/v2_202404250742/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1665268124002552" "issn" => "16652681" "doi" => "10.1016/j.aohep.2024.101461" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101292.74" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 2:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Prevalence of Immunoglobulin G against Hepatitis A Virus and Hepatitis E Virus in healthcare personnel" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jorge A. Garay-Ortega, Aleida Bautista-Santos, Rosalba Moreno-Alcántar" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Jorge A." "apellidos" => "Garay-Ortega" ] 1 => array:2 [ "nombre" => "Aleida" "apellidos" => "Bautista-Santos" ] 2 => array:2 [ "nombre" => "Rosalba" "apellidos" => "Moreno-Alcántar" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002552?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002552/v2_202404250742/en/main.assets" ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Noninvasive markers of hepatic fibrosis and their clinical application in coronary artery disease." "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "José A. Velarde-Ruiz Velasco, José R. Barrientos-Avalos, Jorge A. Martínez-Ortiz, Francisco A. Félix-Téllez, Neisser Morales-Victorino, Claudia Vásquez-Veloza, Diana K. Tapia-Calderon" "autores" => array:7 [ 0 => array:3 [ "nombre" => "José A. Velarde-Ruiz" "apellidos" => "Velasco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "José R." "apellidos" => "Barrientos-Avalos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "nombre" => "Jorge A." "apellidos" => "Martínez-Ortiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0003" ] ] ] 3 => array:3 [ "nombre" => "Francisco A." "apellidos" => "Félix-Téllez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 4 => array:3 [ "nombre" => "Neisser" "apellidos" => "Morales-Victorino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0004" ] ] ] 5 => array:3 [ "nombre" => "Claudia" "apellidos" => "Vásquez-Veloza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Diana K." "apellidos" => "Tapia-Calderon" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Department of Gastroenterology, Hospital Civil de Guadalajara, Fray Antonio Alcalde" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Department of Endocrinology, Hospital Civil de Guadalajara, Fray Antonio Alcalde" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Department of Internal medicine, Hospital Regional Lic. Adolfo López Mateos, ISSSTE" "etiqueta" => "3" "identificador" => "aff0003" ] 3 => array:3 [ "entidad" => "Department of Cardiology, Hospital Regional Lic. Adolfo López Mateos, ISSSTE" "etiqueta" => "4" "identificador" => "aff0004" ] 4 => array:3 [ "entidad" => "Department of Radiology, Hospital Regional Lic. Adolfo López Mateos, ISSSTE" "etiqueta" => "5" "identificador" => "aff0005" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0006" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee. The identity of the patients is protected. Consentment was obtained.</p><p id="para0007" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0008" class="elsevierStylePara elsevierViewall">None</p><p id="para0009" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0010" class="elsevierStylePara elsevierViewall">None</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Reliable knowledge of the prevalence of occult CAD, particularly anatomically confirmed CAD is limited and cardiovascular risk (CVR) models only predict the risk of an acute coronary event within a set period. It has been described that a FIB-4 score is associated with a higher CVR. Determine what is the utility of noninvasive markers of liver fibrosis in CAD.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">A cross-sectional study was conducted in two tertiary centers in central and western Mexico from March 2019 to April 2023. Patients who required percutaneous coronary angiography were studied and demographic data and coronary angiographic were recorded. Noninvasive fibrosis indexes were calculated. Continuous variables were subjected to a distribution analysis and equality of variances to subsequently perform a mean comparison analysis with U-Mann-Whitney test between patients with monovascular, bivascular and trivascular involvement. A correlation analysis was also performed between the invasive markers and the Syntax index.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">A total of 168 patients were included with a mean age of 66 ± 12 years with a predominance of male sex with 75.6% (n= 127). Angiographic findings included 37.5%, monovascular, 32.7%, bivascular and 29.8% trivascular involvement. Comparison of means of noninvasive markers of fibrosis demonstrated a significant difference in HFS between patients with monovascular (0.17 ± 0.18), bivascular (0.27 ± 0.18) and trivascular (0.30 ± 0.25) coronary artery disease, p=< 0.001. A correlation was also demonstrated between non-invasive markers and Syntax score: FIB-4 (r=: 820, p=<0.001), APRI (r=: 766, p=<0.001), HFS (r= 869, p=<0.001), (r= 820, p=<0.001), NFS (r= 807 p=<0.001)</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">The score of noninvasive tools to assess liver fibrosis correlates positively with the complexity of CAD and could be considered as noninvasive tools to be used in the assessment CVR.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Patients" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002564/v2_202404250742/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S2/v2_202404250742/S1665268124002564/v2_202404250742/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002564?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 6 | 5 | 11 |
| 2024 September | 7 | 15 | 22 |
| 2024 August | 10 | 9 | 19 |
| 2024 July | 6 | 9 | 15 |
| 2024 June | 9 | 4 | 13 |
| 2024 May | 10 | 6 | 16 |
| 2024 April | 8 | 3 | 11 |
| 2024 March | 9 | 8 | 17 |
