Catheter cryoablation of atrio-ventricular nodal reentrant tachycardia. A clinical review
Crioablación con catéter de la taquicardia por reentrada intranodal. Una revisión clínica
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Banchs, William R. Davidson Jr, Erica D. Penny-Peterson, Soraya M. Samii, Deborah L. Wolbrette, Gerald V. Naccarelli, Mario D. Gonzalez" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Giselle" "apellidos" => "Baquero" ] 1 => array:2 [ "nombre" => "Javier E." "apellidos" => "Banchs" ] 2 => array:2 [ "nombre" => "William R." "apellidos" => "Davidson Jr" ] 3 => array:2 [ "nombre" => "Erica D." "apellidos" => "Penny-Peterson" ] 4 => array:2 [ "nombre" => "Soraya M." "apellidos" => "Samii" ] 5 => array:2 [ "nombre" => "Deborah L." "apellidos" => "Wolbrette" ] 6 => array:2 [ "nombre" => "Gerald V." "apellidos" => "Naccarelli" ] 7 => array:2 [ "nombre" => "Mario D." "apellidos" => "Gonzalez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X1405994010900466?idApp=UINPBA00004N" "url" => "/14059940/0000008000000004/v0_201307091108/X1405994010900466/v0_201307091110/en/main.assets" ] "itemAnterior" => array:16 [ "pii" => "X140599401090044X" "issn" => "14059940" "estado" => "S300" "fechaPublicacion" => "2010-10-01" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Arch Cardiol Mex. 2010;80:272-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3426 "formatos" => array:3 [ "EPUB" => 36 "HTML" => 3059 "PDF" => 331 ] ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Una revisión crítica del proceso de ″peer review″" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "272" "paginaFinal" => "282" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A critical review of the ″peer review″ process" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n04-13190044fig1.jpg" "Alto" => 624 "Ancho" => 988 "Tamanyo" => 67926 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando Alfonso" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Fernando" "apellidos" => "Alfonso" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X140599401090044X?idApp=UINPBA00004N" "url" => "/14059940/0000008000000004/v0_201307091108/X140599401090044X/v0_201307091109/es/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Catheter cryoablation of atrio-ventricular nodal reentrant tachycardia. A clinical review" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "283" "paginaFinal" => "288" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Walid Amara, Antonio De Sisti, Laura Romero, Joelci Tonet" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Walid" "apellidos" => "Amara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Antonio" "apellidos" => "De Sisti" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "nombre" => "Laura" "apellidos" => "Romero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 3 => array:3 [ "nombre" => "Joelci" "apellidos" => "Tonet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Cardiology Department, le Raincy-Montfermeil Hospital, Montfermeil, France." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Cardiology Department, Poissy-St Germain-en-Laye Hospital, Poissy, France." "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Cardiology Institute, Rhythmology Unit, Pitié-Salpêtrière Hospital, Paris, France. " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Crioablación con catéter de la taquicardia por reentrada intranodal. Una revisión clínica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n04-13190045fig1.jpg" "Alto" => 875 "Ancho" => 1958 "Tamanyo" => 177753 ] ] "descripcion" => array:1 [ "en" => "RF: radiofrequency; CRYO: cryoenergy." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introduction</span></p><p class="elsevierStylePara">Atrioventricular nodal reentrant tachycardia AV-nodal reentry tachycardia (AVNRT) is one of the most frequent supraventricular tachycardia targeted for endocardial catheter ablation. Although radiofrequency (RF) ablation remains the standard for the treatment of AVNRT worldwide, according to published data a small risk of irreversible complete atrioventricular (AV) block remains.<span class="elsevierStyleSup">1-3</span> Particularly in young individuals, physicians and patients may be hesitant to perform RF catheter ablation because of the risk of inadvertent AV block, necessitating implantation of a permanent pacemaker (PM). Cryoablation is a new method in cardiac electrophysiology for percutaneous catheter ablation of cardiac arrhythmias. Cryoablation is an alternative to RF therapy for the treatment of AVNRT without any reported case of permanent AV block.<span class="elsevierStyleSup">4 </span>The safety profile of cryoablation is also related to the reversibility of the cryothermal effect during cryomapping at -30° C, which allows for the functional assessment of a particular site before permanent cryoablation at - 80° C. In this way, the targeted tissue may be confirmed as safe for ablation. This can be useful in high-risk ablations, for example, next to the His bundle or the compact AV node. In the last decade, several studies have been addressed to AVNRT cryoablation. This article is a review of acute and long-term effects of cryoablation in patients suffering of AVNRT episodes. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Principles of cryoablation </span></p><p class="elsevierStylePara">Cryocatheter ablation is performed by using a cryoablation system (CryoCath, Inc.) that consists of a control console and a 7F steerable catheter with a 4- or 6-mm-tip electrode and uses N<span class="elsevierStyleInf">2</span>O as the refrigerant fluid. The console delivers the refrigerant fluid to the tip of the cryo-catheter through a hollow injection tube. The refrigerant fluid undergoes a phase change (from liquid to gas) at the tip of the cryocatheter, resulting in cooling of the adjacent myocardial tissue. The gas is then removed through a second coaxial tube under vacuum.</p><p class="elsevierStylePara">The protocol of cryoablation procedure includes a preliminary cryomapping and a subsequent cryo-applicaction after successful and uncomplicated cryomapping.<span class="elsevierStyleSup">5</span> Cryomapping is carried out first at a cryocatheter tip temperature of -30 to -40° C for a maximal duration of 60 s to test the electrophysiological effects on the target site by using programmed stimulation, which reproducibly demonstrated dual nodal physiology or induced AVNRT (<span class="elsevierStyleBold">Figure 1</span>). In case of ineffective results or AV-block, cryomap-ping is stopped and then repeated at new target sites. Cryoablation, which creates a permanent lesion by cooling the tip temperature to -80° C generally for 4 minutes duration, is initiated immediately following successful cryomapping, defined as block of the slow pathway conduction or the non-inducibility of AVNRT. Programmed stimulation is repeated all the time during cryoablation to confirm the effectiveness of the ablation. If AVNRT is still inducible or AV-block occurs, cryoablation is stopped and cryomapping is repeated at a new target site. It is important to mention that, in contrast with radiofrequency catheter ablation of AVNRT, cryotherapy did not incluce ectopic rhythms.<span class="elsevierStyleSup">5 </span></p><p class="elsevierStylePara"><img src="293v80n04-13190045fig1.jpg" alt="Figure 1. RF: radiofrequency; CRYO: cryoenergy."></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 1. </span>RF: radiofrequency; CRYO: cryoenergy.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Advantages of cryoablation </span></p><p class="elsevierStylePara">Contrarily to RF, during cryomapping and cryoablation the cryocatheter tip adheres to the myocardial tissue because of ice formation. In comparison to RF, cryoablation induces less endothelium and connective tissue damages, limiting thrombi generation, as well as the risk of cardiac perforation and tamponade.<span class="elsevierStyleSup">5,6</span> The adjacent structures like artery or vein vessels or the esophagus are preserved by the cryotechnique (<span class="elsevierStyleBold">Figure 2</span>). Contrarily to RF, cryoablation is painless, which reduces the need of anesthesia and sedation (<span class="elsevierStyleBold">Table 1</span>).</p><p class="elsevierStylePara"><img src="293v80n04-13190045fig2.jpg" alt="Figure 2. RF: radiofrequency; CRYO: cryoenergy"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 2.</span> RF: radiofrequency; CRYO: cryoenergy</p><p class="elsevierStylePara"><img src="293v80n04-13190045fig3.jpg" alt="Table 1. Safe cryablation profile and clinical implications."></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Clinical results of cryoablation for AVNRT</span></p><p class="elsevierStylePara">Cryoablation for AVNRT has been the object of numerous published studies in the last decade.<span class="elsevierStyleSup">4-21</span> Preliminary experiences have been conducted using a 4-mm tip catheter, nowadays employed especially in pediatric patients. In one of these first reports, Kimman et al,<span class="elsevierStyleSup">8</span> compared acute and long-term effects of RF and cryoablation in a prospective, randomized trial enrolling 102 patients with AVNRT. Procedural success using a 4-mm-tip catheter was identical between the two groups (91% and 93%, respectively) with similar fluoroscopy and procedural times. Long-term clinical success was also comparable showing 10% of recurrences in both groups. Similar results have been reported by Zrenner et al.<span class="elsevierStyleSup">9</span> in 200 patients randomly assigned to RF or cryoablation. Acute success rate was 97%, similar to that of RF. Nevertheless, recurrence rate was significantly higher in cryoablation patients than in the RF group (1% <span class="elsevierStyleItalic">vs.</span> 10%; <span class="elsevierStyleItalic">p</span> < 0.03). Subsequently, several studies have been published enrolling solely patients undergoing cryoablation, and mainly using a 6-mm-tip catheter.<span class="elsevierStyleSup">4.10-21</span> Globally, acute procedural success rate for AVNRT cryoablation reported in the literature ranges from 85% to 99% (<span class="elsevierStyleBold">Table 2</span>), not so far from acute success described in RF series.<span class="elsevierStyleSup">1-3</span> In studies using RF the incidence of recurrence was low (3% to 5%), but permanent AV-block with a PM implantation has been reported to be from 1% to 2% in experimented centers.<span class="elsevierStyleSup">1-3</span> Overall, recurrence rate in studies involving cryoablation ranged from 7% to 20% (<span class="elsevierStyleBold">Table 2</span>), higher than with RF catheter ablation. These inhomogeneous long-term results reported in cryoablation series could be explained by several reasons, like different cryocatheter size,<span class="elsevierStyleSup">4,16,17 </span>patients age,<span class="elsevierStyleSup">22</span> inclusion of patients with complex anatomy,<span class="elsevierStyleSup">4</span> as well as different follow-up duration. Additionally, most of these studies have been planned without a control group of patients treated with RF. However, two recent non-randomized studies,<span class="elsevierStyleSup">13,18</span> in which a 6-mm cryocatheter was used, confirmed that acute success rate was similar between cryoablation and RF but recurrence rate was significantly higher with cryoablation. </p><p class="elsevierStylePara"><img src="293v80n04-13190045fig4.jpg" alt="Table 2. Comparison among studies."></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Long-term predictive criteria</span></p><p class="elsevierStylePara">Some authors focused on long-term predictive criteria in AVNRT cryoablation patients. There are some evidences that a 6-mm-tip cryocatheter is superior to a 4-mm-tip in long-term results.<span class="elsevierStyleSup">4,16,17</span> Rivard et al,<span class="elsevierStyleSup">17</span> found that cryoablation with a 4-mm-tip catheter, when compared with 6-mm-tip, is associated with a 2.5-fold increased risk of arrhythmia recurrence during the follow-up. Sandilands et al,<span class="elsevierStyleSup">15 </span>found that complete anterograde slow pathway conduction suppression is associated with long-term clinical success. However, residual persistence of slow pathway conduction has not been found as a predictor of AVNRT recurrence by other authors.<span class="elsevierStyleSup">4,14,16</span> Experimentally, a freezing-thawing-freezing cycle has been described to be associated with more extensive lesions.<span class="elsevierStyleSup">23</span> Whereas some authors21 described in pediatric patients a long-term better effect of a "bonus" cryo-application at the effective site, others<span class="elsevierStyleSup">4,14</span> did not observe any significant effect in adults. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Inadvertent AV-block during cryoablation</span></p><p class="elsevierStylePara">Up to now, to our knowledge, no case of complete AV-block necessitating PM implant after cryoablation has been reported in the literature although this complication can be possible. Nevertheless, inadvertent AV-block, preceded by preliminary successful and uncomplicated cryomapping, ranges between 7% and 23%, when including also unwanted fast pathway lesion with PR prolongation (<span class="elsevierStyleBold">Table 2</span>). Despite that AV-block occurrence was not uncommon, AV conduction rapidly recovered with tissue warming in all series describing this complication (<span class="elsevierStyleBold">Figure 3</span>). In a study of De Sisti et al,<span class="elsevierStyleSup">4</span> all AV blocks occurring during cryoablation were transient, confirming the safety profile of cryoablation. After cryoablation interruption, 2nd - 3<span class="elsevierStyleSup">rd</span> AV-block lasted generally few seconds, while 1<span class="elsevierStyleSup">st </span>degree AV-block sometimes persisted, but AV conduction recovered after hours or some days (up to 4 days) in these patients. However, inadvertent fast pathway lesion with residual permanent 1st degree AV-block has been recently described, but these patients underwent multiple ablation procedures and presented a small Kock's triangle.<span class="elsevierStyleSup">24 </span> Thus, adverse but still reversible effects on AV conduction may be observed during cryoablation in spite of the lack of previous deleterious effects of cryomapping. As underlined by Fischbach,<span class="elsevierStyleSup">25</span> this experience demonstrates that the cryolesion created during cryoablation may expand relative to that suggested by cryomapping. </p><p class="elsevierStylePara"><img src="293v80n04-13190045fig5.jpg" alt="Figure 3. Example of inadvertent AV-block during cryoablation. Despite a successful and uncomplicated preliminary cryomapping (-30° C), 10 sec from the beginning of the cryoablation at -80° C, a 2/1 AV-block appeared. AV-block was transient, followed by complete AV recovery few seconds later. I, II, V1: surface ECG leads; ABL: ablation catheter; HIS: His catheter; CS: coronary sinus catheter."></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 3</span>. Example of inadvertent AV-block during cryoablation. Despite a successful and uncomplicated preliminary cryomapping (-30° C), 10 sec from the beginning of the cryoablation at -80° C, a 2/1 AV-block appeared. AV-block was transient, followed by complete AV recovery few seconds later. I, II, V1: surface ECG leads; ABL: ablation catheter; HIS: His catheter; CS: coronary sinus catheter.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Clinical implications</span></p><p class="elsevierStylePara">It has been assumed that the cornerstone of cryotechnology is the capability to test its effect by creating a reversible lesion at a less critical temperature (-30 to -40° C) and, thereby, assessing a risk of AV-block. Cryoadherence prevents dislodgement of the catheter tip and therefore avoids unwanted energy delivery at the compact AV node or His bundle. Junctional ectopy, a sensitive marker of successful RF ablation,<span class="elsevierStyleSup">26</span> does not occur during cryoablation, which can facilitate monitoring during ablation. If this is the case, there will be a significant proportion of patients, especially young ones and those with particular AV node anatomy, in whom a less efficacious action may be preferred over the risk of needing a PM implantation, a disastrous event in the young population. However, inadvertent AV-block can occur despite an uncomplicated cryomapping. It has been observed in an animal model that the minimal application of cryoenergy to achieve complete nodal AV-block is of 10 sec in duration.<span class="elsevierStyleSup">27 </span>These data stress the need for a careful attention when ablating with cryoenergy instead of RF. Nevertheless, cryoablation's safe profile is counterbalanced by a slightly higher recurrence rate of arrhythmias during the follow-up. </p><p class="elsevierStylePara">Procedural target, anatomic sites, and markers of successful ablation are not the same between cryoablation and RF. Atrio/ventricular amplitude ratio at successful target when using cryoablation tends to be higher (<span class="elsevierStyleBold">Figure 4</span>) than that usually recommended when employing RF. Absence of junctional rhythm during cryoablation facilitates fast pathway monitoring, whereas during RF it constitutes a common accepted marker of success.</p><p class="elsevierStylePara"><img src="293v80n04-13190045fig6.jpg" alt="Figure 4. Note on ABL 1-2 the slow pathway potential and an atrio/ventricular amplitude ratio of about 1 recorded at the successful site before cryoapplication, slightly above the coronary sinus ostium. Procedural target, anatomic sites and markers of successful ablation are not the same between cryoablation and RF. Atrio/ventricular amplitude ratio at successful target when using cryoablation tends to be higher than that usually recommended when employing RF. I, II, III, V1: surface ECG leads; ABL: ablation catheter; CS: coronary sinus catheter; RV: right ventricle."></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 4. </span>Note on ABL 1-2 the slow pathway potential and an atrio/ventricular amplitude ratio of about 1 recorded at the successful site before cryoapplication, slightly above the coronary sinus ostium. Procedural target, anatomic sites and markers of successful ablation are not the same between cryoablation and RF. Atrio/ventricular amplitude ratio at successful target when using cryoablation tends to be higher than that usually recommended when employing RF. I, II, III, V1: surface ECG leads; ABL: ablation catheter; CS: coronary sinus catheter; RV: right ventricle.</p><p class="elsevierStylePara">Recurrence rate seems to be lower along the learning curve effect, and the use of 6-mm-tip catheters. Finally, a limitation for a widespread use of cryocatheters is their cost, which is higher in France than catheters commonly used in RF. </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conclusions</span></p><p class="elsevierStylePara">Current experiences indicate that cryoablation for AVNRT is effective and safe. However, its use seems to be counteracted by a slightly lower long-term efficacy when compared to radiofrequency. Further studies evaluating long-term success of cryoablation versus radiofrequency are warranted. However, for high-risk ablations, cryoenergy is very helpful and should be systematically used. </p><hr></hr><p class="elsevierStylePara"><span class="elsevierStyleItalic">Correspondence author:</span> Joelci Tonet,<br></br> Hôpital de La Pitié-Salpêtrière, Institut de Cardiologie, Unité de Rythmologie, 47-83. Boulevard de l'Hôpital, 75651 Paris, France.<br></br> Fax: 33142163057.<br></br><span class="elsevierStyleItalic">E-mail:</span><a href="mailto:joelci.tonet@psl.aphp.fr" class="elsevierStyleCrossRefs">joelci.tonet@psl.aphp.fr</a></p><p class="elsevierStylePara">Received on March 19, 2010;<br></br> accepted on September 19, 2010. </p>" "pdfFichero" => "293v80n04a13190045pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec192520" "palabras" => array:1 [ 0 => "TRNAV; Crioablación; Bloqueo AV; Francia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec192519" "palabras" => array:1 [ 0 => "AVNRT; Cryoablation; AV-block; France" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "Cryoablation is a new method in interventional cardiac electrophysiology for percutaneous catheter ablation of cardiac arrhythmias. Cryothermal mapping enables the functional assessment of a particular site before permanent ablation. In this way, the targeted tissue may be confirmed as safe for ablation. This is useful in high-risk ablation, for example, next to the His bundle or the compact AV node. In the last decade, several studies have been addressed to AV-nodal reentry tachycardia (AVNRT) cryoablation. Current experiences indicate that cryoablation for AV-nodal reentry tachycardia is effective and safe. However, its wide use seems to be somewhat limited by a slightly lower efficacy when compared to radiofrequency. Further studies evaluating long-term success of cryothermal ablation versus radiofrequency are warranted. However, for high-risk ablations, cryoenergy is very helpful and should be systematically used. This article is a review of acute and long-term effects of cryoablation in patients suffering of AV-nodal reentry tachycardia episodes." ] "es" => array:1 [ "resumen" => "La crioablación es un nuevo método en la electrofisiología cardiaca intervensionista para la ablación percutánea de las arritmias cardiacas. El mapeo criotérmico permite la evaluación funcional de un sitio en particular antes de la ablación permanente; de esta manera, el tejido blanco puede confirmarse como seguro para el procedimiento. Esto es útil en la ablación de alto riesgo, por ejemplo, cerca del haz de His o del nodo AV compacto. En la última década, varios estudios se han orientado a la crioablación para la taquicardia de reentrada del nodo AV (TRNAV). Las experiencias actuales indican que la crioablación de la taquicardia de reentrada del nodo AV es efectiva y segura. Sin embargo, la apertura para ampliar su uso está parcialmente limitada por su eficacia ligeramente menor al compararla con el empleo de la radiofrecuencia. Se justifican ensayos clínicos futuros con objeto de evaluar el éxito a largo plazo de la ablación criotérmica en comparación con la radiofrecuencia. Para las ablaciones de alto riesgo, la crioenergía es muy útil y debería ser usada sistemáticamente. Este artículo consiste en una revisión sobre los efectos inmediatos y a largo plazo de la crioablación en pacientes que presentan episodios de taquicardia por reentrada del nodo AV." ] ] "multimedia" => array:6 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n04-13190045fig1.jpg" "Alto" => 875 "Ancho" => 1958 "Tamanyo" => 177753 ] ] "descripcion" => array:1 [ "en" => "RF: radiofrequency; CRYO: cryoenergy." ] ] 1 => array:8 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n04-13190045fig2.jpg" "Alto" => 1200 "Ancho" => 1887 "Tamanyo" => 305493 ] ] "descripcion" => array:1 [ "en" => "RF: radiofrequency; CRYO: cryoenergy" ] ] 2 => array:8 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "293v80n04-13190045fig3.jpg" "imagenAlto" => 695 "imagenAncho" => 1012 "imagenTamanyo" => 131607 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Safe cryablation profile and clinical implications." ] ] 3 => array:8 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "293v80n04-13190045fig4.jpg" "imagenAlto" => 929 "imagenAncho" => 2045 "imagenTamanyo" => 275638 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Comparison among studies." ] ] 4 => array:7 [ "identificador" => "fig3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n04-13190045fig5.jpg" "Alto" => 666 "Ancho" => 1008 "Tamanyo" => 98963 ] ] "descripcion" => array:1 [ "en" => "3190045fig5.jpg" width="1008" height="666" alt="Figure 3. Example of inadvertent AV-block during cryoablation. Despite a successful and uncomplicated preliminary cryomapping (-30° C), 10 sec from the beginning of the cryoablation at -80° C, a 2/1 AV-block appeared. AV-block was transient, followed by complete AV recovery few seconds later. I, II, V1: surface ECG leads; ABL: ablation catheter;" ] ] 5 => array:7 [ "identificador" => "fig4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "293v80n04-13190045fig6.jpg" "Alto" => 583 "Ancho" => 1000 "Tamanyo" => 71866 ] ] "descripcion" => array:1 [ "en" => "3190045fig6.jpg" width="1000" height="583" alt="Figure 4. Note on ABL 1-2 the slow pathway potential and an atrio/ventricular amplitude ratio of about 1 recorded at the successful site before cryoapplication, slightly above the coronary sinus ostium. Procedural target, anatomic sites and markers of successful ablation are not the same between cryoablation and RF. Atrio/ventricular amplitude ratio at successful target when using cryoablation tends to be higher than that usually recommended when employing RF. I, II, III, V1: surface ECG leads; ABL: ablation catheter; C" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Catheter ablation of accessory pathways, atrioventricular nodal reentrant tachycardia, and the atrioventricular junction: final results of a prospective, multi-center clinical trial." 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Article information
ISSN: 14059940Original language: English
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| 2022 December | 53 | 3 | 56 |
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| 2020 December | 28 | 8 | 36 |
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| 2020 August | 24 | 4 | 28 |
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| 2020 June | 16 | 5 | 21 |
| 2020 May | 34 | 5 | 39 |
| 2020 April | 15 | 2 | 17 |
| 2020 March | 25 | 2 | 27 |
| 2020 February | 27 | 6 | 33 |
| 2020 January | 29 | 2 | 31 |
| 2019 December | 33 | 9 | 42 |
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| 2019 March | 18 | 3 | 21 |
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| 2018 December | 14 | 2 | 16 |
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| 2018 August | 11 | 0 | 11 |
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| 2018 June | 9 | 1 | 10 |
| 2018 May | 14 | 1 | 15 |
| 2018 April | 7 | 1 | 8 |
| 2018 March | 10 | 0 | 10 |
| 2018 February | 10 | 1 | 11 |
| 2018 January | 7 | 0 | 7 |
| 2017 December | 10 | 0 | 10 |
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| 2017 August | 16 | 0 | 16 |
| 2017 July | 12 | 0 | 12 |
| 2017 June | 14 | 3 | 17 |
| 2017 May | 24 | 2 | 26 |
| 2017 April | 12 | 1 | 13 |
| 2017 March | 17 | 1 | 18 |
| 2017 February | 21 | 4 | 25 |
| 2017 January | 9 | 2 | 11 |
| 2016 December | 19 | 3 | 22 |
| 2016 November | 23 | 4 | 27 |
| 2016 October | 26 | 0 | 26 |
| 2016 September | 11 | 1 | 12 |
| 2016 August | 10 | 0 | 10 |
| 2016 July | 16 | 5 | 21 |
| 2016 June | 47 | 15 | 62 |
| 2016 May | 50 | 13 | 63 |
| 2016 April | 30 | 14 | 44 |
| 2016 March | 40 | 21 | 61 |
| 2016 February | 34 | 18 | 52 |
| 2016 January | 45 | 19 | 64 |
| 2015 December | 48 | 20 | 68 |
| 2015 November | 19 | 16 | 35 |
| 2015 October | 28 | 21 | 49 |
| 2015 September | 42 | 9 | 51 |
| 2015 August | 44 | 10 | 54 |
| 2015 July | 37 | 9 | 46 |
| 2015 June | 11 | 11 | 22 |
| 2015 May | 18 | 2 | 20 |
| 2015 April | 15 | 6 | 21 |
| 2015 March | 18 | 4 | 22 |
| 2015 February | 15 | 1 | 16 |
| 2015 January | 36 | 2 | 38 |
| 2014 December | 67 | 5 | 72 |
| 2014 November | 44 | 2 | 46 |
| 2014 October | 53 | 7 | 60 |
| 2014 September | 61 | 1 | 62 |
| 2014 August | 30 | 1 | 31 |
| 2014 July | 41 | 3 | 44 |
| 2014 June | 46 | 4 | 50 |
| 2014 May | 34 | 0 | 34 |
| 2014 April | 27 | 2 | 29 |
| 2014 March | 55 | 2 | 57 |
| 2014 February | 35 | 1 | 36 |
| 2014 January | 42 | 1 | 43 |
| 2013 December | 47 | 2 | 49 |
| 2013 November | 46 | 6 | 52 |
| 2013 October | 47 | 5 | 52 |
| 2013 September | 41 | 2 | 43 |
| 2013 August | 79 | 1 | 80 |
| 2013 July | 46 | 2 | 48 |
| 2013 June | 15 | 0 | 15 |
| 2013 May | 22 | 0 | 22 |
| 2013 April | 24 | 0 | 24 |
| 2013 March | 17 | 0 | 17 |
| 2013 February | 9 | 0 | 9 |
| 2013 January | 5 | 0 | 5 |
| 2012 December | 6 | 0 | 6 |
| 2012 November | 2 | 0 | 2 |
| 2012 October | 9 | 0 | 9 |
| 2012 September | 1 | 0 | 1 |
| 2010 September | 1019 | 0 | 1019 |
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