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Original article
Multimodal Rehabilitation Programme in Elective Colorectal Surgery: Impact on Hospital Costs
Impacto de un programa de rehabilitación multimodal en cirugía electiva colorrectal sobre los costes hospitalarios
Sílvia Salvansa, M. José Gil-Egeaa,
Corresponding author
35780@parcdesalutmar.cat

Corresponding author.
, Miguel Peraa, Leyre Lorentea, Francesc Cotsb, Marta Pascuala, Sandra Alonsoa, Ricard Courtiera, Luis Grandea
a Unidad de Cirugía Colorrectal, Servicio de Cirugía General y Digestiva, Hospital Universitario del Mar, Barcelona, Spain
b Servicio de Control de Gestión, Parc de Salut Mar, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In recent years&#44; there has been a slow but steady increase in the use of multimodal rehabilitation &#40;MMRH&#41; programmes &#40;also called &#8220;fast track&#8221;&#41; proposed by Kehlet<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> after elective colorectal surgery&#46; These programmes&#44; which require the coordination of different specialists&#44; are a combination of different perioperative care strategies to reduce surgical stress and facilitate postoperative patient recovery&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> The implementation of these measures has reduced hospital stays to 2&#8211;4 days without increasing morbidity<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a>&#59; additionally&#44; the experience of some authors indicates that such programmes may reduce postoperative complication rates&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In 2005&#44; the Enhanced Recovery After Surgery Project &#40;ERAS&#41;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> was published&#44; which combines different strategies for perioperative care based on the best scientific evidence&#46; Since the emergence of the ERAS protocols&#44; several randomised clinical trials and meta-analyses of new proposals for multidisciplinary performance have been published&#44; with the aim of improving the functional recovery of patients following elective colorectal surgery&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;11&#8211;13</span></a> Although each specific strategy is beneficial in itself for achieving the best results&#44; they should all be used together&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Furthermore&#44; decreasing hospital stays and&#44; in some cases&#44; reducing postoperative complications must lower hospital costs&#46; However&#44; very few studies have assessed the impact of MMRH programmes on hospital costs after colorectal surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In March 2006&#44; the Colorectal Surgery unit of the Hospital del Mar in Barcelona launched an MMRH protocol for patients undergoing elective colorectal surgery&#46; In the analysis of the initial results with a group of 90 patients&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> we showed that MMRH is a safe protocol &#40;as it does not increase complications&#41; that reduces hospital stays to three days&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this study is to confirm our preliminary results by increasing the number of patients in the MMRH programme and to analyse the impact on hospital costs&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study Design</span><p id="par0025" class="elsevierStylePara elsevierViewall">A prospective comparative study of two consecutive cohorts of patients undergoing elective colorectal surgery&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study Population</span><p id="par0030" class="elsevierStylePara elsevierViewall">The MMRH group consisted of 231 patients undergoing elective colorectal surgery between March 2006 and December 2007&#46; The control group included 134 patients who underwent surgery in 2005&#44; before the implementation of the MMRH protocol&#46; Inclusion criteria were all patients undergoing scheduled colon and rectal surgery&#46; No exclusion criteria were established&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The protocol of the MMRH group consisted of preoperative&#44; intraoperative and postoperative strategies&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> The <span class="elsevierStyleItalic">preoperative</span> strategies were providing oral and written information about the surgical procedure and the MMRH programme by the surgeon and a nurse from the hospital Colorectal Surgery Unit&#59; performing colon preparation with polyethylene glycol &#40;Bohm Laboratories&#44; S&#46;A&#46;&#41; while administering a hydrocarbon solution &#40;135<span class="elsevierStyleHsp" style=""></span>g carbohydrate in 1000<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">3</span>&#41; as enteral nutrition &#40;Edanec<span class="elsevierStyleSup">&#174;</span>&#44; Abbott Laboratories&#44; S&#46;A&#46;&#41;&#59; prescribing a preoperative 6-h liquids and solids fast&#59; providing antibiotic prophylaxis with metronidazole 1<span class="elsevierStyleHsp" style=""></span>g gentamicin 240<span class="elsevierStyleHsp" style=""></span>mg and antithrombotic bemiparin 2500 UI preoperatively and daily postoperatively for 4 weeks&#46; During the <span class="elsevierStyleItalic">intraoperative</span> phase&#44; analgesia was administered through an epidural catheter&#44; and short-acting anaesthetics were used&#59; hydration was performed at an adjusted rate of 6&#8211;8<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#47;h&#59; hypothermia was prevented with temperature-controlled fluid therapy and a heating blanket&#59; and intra-abdominal drains and nasogastric tube placement were avoided&#46; During the <span class="elsevierStyleItalic">postoperative</span> phase&#44; multimodal analgesia was administered&#44; the diet resumed gradually 6<span class="elsevierStyleHsp" style=""></span>h after surgery&#44; and early mobilisation was encouraged&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The most important differential strategies for the control group protocol were as follows&#46; During the <span class="elsevierStyleItalic">preoperative</span> phase&#44; oral communication was only provided by the surgeon&#59; the colon was prepared using Fosfosoda<span class="elsevierStyleSup">&#174;</span> &#40;Fleet Company Inc&#46;&#44; VA&#44; USA&#41; while administering intravenous hydration of 1000<span class="elsevierStyleHsp" style=""></span>ml of 5&#37; dextrose with 60<span class="elsevierStyleHsp" style=""></span>mEq KCl&#59; and preoperative fasting began the night before surgery&#46; During the <span class="elsevierStyleItalic">intraoperative</span> phase&#44; fluid therapy was administered at the discretion of the attending anaesthesiologist at a rate of approximately 10&#8211;14<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#47;h&#44; almost twice the established rate for the MMRH protocol&#46; During the <span class="elsevierStyleItalic">postoperative</span> phase&#44; the diet was resumed according to the surgeon&#39;s criterion&#44; usually with the onset of peristalsis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In both groups&#44; discharge occurred when the patient was able to tolerate a solid diet&#44; had good pain control with oral analgesia and was ambulatory&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Variables</span><p id="par0050" class="elsevierStylePara elsevierViewall">The demographic and clinical characteristics of the patients included in each group were compared&#46; Medical and surgical complications occurring within 30 days after surgery in both groups were recorded&#46; The average length of stay and readmission rate per group was also included&#46; The nursing staff or attending physician&#39;s compliance with the MMRH programme&#39;s protocol for the start of the diet and the withdrawal of fluid therapy was analysed&#46; Tolerance of diet and ambulation were measured as parameters of functional recovery&#46; We analysed the progression of hospital discharge in both groups&#46; The hospital discharge rate per day was studied for each group&#46; Finally&#44; total and specific costs were calculated &#40;per hospitalisation unit&#44; laboratory&#44; radiology&#44; pharmacy&#44; surgical suite and disease&#41; per patient in each group&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Cost Analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Our hospital cost accounting provides patient-level details&#46; It is characterised by a &#8220;full-costing&#8221; system and for basing the allocation of costs to activities on a cost-benefit analysis &#40;CBA&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> This cost analysis system ensures that all of the expenses are shared between all of the episodes&#46; The cost of each episode is the sum of the costs of all variable costs &#40;direct costs&#41; plus the set of general costs charged per activity &#40;indirect costs&#41;&#46; The cost information available allows the disaggregation of costs&#44; such as inpatient unit&#44; laboratory&#44; radiology&#44; pharmacy&#44; operating room and disease&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical Analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">A descriptive and statistical comparison of variables was performed&#44; considering a <span class="elsevierStyleItalic">P</span>-value of less than &#46;05 to be statistically significant&#46; Qualitative variables are expressed in absolute numbers or proportions&#44; and quantitative variables are expressed as the median and range or as the mean and standard deviation&#46; The test of the hypothesis was the Chi-squared test for qualitative ordinal variables &#40;comparison of proportions&#41;&#44; Student&#39;s <span class="elsevierStyleItalic">t</span>-test for continuous variables when their applicability criteria were met and the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test when applicability criteria were not met&#46; All of the data were analysed using SPSS Version 12&#46;0&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">There were no differences in the patient characteristics or surgical procedures performed between the two study groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the overall morbidity of both groups&#59; there were no significant differences between them&#46; This morbidity rate also included patients who were readmitted&#46; We did not observe significant differences when comparing medical and surgical complications&#46; Surgical site infections were analysed separately&#44; and they also showed no differences&#46; Finally&#44; mortality in both groups was less than 5&#37;&#44; and the differences were not statistically significant&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows a statistically significant decrease of three days in the average hospital stay of patients in the MMRH group compared with control patients&#59; however&#44; no differences were found in the percentage of readmissions&#46; The three-day decrease was maintained when analysing the total stay as the sum of the initial stay and the readmission stay&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows an analysis of different aspects included in the programme to reflect the MMRH protocol compliance and functional recovery of patients&#44; such as the beginning of ambulation and diet&#44; diet tolerance and intravenous fluid therapy withdrawal&#46; The percentage of patients discharged on a given postoperative day is also shown&#46; We note that only 55 and 68&#37; of patients started the diet and ambulated&#44; respectively&#44; on the first postoperative day&#46; On the fifth postoperative day&#44; only 37&#37; of patients were discharged&#44; although 80&#37; of the patients met the discharge criteria&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows the progression to hospital discharge in the both groups&#46; Statistically significant differences were observed on the fifth postoperative day &#40;37&#37; vs 20&#37;&#41;&#44; the sixth postoperative day &#40;66&#37; vs 43&#37;&#41; and the eighth postoperative day &#40;69&#37; vs 47&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> shows the hospital costs per patient in each group&#46; We found a significant reduction in total cost of 912 &#8364; per patient in the MMRH group compared with the control group&#46; This significant reduction of costs was found mainly for the hospitalisation unit&#44; with a cost decrease of 831 &#8364; in the MMRH group&#46; We also observed a significant reduction in laboratory costs&#46; The costs per patient for radiology and pharmacy were also lower in the MMRH group&#44; but this difference did not reach statistical significance&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">First&#44; the present study confirms the preliminary results published by our group<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> in a series with a larger number of patients included in the MMRH protocol&#46; This protocol is safe&#44; does not increase patient morbidity or mortality and reduces hospital stay by three days compared with conventional perioperative care&#46; These results are also consistent with previous studies and systematic reviews&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;13</span></a> Second&#44; this study shows how faster patient recovery is associated with a significant reduction in hospital costs&#46; Although it is obvious&#44; little published work has quantified this cost reduction&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Although the overall morbidity and mortality in this study were similar to that described in other studies on the implementation of MMRH programmes&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;19</span></a> we found no differences in postoperative complications between groups&#46; Therefore&#44; we can say that the hospital stay reductions were not caused by reduced morbidity&#46; The impact of MMRH programmes on postoperative morbidity is controversial&#46; In the systematic review by Wind et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> morbidity rates between 8&#37; and 75&#37; were found&#59; however&#44; the differences between groups reached statistical significance only in one study&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> A systematic review of the Cochrane Database<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> showed a reduction in overall complications&#44; but the most serious complications did not decrease&#46; The absence of differences in morbidity in our study and in others may be related to several reasons&#46; First&#44; each study used different definitions of complications and different classifications&#46; Second&#44; the need to optimise the implemented protocol in accordance with all the recommendations of ERAS protocols may have minimised differences in morbidity&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> For example&#44; we established a 6<span class="elsevierStyleHsp" style=""></span>h preoperative fast&#44; while the ERAS protocol consensus recommends fluid intake 2<span class="elsevierStyleHsp" style=""></span>h before anaesthetic induction and solid intake 6<span class="elsevierStyleHsp" style=""></span>h<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> before anaesthesia&#46; We also need to improve the treatment of postoperative nausea and vomiting<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> by implementing strategies to prevent postoperative ileus&#44; such as administering magnesium hydroxide<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and other prokinetics&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Currently&#44; we are considering implementing some of these strategies with the intention of improving our protocol&#46; For example&#44; beginning two years ago&#44; patients undergoing colon resection did not receive preoperative bowel preparation&#44; based on the scientific evidence&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> The implementation of all the recommendations recently examined by the ERAS group could significantly reduce postoperative morbidity&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">We have achieved a significant reduction in hospital stay despite a low level of compliance with the MMRH programme&#46; Protocol compliance has been identified as one of the problems of MMRH programmes&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> reflecting the difficulty of changing a traditional protocol and implementing new strategies for perioperative care&#46; However&#44; this problem has hardly been studied&#46; In a previous study&#44; we observed that compliance with a new protocol is initially low but gradually improves&#44; along with the results of the MMRH programme and the experience of the professionals involved&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Delaney et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> also observed that the hospital stay was shorter when these programmes were implemented by experienced surgeons&#46; The difficulty of implementing an ERAS protocol outside clinical trials has been recently investigated by Ahmed et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> The authors found that protocol compliance was lower in daily practice compared with compliance during a clinical trial&#46; Interestingly&#44; as in the present study&#44; the clinical results improved despite low compliance&#46; This suggests that greater compliance could further improve postoperative recovery and even reduce morbidity&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Moreover&#44; the reduction to a three-day hospital stay was achieved without increasing the rate of readmission&#46; Reducing inappropriate hospital stay often comes at the expense of increasing the percentage of readmissions&#46; In the study by Basse et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> the average hospital stay was only two days in the MMRH programme&#44; but readmission was necessary in 20&#37; of patients&#46; Our readmission rate since starting the MMRH programme is acceptable&#44; as it does not exceed the 10&#37; recommended by some authors&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Another aspect that should be discussed is the inability to discharge patients even when they fulfilled the established clinical criteria&#46; This is a very important limiting factor for improving the results&#46; For example&#44; in this study&#44; only 37&#37; of patients in the MMRH group were discharged on the fifth postoperative day&#44; although 80&#37; of them met the criteria to be discharged&#46; We believe that in our country&#44; the main cause is a lack of adequate social or family support&#46; According to a report by the Ministry of Health and Social Services for the Elderly in Spain&#44; 21&#37; of people over the age of 65 years live alone&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Greater collaboration with discharge care programmes should improve these results&#46; The patient&#39;s fear and insecurity about continuing recovery at home could be another cause for discharge delays&#46; Maessen et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> also found delays in hospital discharge among patients who met the discharge criteria&#46; The authors propose better home health care after early discharge&#46; We believe that analysing patient satisfaction after their participation in an MMRH programme might lead to a better understanding of the problem&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">After confirming that our MMRH programme improved our patients&#8217; functional recovery&#44; we evaluated the programme&#39;s impact on hospital costs&#46; This is a very important point because there is a growing need to improve economic efficiency in perioperative care without compromising results&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> We found a reduction of nearly 1000 euros per patient in total costs in the MMRH group compared with the control group&#46; The main factor contributing to this statistically significant difference was the reduction in the costs associated with the hospitalisation unit&#46; This result is consistent with the decline we have observed in the three-day hospital stay in the MMRH group&#46; This cost reduction was also described by the group at the Cleveland Clinic after they initiated a clinical pathway for postoperative care after ileoanal reservoir surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> In that study&#44; the direct costs and complications were analysed for the first 30 postoperative days and longer term&#46; The patients who were treated according to a MMRH protocol were matched with controls who received conventional care from a different group of surgeons&#46; The major complication rates were comparable&#44; and there were no differences in the rates of readmission or reoperation&#46; The patients in the MMRH group had a shorter hospital stay&#44; and the median direct cost per patient within 30 days was almost 1000 USD less than that of patients receiving traditional care&#44; mainly because of a decrease in the costs of anaesthesia&#44; nursing care&#44; lab tests and other services such as respiratory therapy&#44; stoma management education and nutrition services&#46; In the present study&#44; the decrease in costs was not only related to the Hospitalisation Unit&#59; laboratory costs were also significantly lower in the MMRH group&#46; The costs per patient in radiology and pharmacy were lower&#44; but the difference was not statistically significant&#46; Another economic benefit that should be expected by the institution is greater availability of beds&#46; The reduction in hospital costs even with a low level of compliance with the protocol indicates that&#44; at present&#44; resource utilisation and the costs of perioperative care are far from optimal in most institutions&#46; As highlighted in the meta-analysis by Adamina et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> MMRH programmes optimise resources while accelerating the recovery of patients&#44; thus reducing hospital stay&#46; Additionally&#44; the results of the LAFA3 study<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> move in the same direction&#46; LAFA3 is the first randomised&#44; prospective four-cohort study conducted in nine centres in the Netherlands to show that the combination of laparoscopic surgery with perioperative MMRH care leads to faster recovery compared with other treatment combinations&#46; This combination is able to reduce costs primarily by reducing hospital stay&#44; although this cost reduction was not statistically significant&#46; Therefore&#44; these programmes should be used routinely for colorectal surgery&#46; Such routine use is especially important in times of serious economic difficulties&#44; as is currently the case&#46; In this regard&#44; further studies specifically designed to investigate how to minimise costs will provide additional information that may be useful for making treatment choices and investment strategies in hospitals&#44; as was the case of the TAPAS study&#44; a three-cohort prospective study conducted in five Dutch hospitals&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; this study demonstrates that the use of a MMRH protocol for elective colorectal surgery reduces both hospital stay and costs without increasing postoperative morbidity or the percentage of readmissions&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of Interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multimodal rehabilitation &#40;MMRH&#41; programmes in surgery have proven to be beneficial in functional recovery of patients&#46; The aim of this study is to evaluate the impact of a MMRH programme on hospital costs&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A comparative study of 2 consecutive cohorts of patients undergoing elective colorectal surgery has been designed&#46; In the first cohort&#44; we analysed 134 patients who received conventional perioperative care &#40;control group&#41;&#46; The second cohort included 231 patients treated with a multimodal rehabilitation protocol &#40;fast-track group&#41;&#46; Compliance with the protocol and functional recovery after fast-track surgery were analysed&#46; We compared postoperative complications&#44; length of stay and readmission rates in both groups&#46; The cost analysis was performed according to the system &#8220;full-costing&#8221;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">There were no differences in clinical features&#44; type of surgical excision and surgical approach&#46; No differences in overall morbidity and mortality rates were found&#46; The mean length of hospital stay was 3 days shorter in the fast-track group&#46; There were no differences in the 30-day readmission rates&#46; The total cost per patient was significantly lower in the fast-track group &#40;fast-track&#58; 8107<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4117 euros vs control&#58; 9019<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4667 euros&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;&#46; The main factor contributing to the cost reduction was a decrease in hospitalisation unit costs&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The application of a multimodal rehabilitation protocol after elective colorectal surgery decreases not only the length of hospital stay but also the hospitalisation costs without increasing postoperative morbidity or the percentage of readmissions&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los programas de rehabilitaci&#243;n multimodal &#40;RHMM&#41; en cirug&#237;a han demostrado un beneficio en la recuperaci&#243;n funcional de los pacientes&#46; Nuestro objetivo fue evaluar el impacto de un programa de RHMM en los costes hospitalarios&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo comparativo de cohortes consecutivas de pacientes intervenidos de cirug&#237;a colorrectal electiva&#46; En la primera cohorte analizamos 134 pacientes que recibieron un control postoperatorio convencional &#40;grupo control&#41;&#46; En la segunda cohorte se incluye a 231 pacientes tratados con un programa de RHMM &#40;grupo RHMM&#41;&#46; Se analiza el cumplimiento del protocolo y la recuperaci&#243;n funcional de los pacientes del grupo RHMM&#46; Se comparan las complicaciones postoperatorias&#44; la estancia hospitalaria y los reingresos en ambos grupos&#46; El an&#225;lisis de costes se ha basado en la contabilidad anal&#237;tica del centro&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las caracter&#237;sticas demogr&#225;ficas y cl&#237;nicas de los pacientes fueron similares entre grupos&#46; No encontramos diferencias en la morbimortalidad global&#46; La estancia media postoperatoria fue 3 d&#237;as menor en el grupo RHMM&#46; No se observaron diferencias significativas en la tasa de reingresos&#46; Los costes totales por paciente fueron significativamente menores en el grupo RHMM &#40;RHMM&#58; 8&#46;107<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;117 euros vs control&#58; 9&#46;019<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;667 euros&#59; P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46; El principal factor que contribuy&#243; a la reducci&#243;n de los costes fue el descenso de los gastos de la Unidad de Hospitalizaci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La aplicaci&#243;n de un protocolo de RHMM en cirug&#237;a electiva colorrectal reduce&#44; no solo la estancia hospitalaria&#44; sino tambi&#233;n los costes hospitalarios&#44; sin aumentar la morbilidad postoperatoria ni el porcentaje de reingresos&#46;</p>"
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0055">Please cite this article as&#58; Salvans S&#44; Gil-Egea MJ&#44; Pera M&#44; Lorente L&#44; Cots F&#44; Pascual M&#44; et al&#46; Impacto de un programa de rehabilitaci&#243;n multimodal en cirug&#237;a electiva colorrectal sobre los costes hospitalarios&#46; Cir Esp&#46; 2013&#59;91&#58;638&#8211;644&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0060">Presented at the XIII National Meeting of the Spanish Association of Coloproctology &#40;Barcelona&#44; 27&#8211;29 May 2009&#41; and the XXVII National Meeting of Surgery &#40;Las Palmas de Gran Canaria&#44; 21&#8211;24 October 2009&#41;&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 535
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Analysis of protocol compliance &#40;with the items onset of diet and withdrawal of fluid therapy&#41; and functional recovery &#40;with the items tolerance of diet and ambulation&#41; in the MMRH group&#46; The hospital discharge progression rate according to the postoperative day is also shown for the MMRH group&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Analysis of progression of the number of hospital admissions by postoperative day in the MMRH and control groups &#42;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#46;</p>"
        ]
      ]
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">MMRH group n&#61;231&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">93&#47;138&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;859<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">68&#46;8&#177;12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">70&#46;4&#177;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;206<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">ASA 1&#47;2&#47;3&#47;4 &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#47;64&#47;31&#47;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#47;53&#47;44&#47;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#46;992<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Right hemicolectomy&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">57 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;063<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Left hemicolectomy&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;918<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anterior resection of the rectum&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;226<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;000<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Other<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Laparoscopy&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">MMRH group&#58; Hartmann reconstruction &#40;13&#41;&#44; Hartmann procedure &#40;7&#41;&#44; resection for recurrence and carcinomatosis &#40;7&#41;&#46; Control group&#58; Hartmann reconstruction &#40;2&#41;&#44; Hartmann procedure &#40;2&#41;&#44; resection for recurrence &#40;5&#41;&#46;</p>"
            ]
          ]
        ]
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Demographic and Clinical Characteristics of the Patients in Each Group&#46;</p>"
        ]
      ]
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">RHMM group n&#61;231 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Control group n&#61;134 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;718<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;836<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Surgical complications</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">50 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">34 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Surgical site infection</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;720<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Infection of the surgical incision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">18 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;478<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Organ-space infection&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;828<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span> Intra-abdominal abscess&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;340<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Anastomotic leak&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;560<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Mortality</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;149<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              ]
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">MMRH group n&#61;231&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Control group n&#61;134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Stay &#40;days&#41;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;9&#177;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;007<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Readmission&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;815<a class="elsevierStyleCrossRef" href="#tblfn0050"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total stay &#40;days&#41;<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;9&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;1&#177;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;007<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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ISSN: 21735077
Original language: English
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