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Purtscher-like retinopathy in a paediatric patient with haemolytic uraemic syndrome: A case report and literature review
Retinopatía Purtscher-like en paciente pediátrico con síndrome urémico hemolítico: reporte de caso y revisión de la literatura
F. Benvenuto
Corresponding author
dr.benvenutofranco@gmail.com

Corresponding author.
, S. Guillen, L. Marchiscio, J. Falbo, A. Fandiño
Ophthalmology Service - SAMIC Pediatric, Hospital «Prof. Dr. Juan P. Garrahan», Buenos Aires, Argentina
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intraretinal haemorrhages&#44; retinal pallor that occur after chest or head trauma&#46; When the aetiology is not trauma&#44; it is called <span class="elsevierStyleItalic">Purtscher-like</span> and can be seen in pancreatitis&#44; thrombotic microangiopathy such as HUS and autoimmune diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Ocular involvement in pediatric patients with a diagnosis of HUS has been reported in few cases&#44; and is even rarer in a condition that did not require dialysis treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical case</span><p id="par0020" class="elsevierStylePara elsevierViewall">Patient aged 8 years&#44; previously healthy with no relevant pathological history and complete vaccination&#44; who presented with vomiting and diarrhoea of 72&#160;h of evolution&#44; with bloody stools and fever of 38&#160; &#176;C in the last 48&#160;h&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient had pale skin and mucous membranes&#44; unsteady gait and tremor in the limbs&#44; and was hypotensive with a blood pressure of 64&#47;47&#160;mmHg&#46; Admission was decided&#44; initiating treatment with physiological saline solution 40&#160;ml&#47;kg and ceftriaxone 1500&#160;mg&#46; Blood cultures&#44; complete blood count and urine were taken&#46; The presence of blurred vision led to interconsultation with the Ophthalmology Department&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Initial ophthalmological examination produced visual acuity &#40;VA&#41; of 4&#47;10 in both eyes &#40;BE&#41;&#44; anterior segment without abnormalities while fundus examination showed vascular tortuosity&#44; superficial intraretinal haemorrhages in flame&#44; peripapillary retinal whitening and cotton-wool exudates with peripapillary predominance &#40;Purtscher &#34;flecken&#34;&#41; in BE &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">After the first 24&#160;h of hospitalisation the following parameters were recorded&#58; temperature 37&#46;2&#160;&#176;C&#44; blood pressure 110&#47;72&#160;mmHg and diuresis for 24&#160;h was 100&#160;ml&#46; In the control laboratory the values were&#58; haematocrit 31&#37;&#44; haemoglobin 11&#46;6&#160;g&#47;dl&#44; leucocytes 28&#44;730&#160;ml&#44; platelets 21&#44;000&#160;ml&#44; lactate dehydrogenase 3784&#160;U&#47;l&#44; blood creatine 2&#46;4&#160;mg&#47;dl&#44; uric acid 11&#160;mg&#47;dl and urea 238&#160;mg&#47;dl&#46; Proteinuria&#44; hematuria and peripheral blood schistocytes were also observed&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Verotoxin analysis of fecal material was positive&#46; Together with hemolysis and acute renal failure&#44; a diagnosis of HUS was made&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The patient remained admitted for water and electrolyte supplementation and treatment with amlodipine 2&#46;5&#160;mg&#47;every 24&#160;h&#44; erythropoietin 2000&#160;UI&#47;24&#160;h&#44; bisacodyl 5&#160;mg&#47;24&#160;h&#44; omeprazole 20&#160;mg&#47;24&#160;h and folic acid 1&#160;mg&#47;24&#160;h&#46; During hospitalisation&#44; control ultrasound scans were performed&#44; showing kidneys of normal size although the presence of pericardial effusion was found&#44; which evolved favourably with treatment &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The patient was discharged after 2 weeks of hospitalisation&#44; without requiring dialysis treatment&#46; Due to the diagnosis of HUS and the ocular fundus findings&#44; with no history of trauma&#44; the picture was interpreted as <span class="elsevierStyleItalic">Purtscher-like</span> retinopathy&#46; One month after the first check-up&#44; a new check-up was performed&#44; showing a VA of 10&#47;10 in BE&#44; absence of peripapillary whitening and an almost complete decrease in retinal haemorrhages&#44; vascular tortuosity and soft Purtscher &#34;flecken&#34; exudates &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">Purtscher first published haemorrhages and retinal whitening in 2 patients with a history of severe head trauma&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The same findings were later described in patients with severe chest trauma&#44; long bone fractures or no history of trauma but with a diagnosis of different entities such as pancreatitis and collagen diseases&#46; It has been postulated that these characteristic findings may be secondary to thrombotic microangiopathy with endothelial damage and increased platelet consumption&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Purtscher-like</span> retinopathy is a rare entity&#44; occurring in 0&#46;24 patients per 1&#44;000&#44;000 per year&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The pathophysiology of this retinopathy is associated with endothelial damage with occlusion in the pre-capillary arteries by leukocytes&#44; platelets&#44; fibrin and complement aggregates&#46; This would be the cause of the findings usually observed as Purtscher &#34;flecken&#34; cotton-wool exudates&#44; retinal haemorrhages&#44; macular edema and cherry red pseudo-stain&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The present patient was diagnosed at the clinical and laboratory level with HUS&#44; and reported visual disturbances from the first hospital visit&#46; Due to the rapid diagnosis and prompt treatment of HUS&#44; the patient did not require dialysis&#46; Fundus findings were consistent with <span class="elsevierStyleItalic">Purtscher-like</span> retinopathy&#46; The pathogenesis of HUS that explains this is the result of thrombotic microangiopathy with endothelial damage probably induced by the exotoxin&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Purtscher-like</span> retinopathy is a rare ophthalmological condition associated with severe multi-systemic diseases&#46; We have found no reports in the literature of this retinopathy due to HUS in patients who have not required dialysis treatment&#46; Fundus examination in patients with this disease is of great help in the diagnosis of this retinopathy&#46;</p></span><span id="sec1015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect1041">Conflict of interests</span><p id="par1061" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Funding</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have not received any funding for this work&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">An 8-year-old boy presented with fever&#44; vomits&#44; bloody diarrhoea&#44; and blurred vision&#46; The patient was diagnosed with Haemolytic Uraemic Syndrome &#40;HUS&#41; due to the symptoms and a positive Verotoxin stool test&#46; Funduscopic examination showed retinal involvement in both eyes&#44; peri-papillary paleness&#44; retinal haemorrhages&#44; and soft &#34;Purtscher Fleckens&#8221; exudates&#46; A favourable outcome was achieved after hospital admission and systemic treatment&#46; Dialysis treatment was not needed due the preserved diuresis&#46; Although Purtscher-like retinopathy is very uncommon&#44; ocular examination is mandatory in patients with pancreatitis&#44; autoimmune diseases&#44; and thrombotic microangiopathies&#44; such as HUS&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso cl&#237;nico de un paciente de 8 a&#241;os de edad con un cuadro febril&#44; v&#243;mitos&#44; diarrea con sangre y visi&#243;n borrosa&#46; El paciente fue diagnosticado de S&#237;ndrome Ur&#233;mico Hemol&#237;tico &#40;SHU&#41; por cl&#237;nica y detecci&#243;n de Verotoxina en materia fecal&#46; La exploraci&#243;n fundosc&#243;pica mostr&#243; compromiso retinal en ambos ojos&#44; palidez peripapilar&#44; hemorragias retinianas y exudados blandos en forma de Purtscher Flecken&#46; La evoluci&#243;n fue favorable tras la internaci&#243;n y tratamiento sist&#233;mico&#44; no requiriendo di&#225;lisis por diuresis conservada&#46; La exploraci&#243;n oftalmol&#243;gica de estos pacientes es fundamental para el estudio del paciente&#44; ya que&#44; a pesar de ser infrecuente&#44; la retinopat&#237;a <span class="elsevierStyleItalic">Purtscher-like</span> puede verse en cuadros de pancreatitis&#44; enfermedades autoinmunes y microangiopat&#237;as tromb&#243;ticas como el SHU&#46;</p></span>"
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Article information
ISSN: 21735794
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos