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Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) The association between intestinal microbiome and autoimmune uveitis
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Vol. 97. Issue 5.
Pages 264-275 (May 2022)
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Vol. 97. Issue 5.
Pages 264-275 (May 2022)
Review
The association between intestinal microbiome and autoimmune uveitis
La asociación entre microbioma intestinal y uveítis autoinmune
D. Kalogeropoulosa,
Corresponding author
dkalog1990@gmail.com

Corresponding author.
, R. Barryb,c, C. Kalogeropoulosa
a Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
b Institute of Clinical Sciences, University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom
c Department of Ophthalmology, Birmingham & Midland Eye Centre, Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom
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Abstract
Introduction and objectives

The microbiome is strongly implicated in a wide spectrum of immune-mediated diseases, whereas gut commensal microbiota plays a pivotal role in immune and intestinal homeostasis.

Materials and methods

A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items.

Results

Due to complex interactions with the host genetics and other factors, intestinal dysbiosis has been linked to various immune-mediated disorders. In particular, the role of intestinal microbiota in the pathogenesis of uveitis has been demonstrated by several studies, indicating that changes in the microbiome can trigger autoimmune ocular inflammatory processes or affect their severity.

Conclusions

This review summarizes how alterations in the intestinal microbiota can conduce to immune-mediated ocular pathologies and how microbiome can be targeted in order to form novel therapeutic approaches to treat these severe and potentially blinding conditions.

Keywords:
Microbiome
Uveitis
Autoimmune diseases
Homeostasis
Antibiotics
Resumen
Introducción y objetivos

El microbioma está fuertemente implicado en un amplio espectro de enfermedades inmunomediadas, mientras que la microbiota comensal intestinal juega un papel fundamental en la homeostasis inmunológica e intestinal.

Materiales y métodos

Se realizó una búsqueda exhaustiva de la literatura en la base de datos PubMed. Se realizó una búsqueda adicional en Google Scholar para completar los elementos recopilados.

Resultados

Debido a las complejas interacciones con la genética del huésped y otros factores, la disbiosis intestinal se ha relacionado con varios trastornos inmunomediados. En particular, el papel de la microbiota intestinal en la patogenia de la uveítis ha sido demostrado por varios estudios, lo que indica que los cambios en el microbioma pueden desencadenar procesos inflamatorios oculares autoinmunes o afectar su gravedad.

Conclusiones

Esta revisión resume cómo las alteraciones en la microbiota intestinal pueden conducir a patologías oculares inmunomediadas y cómo el microbioma puede ser dirigido para formar nuevos enfoques terapéuticos para tratar estas condiciones severas y potencialmente cegadoras.

Palabras clave:
Microbioma
Uveítis
Enfermedades autoinmunes
Homeostasis
Antibióticos

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