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=> array:12 [ "idiomaDefecto" => true "titulo" => "Usefulness of integrated dual-source multislice computed tomography and cardiac SPECT in a patient with previous myocardial infarction" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "33" "paginaFinal" => "35" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilidad de la evaluación integral con tomografía multicorte de doble-tubo de rayos X y SPECT cardiaco en una paciente con antecedentes de infarto" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n01-13149369fig1.jpg" "Alto" => 837 "Ancho" => 958 "Tamanyo" => 97453 ] ] "descripcion" => array:1 [ "en" => "Retrospective ECG-gated dual-energy CT scan reconstruction; merging 70% of the 140-kV spectrum and 30% of the 100-kV spectrum shown as volume rendering of the right coronary artery (RCA) (A); curved multiplanar reconstruction revealing the presence of two-highly calcified plaques in the RCA (arrows in B and C), and a longitudinal multiplanar image at the stent level in the RCA, processed with a s edge-enhancing kernel (B46f) to optimize the visualization of the stent lumen which demonstrated a mild neointimal hyperplasia (arrows in D)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Enrique Vallejo, Hermes Ilarraza, Oscar Quiroz, Carlos Rodríguez, José Luis Ramírez-Arias" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Enrique" "apellidos" => "Vallejo" ] 1 => array:2 [ "nombre" => "Hermes" "apellidos" => "Ilarraza" ] 2 => array:2 [ "nombre" => "Oscar" "apellidos" => "Quiroz" ] 3 => array:2 [ "nombre" => "Carlos" "apellidos" => "Rodríguez" ] 4 => array:2 [ "nombre" => "José Luis" "apellidos" => "Ramírez-Arias" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1405994010493694?idApp=UINPBA00004N" "url" => "/14059940/0000008000000001/v0_201307091134/X1405994010493694/v0_201307091134/en/main.assets" ] "itemAnterior" => array:16 [ "pii" => "X1405994010493678" "issn" => "14059940" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Arch Cardiol Mex. 2010;80:27-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2545 "formatos" => array:3 [ "EPUB" => 28 "HTML" => 2051 "PDF" => 466 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Síndrome metabólico en la República Mexicana" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "27" "paginaFinal" => "28" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Metabolic syndrome in Mexico" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Elisa Nishimura-Meguro" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Elisa" "apellidos" => "Nishimura-Meguro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1405994010493678?idApp=UINPBA00004N" "url" => "/14059940/0000008000000001/v0_201307091134/X1405994010493678/v0_201307091134/es/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Concordance of congenital heart defects in two pairs of monozygotic twins: pulmonary stenosis and tetralogy of Fallot" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "29" "paginaFinal" => "32" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Carlos Alva, Felipe David Gómez, Santiago Jiménez-Arteaga, Lucelli Yáñez, Lilia Ochoa" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Carlos" "apellidos" => "Alva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Felipe David" "apellidos" => "Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "nombre" => "Santiago" "apellidos" => "Jiménez-Arteaga" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 3 => array:3 [ "nombre" => "Lucelli" "apellidos" => "Yáñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 4 => array:3 [ "nombre" => "Lilia" "apellidos" => "Ochoa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Director of Congenital Heart Disease Department, Hospital, Centro Médico Nacional Siglo XXI" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Staff Member of Congenital Heart Disease Department, Hospital, Centro Médico Nacional Siglo XXI" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Fellow in Human Genetics Department, Hospital, Centro Médico Nacional Siglo XXI " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Concordancia en los defectos cardiacos congénitos, en dos pares de gemelos monocigóticos: estenosis pulmonar y tetralogía de Fallot" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n01-13149368fig1.jpg" "Alto" => 754 "Ancho" => 1000 "Tamanyo" => 111246 ] ] "descripcion" => array:1 [ "en" => "A. Thirteen years-old monozygotic female twins with severe pulmonary valve stenosis." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introduction</span></p><p class="elsevierStylePara">Since Price's report in 1950,<span class="elsevierStyleSup">1</span> it has been recognized that monozygotic twins provide an opportunity to study genetic contribution in the development of cardiovascular malformations. The incidence of congenital heart defects among singletons is 6/1000 live births, compared to 17.2/1000 in monozygotic twins, while in dizygotic twins the incidence is approximately 8/1000.<span class="elsevierStyleSup">2</span> When both twins are affected, concordance is said to occur. Concordance incidence in dizygotic twins is 5%, compared to 25% in monozygotic twins.<span class="elsevierStyleSup">3</span> In this paper, two pairs of monozygotic twins with specific concordance of congenital heart defects are reported. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Case report 1 </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Monozygotic twins with pulmonary stenosis </span></p><p class="elsevierStylePara">U.H. and E.H. were13 year-old monozygotic female twins; both girls had cardiac murmurs and were referred to our hospital. They were completely asymptomatic and their phenotypes were very similar (<span class="elsevierStyleBold">Figure 1A</span>). Both of them had blood type B+; in a fluorescence hybridization test in situ the two girls were negative for chromosome 22q11 microdeletion. Echocardiographic examination showed a severe infundibular and pulmonary valve stenosis in both of them. Systolic gradient measured by Doppler was 140 mmHg in U.H., and 90 mmHg in E.H. During cardiac catheterization, U.H. had right ventricular pressures of 120/8 and 30/10 in the pulmonary artery, and E.H. had 200/14. Echocardiogram and selective angiogram showed severe dysplastic pulmonary valve in the right ventricle of both twins.</p><p class="elsevierStylePara"><img src="293v80n01-13149368fig1.jpg" alt="Figure 1A. Thirteen years-old monozygotic female twins with severe pulmonary valve stenosis."></img></p><p class="elsevierStylePara"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Figure 1A.</span></span><span class="elsevierStyleItalic"> Thirteen years-old monozygotic female twins with severe pulmonary valve stenosis.</span></p><p class="elsevierStylePara">In June 2006, the two patients underwent cardiac surgical correction with transannular patch under cardiopulmonary bypass. During surgery, severe pulmonary valve stenosis with hypoplastic annulus was found in both of them. In addition, U.H. presented infundibular stenosis which was removed. The patients recovered uneventfully from operation. Today, six years after the procedure, both patients are asymptomatic with normal development and a control echocardiogram revealed a residual gradient below 20 mmHg and minimal pulmonary insufficiency. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Case report 2 </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Monozygotic twins with Tetralogy of Fallot </span></p><p class="elsevierStylePara">J.T. and N. T. were 8 year-old male monozygotic twins, with almost identical phenotypes (<span class="elsevierStyleBold">Figure 1B</span>). Both had blood O+; in a fluorescence hybridization test in situ the two boys were negative for microdeletion in chromosome 22q11. In both twins, Tetralogy of Fallot was diagnosed by echocardiogram, cardiac catheterization and angiocardiogram. In the first twin a Blalock-Taussig shunt had been performed. This patient had stress dyspnea and physical examination revealed cyanosis ++. Echocardiogram demonstrated Tetralogy of Fallot with an obstructive 60 mmHg gradient in the right ventricular outflow tract. </p><p class="elsevierStylePara"><img src="293v80n01-13149368fig2.jpg" alt="Figure 1B. Eight years-old monozygotic male twins with tetralogy of Fallot."></img></p><p class="elsevierStylePara"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Figure 1B.</span></span><span class="elsevierStyleItalic">Eight years-old monozygotic male twins with tetralogy of Fallot.</span></p><p class="elsevierStylePara">Cardiac catheterization confirmed the echocardiogram diagnosis and an additional stenosis was found at the origin of the left pulmonary artery (<span class="elsevierStyleBold">Figure 2a</span>). The McGoon index was 1.3. In February 2008 surgical correction was performed with transannular patch, pulmonary valve prosthesis, and patches in left main coronary and pulmonary arteries; the ventricular septal defect was closed too. During surgery a laceration of the pulmonary artery with important bleeding occurred as a complication. In the intensive care unit, the patient developed pneumonia due to <span class="elsevierStyleItalic">Sthaphylocococus aureus,</span> with bad and long evolution. It was not possible to disconnect the patient from ventilator. Fifteen days later, this twin died because of septic shock.</p><p class="elsevierStylePara"><img src="293v80n01-13149368fig3.jpg" alt="Figure 2A. Angiogram of the main pulmonary artery in one of the twins with Tetralogy of Fallot. Severe pulmonary stenosis at the origin of the left pulmonary artery is documented."></img></p><p class="elsevierStylePara"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Figure 2A.</span></span><span class="elsevierStyleItalic">Angiogram of the main pulmonary artery in one of the twins with Tetralogy of Fallot. Severe pulmonary stenosis at the origin of the left pulmonary artery is documented.</span></p><p class="elsevierStylePara">In the second twin no previous shunt was done. During physical examination cyanosis ++ it was seen and arterial saturation was 82%. Echocardiography and angiocardiography showed favorable anatomy (<span class="elsevierStyleBold">Figure 2B</span>). The McGoon index was 2.1. Total surgical correction was performed in January 28, 2008. He recovered uneventfully. Three months later, an echocardiogram revealed a maximum gradient of 22 mmHg and the patient presented no symptoms. </p><p class="elsevierStylePara"><img src="293v80n01-13149368fig4.jpg" alt="Figure 2B. Selective right ventriculogram in the second twin with Tetralogy of Fallot. Favorable anatomy is shown."></img></p><p class="elsevierStylePara"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Figure 2B.</span></span><span class="elsevierStyleItalic">Selective right ventriculogram in the second twin with Tetralogy of Fallot. Favorable anatomy is shown.</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Discussion </span></p><p class="elsevierStylePara">Monozygotic twins are less frequent than dizygotic twins and account for approximately a third of total number of twins, but incidence of congenital anomalies in monozygotic twins is about 10%.<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">Congenital heart disease concordance in monozygotic twins occurs at a frequency of 25%, which is high when compared to other congenital disorders. However, in previous literature usually it is not specified whether concordance refers to either the presence of the same cardiac defect in both twins, or to some cardiac malformation present in the two. We will refer to specific concordance in the former concept.</p><p class="elsevierStylePara">There are very few reports on specific concordance of congenital cardiac malformations. After detailed search of the literature (PubMed/Medline) only three reports of twins with tetralogy of Fallot were found. In one of the reports, both twins had pulmonary atresia and the same intracardiac defects, with anatomic differences in large vessels. Both patients were positive for microdeletion in chromosome 22q11.<span class="elsevierStyleSup">5</span> In France, a pair of twins had the same disorder, but they were negative for microdeletion in chromosome 22q11 (as in both of our cases); it was reported by Laugel <span class="elsevierStyleItalic">et al</span> in 2001 V.<span class="elsevierStyleSup">6</span> The first monozygotic pair of twins with Tetralogy of Fallot in India was reported by Patel AB <span class="elsevierStyleItalic">et al</span> in 2002.<span class="elsevierStyleSup">7</span> In these works, authors concluded that the differences found could not be explained on genetic grounds and suggested the influence of other factors in the developing embryo.</p><p class="elsevierStylePara">There are two other reports of specific concordance. In the first, the presence of persistent truncus arteriosus in both monozygotic twins, without DiGeorge phenotype syndrome and no deletion in chromosome 22q11 is described.<span class="elsevierStyleSup">8</span> The second report presents a successfully operated pair of twins with ventricular septal defect.<span class="elsevierStyleSup">9</span></p><p class="elsevierStylePara">This work, in which we have studied two pairs of identical twins, one with pulmonary valve stenosis and the other with Tetralogy of Fallot, adds to the few published cases of specific concordance. Just like in the previous reports, both twins had the same disorder, with minor differences, particularly in the severity of the lesion. In agreement with other authors, these differences could be explained by the influence of other factors probably acquired during the first stages of embryonic development. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgements</span></p><p class="elsevierStylePara">Authors are thankful to Hector Alva PhD for his help in the preparation of the English manuscript.</p><hr></hr><p class="elsevierStylePara"><span class="elsevierStyleItalic">Corresponding author:<br></br></span>Carlos Alva.<br></br> Congenital Heart Disease Department, Cardiology Hospital, Centro Médico Nacional Siglo XXI, Av.Cuauhtémoc 330, Col. Doctores, México City CP 06720, México.<br></br> Phone: 5255 5585 2443. <span class="elsevierStyleItalic">E mail:</span><a href="mailto:echoca@yahoo.com" class="elsevierStyleCrossRefs">echoca@yahoo.com</a></p><p class="elsevierStylePara"> Received: December 12, 2008;<br></br> accepted September 23, 2009.</p>" "pdfFichero" => "293v80n01a13149368pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec192677" "palabras" => array:1 [ 0 => "Cardiopatías congénitas en gemelos; Gemelos monocigotos con lesiones congénitas; Concordancia específica entre gemelos; Gemelos monocigóticos; Estenosis valvular pulmonar; Tetralogía de Fallot" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec192676" "palabras" => array:1 [ 0 => "Congenital heart disease in twins; Congenital lesions in twins; Specific concordance in twins; Monozygotic twins; Valvar pulmonary stenosis; Tetralogy of Fallot" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Two pairs of twins with specific concordance in congenital heart lesions are presented. We reviewed all the monozygotic twins with specific concordance in congenital heart lesions in the last 18 years. Two pairs were found. First, a pair of 13 years-old monozygotic female twins; a severe infundibular and pulmonary valve stenosis was discovered in both girls. In the second pair of twins (8 years-old boys), Tetralogy of Fallot was diagnosed by echocardiogram, cardiac catheterization and angicardiography. In fluorescence hybridization test in situ all patients were negative for microdeletion in chromosome 22q11. Anatomic differences between twins are not enough explained on genetic bases; its necessary to consider the role of other factors, probably acquired during the first stages of embryonic development. These are the two first pairs of twins with specific concordance in congenital cardiac lesions reported in Mexico." ] "es" => array:1 [ "resumen" => "Concordancia de defectos cardiacos congénitos en dos pares de gemelos monocigóticos. Se presentan dos pares de gemelos con concordancia específica en sus lesiones cardiacas congénitas. Se revisaron todos los gemelos monocigóticos con concordancia específica en sus lesiones cardiacas congénitas en los últimos 18 años. Se encontraron dos pares de gemelos. El primer par, dos gemelas monocigóticas de 13 años de edad, en ambas se encontró severa estenosis infundibular y valvular pulmonar. En el segundo par, dos gemelos de 8 años de edad, se diagnosticó en ambos, mediante ecocardiografía, cateterismo cardiaco y angiocardiografía tetralogía de Fallot. La prueba de hibridación por fluorescencia fue, en ambos pares, negativa para microdeleción del cromosoma 22q11. Las diferencias anatómicas entre los gemelos estudiados, no se explican suficientemente sobre bases genéticas exclusivamente; es necesario, considerar la participación de otros factores adquiridos, probablemente durante los primeros estadios del desarrollo embriológico. Estos son los dos primeros casos de gemelos con concordancia específica reportados en México." ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n01-13149368fig1.jpg" "Alto" => 754 "Ancho" => 1000 "Tamanyo" => 111246 ] ] "descripcion" => array:1 [ "en" => "A. Thirteen years-old monozygotic female twins with severe pulmonary valve stenosis." ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n01-13149368fig2.jpg" "Alto" => 741 "Ancho" => 991 "Tamanyo" => 125868 ] ] "descripcion" => array:1 [ "en" => "B. Eight years-old monozygotic male twins with tetralogy of Fallot." ] ] 2 => array:8 [ "identificador" => "fig3" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n01-13149368fig3.jpg" "Alto" => 816 "Ancho" => 1004 "Tamanyo" => 85353 ] ] "descripcion" => array:1 [ "en" => "A. Angiogram of the main pulmonary artery in one of the twins with Tetralogy of Fallot. Severe pulmonary stenosis at the origin of the left pulmonary artery is documented." ] ] 3 => array:8 [ "identificador" => "fig4" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n01-13149368fig4.jpg" "Alto" => 808 "Ancho" => 991 "Tamanyo" => 89704 ] ] "descripcion" => array:1 [ "en" => "B. 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Original language: English
Year/Month | Html | Total | |
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2024 November | 4 | 0 | 4 |
2024 October | 19 | 5 | 24 |
2024 September | 31 | 5 | 36 |
2024 August | 24 | 4 | 28 |
2024 July | 28 | 3 | 31 |
2024 June | 38 | 5 | 43 |
2024 May | 28 | 5 | 33 |
2024 April | 23 | 1 | 24 |
2024 March | 49 | 5 | 54 |
2024 February | 72 | 5 | 77 |
2024 January | 64 | 4 | 68 |
2023 December | 60 | 14 | 74 |
2023 November | 56 | 4 | 60 |
2023 October | 73 | 4 | 77 |
2023 September | 51 | 3 | 54 |
2023 August | 84 | 8 | 92 |
2023 July | 81 | 5 | 86 |
2023 June | 56 | 3 | 59 |
2023 May | 82 | 12 | 94 |
2023 April | 55 | 0 | 55 |
2023 March | 36 | 0 | 36 |
2023 February | 18 | 4 | 22 |
2023 January | 13 | 3 | 16 |
2022 December | 26 | 2 | 28 |
2022 November | 44 | 11 | 55 |
2022 October | 25 | 4 | 29 |
2022 September | 23 | 5 | 28 |
2022 August | 28 | 9 | 37 |
2022 July | 19 | 8 | 27 |
2022 June | 17 | 10 | 27 |
2022 May | 28 | 4 | 32 |
2022 April | 21 | 9 | 30 |
2022 March | 36 | 13 | 49 |
2022 February | 36 | 6 | 42 |
2022 January | 53 | 12 | 65 |
2021 December | 24 | 11 | 35 |
2021 November | 44 | 8 | 52 |
2021 October | 53 | 11 | 64 |
2021 September | 32 | 11 | 43 |
2021 August | 42 | 6 | 48 |
2021 July | 28 | 4 | 32 |
2021 June | 16 | 6 | 22 |
2021 May | 24 | 7 | 31 |
2021 April | 78 | 25 | 103 |
2021 March | 67 | 7 | 74 |
2021 February | 40 | 6 | 46 |
2021 January | 37 | 14 | 51 |
2020 December | 44 | 9 | 53 |
2020 November | 56 | 4 | 60 |
2020 October | 43 | 4 | 47 |
2020 September | 26 | 4 | 30 |
2020 August | 26 | 5 | 31 |
2020 July | 21 | 0 | 21 |
2020 June | 17 | 6 | 23 |
2020 May | 36 | 7 | 43 |
2020 April | 26 | 2 | 28 |
2020 March | 27 | 1 | 28 |
2020 February | 13 | 6 | 19 |
2020 January | 32 | 7 | 39 |
2019 December | 25 | 9 | 34 |
2019 November | 16 | 7 | 23 |
2019 October | 19 | 4 | 23 |
2019 September | 22 | 0 | 22 |
2019 August | 12 | 7 | 19 |
2019 July | 14 | 2 | 16 |
2019 June | 37 | 13 | 50 |
2019 May | 73 | 27 | 100 |
2019 April | 61 | 6 | 67 |
2019 March | 15 | 10 | 25 |
2019 February | 9 | 6 | 15 |
2019 January | 6 | 0 | 6 |
2018 December | 14 | 3 | 17 |
2018 November | 21 | 1 | 22 |
2018 October | 16 | 11 | 27 |
2018 September | 12 | 4 | 16 |
2018 August | 6 | 1 | 7 |
2018 July | 9 | 0 | 9 |
2018 June | 9 | 1 | 10 |
2018 May | 5 | 0 | 5 |
2018 April | 4 | 1 | 5 |
2018 March | 4 | 0 | 4 |
2018 February | 12 | 0 | 12 |
2018 January | 9 | 0 | 9 |
2017 December | 19 | 0 | 19 |
2017 November | 9 | 0 | 9 |
2017 October | 9 | 3 | 12 |
2017 September | 4 | 0 | 4 |
2017 August | 8 | 1 | 9 |
2017 July | 8 | 1 | 9 |
2017 June | 10 | 0 | 10 |
2017 May | 12 | 1 | 13 |
2017 April | 7 | 1 | 8 |
2017 March | 10 | 1 | 11 |
2017 February | 8 | 0 | 8 |
2017 January | 9 | 0 | 9 |
2016 December | 8 | 0 | 8 |
2016 November | 12 | 0 | 12 |
2016 October | 13 | 0 | 13 |
2016 September | 12 | 2 | 14 |
2016 August | 9 | 0 | 9 |
2016 July | 15 | 0 | 15 |
2016 June | 65 | 2 | 67 |
2016 May | 73 | 10 | 83 |
2016 April | 35 | 6 | 41 |
2016 March | 41 | 4 | 45 |
2016 February | 37 | 8 | 45 |
2016 January | 46 | 7 | 53 |
2015 December | 70 | 8 | 78 |
2015 November | 51 | 10 | 61 |
2015 October | 51 | 7 | 58 |
2015 September | 64 | 6 | 70 |
2015 August | 43 | 4 | 47 |
2015 July | 50 | 5 | 55 |
2015 June | 49 | 0 | 49 |
2015 May | 59 | 4 | 63 |
2015 April | 48 | 9 | 57 |
2015 March | 44 | 1 | 45 |
2015 February | 38 | 1 | 39 |
2015 January | 75 | 6 | 81 |
2014 December | 66 | 5 | 71 |
2014 November | 71 | 6 | 77 |
2014 October | 90 | 2 | 92 |
2014 September | 67 | 6 | 73 |
2014 August | 52 | 2 | 54 |
2014 July | 53 | 5 | 58 |
2014 June | 53 | 3 | 56 |
2014 May | 51 | 1 | 52 |
2014 April | 35 | 1 | 36 |
2014 March | 91 | 9 | 100 |
2014 February | 58 | 6 | 64 |
2014 January | 61 | 10 | 71 |
2013 December | 50 | 11 | 61 |
2013 November | 66 | 9 | 75 |
2013 October | 69 | 5 | 74 |
2013 September | 61 | 4 | 65 |
2013 August | 64 | 4 | 68 |
2013 July | 64 | 7 | 71 |
2013 June | 29 | 4 | 33 |
2013 May | 49 | 5 | 54 |
2013 April | 35 | 11 | 46 |
2013 March | 23 | 5 | 28 |
2013 February | 13 | 4 | 17 |
2013 January | 9 | 1 | 10 |
2012 December | 5 | 1 | 6 |
2012 November | 1 | 1 | 2 |
2012 October | 4 | 1 | 5 |
2010 January | 472 | 0 | 472 |