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Primary trochlear headache. A periorbital pain with a specific diagnosis and treatment
Cefalea troclear primaria. Un dolor periorbitario con diagnóstico y tratamiento específicos
P. Sánchez Ruiza,
Corresponding author
prado_sanchez_ruiz@hotmail.com

Corresponding author.
, C. Martín Villaescusab, A. Duat Rodrígueza, V. Cantarín Extremeraa, M.L. Ruiz-Falcó Rojasa
a Servicio de Neurología: Hospital Infantil Niño Jesús, Madrid, Spain
b Servicio de Oftalmología. Hospital Infantil Niño Jesús, Madrid, Spain
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referred by the Emergency Dept&#46; due to disabling headache refractory to painkillers with 10 days evolution&#46; The patient referred atypical pain located in the left supraorbital inner angle with hemicranial and ipsolateral irradiation&#44; insidious onset and progressively increasing intensity&#46; Said headache coursed with episodes alternating high intensity pain &#40;about 5<span class="elsevierStyleHsp" style=""></span>min duration&#41; with moderate residual pain&#46; Since onset the patient referred moderate photophobia as well as abdominalgia with incoercible vomiting&#46; The patient did not exhibit trigeminal-autonomous symptomatology or visual alterations&#46; Arterial pressure and cardiac frequency as well as neurological examination and study with devices were normal&#46; Ophthalmological examination discarded visual acuity deficit and normal ocular fundus&#46; Reactivity and pupil reflex as well as ocular motility were also normal&#46; However&#44; palpation of the trochlea in the upper inner angle of the left eye produced increased pain intensity giving rise to paleness&#44; sweating and vomiting&#46; Due to the refractory nature of the pain&#44; a study with basic analytics and thyroid function was requested with normal results&#46; Cerebral resonance was carried out on the first day of admittance to discard secondary origin of the headache&#46; The study was expanded with angioresonance sequences in order to discard venous sinus thrombosis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Due to the unilateral characteristic of the pain and suspecting trigeminal-autonomous headache&#44; carbamazepine and subsequently indometacin were prescribed without improvement&#46; Before being admitted&#44; the patient had received topiramate treatment as prophylaxis for migraine&#46; Finally&#44; after ocular examination findings&#44; topical injection of anesthetic with lidocaine and corticoids was indicated &#40;5<span class="elsevierStyleHsp" style=""></span>mg triamcinolone&#41; in the left trochlear region&#44; giving rise to remarkable improvement&#46; Forty-eight hours later&#44; the patient was discharged without digestive symptoms and hardly any orbital or hemicranial pain&#46; In a follow-up visit 3 months later the patient remained asymptomatic without requiring additional infiltrations&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The trochlea is a cartilage structure located in the superomedial extreme of the orbit&#44; containing the tendon of the upper oblique muscles and innervated by sensitive ophthalmic nerve ramifications&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Its location is very close to the supra-and infra-trochlear nerves&#46; The trochlea is important because its sensitive innervation generates nociceptive afferents on the trigeminal nerve&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> thus becoming an activation point for various types of headaches&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;4</span></a> The pain originated by the trochlea is periorbital with frontal and ipsolateral irradiation in up to two thirds of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The latest international classification of headaches<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> includes headaches associated to trochleitis described by the group of Yang&#252;ela et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In this type of headache&#44; the friction produced by the tendon of the upper oblique muscle when moving under the trochlea produces trochlear inflammation or trochleitis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Even though the etiology thereof is generally idiopathic&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> the literature describes cases of selfimmune&#44; rheumatological&#44; traumatic or tumoral origin&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> In fact&#44; a recent publication reported the case of trochleitis associated to sinusitis in a pediatric patient&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In some cases trochleitis could be bilateral<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;7&#44;8</span></a> and could associate diplopia in vertical gaze or supraduction limitations&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Yang&#252;ela et al&#46; also described other patients with trochlea-originated headaches without associated inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This clinic condition is known as primary trochlear headache and&#44; even though it has been observed that it is more frequent than trochleitis<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> it is not yet included in the latest headache classification&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The clinic of these patients is similar to that of trochleitis patients although pain is more intense and disabling&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Referred pain could have abrupt or insidious onset &#40;25&#37; or 75&#37;&#44; respectively&#41;&#44; with chronic &#40;90&#37;&#41; or intermittent pattern &#40;10&#37;&#41;&#44; in which the majority of patients describe continuous baseline pain with highly significant pain outbreaks&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> During exacerbation&#44; pain could be daily in up to 85&#37; of cases and could become more acute in sleep in up to 50&#37; of cases &#40;due to the eye movements of the REM sleep phase&#41;&#44; which makes it necessary to visit the Emergency Department in up to 70&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In contrast with trochleitis&#44; there is no limitation of ocular motility or associated diplopia&#46; Diagnostic is by exclusion&#46; In this entity it is believed that the physiopathological origin of the pain derives from the mechanical irritation occurring in the supra-and infra-trochlear nerves due to close anatomical contact with the trochlea&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Accordingly&#44; the characteristics of the headache described in the present clinic case appeared to be compatible with said condition&#46; Activities such as reading that induces greater use of the upper oblique muscle could produce an increase of pain&#44; constituting a trigger factor although a clear trigger is not always apparent&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In this case&#44; the patient had no visual deficit and denied any recent activity that could have triggered the clinic&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">It is important to take into account that nociceptive stimuli of the trochlea could trigger and perpetuate other types of headaches&#44; making diagnostic more difficult&#46; In primary trochlear headache it has been observed that up to 60&#37; of patients could associate other types of headaches&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> The literature has described cases of paroxysmal hemicranial with trochlear disease&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The importance of all this lies in that headaches associated to trochleodynia will not improve if the trochlea is not treated&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;9</span></a> This explains that in the present case the patient associated digestive symptomatology and photophobia to periorbital pain&#44; making it more typical of migraine&#46; Accordingly&#44; it is important to explore the trochlea in all pediatric patients with periorbital pain because some maneuvers could act as pain triggers &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; It must be taken into account that said maneuvers can also be positive in patients with other orbital diseases such as tumors&#44; myositis or thyroid disease&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">It is recommendable to screen for a secondary diseases in patients with trochlear pain&#44; including rheumatologic profile&#44; thyroid autoimmunity<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> well as&#124;as&#44; orbital imaging test to evidence trochlear inflammation or tumor infiltration&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Some authors have considered that if anamnesis&#44; physical examination do&#44; not indicate any other systemic process&#44; it might not be&#44; required to carry out supplementary studies10because etiology is idiopathic in the majority of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> In the present case&#44; image test was taken to discard intracranial disease&#44; trochlear inflammation&#46; Analytical studies were requested after the diagnostic had a clear direction&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Treatment for patients with primary trochlear pain with or without trochlear inflammation consists in the injection of nonsteroid anti-inflammatories&#44; with the option of applying local corticoids in refractory cases&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The addition of a local anesthetic enables a quick confirmation test&#46; Said treatment usually produces a remarkable improvement of symptoms within 48<span class="elsevierStyleHsp" style=""></span>h and in up to 90&#37; of patients<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> due to the fact that it diminishes nociceptive afferents on the trigeminal nerve&#46; If relapses occur&#44; new injections can be carried out&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8</span></a> Descriptions of side effects include minor local hematomas&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In view of the above and even though literature is scarce and headaches with trochlear pain are not very frequent&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> this entity must be taken into account in all periorbital headaches&#44; including pediatric patients&#46; Trochlear examination is increasingly important in children who may not be able to describe the characteristics of their pain in full detail&#46; To date&#44; not many pediatric cases have been described in the literature&#44; probably because said entity is infradiagnosed&#46; It is yet to be determined whether pediatric patients have different characteristics in what concerns origin&#44; treatment and prognosis of this condition when larger series are published&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">No conflict of interests was described by the authors&#46;</p></span></span>"
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            2 => "Steroid injection"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Primary trochlear headache is a little-known cause of periorbital headache described in adults&#46; It can involve very disabling pain&#46; In addition&#44; it can be associated with other types of headaches&#44; making them even more difficult to identify&#46; To diagnose this pathology&#44; it is necessary that the examination of the trochlea be incorporated into the usual clinical practice of the patient with headache&#44; which will allow the establishment of an adequate treatment&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The case is presented of an adolescent patient with a diagnosis of migraine&#44; who was admitted with a disabling headache secondary to a primary trochlear headache&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La cefalea troclear primaria es una causa de cefalea periorbitaria descrita en adultos&#44; poco conocida&#46; Esta entidad puede dar lugar a un dolor muy invalidante&#46; Adem&#225;s&#44; puede asociarse a otro tipo de cefaleas&#44; dificultando a&#250;n m&#225;s su identificaci&#243;n&#46; Para diagnosticar esta patolog&#237;a es necesario que la exploraci&#243;n de la tr&#243;clea sea incorporada en la pr&#225;ctica cl&#237;nica habitual del paciente con cefalea&#44; lo cual permitir&#225; poder establecer un tratamiento adecuado&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de una paciente adolescente con diagn&#243;stico de migra&#241;a que ingres&#243; por un cuadro de cefalea invalidante secundaria a una cefalea troclear primaria&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; S&#225;nchez Ruiz P&#44; Mart&#237;n Villaescusa C&#44; Duat Rodr&#237;guez A&#44; Cantar&#237;n Extremera V&#44; Ruiz-Falc&#243; Rojas ML&#46; Cefalea troclear primaria&#46; Un dolor periorbitario con diagn&#243;stico y tratamiento espec&#237;ficos&#46; Arch Soc Esp Oftalmol&#46; 2020&#59;95&#58;150&#8211;152&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">trochlea examination maneuver&#46; A&#41; palpation of upper inner angle of the orbit triggers pain&#46; B&#41; said pain intensifies in supraduction gaze position&#46;</p>"
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ISSN: 21735794
Original language: English
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