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Presentación de siete casos y revisión de la literatura" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "135" "paginaFinal" => "139" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Congenital coronary fistula. Clinical presentation in 7 cases and literature review" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v79n02-13145964fig1.jpg" "Alto" => 787 "Ancho" => 2045 "Tamanyo" => 165526 ] ] "descripcion" => array:1 [ "es" => "ico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 2000-2007"> " ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alfa Larissa Nava-Oliva, Felipe David-Gómez, Arturo Martínez-Sánchez, José Ortegón-Cardeña, Santiago Jiménez-Arteaga, Diana López-Gallegos, Luceli Yáñez-Gutiérrez, Carlos Riera, Carlos Alva" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Alfa Larissa" "apellidos" => "Nava-Oliva" ] 1 => array:2 [ "nombre" => "Felipe" "apellidos" => "David-Gómez" ] 2 => array:2 [ "nombre" => "Arturo" "apellidos" => "Martínez-Sánchez" ] 3 => array:2 [ "nombre" => "José" "apellidos" => "Ortegón-Cardeña" ] 4 => array:2 [ "nombre" => "Santiago" "apellidos" => "Jiménez-Arteaga" ] 5 => array:2 [ "nombre" => "Diana" "apellidos" => "López-Gallegos" ] 6 => array:2 [ "nombre" => "Luceli" "apellidos" => "Yáñez-Gutiérrez" ] 7 => array:2 [ "nombre" => "Carlos" "apellidos" => "Riera" ] 8 => array:2 [ "nombre" => "Carlos" "apellidos" => "Alva" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1405994009459645?idApp=UINPBA00004N" "url" => "/14059940/0000007900000002/v0_201307091159/X1405994009459645/v0_201307091201/es/main.assets" ] "itemAnterior" => array:16 [ "pii" => "X1405994009459629" "issn" => "14059940" "estado" => "S300" "fechaPublicacion" => "2009-04-01" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Arch Cardiol Mex. 2009;79:127-31" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4388 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 3901 "PDF" => 450 ] ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Registro ambulatorio electrocardiográfico Holter al momento de un evento de muerte súbita" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "127" "paginaFinal" => "131" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ambulatory electrocar diographic recording (Holter) at the moment of a sudden death event" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v79n02-13145962fig1.jpg" "Alto" => 595 "Ancho" => 1575 "Tamanyo" => 263763 ] ] "descripcion" => array:1 [ "es" => "olimitado de torsión de puntas. Extrasístoles supraventriculares y ventriculares muy precoces (una pareja), frecuencia cardiaca basal sinusal, pero con tendencia a ser alta. Después, fibrilación ventricular de larga duración y cambios en sus modelos electrocardiográficos, que muestran mayor y menor grado de desorganización "> <span class="elsevierStyleBold">Figura 1A</span> Registro condensado. Bloqueo de rama " ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Margarita Dorantes-Sánchez, Jesús Castro-Hevia, Yanela Fayad-Rodríguez, Francisco Tornés-Bárzaga, Roberto Zayas-Molina" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Margarita" "apellidos" => "Dorantes-Sánchez" ] 1 => array:2 [ "nombre" => "Jesús" "apellidos" => "Castro-Hevia" ] 2 => array:2 [ "nombre" => "Yanela" "apellidos" => "Fayad-Rodríguez" ] 3 => array:2 [ "nombre" => "Francisco" "apellidos" => "Tornés-Bárzaga" ] 4 => array:2 [ "nombre" => "Roberto" "apellidos" => "Zayas-Molina" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1405994009459629?idApp=UINPBA00004N" "url" => "/14059940/0000007900000002/v0_201307091159/X1405994009459629/v0_201307091201/es/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Clinical evidence of the antiarrhythmic effect of a magistral suspension of propafenone: A case report" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "132" "paginaFinal" => "134" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Lina Barranco-Garduño, Janett Flores-Pérez, Hugo Juárez-Olguín, Jesús Bobadilla-Chávez, Héctor Osnaya, Carmen Flores-Pérez" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Lina" "apellidos" => "Barranco-Garduño" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Janett" "apellidos" => "Flores-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "nombre" => "Hugo" "apellidos" => "Juárez-Olguín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 3 => array:3 [ "nombre" => "Jesús" "apellidos" => "Bobadilla-Chávez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] ] ] 4 => array:3 [ "nombre" => "Héctor" "apellidos" => "Osnaya" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "affe" ] ] ] 5 => array:3 [ "nombre" => "Carmen" "apellidos" => "Flores-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "afff" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP). México, D.F. México. Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México. México, D.F." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP). México, D.F. México. Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México. México, D.F." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP). México, D.F. México. Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México. México, D.F." "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] 3 => array:3 [ "entidad" => "Servicio de Cardiología, INP. " "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "affd" ] 4 => array:3 [ "entidad" => "Servicio de Cardiología, INP. " "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "affe" ] 5 => array:3 [ "entidad" => "Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP). México, D.F. México." "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "afff" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evidencia clínica del efecto antiarrítmico de una suspensión extemporánea de propafenona. Reporte de un caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v79n02-13145963fig1.jpg" "Alto" => 604 "Ancho" => 929 "Tamanyo" => 148947 ] ] "descripcion" => array:1 [ "en" => "afenone treatment"> <span class="elsevierStyleBold">Figure 1</span> Electrocardiogram with supraventri" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introduction</span></p><p class="elsevierStylePara">Supraventricular tachycardia (SVT) is frequently manifested in emergency pediatric care units and is difficult to solve because the hemodynamic state of the patient may be involved. </p><p class="elsevierStylePara">The frequency of this disorder ranges from 1 in 250 to 1000 children.<span class="elsevierStyleSup">1</span> Forty percent of children who has SVT suffer from factors that predispose them to this condition, such as congenital heart disease, Wolff-Parkinson-White (WPW) syndrome, infections, fever or adverse reactions due to exposure to various different drugs. SVT is characterized by episodes of rapid cardiac rhythm caused by abnormal electrical circuits in the heart. The electrocardiogram (EKG) shows short PR interval, delta wave and complex prolongation of QRS. Propafenone is beta-blocking drug recommended for the treatment of SVT. It acts as a potent sodium channel blocker and is a weak b-adrenergic and calcium antagonist. Its main electro-physiological effect is to slow down conduction in tissues of quick response. Due its main electrophysiological effects, propafenone has a wide spectrum of activity and efficacy for the treatment against SVT including those of the WPW syndrome and recurrent atrial fibrillation. It has also been used safely in the treatment o various tachyarrhythmias among children.<span class="elsevierStyleSup">2</span> The efficacy and safety of propafenone for the treatment of infantile arrhythmia has been reported, with an average dose of 300mg/m<span class="elsevierStyleSup">2</span>/day (ranging from 250-400 ng/mL) every 8h.<span class="elsevierStyleSup">3</span> Children with SVT were successfully treated with this drug without adverse or proarrhythmic effects. Due to its pharmacokinetic characteristics, propafenone has variable bioavailability when taken orally.<span class="elsevierStyleSup">4</span> The therapeutic plasmatic concentrations are between 0.2 and 1.5µg/ mL, following a dose of 150-200 mg/m<span class="elsevierStyleSup">2</span>/day, with a dose increase of up to 600 mg/m<span class="elsevierStyleSup">2</span>/day.<span class="elsevierStyleSup">5</span> Its elimination is of 11 mL/min/kg. Though uncommon, especially in cases of very high doses, adverse effects include lack of appetite, bloating sensation, feeling of nausea, bitter taste, and in some cases blurred vision and dizziness.<span class="elsevierStyleSup">6</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Clinical case</span></p><p class="elsevierStylePara">The case of a 2-year-old boy, born and resident in <span class="elsevierStyleItalic">Xochimilco, Mexico City,</span> who had been given cardiological health care at the National Pediatric Institute from May 2005 (since the age of four months) is described. The boy was diagnosed with secondary SVT of the WPW syndrome, and treated with a magistral suspension of propafenone, starting May 2005. The drug was prepared according to an approved formula tested previously in laboratory studies.<span class="elsevierStyleSup">7</span> The mother is an apparently healthy 29-year-old housewife; the father, aged 31 years, has a degree in hotel administration, is apparently healthy and smokes 3/24, whilst denying alcoholism or drug addiction. The parents mentioned genetic inheritance of arterial hypertension on the paternal side and the patient has an apparently healthy 4- year-old brother. </p><p class="elsevierStylePara">This child is the outcome of a second pregnancy, which evolved normally with prenatal control from the first term of gestation, and the mother reported consuming iron and folic acid. It is reported that during the 37th week of gestation, an abdominal ultrasound was carried out which indicated extreme fetal suffering, due to nuchal cord, which required an urgent cesarean section to be carried out on February 16, 2005, producing a single outcome, with an Apgar score of 7/9, at 37 weeks of gestation, weight of 2.500 kg, size 49 cm, without any complications at birth, the child and mother left the hospital 72 hours later. He was breast fed until the end of the first year, taking solids at 6 months, and is currently incorporated into the family diet, which includes; vegetable consumption 3-4/7, fruit 7/7, red meat 4/7 and green vegetables 3/7, egg 1/7, milk and derivatives 3/7, pulses 1/7. He does not eat lentils or beans, only in soup. Psycho-motor development was as follows: social smile at four months, sitting up at 6/2, crawling 8/2, with walking now in process. His vaccines are complete.</p><p class="elsevierStylePara">His current illness began on May 11, 2005, suffering from tachycardia, sweating and indications of poor perfusion, suffering from sweating with a cardiac frequency of 310 per minute and general signs of poor perfusion; together resulting in a diagnosis of SVT. </p><p class="elsevierStylePara">After non effective vagal stimulation maneuvers, propafenone was administered intravenously, however, due to unsuccessful therapeutic actions, patient underwent one attempt of transthoracic electrical cardioversion to restore normal sinus rhythm (<span class="elsevierStyleBold">Figure 1</span>).</p><p class="elsevierStylePara"><img src="293v79n02-13145963fig1.jpg" alt="Figure 1 Electrocardiogram with supraventricular tachycardia taken before the propafenone treatment"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 1</span> Electrocardiogram with supraventricular tachycardia taken before the propafenone treatment</p><p class="elsevierStylePara">The child was placed in the Intensive Therapy Unit to monitor and stabilize hemodynamic activity and was discharged on May 15, 2005. From the time he was placed in hospital, he received treatment with a magistral suspension of propafenone as previously was mentioned, he received at the beginning 3 mg/8h for 4 months, followed by 6 mg/8h, and finally 11 mg/8h. He has been without symptoms for the last year. <span class="elsevierStyleBold">Figure 1</span> shows an EKG with SVT that was taken before propafenone treatment. <span class="elsevierStyleBold">Figure 2</span> shows the current EKG with SVT of the patient after one year of treatment with propafenone suspension. </p><p class="elsevierStylePara"><img src="293v79n02-13145963fig2.jpg" alt="Figure 2 Current electrocardiogram of the patient with supraventricular tachycardia after one year of treatment with propafenone suspension"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 2</span> Current electrocardiogram of the patient with supraventricular tachycardia after one year of treatment with propafenone suspension</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Discussion</span></p><p class="elsevierStylePara">Research undertaken in the pharmacological laboratory of the National Pediatric Institute includes the development and evaluation of drugs at adequate doses for pediatric use, which are currently not available in our country. On this occasion, a magistral suspension was prepared using commercial tablets. The suspension was prepared by grinding 1 tablet of 150 mg of hydrochloride propafenone (Norfenon, Abbott Lab, Mexico) in a mortar. The finely ground tablets were then powdered and forced to pass through a mesh (size 100) in order to homogenize the particle size. Pomegranate syrup (La Madrileña, Mexico), which was used as diluent, was added to obtain a final concentration of 1.5 mg/mL of propafenone. </p><p class="elsevierStylePara">The obtained suspension was subjected to stability tests over a 90 day period, stored at room temperature (15 ± 5 °C) and refrigeration (3-5 °C), and turned out to be stable; neither physicochemical changes nor microbiological growth were observed. High performance liquid chromatography was used to validate dosage and to determinate the plasmatic levels of the drug.<span class="elsevierStyleSup">8</span></p><p class="elsevierStylePara">Previous to this study we carried out an analysis of the bioavailability of the suspension utilized for the present study compared with commercial tablets.<span class="elsevierStyleSup">7</span> The results of that study showed acceptable value of bioavailability as previously reported.<span class="elsevierStyleSup">9</span> Results demonstrate the reliability to administrate the drug. Plasma levels observed in children with SVT reached concentrations after they took the suspension. There are not reports in children that mention therapeutics range of propafenone, in this study we found that plasma concentration of drug was correlated with the clinical improvement of patients. The EKG done simultaneously during monitoring of propafenone showed an improvement respect initial exam reported during the diagnostic process.</p><p class="elsevierStylePara">To monitor propafenone levels in the patient, concentration of drug was measured at 3.5 h post administration, obtaining 11.7 ng/mL (0.0117 µg/mL) of propafenone in plasma. This result coincided with the dose administered; however, it differed from results reported in the literature, even though the clinical response of the patient was favorable with a dose of 2.5 mg/kg/day. The patient´s health improved under the constant medical care by the personnel of the Cardiological Health Care Unit, and monitoring through EKG, reveling a favorable evolution of the patient. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Limitations of case</span></p><p class="elsevierStylePara">During clinical surveillance, the patient was maintained in control of the disease that was enough for physician to decide not to ask for therapeutic monitoring of propafenone levels, but if this would be indicated, a strong relationship between levels and therapeutic response.</p><p class="elsevierStylePara">We concluded that chronic use of propafenone is indicated for patients with SVT secondary to WPW syndrome.</p><p class="elsevierStylePara">As a temporal solution the use of magistral formulations in pediatric population has to be evaluated in terms of safety and efficacy but in terms of relationship between risk-benefit during prolonged use of propafenone, overall when such relationship will be compared with a spontaneous favorable evolution in the group of patients younger than one year of age diagnosed of WPW syndrome. </p><p class="elsevierStylePara">This study was supported partially by Abbott Laboratories, specifically for its presentation in the 35<span class="elsevierStyleSup">th</span> Annual Meeting of American College of Clinical Pharmacology, held in Cambridge (MA), 2006 September 16-19.</p><p class="elsevierStylePara">There is not conflict of interest. </p><hr></hr><p class="elsevierStylePara"> *<span class="elsevierStyleItalic">Corresponding author:</span> Carmen Flores Pérez.<br></br> Avenida Imán No.1 3er piso, Colonia Cuicuilco, 04530 México, D.F. México.<br></br> Telephone & Fax: (55) 5255-1084-3883.<br></br> Correo electrónico: <a href="mailto:cfp3575@yahool.com.mx" class="elsevierStyleCrossRefs">cfp3575@yahool.com.mx</a></p><p class="elsevierStylePara">Received: July 4, 2007;<br></br> accepted: December 15, 2008.</p>" "pdfFichero" => "293v79n02a13145963pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec193039" "palabras" => array:1 [ 0 => "Antiarrítmicos; Farmacología; Niños; Propafenona; Taquicardia supraventricular; México" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec193038" "palabras" => array:1 [ 0 => "Antiarrhythmic agent; Children; Pharmacology; Propafenone; Supraventricular tachycardia; Mexico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Propafenone is an antiarrhythmic that has been used for the treatment of tachiarrytmias in both adults and children. The aim of this study was to analyze the pharmacologic effect of a magistral suspension of propafenone, due to lack of an adequate commercial formulation for use in children. In this study we present, a case of a 2-year-old boy that was diagnosed with Wolff-Parkinson White syndrome and treated with a magistral suspension of propafenone. He has now been one year with no symptoms, no tachycardia and no cyanosis. The clinical status of the patient under treatment with propafenone was improved through constant medical care in the Cardiological Health Care Unit. The use of a magistral formulation of propafenone developed in our laboratory offers a temporal solution due to lack of medicines for children." ] "es" => array:1 [ "resumen" => "La propafenona es un antiarrítmico utilizado para el tratamiento de taquiarritmias tanto en niños como en adultos. El objetivo de este estudio fue analizar el efecto farmacológico de una suspensión extemporánea de propafenona, debido a la falta de una presentación comercial adecuada para uso en niños. Se trata de un niño de 2 años de edad diagnosticado con síndrome Wolff-Parkinson White, quien fue tratado con la preparación extemporánea de propafenona. Antes del tratamiento el paciente presentó taquicardia supraventricula; durante el seguimiento y bajo el tratamiento mencionado el paciente no mostró datos de taquicardia, ni cianosis, ni efectos adversos. El estado clínico del paciente bajo tratamiento con propafenona mejoró a través del constante cuidado médico por parte de la Unidad de Cuidados Intensivos del Servicio de Cardiología. El uso de una formulación extemporánea de propafenona desarrollada en nuestro laboratorio ofrece una solución temporal ante la falta de medicamentos para niños." ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v79n02-13145963fig1.jpg" "Alto" => 604 "Ancho" => 929 "Tamanyo" => 148947 ] ] "descripcion" => array:1 [ "en" => "afenone treatment"> <span class="elsevierStyleBold">Figure 1</span> Electrocardiogram with supraventri" ] ] 1 => array:7 [ "identificador" => "fig2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v79n02-13145963fig2.jpg" "Alto" => 616 "Ancho" => 916 "Tamanyo" => 116705 ] ] "descripcion" => array:1 [ "en" => "a after one year of treatment with propafenone suspension"> <span class="elsevierStyleBold">Figure 2</span> Current electrocardiogram of the " ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Pharmacologic management of supraventricular tachycardias in children." 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Original language: English
Year/Month | Html | Total | |
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2024 November | 2 | 0 | 2 |
2024 October | 18 | 6 | 24 |
2024 September | 11 | 5 | 16 |
2024 August | 17 | 2 | 19 |
2024 July | 11 | 5 | 16 |
2024 June | 11 | 3 | 14 |
2024 May | 14 | 5 | 19 |
2024 April | 8 | 1 | 9 |
2024 March | 28 | 6 | 34 |
2024 February | 44 | 8 | 52 |
2024 January | 36 | 10 | 46 |
2023 December | 36 | 12 | 48 |
2023 November | 26 | 9 | 35 |
2023 October | 30 | 10 | 40 |
2023 September | 24 | 2 | 26 |
2023 August | 28 | 8 | 36 |
2023 July | 8 | 5 | 13 |
2023 June | 17 | 6 | 23 |
2023 May | 25 | 1 | 26 |
2023 April | 10 | 5 | 15 |
2023 March | 9 | 1 | 10 |
2023 February | 12 | 25 | 37 |
2023 January | 11 | 4 | 15 |
2022 December | 30 | 4 | 34 |
2022 November | 26 | 4 | 30 |
2022 October | 22 | 8 | 30 |
2022 September | 22 | 7 | 29 |
2022 August | 25 | 9 | 34 |
2022 July | 21 | 6 | 27 |
2022 June | 28 | 5 | 33 |
2022 May | 33 | 8 | 41 |
2022 April | 28 | 13 | 41 |
2022 March | 36 | 5 | 41 |
2022 February | 26 | 3 | 29 |
2022 January | 30 | 11 | 41 |
2021 December | 11 | 12 | 23 |
2021 November | 27 | 7 | 34 |
2021 October | 24 | 12 | 36 |
2021 September | 11 | 8 | 19 |
2021 August | 13 | 5 | 18 |
2021 July | 26 | 7 | 33 |
2021 June | 20 | 5 | 25 |
2021 May | 34 | 7 | 41 |
2021 April | 60 | 6 | 66 |
2021 March | 35 | 10 | 45 |
2021 February | 15 | 5 | 20 |
2021 January | 23 | 10 | 33 |
2020 December | 18 | 6 | 24 |
2020 November | 22 | 4 | 26 |
2020 October | 15 | 4 | 19 |
2020 September | 24 | 7 | 31 |
2020 August | 21 | 6 | 27 |
2020 July | 21 | 8 | 29 |
2020 June | 12 | 2 | 14 |
2020 May | 16 | 4 | 20 |
2020 April | 10 | 2 | 12 |
2020 March | 9 | 2 | 11 |
2020 February | 9 | 2 | 11 |
2020 January | 15 | 6 | 21 |
2019 December | 30 | 2 | 32 |
2019 November | 10 | 2 | 12 |
2019 October | 20 | 2 | 22 |
2019 September | 10 | 3 | 13 |
2019 August | 9 | 0 | 9 |
2019 July | 9 | 5 | 14 |
2019 June | 35 | 9 | 44 |
2019 May | 112 | 16 | 128 |
2019 April | 34 | 3 | 37 |
2019 March | 5 | 2 | 7 |
2019 February | 9 | 4 | 13 |
2019 January | 2 | 3 | 5 |
2018 December | 4 | 4 | 8 |
2018 November | 3 | 1 | 4 |
2018 October | 3 | 15 | 18 |
2018 September | 8 | 2 | 10 |
2018 August | 2 | 2 | 4 |
2018 July | 5 | 7 | 12 |
2018 June | 1 | 7 | 8 |
2018 May | 4 | 11 | 15 |
2018 April | 2 | 2 | 4 |
2018 March | 1 | 1 | 2 |
2018 February | 4 | 0 | 4 |
2018 January | 0 | 1 | 1 |
2017 December | 4 | 2 | 6 |
2017 November | 3 | 1 | 4 |
2017 October | 4 | 1 | 5 |
2017 September | 4 | 1 | 5 |
2017 August | 7 | 1 | 8 |
2017 July | 6 | 2 | 8 |
2017 June | 12 | 17 | 29 |
2017 May | 8 | 0 | 8 |
2017 April | 5 | 2 | 7 |
2017 March | 10 | 27 | 37 |
2017 February | 13 | 6 | 19 |
2017 January | 4 | 0 | 4 |
2016 December | 9 | 0 | 9 |
2016 November | 11 | 1 | 12 |
2016 October | 16 | 1 | 17 |
2016 September | 11 | 0 | 11 |
2016 August | 10 | 1 | 11 |
2016 July | 11 | 2 | 13 |
2016 June | 36 | 2 | 38 |
2016 May | 30 | 24 | 54 |
2016 April | 18 | 2 | 20 |
2016 March | 33 | 4 | 37 |
2016 February | 22 | 8 | 30 |
2016 January | 21 | 5 | 26 |
2015 December | 25 | 5 | 30 |
2015 November | 27 | 5 | 32 |
2015 October | 36 | 9 | 45 |
2015 September | 31 | 4 | 35 |
2015 August | 38 | 3 | 41 |
2015 July | 51 | 7 | 58 |
2015 June | 21 | 2 | 23 |
2015 May | 31 | 1 | 32 |
2015 April | 22 | 12 | 34 |
2015 March | 29 | 7 | 36 |
2015 February | 23 | 2 | 25 |
2015 January | 43 | 3 | 46 |
2014 December | 54 | 5 | 59 |
2014 November | 39 | 4 | 43 |
2014 October | 54 | 5 | 59 |
2014 September | 42 | 4 | 46 |
2014 August | 39 | 2 | 41 |
2014 July | 33 | 1 | 34 |
2014 June | 31 | 1 | 32 |
2014 May | 35 | 1 | 36 |
2014 April | 38 | 1 | 39 |
2014 March | 58 | 12 | 70 |
2014 February | 59 | 8 | 67 |
2014 January | 60 | 2 | 62 |
2013 December | 60 | 10 | 70 |
2013 November | 49 | 6 | 55 |
2013 October | 46 | 8 | 54 |
2013 September | 46 | 10 | 56 |
2013 August | 64 | 6 | 70 |
2013 July | 59 | 8 | 67 |
2013 June | 24 | 2 | 26 |
2013 May | 23 | 6 | 29 |
2013 April | 27 | 14 | 41 |
2013 March | 32 | 13 | 45 |
2013 February | 14 | 7 | 21 |
2013 January | 16 | 3 | 19 |
2012 December | 10 | 6 | 16 |
2012 November | 6 | 4 | 10 |
2012 October | 3 | 3 | 6 |
2009 March | 649 | 0 | 649 |