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(A) The t-SNE plot displayed the composition of different cell subtypes in HCC. (B) The dynamics of risk score in 9 main cell types are represented in the t-SNE plot. (C) The expression levels of driver genes in different cell types vary. (D) The distribution of driver gene expression varies across different cell types. (E) Different intensity ratios of signal pathway in high- and low-risk groups in HCC. (F) Expression levels of pathway-associated genes in different cell types. (G) Contribution ratios of intercellular communication pairs in HCC samples. (H) Global view of intercellular communication among different cell types. (I) Heatmap of different cellular pathways. (J) Roles played by different cells in different pathways. (K) Enrichment of pathway genes in HCV, cirrhosis, HCC. (L) PPI network graph of risk model genes and pathway genes.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xiaojing Zhang, Xinye Chen" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Xiaojing" "apellidos" => "Zhang" ] 1 => array:2 [ "nombre" => "Xinye" "apellidos" => "Chen" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124003557?idApp=UINPBA00004N" "url" => "/16652681/unassign/S1665268124003557/v1_202409200430/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letters to the editor</span>" "titulo" => "Development of a biodegradable prosthesis through tissue engineering, for the organ-replacement or substitution of the extrahepatic bile duct" "tieneTextoCompleto" => true "saludo" => "Dear Dr. Norberto Chávez-Tapia," "autores" => array:9 [ 0 => array:3 [ "autoresLista" => "Alan Isaac Valderrama-Treviño" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Alan Isaac" "apellidos" => "Valderrama-Treviño" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Angiology, Vascular and Endovascular Surgery, Hospital General de México, Dr. Eduardo Liceaga, Mexico City, Mexico" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "autoresLista" => "Andrés E. Castell-Rodríguez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Andrés E." "apellidos" => "Castell-Rodríguez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Laboratory of experimental immunotherapy and tissue engineering, Faculty of Medicine, UNAM, CDMX, Mexico" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "autoresLista" => "Rolando Hernández-Muñoz" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Rolando" "apellidos" => "Hernández-Muñoz" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Cell Biology and Development, Institute of Cellular Physiology, UNAM, CDMX, Mexico" "identificador" => "aff0003" ] ] ] 3 => array:3 [ "autoresLista" => "Nadia A. Vázquez-Torres" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Nadia A." "apellidos" => "Vázquez-Torres" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Laboratory of experimental immunotherapy and tissue engineering, Faculty of Medicine, UNAM, CDMX, Mexico" "identificador" => "aff0002a" ] ] ] 4 => array:3 [ "autoresLista" => "Andrés Macari-Jorge" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Andrés" "apellidos" => "Macari-Jorge" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Pathology, Medica Sur Hospital, CDMX, Mexico" "identificador" => "aff0004" ] ] ] 5 => array:3 [ "autoresLista" => "Baltazar Barrera-Mera" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Baltazar" "apellidos" => "Barrera-Mera" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Physiology, Faculty of Medicine, UNAM, CDMX, Mexico" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "autoresLista" => "Alfredo Maciel-Cerda, Ricardo Vera-Graziano" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Alfredo" "apellidos" => "Maciel-Cerda" ] 1 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Vera-Graziano" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Materials Research Institute, UNAM, CDMX, Mexico" "identificador" => "aff0006" ] ] ] 7 => array:3 [ "autoresLista" => "Natalia Nuño-Lámbarri" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Natalia" "apellidos" => "Nuño-Lámbarri" "email" => array:1 [ 0 => "nlambarri@gmail.com" ] ] ] "afiliaciones" => array:2 [ 0 => array:2 [ "entidad" => "Traslational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico" "identificador" => "aff0007" ] 1 => array:2 [ "entidad" => "Department of Surgery, Faculty of Medicine, The National Autonomous University of Mexico (UNAM), Mexico City, Mexico" "identificador" => "aff0008" ] ] ] 8 => array:4 [ "autoresLista" => "Eduardo E. Montalvo-Javé" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Eduardo E." "apellidos" => "Montalvo-Javé" "email" => array:1 [ 0 => "montalvoeduardo@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0001" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:2 [ "entidad" => "Department of Surgery, Faculty of Medicine, The National Autonomous University of Mexico (UNAM), Mexico City, Mexico" "identificador" => "aff0008a" ] 1 => array:2 [ "entidad" => "Hepato Pancreato and Biliary Clinic, Department of General Surgery, “Hospital General de Mexico”, Dr. Eduardo Liceaga, Mexico City, Mexico" "identificador" => "aff0009" ] 2 => array:2 [ "entidad" => "Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Corresponding authors" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0002" class="elsevierStylePara elsevierViewall">Following Dr. Ilya Klabukov comments, I am sending you the response:</p><p id="para0003" class="elsevierStylePara elsevierViewall">Dr. Ilya Klabukov,</p><p id="para0004" class="elsevierStylePara elsevierViewall">Thank you for your thoughtful letter regarding our article on the development and evaluation of a copolymer-based electrospun scaffold for extrahepatic bile duct replacement. We are pleased to hear that you found our study and its implications for advancements in tissue engineering and regenerative medicine to be of interest.</p><p id="para0005" class="elsevierStylePara elsevierViewall">Your insights on the historical context provided by William Mayo and Hans Kehr, as well as the evolution of hepatobiliary surgery, are highly appreciated. We agree that while tissue engineering still adheres closely to the fundamental principles of medical physiology, exploring the role of abstractions could indeed lead to new breakthroughs in the field.</p><p id="para0006" class="elsevierStylePara elsevierViewall">We look forward to further discussions on this topic and welcome any additional thoughts you may have.</p><p id="para0007" class="elsevierStylePara elsevierViewall">Respectfully,</p><p id="para0008" class="elsevierStylePara elsevierViewall">Dr. Natalia Nuño-Lámbarri and Dr. Eduardo Montalvo-Javé</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-09-02" "fechaAceptado" => "2024-09-02" ] "idiomaDefecto" => "en" "url" => "/16652681/unassign/S1665268124003715/v1_202410210405/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/unassign/S1665268124003715/v1_202410210405/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268124003715?idApp=UINPBA00004N" ]
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