P-28 CHARACTERIZATION OF CHRONIC LIVER DISEASE, CIRRHOSIS, AND HEPATOCELLULAR CARCINOMA PROGRESSION IN A COLOMBIAN HEALTH MAINTENANCE ORGANIZATION: A TEN-YEAR RETROSPECTIVE STUDY

Conflict of interest

Yes, Roche employee as co-authors

Introduction and Objectives

Chronic liver disease (CLD), cirrhosis, and hepatocellular carcinoma (HCC) pose a significant global health burden. In Colombia, these conditions challenge the healthcare system, necessitating a thorough understanding of their progression and impact. This study aimed to evaluate the prevalence, progression, median survival time and transition rates of patients with CLD, cirrhosis, and HCC in a Colombian Health Maintenance Organization.

Patients / Materials and Methods

This retrospective cohort study was conducted from 2012 to 2022, identifying patients with CLD, cirrhosis, and HCC using ICD-10 codes from a claims database and electronic health records. The focus was on the cumulative 5- and 10-year survival rates of patients with cirrhosis and HCC.

Results and Discussion

The study included 33,315 CLD patients (median age: 49.1 years; 57.14% female), with the primary causes being fatty liver disease (82.98%) and chronic viral hepatitis (5.18%). Among these, 1,021 developed cirrhosis (median age: 61.45 years; 52.89% female), and 67 progressed to HCC (median age: 67.18 years; 50.75% male). The incidence rate was 165.03 per 10,000 patients. The probabilities of progression from CLD to cirrhosis at 5 and 10 years were 4% and 7%, respectively, whereas the probabilities of developing HCC from cirrhosis were 6% at 5 years and 20% at 10 years. The 5-year and 10-year cumulative survival rates for cirrhosis were 80% and 63%, respectively, whereas those for HCC were 34% and 23%, respectively.

Conclusions

This study provides a comprehensive overview of CLD in Colombia, identifying fatty liver disease as its primary etiology. It reveals the significant risks of disease progression and reduced survival rates in advanced liver conditions, underscoring the need for improved monitoring and therapeutic interventions within the Colombian healthcare system. Future research should focus on developing effective healthcare strategies to enhance outcomes in these populations.