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Original article
Stratification by demographic and clinical data of the antibiotic susceptibility of Escherichia coli from urinary tract infections of the community
Estratificación por datos clínicos y demográficos de la sensibilidad antibiótica de Escherichia coli de infecciones del tracto urinario de origen comunitario
Martín C. Gradosa, Israel J. Thuissardb, Juan-Ignacio Alósa,b,
Corresponding author
nachoalos@telefonica.net

Corresponding author.
a Servicio Microbiología, Hospital Universitario de Getafe, Getafe, Carretera de Toledo km 12,500, 28905 Getafe, Madrid, Spain
b Universidad Europea, Villaviciosa de Odón, Calle Tajo s/n, 28670 Villaviciosa de Odón, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Urinary tract infections &#40;UTI&#41; are common and contribute a significant burden to population health&#46; In the United States&#44; UTI account for approximately 10 million ambulatory visits and an estimated &#36;2&#46;000 in total cost each year&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In Spain&#44; one third of visits to primary care are due to infectious processes&#46; Of these&#44; 10&#37; are urinary infections&#44; most uncomplicated acute cistitis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">UTI are one of the most common reasons for prescription of antimicrobials in primary care&#46; Appropriate empirical therapy is important since treatment with an antimicrobial to which the uropathogen is resistant is associated with more clinical and microbiological failures&#44; a longer median time to symptom resolution&#44; higher re-consultation rates&#44; and more subsequent antibiotics&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Acute uncomplicated UTI in women is generally managed effectively and safely by empirical antibiotic therapy without a urine culture&#44; laboratory testing is undertaken when empirical therapy fails&#46; In recurrent UTI and in complicated UTI&#44; urine cultures and antimicrobial susceptibility tests are recommended&#46; For these reasons laboratory-based surveillance suffers from requesting bias&#44; and probably overestimate resistance rates&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Antimicrobial resistance in common urinary pathogens is increasing at an alarming rate&#44; as a result of overuse and misuse of antibiotics&#46; Resistance patterns vary by geographic location&#44; but are rising in Spain and globally&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Knowledge of local susceptibility patterns is important for the selection of appropriate empirical therapy of UTI&#46; Reporting updated local susceptibility patterns<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> of the most frequently isolated microorganisms from urine samples influence physician decisions on therapeutic choices<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> allowing to choose more appropriate and effective treatments&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Among outpatients&#44; <span class="elsevierStyleItalic">Escherichia coli</span> is the main urinary tract pathogen&#44; accounting for 60&#8211;85&#37; of isolates&#46; There are many studies in literature on the antibiotic susceptibility of <span class="elsevierStyleItalic">E&#46; coli</span> and other uropathogens&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;9-12</span></a> but there are few studies&#44; and less in primary care&#44; evaluating the susceptibility of this microorganism considering some demographic and clinical data of patients such as sex&#44; age and type of UTI&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13-15</span></a> Our hypothesis is that if there were differences in the susceptibility patterns according to these characteristics of the patients&#44; these last data would be more useful to guide clinicians to choose a more appropriate empirical treatment&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Our goal was to determine the antibiotic susceptibility patterns of <span class="elsevierStyleItalic">E&#46; coli</span> strains isolated from adult patients with UTI attended at primary care centers in Getafe &#40;Madrid&#44; Spain&#41;&#44; to compare them with the global laboratory susceptibility data of adults with positive urine cultures in primary care&#44; and to stratify the results by age&#44; and type of UTI&#44; determined by clinical data&#44; to verify if there are statistically significant variations&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Design and study population</span><p id="par0040" class="elsevierStylePara elsevierViewall">A cross-sectional prospective study was carried out&#46; Inclusion criteria&#58; Isolates of <span class="elsevierStyleItalic">E&#46; coli</span> from urine &#40;10<span class="elsevierStyleSup">4</span>&#8211;10<span class="elsevierStyleSup">5</span><span class="elsevierStyleHsp" style=""></span>cfu&#47;ml&#41; of adult patients&#44; aged 18 and older&#44; of all the primary care Centers in the Getafe area &#40;Madrid&#44; Spain&#41;&#59; they were randomly selected from June 2016 to April 2017&#44; one per patient&#59; clinical and demographic data of the patients were obtained&#46; Exclusion criteria&#58; Isolates of <span class="elsevierStyleItalic">E&#46; coli</span> from urine of patients aged less than 18 years&#44; of hospital wards&#44; and of the emergency department&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The study protocol &#40;17&#47;82&#41; was approved by the Comit&#233; &#201;tico de Investigaci&#243;n con Medicamentos of Hospital Universitario de Getafe&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Data and variables</span><p id="par0050" class="elsevierStylePara elsevierViewall">Clinical and demographic data &#40;gender and age&#41; were analyzed and&#44; taking into account these features&#44; the episodes were classified as complicated UTI&#44; uncomplicated UTI or asymptomatic bacteriuria&#44; according to the Spanish Society of Infectious Diseases and Clinical Microbiology &#40;SEIMC&#41; guidelines<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#59; complicated UTI was considered in all men&#44; and in patients with diabetes&#44; indwelling catheter&#44; neurogenic bladder&#44; obstructive uropathy&#44; history of pathologies or spinal surgeries&#44; invasive urological procedure in the previous 3 months or immunosupresion&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The antibiotic susceptibility of the strains of <span class="elsevierStyleItalic">E&#46; coli</span> was determined by broth microdilution &#40;MicroScan panels&#44; California&#44; USA&#41; to the following antibiotics&#58; amoxicillin&#44; amoxicillin&#47;clavulanic acid&#44; fosfomycin&#44; cotrimoxazole&#44; nitrofurantoin&#44; ciprofloxacin&#44; gentamicin&#44; cefotaxime&#44; and imipenem&#46; The results were interpreted according to the 2016 EUCAST guidelines<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> except for amoxicillin&#47;clavulanic in which the 2016 CLSI guidelines were used&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Global laboratory susceptibility data of adults of primary care with significant isolation of <span class="elsevierStyleItalic">E&#46; coli</span> from urine cultures were obtained from our laboratory computer system&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Statistical analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">For the descriptive analysis&#44; the absolute &#40;<span class="elsevierStyleItalic">n</span>&#41; and relative &#40;&#37;&#41; frequencies were used to express the qualitative variables&#46; Following the confirmation of the parametric behavior&#44; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41; or median &#91;interquartile range&#59; IQR&#93; were used to express the quantitative variables&#46; To test the statistically significant differences scenarios either the chi-square test or Fisher&#39;s exact test was performed for qualitative variables&#46; Besides&#44; either Student <span class="elsevierStyleItalic">T</span> test or <span class="elsevierStyleItalic">U</span>-Mann Whitney was used for quantitative variables according to the normality test&#46; When the <span class="elsevierStyleItalic">p</span>-value was inferior to the alpha error &#40;5&#37;&#41;&#44; a statistical significance was considered&#46; The data analysis was performed with IBM SPSS statistics version 21&#46;0 &#40;IBM Corp&#59; USA&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Results</span><p id="par0070" class="elsevierStylePara elsevierViewall">In our health care area 30&#44;144 urine cultures were processed in 2016&#44; of which 19&#44;533 &#40;64&#46;8&#37;&#41; came from adult patients of primary care&#46; <span class="elsevierStyleItalic">E&#46; coli</span> was isolated in 2140 &#40;61&#46;4&#37; of the considered positive cultures&#41;&#59; its antibiotic susceptibility is represented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Of the 100 patients included&#44; 15&#37; were male and 85&#37; female&#46; The mean age was 58&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;8 years&#44; 49 had complicated UTI&#44; 44 uncomplicated UTI&#44; and 7 had asymptomatic bacteriuria&#46; Patients with uncomplicated UTI &#40;44&#44; all women&#41; had a mean age of 54&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;0 years&#59; Patients with complicated UTI &#40;49 in total&#44; 15 males and 34 females&#41; had a mean age of 63&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;2 years&#44; significantly higher &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The overall analysis of antibiotic susceptibility of the 100 <span class="elsevierStyleItalic">E&#46; coli</span> strains was&#58; amoxicillin &#40;47&#37;&#41;&#44; amoxicillin&#47;clavulanic acid &#40;86&#37;&#41;&#44; fosfomycin &#40;99&#37;&#41;&#44; cotrimoxazole &#40;73&#37;&#41;&#44; ciprofloxacin &#40;74&#37;&#41;&#44; gentamicin &#40;92&#37;&#41;&#44; nitrofurantoin &#40;99&#37;&#41;&#44; cefotaxime &#40;93&#37;&#41;&#44; and imipenem &#40;100&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The antibiotic susceptibility of part of these strains stratified in those with complicated UTI &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>49&#41; and those with uncomplicated UTI &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#41; as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">When we compare the stratified antibiotic susceptibility&#44; we found that strains isolated from patients with uncomplicated UTI showed significantly greater susceptibility than those of complicated UTI to amoxicillin &#40;65&#46;9&#37; <span class="elsevierStyleItalic">vs</span>&#46; 30&#46;6&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; amoxicillin&#47;clavulanic acid &#40;95&#46;5&#37; <span class="elsevierStyleItalic">vs</span>&#46; 77&#46;6&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;013&#41; and ciprofloxacin &#40;81&#46;8&#37; <span class="elsevierStyleItalic">vs</span>&#46; 63&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;047&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In complicated UTI&#44; susceptibility to ciprofloxacin was significantly greater in the &#8804;65 years age group compared to the older age group &#40;78&#46;3&#37; <span class="elsevierStyleItalic">vs</span>&#46; 50&#37;&#44; respectively&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;041&#41;&#46; In the rest of antibiotics&#44; no statistically significant differences were obtained when comparing by age &#40;&#8804;65 years <span class="elsevierStyleItalic">versus</span><span class="elsevierStyleHsp" style=""></span>&#62;65 years&#41;&#44; both in uncomplicated and complicated UTI&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">Antimicrobial resistance in common urinary pathogens is increasing at an alarming rate&#46; Because of the predominance of <span class="elsevierStyleItalic">E&#46; coli</span> as causative agent&#44; resistance to this species is often of epidemiologic resistance studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12&#44;19</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Laboratory-based surveillance suffers from requesting bias since primary care physicians are advised against urine sampling in cases of uncomplicated UTI in non-pregnant women at least at first presentation&#46; Urine culture is recommended for patients with complicated infection&#44; and to guide a change of antimicrobials for women who do not respond to initial therapy&#46; Since patients who fail initial empirical therapy for UTI have more risk factors for antimicrobial resistance&#44; complications or recurrence and are more likely to be tested&#44; laboratory-based surveillance is likely to overestimate resistance rates&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Cumulative reports on antimicrobial susceptibility data provided by microbiological laboratories are important for selecting empiric treatments&#46; There are many studies on antibiotic sensitivity of <span class="elsevierStyleItalic">E&#46; coli</span> and other uropathogens&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;9-12</span></a> Weaknesses of these studies included a deficit of clinical data or even demographic data&#46; A first or second episode of uncomplicated cystitis in a young woman is not the same as a UTI in a male with multiple episodes treated with antibiotics&#46; Other methods of surveillance are required to provide unbiased estimates of antimicrobial resistance&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">To identify individual patient or clinical characteristics that predict antimicrobial resistance&#44; culture results should be linked to patient demographics and clinical characteristics&#59; however&#44; urine samples are often submitted to the laboratory with insufficient supplementary clinical information&#46; One strength of our study is that we have reviewed medical records &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&#46; In fact&#44; we have more patients with complicated UTI &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>49&#41; than with uncomplicated UTI &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#41; because in many uncomplicated UTI&#44; the most common type of urinary infection in primary care&#44; urine cultures are not send to the laboratory&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">As expected&#44; there were few differences in susceptibility between the global data of our laboratory &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2140&#41; and the data of the 100 strains included in this work &#40;see <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; but there were differences in some antibiotics between strains from uncomplicated UTI and complicated UTI&#44; and depending on the age in ciprofloxacin in patients with complicated UTI&#46; In cefotaxime&#44; there was not a statistically significant difference due&#44; in our opinion&#44; to the restricted sample size&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The data from the present study indicate that ciprofloxacin&#44; ampicillin&#44; and amoxicillin&#47;clavulanic acid non-susceptibility in <span class="elsevierStyleItalic">E&#46; coli</span> are associated mostly with isolates from complicated UTI&#46; Explanation could be previous antibiotic treatments that would have selected resistant strains that colonize patients and cause infections in the next weeks&#47;months&#46; In a recent study&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> an important variation in susceptibility to ciprofloxacin between cases of uncomplicated and complicated UTI were also observed&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Reviewing the medical records of this study&#44; we ascertain that amoxicillin&#47;clavulanic acid and ciprofloxacin are frequently used for the empirical treatment of complicated UTIs &#40;data not shown&#41;&#44; which would explain the selection of resistances to these antibiotics and the differences with the strains isolated from uncomplicated UTI&#46; We suggest not using these antibiotics in the empirical treatment of complicated UTI since susceptibility to both is less than 80&#37;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">It is important to note that the susceptibility to fosfomycin and nitrofurantoin remains high in all groups of patients analyzed&#46; They would be an excellent option for the empirical treatment of cases of uncomplicated UTI&#44; as it is stated in several guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;16</span></a> However&#44; this is not the case of cotrimoxazole&#44; 25&#37; of strains are resistant&#46; Although amoxicillin&#47;clavulanic acid and ciprofloxacin are not considered appropriate empirical treatments for uncomplicated UTI&#44; they would be an alternative as the rates of susceptibility are 95&#46;5&#37; and 81&#46;8&#37; respectively&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">A limitation of our study is that it was performed in a single-center &#40;population 218&#44;945 inhabitants&#41;&#44; but in our opinion they warn of the convenience of stratify susceptibility data to obtain more usefulness of them&#46; The subset of patients in some groups was of inadequate size to show statistical significances&#46; Another limitation is that <span class="elsevierStyleItalic">E&#46; coli</span> data underestimate resistance rates because they exclude bacteria like&#44; for example&#44; <span class="elsevierStyleItalic">Enterobacter cloace</span> and <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> with intrinsic resistance to various antibiotics&#44; although these species are rare in UTI in primary care&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In future it would be of interest to expand some group to obtain&#47;to discard statistically differences in antibiotic susceptibility&#46; Also&#44; to evaluate the evolution over the time&#44; as antibiotic resistance is dynamic&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">We conclude that clinical and demographic data are of great importance in the results of antibiotic susceptibility in <span class="elsevierStyleItalic">E&#46; coli</span> causing UTI and would be more useful than global data in the choice of empirical treatments&#46; Antibiograms stratified by patient characteristics may better facilitate empirical antibiotic selection for UTI in primary care&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflict of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Aim</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the patterns of antibiotic susceptibility of <span class="elsevierStyleItalic">Escherichia coli</span> strains isolated from adult patients with urinary tract infection &#40;UTI&#41;&#44; and to stratify the results by age and type of UTI to verify if there are statistically significant differences that can help physicians to prescribe better empirical antibiotherapy&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional prospective study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Location</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Community of Getafe &#40;Madrid&#41;&#46; Primary care level&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Participants</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">100 <span class="elsevierStyleItalic">E&#46; coli</span> strains&#44; randomly chosen&#44; isolated from the urine &#40;10<span class="elsevierStyleSup">4</span>&#8211;10<span class="elsevierStyleSup">5</span><span class="elsevierStyleHsp" style=""></span>cfu&#47;ml&#41; of different patients from primary care centers in the Getafe area&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Main measurements</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The antibiotic susceptibility of the strains was evaluated and the results were stratified by age and type of UTI&#46; The clinical and demographic data of the patients were analyzed&#44; classifying each episode as complicated UTI or uncomplicated UTI&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Strains isolated from patients with uncomplicated UTI showed significantly greater susceptibility than those of complicated UTI to amoxicillin &#40;65&#46;9&#37; <span class="elsevierStyleItalic">vs</span>&#46; 30&#46;6&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; amoxicillin&#47;clavulanic acid &#40;95&#46;5&#37; <span class="elsevierStyleItalic">vs</span>&#46; 77&#46;6&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;013&#41; and ciprofloxacin &#40;81&#46;8&#37; <span class="elsevierStyleItalic">vs</span>&#46; 63&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;047&#41;&#46; In complicated UTI&#44; susceptibility to ciprofloxacin was significantly greater in the &#8804;65 years age group compared to the older age group &#40;78&#46;3&#37; <span class="elsevierStyleItalic">vs</span>&#46; 50&#37;&#44; respectively&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;041&#41;&#46; In the rest of antibiotics&#44; no statistically significant differences were obtained when comparing by age &#40;&#8804;65 years <span class="elsevierStyleItalic">versus</span> &#62;65 years&#41;&#44; both in uncomplicated and complicated UTI&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Clinical and demographic data of patients with UTI are of great importance in the results of the antibiotic susceptibility in <span class="elsevierStyleItalic">E&#46; coli</span>&#46; Antibiograms stratified by patient characteristics may better facilitate empirical antibiotic selection for UTI in primary care&#46;</p></span>"
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        "resumen" => "<span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivo</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Determinar los patrones de sensibilidad antibi&#243;tica de cepas de <span class="elsevierStyleItalic">Escherichia coli</span> aisladas de pacientes adultos con infecci&#243;n del tracto urinario &#40;ITU&#41;&#44; y estratificar los resultados por edad y tipo de ITU para verificar si existen diferencias estad&#237;sticamente significativas que puedan ayudar a los m&#233;dicos a la prescripci&#243;n de una mejor antibioterapia emp&#237;rica&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Dise&#241;o</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal prospectivo&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Emplazamiento</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Comunidad de Getafe &#40;Madrid&#41;&#46; Nivel de atenci&#243;n primaria&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Participantes</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">100 cepas de <span class="elsevierStyleItalic">E&#46; coli</span>&#44; escogidas al azar&#44; aisladas de orina &#40;10<span class="elsevierStyleSup">4</span> -&#62;10<span class="elsevierStyleSup">5</span><span class="elsevierStyleHsp" style=""></span>ufc&#47;ml&#41; de diferentes pacientes de centros de atenci&#243;n primaria del &#225;rea de Getafe&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Mediciones principales</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Se evalu&#243; la sensibilidad antibi&#243;tica de las cepas y los resultados se estratificaron por edad y tipo de ITU&#46; Se analizaron los datos cl&#237;nicos y demogr&#225;ficos de los pacientes de los que proven&#237;an&#44; clasific&#225;ndose cada episodio como ITU complicada o ITU no complicada&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Las cepas aisladas de pacientes con ITU no complicada mostraron una sensibilidad antibi&#243;tica significativamente mayor que las de ITU complicada a amoxicilina &#40;65&#44;9&#37; <span class="elsevierStyleItalic">vs</span>&#46; 30&#44;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; amoxicilina&#47;clavul&#225;nico &#40;95&#44;5&#37; <span class="elsevierStyleItalic">vs</span>&#46; 77&#44;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;013&#41; y ciprofloxacino &#40;81&#44;8&#37; <span class="elsevierStyleItalic">vs</span>&#46; 63&#44;3&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;047&#41;&#46; En la ITU complicada&#44; la sensibilidad al ciprofloxacino fue significativamente mayor en el grupo de edad &#8804;65 a&#241;os en comparaci&#243;n con el grupo de mayor edad &#40;78&#44;3&#37; <span class="elsevierStyleItalic">vs</span>&#46; 50&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;041&#41;&#46; Para el resto de antibi&#243;ticos no se observaron diferencias significativas cuando se compararon por edad &#40;&#8804;65 <span class="elsevierStyleItalic">versus</span><span class="elsevierStyleHsp" style=""></span>&#62;65&#41;&#44; tanto en ITU no complicada como complicada&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusiones</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Los datos cl&#237;nicos y demogr&#225;ficos de los pacientes con ITU son de gran importancia en los resultados de la sensibilidad antibi&#243;tica en <span class="elsevierStyleItalic">E&#46; coli</span>&#46; Los antibiogramas estratificados por caracter&#237;sticas de los pacientes podr&#237;an facilitar una mejor selecci&#243;n de antibioterapia emp&#237;rica para las ITU en atenci&#243;n primaria&#46;</p></span>"
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                  \t\t\t\t" scope="col">&#37;S this study&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cefotaxime&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">93&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;207&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Imipenem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">99&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            1 => array:3 [
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">When comparing data of cUTI and uUTI&#46;</p>"
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Global antibiotic susceptibility of <span class="elsevierStyleItalic">Escherichia coli</span> strains from urine cultures of adult outpatients in 2016&#44; antibiotic susceptibility of the 100 isolates of the present study&#44; and the same stratified by type of UTI&#44; complicated <span class="elsevierStyleItalic">versus</span> uncomplicated&#46;</p>"
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          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">What is known about the subject</span><p id="par0150" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0155" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">E&#46; coli</span> is the pathogen most frequently involved in UTI&#46; Global data of the antibiotic susceptibility &#40;antibiograms&#41; provided by laboratories influence the choice of empirical treatments&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0160" class="elsevierStylePara elsevierViewall">Most studies report global data of laboratories without stratification&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0165" class="elsevierStylePara elsevierViewall">Few studies evaluate the influence of clinical and demographic data on the results of antibiotic susceptibility&#46;</p></li></ul></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">What this study contributes</span><p id="par0170" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0175" class="elsevierStylePara elsevierViewall">Clinical and demographic data are of great importance in the results of antibiotic susceptibility in <span class="elsevierStyleItalic">E&#46; coli</span> causing UTI&#46; Antibiograms stratified by patient characteristics may better facilitate empirical antibiotic selection for UTI in primary care&#46;</p></li></ul></p></span></span>"
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ISSN: 02126567
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos