Effect of methyl donor supplementation on gut microbiota and hepatic expression of key miRNAs in a murine model of MAFLD
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Sandoval-Rodríguez" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Rebeca" "apellidos" => "Rosas-Campos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "Ángel O." "apellidos" => "Vázquez-Esqueda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 2 => array:3 [ "nombre" => "Marina" "apellidos" => "Galicia-Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 3 => array:3 [ "nombre" => "Juan" "apellidos" => "Armendáriz-Borunda" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 4 => array:3 [ "nombre" => "Ana S." "apellidos" => "Sandoval-Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Institute of Molecular Biology in Medicine, Health Sciences Center, University of Guadalajara, Guadalajara, Mexico" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "School of Medicine and Health Sciences, Tecnologico de Monterrey, Guadalajara, Mexico" "etiqueta" => "2" "identificador" => "aff0002" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ethical statement</span></p><p id="para0006" class="elsevierStylePara elsevierViewall">The protocol was registered and approved by the Ethics Committee.</p><p id="para0007" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Declaration of interests</span></p><p id="para0008" class="elsevierStylePara elsevierViewall">None</p><p id="para0009" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Funding</span></p><p id="para0010" class="elsevierStylePara elsevierViewall">None</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Metabolism-associated fatty liver disease (MAFLD) is the most common liver disease worldwide, and intestinal dysbiosis is associated with its development. Methyl donor supplementation has shown beneficial effects for MAFLD treatment; however, its role on the intestinal microbiota and miRNAs hepatic expression has been poorly studied. The aim of this study was to evaluate the effect of methyl group donor supplementation on gut microbiota and hepatic expression of key miRNAs in a murine model of MAFLD.</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and Patients</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">Twenty-four male C57BL/6J mice were divided into three groups: 1) Control: Conventional diet. 2) HF/FS: Diet rich in fats and sugars for 18 weeks. 3) HFMS: HF/FS diet for the first 10 weeks, followed by a HF/FS diet plus orogastric supplementation with methyl group donors for the last 8 weeks.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">The intestinal microbiota was characterized by 16S rRNA gene sequencing; supplementation with methyl donors modified microbial composition analyzed by beta diversity. In addition, HFMS group strongly tended to increase alpha diversity and induced enrichment of six genus: <span class="elsevierStyleItalic">Acinetobacter, Anaeroplasma, Pseudomonas, Stenotrophomonas, Tuzzerella</span>, and <span class="elsevierStyleItalic">Moraxellaceae</span> family. HFMS group significantly increased SCFAs fecal concentration and restored intestinal permeability dysfunction by increasing <span class="elsevierStyleItalic">Ocln</span> and <span class="elsevierStyleItalic">Cldn1</span> expression; consequently, a decrease in liver inflammation was observed due to a decrease in <span class="elsevierStyleItalic">Tnf-a</span> expression. On the other hand, HFMS group significantly increased hepatic expression of miR-122 and decreased miR-33a expression.</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">This study offers valuable insights into the role of methyl donors as microbiota modifiers, highlighting their ability to promote restoration of intestinal health and liver metabolism. These findings contribute to the proposition that methyl donors could be a promising strategy for treating MAFLD and hepatic related conditions.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and Patients" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S2/v2_202404250742/S1665268124002606/v2_202404250742/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S2/v2_202404250742/S1665268124002606/v2_202404250742/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124002606?idApp=UINPBA00004N" ]
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