Study of gastroesophageal reflux. Interpretation of functional tests in the obese patient

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Interpretation of functional tests in the obese patient" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S8" "paginaFinal" => "S18" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Elizabeth Barba Orozco, Alberto Ezquerra Duran" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Elizabeth" "apellidos" => "Barba Orozco" "email" => array:1 [ 0 => "barba@clinic.cat" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Alberto" "apellidos" => "Ezquerra Duran" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Gastroenterology Department, Neurogastroenterology and Motility Unit, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio del reflujo gastroesofágico. Interpretación de las pruebas funcionales en el paciente obeso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1576 "Ancho" => 3341 "Tamanyo" => 488347 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0285" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "pH impedance monitoring study of obese patient with BMI of 36, showing (1) prolonged acid reflux episode, (2) with incomplete clearance, (3) with post-swallow peristaltic wave." ] ] ] "textoCompleto" => "Pathophysiological mechanisms of gastro-oesophageal reflux diseaseThe pathogenesis of gastro-oesophageal reflux disease (GORD) is complex and involves changes in reflux exposure, oesophageal epithelial resistance, and visceral sensitivity.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> Under normal circumstances, the passage of gastric contents into the oesophagus is prevented by the oesophagogastric junction (OGJ), which forms an anti-reflux barrier. The OGJ is made up of several anatomical structures that play an important role in maintaining the anti-reflux barrier. The lower oesophageal sphincter (LOS) and the crural diaphragm (CD) constitute the intrinsic and extrinsic sphincter, respectively. Under normal conditions the two sphincters overlap and are anchored to each other by the phrenoesophageal ligament.<a class="elsevierStyleCrossRef" href="#bib0005">1</a>Incompetence of the anti-reflux barrier<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">1Transient lower oesophageal sphincter relaxation "TLOSR": TLOSR is the major mechanism underlying gastro-oesophageal reflux (GOR). Most reflux episodes occur during TLOSR episodes. TLOSRs are episodes of complete and prolonged relaxation of the LOS, not triggered by swallowing and accompanied by CD inhibition.<a class="elsevierStyleCrossRefs" href="#bib0010">2,3</a> A set of manometric criteria for TLOSRs have been proposed: a main criterion, relaxation of the LOS for more than 10 s in the absence of swallowing 4 s before and 2 s after LOS relaxation and several additional criteria, presence of reflux by means of manometry-impedance monitoring, oesophageal shortening, single cavity phenomenon, crural diaphragm inhibition, relaxation of the upper oesophageal sphincter (UOS) without subsequent swallowing, and secondary peristalsis.<a class="elsevierStyleCrossRef" href="#bib0010">2</a></li><li class="elsevierStyleListItem" id="lsti0010">2Hypotension of the LOS and GOR induced by abrupt increases in intragastric pressure in the context of a hypotensive LOS (<10 mmHg (<10 mmHg).<a class="elsevierStyleCrossRefs" href="#bib0005">1,2</a></li><li class="elsevierStyleListItem" id="lsti0015">3Anatomical abnormalities of the OJG. In patients with hiatal hernia, the function of the crural diaphragm is compromised by its axial displacement and atrophy secondary to dilatation of the diaphragmatic hiatus. In addition, the presence of a hiatal hernia leads to a decrease in the intraluminal pressure of the OJG favouring reflux episodes.<a class="elsevierStyleCrossRef" href="#bib0010">2</a></li><li class="elsevierStyleListItem" id="lsti0020">4Impaired oesophageal clearance. Prolonged exposure of the oesophageal mucosa to gastric juice correlates with the severity of erosive oesophagitis and the presence of Barrett's oesophagus.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> The two main causes of prolonged reflux exposure and impaired oesophageal clearance are defects in oesophageal peristalsis and saliva production. Impaired oesophageal emptying and retrograde flow phenomena of reflux gastric contents are also present in patients with hiatal hernia.<a class="elsevierStyleCrossRef" href="#bib0025">5</a></li></ul>Pathophysiological mechanisms of gastro-oesophageal reflux disease in obese patientsIn patients with obesity, an increase in intra-abdominal pressure has been identified in patients with obesity, due to the transmission of gravitational force from the adipose tissue to the abdominal cavity favouring reflux episodes through abrupt increases in intragastric pressure.<a class="elsevierStyleCrossRef" href="#bib0025">5</a> The gastric volume of obese patients is higher than in the normopese population, which could favour reflux episodes of higher volume. Another theory is that obese patients may have slowed gastric emptying, due to neural and humoral mechanisms, and that this favours the presence of GORD.<a class="elsevierStyleCrossRef" href="#bib0025">5</a> Obese patients have a higher incidence of hiatal hernia, with figures of up to 50%, which is also associated with an increased risk for GORD.<a class="elsevierStyleCrossRef" href="#bib0030">6</a> It has been shown that TLOSR is more common in obese patients than in normal weight patients, and in one published series of patients in up to 51% of obese patients manometry revealed dysmotility.<a class="elsevierStyleCrossRef" href="#bib0030">6</a> The underlying mechanisms of GORD in obese patients are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>High-resolution oesophageal manometry (HR-OM)Oesophageal manometry is the technique for studying and quantifying the contractile motor activity of the oesophagus and is therefore the technique of choice for the diagnosis of oesophageal motility disorders (OMD). HR-OM assesses oesophageal motility patterns by measuring the amplitude of the contractile events of the oesophagus and its sphincters in relation to time by means of pressure sensors located along the catheter.<a class="elsevierStyleCrossRef" href="#bib0035">7</a> HR-OM probes have 36 pressure sensors spaced 1 cm apart. These sensors collect dynamic information and, using computer software, it is transformed into spatio-temporal graphs called oesophageal pressure topography (OPT).<a class="elsevierStyleCrossRef" href="#bib0035">7</a> A standardised protocol is used to interpret OPT as described in Chicago Classification v 4.0.<a class="elsevierStyleCrossRef" href="#bib0040">8</a> The indications for HR-OM are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>HR-OM protocol Chicago v4.0The study starts with the patient in the supine position, after intubation of the manometry catheter via the transnasal route. Once the catheter is in place, a 60-second stabilisation period is required, followed by 3 deep breaths to confirm placement and the passage of at least 3 sensors from the distal end of the catheter into the gastric chamber. The resting pressure is then recorded for 30 s to identify anatomical landmarks: the upper oesophageal sphincter (UOS) and lower oesophageal sphincter (LOS), the respiratory inversion point (RIP) and the baseline OJG pressure. This is followed by 10 swallows of 5 ml water or saline. The protocol is completed with the patient supine and with the multiple swallow test, by administering 5 liquid swallows of 2 ml with 2–3 seconds between each swallow.<a class="elsevierStyleCrossRef" href="#bib0045">9</a> The aim of this test is to assess peristaltic reserve. Once this part is completed, the patient is placed upright, and the resting pressure is performed again for 30 s. Five liquid swallows of 5 ml are performed with at least 30 s between each swallow and finished with the 200 ml liquid overload test, to determine the presence of brief obstructive or hyperpressive patterns in case of impaired motility or relaxation of the LOS.<a class="elsevierStyleCrossRef" href="#bib0050">10</a>Manometric study of swallowingTo assess and classify swallowing, certain parameters have to be calculated on the OPT: the integrated relaxation pressure (IRP), a measure of LOS relaxation of swallowing. Oesophageal contractile function through the distal contractile integral (DCI), which measures the strength of oesophageal contraction, distal latency (DL), a measure of time to identify premature or spastic waves, and peristaltic integrity, which describes the presence or absence of fragmented peristaltic waves. The HR-OM allows for the assessment of intra-oesophageal pressurisation patterns. Oesophageal pressurisation occurs when swallowed fluid is trapped between two contracting oesophageal segments.<a class="elsevierStyleCrossRef" href="#bib0040">8</a><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the classification of OMDs.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Manometric assessment of OGJThe OGJ has unique characteristics that make manometric assessment challenging. First, the OGJ pressure comprises the pressure of the LOS and the CD. Second, its morphology is influenced by the anatomical integrity of the OGJ, which is affected in the presence of a hiatal hernia, and the arrangement of the LOS and CD is dynamic, one manometric recording can identify from the overlap of both elements to the presence of an overt hiatal hernia. Third, the OGJ shows marked radial and axial asymmetry in pressure morphology.<a class="elsevierStyleCrossRef" href="#bib0035">7</a> Finally, when the LOS and CD are separated, the RIP, which is where the pressure change occurs during inspiration from negative intrathoracic pressure to positive intragastric pressure, can be located above the LOS or between the CD and LOS. There is evidence that the relative location of the RIP to the LES is more associated with pathological oesophageal acid reflux exposure than the presence and size of the hiatal hernia.<a class="elsevierStyleCrossRefs" href="#bib0035">7,8</a>The Chicago Consensus version 4 classifies the OGJ into three subtypes according to morphology<a class="elsevierStyleCrossRef" href="#bib0040">8</a>:<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025">•Type 1, absence of hiatal hernia: overlapping LOS and CD, separation <1 cm.</li><li class="elsevierStyleListItem" id="lsti0030">•Type 2, hiatal hernia with the RIP proximal to the CD: separation of the LOS and CD>1 cm and RIP between CD and LOS.</li><li class="elsevierStyleListItem" id="lsti0035">•Type 3, hiatal hernia with the IRP proximal to the LOS: separation of the LOS and CD>1 cm and RIP above the LOS.</li></ul>HR-OM and impedanceHR-OM and impedance allows simultaneous assessment of oesophageal movements through HR-OM and the transit of the swallowed bolus by means of impedance without the need for radiological studies.<a class="elsevierStyleCrossRef" href="#bib0055">11</a> Good correlation has been demonstrated in the measurement of bolus transit and oesophageal clearance measured by impedance versus videofluoroscopy considered the gold standard.<a class="elsevierStyleCrossRef" href="#bib0060">12</a> The basic principle of impedance measurements is to evaluate the resistance to the passage of an alternating current between two electrodes. The resistance to the passage of the current is influenced by the conductive medium.<a class="elsevierStyleCrossRef" href="#bib0065">13</a> During saline swallowing, as it is a good conductor, the impedance decreases as the bolus progresses, returning to its baseline value once the bolus is cleared, allowing assessment of whether the bolus transit is complete or incomplete or whether it is retained.<a class="elsevierStyleCrossRef" href="#bib0070">14</a>Manometry in GORDHR-OM should always be requested for GORD prior to placement of the pH-monitoring probe to locate the LOS and its correct placement. HR-OM allows the identification of GORD-associated OMD and correct differential diagnosis with other oesophageal diseases that may present the same symptoms as GORD, such as achalasia or other primary OMD. In addition, an HR-OM should be requested in all patients who are candidates for surgical and/or endoscopic anti-reflux techniques to confirm the diagnosis and assess peristaltic reserve.<a class="elsevierStyleCrossRef" href="#bib0075">15</a> Up to one third of patients classified as refractory GORD do not have GORD and present with other disorders, most commonly functional heartburn, but they sometimes present findings compatible with achalasia or rumination syndrome.<a class="elsevierStyleCrossRef" href="#bib0080">16</a>According to the international consensus on the classification of motility disorders in GORD, two motor phenotypes are identified in GORD,<a class="elsevierStyleCrossRef" href="#bib0085">17</a> which are described in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>.<elsevierMultimedia ident="tbl0020"></elsevierMultimedia>Hypomotility-type oesophageal disorders are the most common of the GORD-associated MODs, although spastic disorders (OH and DOS) have also been associated with pathological exposure of the oesophagus to gastric reflux. Up to 38% of patients diagnosed with DOS have pathological acid exposure according to the largest published series,<a class="elsevierStyleCrossRef" href="#bib0090">18</a> and 43% of patients with OH have typical GORD symptoms.<a class="elsevierStyleCrossRef" href="#bib0095">19</a>The international consensus on the classification of motility disorders in GORD proposes a three-step algorithm to characterise oesophageal motility function in the context of GORD study and assessment prior to antireflux surgery. The first step is to assess the integrity of the OGJ, the second step is to assess oesophageal body motility function, and finally to assess the contractile reserve by means of provocative tests.<a class="elsevierStyleCrossRef" href="#bib0085">17</a> The presence of a contractile wave following the multiple swallow test with contractile force, as assessed by DCI (mmHg), greater than the mean of the 10 liquid swallows indicates the presence of contractile reserve and a lower risk of post-fundoplication dysphagia.<a class="elsevierStyleCrossRef" href="#bib0100">20</a> The solid swallow test is another complementary test used to assess contractile reserve. Contractile reserve is considered present if the strength of the peristaltic wave generated after swallowing the solid (a piece of bread or biscuit) is greater than the average of the 10 liquid swallows. A good correlation has been demonstrated in the assessment of contractile reserve with the multiple swallow test and solid swallows in patients meeting manometric criteria for ineffective oesophageal motility. The increased risk for developing post-fundoplication oesophageal symptoms in patients without contractile reserve in both tests has also been confirmed.<a class="elsevierStyleCrossRefs" href="#bib0050">10–20</a> The solid swallow test is complementary to the multiple swallow test in assessing peristaltic reserve and predicting the risk of developing post-fundoplication dysphagia.<a class="elsevierStyleCrossRef" href="#bib0105">21</a>Manometric findings in overweight/obese patientsIn patients with obesity, increased abdominal girth plays a key role in the pathophysiological mechanisms of GORD. Obese patients have disruptions in both the barrier effect of the OGJ and oesophageal peristalsis. A negative association between BMI, LOS pressure and the intra-abdominal segment of the LOS has been demonstrated. Overweight and obese patients more frequently present with hypotensive LOS and disrupted OGJ in the form of hiatal hernia.<a class="elsevierStyleCrossRef" href="#bib0110">22</a> Obese patients have higher intragastric pressure than non-obese patients<a class="elsevierStyleCrossRef" href="#bib0115">23</a>; and there is a positive correlation between BMI and intragastric pressure. The gastro-oesophageal pressure gradient is also found to be increased in overweight or obese patients compared to normopese patients.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> Obese patients have a higher number of TLOSR episodes during the postprandial period (2 h after a meal), 7 episodes compared to 2 episodes in the control group.<a class="elsevierStyleCrossRef" href="#bib0125">25</a> In the supine position, patients with obesity often have an IRP above the limit of normal, which, when changing position to upright, becomes within the normal range. In a recent study, 75% of patients with a diagnosis of oesophagogastric junction outflow obstruction (OGJOO) with elevated supine IRP, after evaluation of IRP in both positions, a diagnosis of OGJOO was excluded. The hypothesis for this increase in supine IRP values is that the effect of gravity on abdominal fat increases intra-abdominal pressure and pressure on the OGJ.<a class="elsevierStyleCrossRef" href="#bib0115">23</a> In a cohort of 147 patients with obesity underwent HR-OM and OMD was identified in up to 34%, according to the Chicago classification version 3.<a class="elsevierStyleCrossRef" href="#bib0130">26</a> A total of 18.4% had a manometric diagnosis of OGJOO, 7.5% of HO, 4.1% of DOS, 2% of IOM, and 1.4% of fragmented peristalsis.<a class="elsevierStyleCrossRef" href="#bib0135">27</a>Manometry findings in patients undergoing bariatric surgeryVertical gastrectomy or gastric sleeve is one of the most commonly used surgical techniques in bariatric surgery. Vertical gastrectomy is a restrictive technique that involves a reduction in gastric volume and gastric accommodation, which leads to an increase in intragastric pressure that favours the onset of upper GI symptoms.<a class="elsevierStyleCrossRef" href="#bib0140">28</a> In patients undergoing vertical gastrectomy, an increase in intragastric pressure above 30 mmHg during LOS contraction after single swallows is characteristic on HR-OM.<a class="elsevierStyleCrossRef" href="#bib0140">28</a> Hypomotility disorders in oesophageal peristalsis occur after vertical gastrectomy, with a decrease in the mean DCI of the 10 liquid swallows and an increase of more than 30% of de novo diagnosis of ineffective oesophageal motility.<a class="elsevierStyleCrossRef" href="#bib0145">29</a>Assessment of gastro-oesophageal reflux in obese patientsIn the symptomatic population, gastrointestinal endoscopy detects erosive oesophagitis in 50% of patients, while 24 h pH-impedance monitoring diagnoses 92% of patients with non-erosive reflux disease (NERD).<a class="elsevierStyleCrossRef" href="#bib0150">30</a><a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a> defines the indications for 24 h pH-impedance monitoring.<elsevierMultimedia ident="tbl0025"></elsevierMultimedia>Twenty-four-hour oesophageal pH monitoringTwenty-four-hour oesophageal pH monitoring in off-PPI (without proton pump inhibitor [PPI] treatment) is the diagnostic benchmark and consists of the recording of oesophageal acidity levels using a probe with acid-sensitive receptors and a computer recording the results. <a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a> describes the variables to be measured in pH monitoring.<elsevierMultimedia ident="tbl0030"></elsevierMultimedia>Normal and pathological findings of 24 h pH monitoringTo test the pathophysiological relationship between obesity and reflux, objective data have been evaluated with pH monitoring, but these results have been contradictory because patients with obesity are more likely to have OGJ disruption<a class="elsevierStyleCrossRef" href="#bib0155">31</a> and an increased gastro-oesophageal pressure gradient, which provides a perfect scenario for reflux to occur. There are patients with obesity who do not have reflux and are asymptomatic,<a class="elsevierStyleCrossRef" href="#bib0160">32</a> the pH recording in the distal oesophagus in asymptomatic individuals shows the presence of occasional episodes of reflux, compatible with physiological reflux which is characterised by episodes of reflux of short duration predominantly in the standing position. A pathological reflux is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Twenty-four-hour pH monitoring and impedance studyMultichannel intraluminal impedance-pH-monitoring (pHz) has the advantage of simultaneously detecting both acid and non-acid reflux, as well as its characteristics which can be liquid, gas, or mixed and the direction of the refluxed material which can be either retrograde or antegrade. With pHz monitoring it has been shown that patients with obesity have more gastro-oesophageal reflux.<a class="elsevierStyleCrossRef" href="#bib0165">33</a>The indications for pHz are:<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0040">1To quantify and characterise oesophagogastric reflux, especially in patients with incomplete response or no response to suppressive therapy with proton pump inhibitors and who have previously undergone endoscopic study and show no disruptions.</li><li class="elsevierStyleListItem" id="lsti0045">2To evaluate the patient with symptoms of atypical reflux or extra-oesophageal manifestations of reflux, such as pharyngeal globus, cough, and dysphonia.</li><li class="elsevierStyleListItem" id="lsti0050">3To evaluate acid and non-acid reflux in patients undergoing bariatric surgery or after second-stage bariatric surgery.</li></ul>pH impedance monitoring techniquepHz is performed technically in the same way as conventional pH-monitoring. The patient needs to fast for 6 h, an HR-OM is performed beforehand to determine how many centimetres away the upper edge of the LOS is located and 5 cm is subtracted from that measurement, because the site where peptidases are inactivated is at that height.The characteristics to be evaluated are:Composition of reflux: impedance monitoring helps classify reflux episodes as gas, liquid, or mixed. Air is a poor conductor and therefore has a high impedance, whereas liquid, which is a good conductor, has a low impedance.Proximal reflux: The proximal extent of an episode is defined by the most proximal impedance measurement segment reached by the liquid component of the reflux episode. Gas reflux episodes are not assigned a proximal extent, as they typically enter the upper oesophageal sphincter and are eliminated.Number of acid and non-acid reflux episodes: the combination of pHz defines the number of reflux episodes with change in impedance monitoring as well as the total number of episodes detected by impedance monitoring alone without pH alteration.Reflux contact time: this determines the presence of reflux time, which is the total amount of time of refluxed material detected by impedance monitoring from the segment located 5 cm above the LOS.Oesophageal clearance time: defined as the mean duration during which reflux is present 5 cm above the LOS.Reflux pH: all of the above parameters are classified as acid and non-acid based on the changes recorded at the time when the reflux occurred and are also determined by the patient's position, either standing or supine. An acid reflux episode is an event with pH falling below 4; a non-acid reflux is defined as the reflux episode in which the pH is above 4; a weakly acid episode defines the episode within a pH 4–7, and alkaline reflux when the pH is >7. <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> shows dual-channel pH monitoring, with short refluxes, and preserved oesophageal clearance.<elsevierMultimedia ident="fig0010"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a> shows the graph of a patient with reflux in both the supine and standing position.<elsevierMultimedia ident="fig0015"></elsevierMultimedia>Interpretation of resultsOnce these characteristics have been determined, we have to evaluate the following parameters in the pHz recording<a class="elsevierStyleCrossRefs" href="#bib0065">13,34</a>:<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0055">1Duration of pHz monitoring: the minimum duration to interpret a study and for it to be valid is 18 h.</li><li class="elsevierStyleListItem" id="lsti0060">2Acid exposure time (AET) determination: this refers to the time the oesophagus is exposed to a pH < 4 and correlates with the presence of reflux. AET < 4%: physiological reflux; AET >4%–<6%: grey area; AET > 6%: pathological reflux.</li><li class="elsevierStyleListItem" id="lsti0065">3Assessment of the number of reflux episodes: acid reflux is considered physiological when there are <40 acid reflux episodes; pathological reflux is when there are >80 episodes of acid reflux.</li><li class="elsevierStyleListItem" id="lsti0070">4Establishment of the association of symptoms with reflux episodes: the symptomatic index is the ratio of the number of symptoms associated with reflux episodes to the total number of symptomatic episodes×100. The clinical symptom is present at least 3 times in 24 h monitoring, and is considered pathological when it happens 2 min. before or after the reflux episode; it is pathological if it is >50%, and the symptom association probability (SAP) is the probability that a patient's symptoms are related to reflux, it is significant if it is >95%.</li><li class="elsevierStyleListItem" id="lsti0075">5DeMeester score assessment: this is the best-known measure for assessing pathological reflux; it is considered impaired when the total DeMeester score is >14.72; this measure considers the percentage of total time at pH < 4, the number of reflux episodes, and the position in which reflux episodes occur.</li><li class="elsevierStyleListItem" id="lsti0080">6Nocturnal baseline impedance: this expresses mucosal integrity and provides evidence of macroscopic and microscopic oesophageal damage after exposure to reflux. It consists of measuring baseline impedance from 3 to 5 cm above the LOS during sleep in 3 periods of 10 min. Values <2292 Ω suggest the presence of GORD.</li><li class="elsevierStyleListItem" id="lsti0085">7Post-reflux swallow-induced peristaltic wave: reflects the integrity of oesophageal peristalsis stimulated by reflux episodes and chemical clearance. It is abnormal when present with a 50% anterograde drop in impedance within 30 s after the reflux event.</li><li class="elsevierStyleListItem" id="lsti0090">8Assessment of nocturnal acid leakage: physiologically, during sleep the frequency of reflux episodes decreases; however, there may be a nocturnal leakage phenomenon, with reflux episodes >1 h in duration during sleep.<a class="elsevierStyleCrossRef" href="#bib0170">34</a></li></ul>pH impedance monitoring in patients with obesityThere are no established normality values for pHz assessment in patients with obesity. In 2016 Doulami et al.<a class="elsevierStyleCrossRef" href="#bib0175">35</a> were the first group to assess normal values for 24 h pHz in volunteers with obesity without reflux and reported a higher number of reflux episodes and an equal or, in some cases, slightly increased median acid bolus clearance exposure, hypothesising that specific cohort values should be used in the assessment of pHz for patients with obesity<a class="elsevierStyleCrossRef" href="#bib0180">36</a>; however, to date we still use the same parameters as those established for healthy non-obese volunteers.<a class="elsevierStyleCrossRef" href="#bib0185">37</a> The values are shown in <a class="elsevierStyleCrossRef" href="#tbl0035">Table 7</a>.<elsevierMultimedia ident="tbl0035"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a> shows a pH impedance monitoring plot.<elsevierMultimedia ident="fig0020"></elsevierMultimedia>Conflict of interestsThe authors have no conflict of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:24 [ 0 => array:3 [ "identificador" => "xres2044372" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1747800" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2044373" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1747799" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Pathophysiological mechanisms of gastro-oesophageal reflux disease" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Incompetence of the anti-reflux barrier" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Pathophysiological mechanisms of gastro-oesophageal reflux disease in obese patients" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "High-resolution oesophageal manometry (HR-OM)" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "HR-OM protocol Chicago v4.0" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Manometric study of swallowing" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Manometric assessment of OGJ" ] 11 => array:2 [ "identificador" => "sec0040" "titulo" => "HR-OM and impedance" ] 12 => array:2 [ "identificador" => "sec0045" "titulo" => "Manometry in GORD" ] 13 => array:2 [ "identificador" => "sec0050" "titulo" => "Manometric findings in overweight/obese patients" ] 14 => array:2 [ "identificador" => "sec0055" "titulo" => "Manometry findings in patients undergoing bariatric surgery" ] 15 => array:2 [ "identificador" => "sec0060" "titulo" => "Assessment of gastro-oesophageal reflux in obese patients" ] 16 => array:2 [ "identificador" => "sec0065" "titulo" => "Twenty-four-hour oesophageal pH monitoring" ] 17 => array:2 [ "identificador" => "sec0070" "titulo" => "Normal and pathological findings of 24 h pH monitoring" ] 18 => array:2 [ "identificador" => "sec0075" "titulo" => "Twenty-four-hour pH monitoring and impedance study" ] 19 => array:2 [ "identificador" => "sec0080" "titulo" => "pH impedance monitoring technique" ] 20 => array:2 [ "identificador" => "sec0085" "titulo" => "Interpretation of results" ] 21 => array:2 [ "identificador" => "sec0090" "titulo" => "pH impedance monitoring in patients with obesity" ] 22 => array:2 [ "identificador" => "sec0095" "titulo" => "Conflict of interests" ] 23 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-10-21" "fechaAceptado" => "2023-01-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1747800" "palabras" => array:8 [ 0 => "GERD" 1 => "Reflux" 2 => "Obesity" 3 => "Overweight" 4 => "Diagnostic tests" 5 => "Esophageal manometry" 6 => "pHmetry" 7 => "pHmetry with impedancemetry" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1747799" "palabras" => array:8 [ 0 => "ERGE" 1 => "Reflujo" 2 => "Obesidad" 3 => "Sobrepeso" 4 => "Pruebas de diagnóstico" 5 => "Manometría esofágica" 6 => "pHmetría" 7 => "pHmetría con impedanciometría" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Overweight and obesity are a public health problem and in 1997 obesity was recognized as a global epidemic by the World Health Organization (WHO). Overweight and obesity affect almost 60% of adults and one in three children in Europe according to the most recent WHO report. Objectively, gastroesophageal reflux disease (GERD) is defined as the presence of characteristic esophageal mucosal damage assessed by endoscopy and/or the demonstra-tion of pathological acid exposure by reflux monitoring studies. The prevalence of GERD is increased in obese patientsIn overweight and obese patients, the clinical symptoms of GERD are especially present in the supine position and this correlates with more frequent episodes of nocturnal reflux in the 24-h pH monitoring, there is also an increase in the number of refluxes with content acid. In the population with symptoms, digestive endoscopy detects data of erosive esophagitis in 50% of patients, while 24-h pH-impedanciometry diagnoses 92% of patients with non-erosive reflux disease (NERD)The presence of persistent GERD in the mucosa affects esophageal motility and patients may develop ineffective esophageal motility-type disorders, so we will review the interpre-tation of the functional tests that determine motility, which is esophageal manometry, and those that determine reflux gastroesophageal, acid and non-acid, which is the pH measure-ment with or without 24-h impedanciometry." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "El sobrepeso y la obesidad son un problema de salud pública y en 1997 la obesidad fue reconocida como una epidemia global por la Organizacio’n Mundial de la Salud (OMS). El sobrepeso y la obesidad afectan a casi un 60% de los adultos y a uno de cada 3 niños del territorio europeo según el informe más reciente de la OMS. De forma objetiva, la enferme-dad por reflujo gastroesofágico (ERGE) se define como la presencia de un daño mucoso esofágico característico evaluado por endoscopia y/o la demostración de una exposición al ácido patológica mediante estudios de monitorización del reflujo. La prevalencia de la ERGE está aumentada en los pacientes con obesidadEn los pacientes con sobrepeso y obesidad, la sintomatología clínica de la ERGE se presenta especialmente en posición en supino y esto se correlaciona con episodios más frecuentes de reflujo nocturno en la pHmetría de 24 h; existe también un incremento en el número de reflujos con contenido ácido. En la población con sintomatología la endoscopia digestiva detecta datos de esofagitis erosiva en un 50% de los pacientes, mientras que la pH impedanciometría de 24 h diagnostica el 92% de los pacientes con enfermedad por reflujo no erosiva (ERNE).La presencia de ERGE persistente en la mucosa afecta la motilidad esofágica y los pacientes pueden desarrollar trastornos de tipo motilidad esofágica ineficaz, por lo que revisaremos la interpretación de las pruebas funcionales que determinan la motilidad, que es la manometría esofágica, y las que determinan el reflujo gastroesófagico, ácido y no ácido, que es la pHmetría con o sin impedanciometría de 24 h." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Barba Orozco E, Ezquerra Duran A, Estudio del reflujo gastroesofágico. Interpretación de las pruebas funcionales en el paciente obeso. Cir Esp. 2023. https://doi.org/10.1016/j.ciresp.2023.01.001" ] ] "multimedia" => array:20 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 967 "Ancho" => 2508 "Tamanyo" => 246268 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0270" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Pathological reflux. The numerical bar on the left shows the pH value from 0 to 8; the red line delimits a pH lower and higher than 4, to determine the episodes of pathological acid reflux with pH < 4, which corresponds to the critical point of the deleterious effect of acid and pepsin. The lower scale shows the hours during which the recording was made, and the yellow bars delimit the times at the beginning and end of meals; the time the patient was in the supine position during sleep can also be measured (green box). In this graph there is a percentage of time with a pH < 4 of 14.8%, with 100 reflux episodes, of short duration due to correct oesophageal clearance. The longest reflux lasted 3 min and a DeMeester score of 15.1." ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1007 "Ancho" => 2508 "Tamanyo" => 252803 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0275" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Obese patient with a BMI of 42 and with episodes of regurgitation. Twenty-four-hour pH monitoring, with proximal and distal oesophageal pH sensor, observing physiological reflux, short duration reflux episodes during the day, with adequate clearance." ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 959 "Ancho" => 2508 "Tamanyo" => 219549 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0280" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Obese patient with a BMI of 38. Twenty-four-hour graph, with pathological acid reflux, total percentage of time with a pH < 4 of 23.8%, standing 26,4%, and supine 20.9%, with a DeMeester score of 85.2." ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1576 "Ancho" => 3341 "Tamanyo" => 488347 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0285" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "pH impedance monitoring study of obese patient with BMI of 36, showing (1) prolonged acid reflux episode, (2) with incomplete clearance, (3) with post-swallow peristaltic wave." ] ] 4 => array:9 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Source: Ricci et al.<a class="elsevierStyleCrossRef" href="#bib0180">36</a>" "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0290" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-reflux barrier incompetence: hypotensive LOS, TLOSR episodes, and presence of hiatal hernia \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Abnormal oesophageal clearance \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Increased intra-abdominal pressure \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Altered transdiaphragmatic pressure gradient \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dietary habits (high fat, low fibre diet) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3389026.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Underlying mechanisms of GORD in obese patients." ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0295" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">The main indications for HR-OM are<a class="elsevierStyleCrossRef" href="#bib0055">11</a>: \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Study of an oesophageal motility disorder in non-organic dysphagia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Study of chest pain of non-cardiological origin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Correct placement of pH-monitoring probes by locating the upper edge of the LOS \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Preoperative study of anti-reflux surgery, to rule out OMD that contradict it \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">To rule out oesophageal involvement by various systemic diseases (scleroderma, neuropathies, myopathies, or endocrinopathies) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">To assess dysphagia after oesophagogastric surgery (antireflux surgery or achalasia surgery) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3389025.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Indications for high-resolution oesophageal manometry." ] ] 6 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0300" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Oesophagogastric junction outflow tract obstruction</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Median IRP above upper limit of normal</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Achalasia type I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100% failed peristalsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131941"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Achalasia type II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100% failed peristalsis and ≥20% of swallows with pan-oesophageal pressurisation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131942"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Achalasia type III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absence of peristalsis and ≥ 20% swallows with premature waves (distal latency <4.5 s) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131943"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oesophagogastric junction outflow tract obstruction \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Evidence of oesophageal peristalsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131944"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Disordered oesophageal peristalsis</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Median IRP within normal limits</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absent contractility \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100% failed peristalsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131945"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ineffective oesophageal motility \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥50% of swallows with failed waves or >70% of swallows with ineffective waves (weak or fragmented) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131946"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Distal oesophageal spasm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥20% of swallows with premature waves (DL < 4.5 s) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131947"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypercontractile oesophagus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥20% of swallows with hypercontractile waves (DCI>8000mmHg*s*cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131948"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal oesophageal motility \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None of the above criteria \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202312080923131949"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3389030.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Chicago Classification v4.0 for oesophageal motility disorders." ] ] 7 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0305" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal motility function \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intact OGJ with normal oesophageal motility \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Impaired motility function \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Disruption of OGJ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypotensive OGJ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hiatal hernia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Defects in oesophageal peristalsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ineffective oesophageal motility \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Absent contractility \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Disruption of OGJ and defects in oesophageal peristalsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">The presence of hiatal hernia is associated with defects in oesophageal peristalsis \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3389028.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Motility phenotypes of GORD." ] ] 8 => array:8 [ "identificador" => "tbl0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0310" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients with typical reflux symptoms, who do not respond after 4 weeks of treatment with proton pump inhibitors \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients with atypical symptoms, who do not respond to 6−8 weeks of proton pump inhibitor therapy \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients who are going to undergo bariatric surgery, asymptomatic or symptomatic, to decide on surgical technique \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients who have undergone vertical gastrectomy, prior to second-stage surgery to decide on duodenal switch or gastric bypass \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3389029.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Indications for 24-hr pH impedance monitoring." ] ] 9 => array:8 [ "identificador" => "tbl0030" "etiqueta" => "Table 6" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0315" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of reflux episodes with reflux below pH 4.0, normal <80 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of refluxes with duration longer than 5 min, ≤3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duration of longest reflux, <9.2 min \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total time of mucosal exposure to acid (minutes) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Percentage of time of mucosal exposure to acid, <4.2% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reflux rate (reflux/hour) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean oesophageal clearance time (minutes/refluxes) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Assessment of symptom correlation (SI) and symptom association probability (SAP) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3389031.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Variables to be measured in pH monitoring." ] ] 10 => array:8 [ "identificador" => "tbl0035" "etiqueta" => "Table 7" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0320" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Values for pH monitoring \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OffPPI \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">On PPI twice a day \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">% time with pH <4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.3% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Standing \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.2% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Supine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.0% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Values for impedance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of reflux episodes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Acid \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-acid \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3389027.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Normal values for pH impedance monitoring." ] ] 11 => array:5 [ "identificador" => "202312080923131941" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 583 "Ancho" => 979 "Tamanyo" => 53833 ] ] ] 12 => array:5 [ "identificador" => "202312080923131942" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx2.jpeg" "Alto" => 548 "Ancho" => 984 "Tamanyo" => 93656 ] ] ] 13 => array:5 [ "identificador" => "202312080923131943" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx3.jpeg" "Alto" => 582 "Ancho" => 991 "Tamanyo" => 94412 ] ] ] 14 => array:5 [ "identificador" => "202312080923131944" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx4.jpeg" "Alto" => 604 "Ancho" => 975 "Tamanyo" => 86874 ] ] ] 15 => array:5 [ "identificador" => "202312080923131945" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx5.jpeg" "Alto" => 594 "Ancho" => 971 "Tamanyo" => 82177 ] ] ] 16 => array:5 [ "identificador" => "202312080923131946" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx6.jpeg" "Alto" => 667 "Ancho" => 949 "Tamanyo" => 74705 ] ] ] 17 => array:5 [ "identificador" => "202312080923131947" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx7.jpeg" "Alto" => 522 "Ancho" => 970 "Tamanyo" => 71609 ] ] ] 18 => array:5 [ "identificador" => "202312080923131948" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx8.jpeg" "Alto" => 571 "Ancho" => 935 "Tamanyo" => 90849 ] ] ] 19 => array:5 [ "identificador" => "202312080923131949" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx9.jpeg" "Alto" => 554 "Ancho" => 907 "Tamanyo" => 93453 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of gastroesophageal reflux disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Tack" 1 => "J.E. Pandolfino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.gastro.2017.09.047" "Revista" => array:8 [ "tituloSerie" => "Gastroenterology" "fecha" => "2018" "volumen" => "154" "numero" => "2" "paginaInicial" => "277" "paginaFinal" => "288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29037470" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0360301620314139" "estado" => "S300" "issn" => "03603016" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The esophagogastric junction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.K. Mittal" 1 => "D.H. Balaban" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199703273361306" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "336" "paginaInicial" => "924" "paginaFinal" => "932" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9070474" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of criteria for the definition of transient lower esophageal sphincter relaxations using high-resolution manometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Roman" 1 => "R. Holloway" 2 => "J. Keller" 3 => "F. Herbella" 4 => "F. Zerbib" 5 => "Y. Xiao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.12920" "Revista" => array:3 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2017" "volumen" => "29" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and esophageal cancer: GERD, Barrett’s esophagus, and molecular carcinogenic pathways" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Schlottmann" 1 => "N.H. Dreifuss" 2 => "M.G. Patti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/17474124.2020.1764348" "Revista" => array:7 [ "tituloSerie" => "Expert Rev Gastroenterol Hepatol" "fecha" => "2020" "volumen" => "14" "numero" => "6" "paginaInicial" => "425" "paginaFinal" => "433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32441160" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity & GERD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Chang" 1 => "F. Friedenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gtc.2013.11.009.Obesity" "Revista" => array:7 [ "tituloSerie" => "Gastroenterol Clin North Am" "fecha" => "2014" "volumen" => "43" "numero" => "1" "paginaInicial" => "161" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24503366" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of esophageal dysmotility in asymptomatic obese patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Côté-Daigneault" 1 => "P. Leclerc" 2 => "J. Joubert" 3 => "M. Bouin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2014/960520" "Revista" => array:8 [ "tituloSerie" => "Can J Gastroenterol Hepatol" "fecha" => "2014" "volumen" => "28" "numero" => "6" "paginaInicial" => "311" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24945185" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0261561416301819" "estado" => "S300" "issn" => "02615614" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-resolution esophageal manometry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Yadlapati" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MOG.0000000000000369" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Gastroenterol" "fecha" => "2017" "volumen" => "33" "numero" => "4" "paginaInicial" => "301" "paginaFinal" => "309" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28426462" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0 ©" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Yadlapati" 1 => "P.J. Kahrilas" 2 => "M.R. Fox" 3 => "R. Yadlapati" 4 => "P. Kahrilas" 5 => "M. Fox" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.14058" "Revista" => array:6 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2021" "volumen" => "33" "numero" => "1" "paginaInicial" => "1" "paginaFinal" => "21" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Shaker" 1 => "N. Stoikes" 2 => "J. Drapekin" 3 => "V. Kushnir" 4 => "M.L. Brunt" 5 => "P.C. Gyawali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ajg.2013.289" "Revista" => array:8 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2013" "volumen" => "108" "numero" => "11" "paginaInicial" => "1706" "paginaFinal" => "1712" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24019081" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0169500216305335" "estado" => "S300" "issn" => "01695002" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patterns of esophageal pressure responses to a rapid drink challenge test in patients with esophageal motility disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Marin" 1 => "J. Serra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.12749" "Revista" => array:7 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2016" "volumen" => "28" "numero" => "4" "paginaInicial" => "543" "paginaFinal" => "553" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26686375" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chicago classification update (v4.0): technical review of high‐resolution manometry metrics for EGJ barrier function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.J. Kahrilas" 1 => "R.K. Mittal" 2 => "S. Bor" 3 => "G. Kohn" 4 => "G. Lenglinger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.14113" "Revista" => array:6 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2021" "volumen" => "33" "numero" => "10" "paginaInicial" => "1" "paginaFinal" => "9" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification for esophagogastric junction (EGJ) complex based on physiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Akimoto" 1 => "S. Singhal" 2 => "T. Masuda" 3 => "S.K. Mittal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/dote/dox048" "Revista" => array:7 [ "tituloSerie" => "Dis Esophagus" "fecha" => "2017" "volumen" => "30" "numero" => "6" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30052901" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modern diagnosis of GERD: the Lyon Consensus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.P. Gyawali" 1 => "P.J. Kahrilas" 2 => "E. Savarino" 3 => "F. Zerbib" 4 => "F. Mion" 5 => "A.J.P.M. Smout" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/gutjnl-2017-314722" "Revista" => array:7 [ "tituloSerie" => "Gut." "fecha" => "2018" "volumen" => "67" "numero" => "7" "paginaInicial" => "1351" "paginaFinal" => "1362" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29437910" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of bolus transit with intraluminal impedance measurement in patients with esophageal motility disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Bogte" 1 => "A.J. Bredenoord" 2 => "J. Oors" 3 => "P.D. Siersema" 4 => "A.J.P.M. Smout" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.12642" "Revista" => array:7 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2015" "volumen" => "27" "numero" => "10" "paginaInicial" => "1446" "paginaFinal" => "1452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26284688" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.O. Katz" 1 => "K.B. Dunbar" 2 => "F.H. Schnoll-Sussman" 3 => "K.B. Greer" 4 => "R. Yadlapati" 5 => "S.J. Spechler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.14309/ajg.0000000000001538" "Revista" => array:8 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2022" "volumen" => "117" "numero" => "1" "paginaInicial" => "27" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34807007" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0360301622003157" "estado" => "S300" "issn" => "03603016" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with refractory reflux symptoms often do not have GERD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.V.K. Herregods" 1 => "M. Troelstra" 2 => "P.W. Weijenborg" 3 => "A.J. Bredenoord" 4 => "A.J.P.M. Smout" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.12620" "Revista" => array:6 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2015" "volumen" => "27" "numero" => "9" "paginaInicial" => "1267" "paginaFinal" => "1273" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification of esophageal motor findings in gastro-esophageal reflux disease: Conclusions from an international consensus group" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.P. Gyawali" 1 => "S. Roman" 2 => "A.J. Bredenoord" 3 => "M. Fox" 4 => "J. Keller" 5 => "J.E. Pandolfino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.13104" "Revista" => array:4 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2017" "volumen" => "29" "numero" => "12" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esophageal spasm: demographic, clinical, radiographic, and manometric features in 108 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Almansa" 1 => "M.G. Heckman" 2 => "K.R. DeVault" 3 => "E. Bouras" 4 => "S.R. Achem" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1442-2050.2011.01258.x" "Revista" => array:7 [ "tituloSerie" => "Dis Esophagus" "fecha" => "2012" "volumen" => "25" "numero" => "3" "paginaInicial" => "214" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21951821" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercontractile esophagus from pathophysiology to management: proceedings of the pisa symposium" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. De Bortoli" 1 => "P.C. Gyawali" 2 => "S. Roman" 3 => "S. Tolone" 4 => "D. Sifrim" 5 => "R. Tutuian" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.14309/ajg.0000000000001061" "Revista" => array:8 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2021" "volumen" => "116" "numero" => "2" "paginaInicial" => "263" "paginaFinal" => "273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33273259" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1470204515002223" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Shaker" 1 => "N. Stoikes" 2 => "J. Drapekin" 3 => "V. Kushnir" 4 => "M.L. Brunt" 5 => "P.C. Gyawali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ajg.2013.289" "Revista" => array:7 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2013" "volumen" => "108" "numero" => "11" "paginaInicial" => "1706" "paginaFinal" => "1712" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24019081" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Solid bolus swallows during high‐resolution manometry complement multiple rapid swallows in predicting symptoms following antireflux surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Greenan" 1 => "B.D. Rogers" 2 => "D. Sifrim" 3 => "C.P. Gyawali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.14336" "Revista" => array:6 [ "tituloSerie" => "Neurogastroenterol Motil" "fecha" => "2022" "volumen" => "34" "numero" => "8" "paginaInicial" => "1" "paginaFinal" => "8" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro-oesophageal reflux disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Anggiansah" 1 => "R. Sweis" 2 => "A. Anggiansah" 3 => "T. Wong" 4 => "D. Cooper" 5 => "M. Fox" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/apt.12208" "Revista" => array:7 [ "tituloSerie" => "Aliment Pharmacol Ther" "fecha" => "2013" "volumen" => "37" "numero" => "5" "paginaInicial" => "555" "paginaFinal" => "563" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23305085" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waist belt and central obesity cause partial hiatus hernia and short-segment acid reflux in asymptomatic volunteers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y.Y. Lee" 1 => "A.A. Wirz" 2 => "J.G. Whiting" 3 => "E.V. Robertson" 4 => "D. Smith" 5 => "A. Weir" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/gutjnl-2013-305803" "Revista" => array:7 [ "tituloSerie" => "Gut." 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Smout" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/nmo.12477" "Revista" => array:7 [ "tituloSerie" => "Neurogastroenterol Motil." "fecha" => "2015" "volumen" => "27" "numero" => "2" "paginaInicial" => "160" "paginaFinal" => "174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25469569" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modern esophageal function testing and gastroesophageal reflux disease in morbidly obese patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Kristo" 1 => "M. Paireder" 2 => "G. Jomrich" 3 => "D.M. Felsenreich" 4 => "M. Nikolic" 5 => "F.B. Langer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11695-019-04020-1" "Revista" => array:8 [ "tituloSerie" => "Obes Surg." 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"fecha" => "2016" "volumen" => "26" "numero" => "10" "paginaInicial" => "2449" "paginaFinal" => "2456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26956879" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manometric and pH-monitoring changes after laparoscopic sleeve gastrectomy: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Balla" 1 => "F. Meoli" 2 => "L. Palmieri" 3 => "D. Corallino" 4 => "M.C. Sacchi" 5 => "E. Ribichini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00423-021-02171-3" "Revista" => array:7 [ "tituloSerie" => "Langenbecks Arch Surg." "fecha" => "2021" "volumen" => "406" "numero" => "8" "paginaInicial" => "2591" "paginaFinal" => "2609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33855600" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of esophageal function tests in diagnosis of gastroesophageal reflux disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.G. Patti" 1 => "U. Diener" 2 => "A. Tamburini" 3 => "D. Molena" 4 => "L.W. Way" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1023/a:1005611602100" "Revista" => array:7 [ "tituloSerie" => "Dig Dis Sci." "fecha" => "2001" "volumen" => "46" "numero" => "3" "paginaInicial" => "597" "paginaFinal" => "602" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11318538" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity: a challenge to esophagogastric junction integrity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.E. Pandolfino" 1 => "H.B. El–Serag" 2 => "Q. Zhang" 3 => "N. Shah" 4 => "S.K. Ghosh" 5 => "P.J. Kahrilas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.gastro.2005.12.016" "Revista" => array:8 [ "tituloSerie" => "Gastroenterology" "fecha" => "2006" "volumen" => "130" "numero" => "3" "paginaInicial" => "639" "paginaFinal" => "649" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16530504" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0360301621034441" "estado" => "S300" "issn" => "03603016" ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity is associated with increased transient lower esophageal sphincter relaxation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.C. Wu" 1 => "L. Mui" 2 => "C.M. Cheung" 3 => "Y. Chan" 4 => "J.J. 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Ayazi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11605-009-0930-7" "Revista" => array:7 [ "tituloSerie" => "J Gastrointest Surg." "fecha" => "2009" "volumen" => "13" "numero" => "8" "paginaInicial" => "1440" "paginaFinal" => "1447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19475461" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inter-reviewer variability in interpretation of pH-impedance studies: the wingate consensus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.P. Gyawali" 1 => "B. Rogers" 2 => "M. Frazzoni" 3 => "E. Savarino" 4 => "S. Roman" 5 => "D. Sifrim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cgh.2020.09.002" "Revista" => array:7 [ "tituloSerie" => "Clin Gastroenterol Hepatol." "fecha" => "2021" "volumen" => "19" "numero" => "9" "paginaInicial" => "1976" "paginaFinal" => "1978.e1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32890752" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normal values of 24H multichannel intraluminal impedance pH-metry in a Greek obese population based on montreal definition of Gerd" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Doulami" 1 => "S. Triantafyllou" 2 => "M. Natoudi" 3 => "K. Albanopoulos" 4 => "E. Menenakos" 5 => "K. Filis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11695-015-1732-5" "Revista" => array:7 [ "tituloSerie" => "Obes Surg." "fecha" => "2016" "volumen" => "26" "numero" => "1" "paginaInicial" => "126" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26003551" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dari S 24-h pH-metry and multichannel intraluminal impedance monitoring in obese patients with and without gastroesophageal reflux disease symptoms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Ricci" 1 => "C. Amella" 2 => "A. Forti" 3 => "A. Rossi" 4 => "G. Bersani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11695-010-0275-z" "Revista" => array:6 [ "tituloSerie" => "Obes Surg" "fecha" => "2011" "volumen" => "21" "paginaInicial" => "48" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20835898" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of esophageal function tests in diagnosis of gastroesophageal reflux disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.G. Patti" 1 => "U. Diener" 2 => "A. Tamburini" 3 => "D. Molena" 4 => "L.W. Way" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1023/a:1005611602100" "Revista" => array:6 [ "tituloSerie" => "Dig Dis Sci." 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Study of gastroesophageal reflux. Interpretation of functional tests in the obese patient

Estudio del reflujo gastroesofágico. Interpretación de las pruebas funcionales en el paciente obeso

Elizabeth Barba Orozco

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barba@clinic.cat

Corresponding author.

, Alberto Ezquerra Duran

Gastroenterology Department, Neurogastroenterology and Motility Unit, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Pathophysiological mechanisms of gastro-oesophageal reflux disease</span><p id="par0005" class="elsevierStylePara elsevierViewall">The pathogenesis of gastro-oesophageal reflux disease &#40;GORD&#41; is complex and involves changes in reflux exposure&#44; oesophageal epithelial resistance&#44; and visceral sensitivity&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Under normal circumstances&#44; the passage of gastric contents into the oesophagus is prevented by the oesophagogastric junction &#40;OGJ&#41;&#44; which forms an anti-reflux barrier&#46; The OGJ is made up of several anatomical structures that play an important role in maintaining the anti-reflux barrier&#46; The lower oesophageal sphincter &#40;LOS&#41; and the crural diaphragm &#40;CD&#41; constitute the intrinsic and extrinsic sphincter&#44; respectively&#46; Under normal conditions the two sphincters overlap and are anchored to each other by the phrenoesophageal ligament&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Incompetence of the anti-reflux barrier</span><p id="par0260" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1</span><p id="par0010" class="elsevierStylePara elsevierViewall">Transient lower oesophageal sphincter relaxation &#34;TLOSR&#34;&#58; TLOSR is the major mechanism underlying gastro-oesophageal reflux &#40;GOR&#41;&#46; Most reflux episodes occur during TLOSR episodes&#46; TLOSRs are episodes of complete and prolonged relaxation of the LOS&#44; not triggered by swallowing and accompanied by CD inhibition&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> A set of manometric criteria for TLOSRs have been proposed&#58; a main criterion&#44; relaxation of the LOS for more than 10&#8201;s in the absence of swallowing 4&#8201;s before and 2&#8201;s after LOS relaxation and several additional criteria&#44; presence of reflux by means of manometry-impedance monitoring&#44; oesophageal shortening&#44; single cavity phenomenon&#44; crural diaphragm inhibition&#44; relaxation of the upper oesophageal sphincter &#40;UOS&#41; without subsequent swallowing&#44; and secondary peristalsis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2</span><p id="par0015" class="elsevierStylePara elsevierViewall">Hypotension of the LOS and GOR induced by abrupt increases in intragastric pressure in the context of a hypotensive LOS &#40;&#60;10&#8201;mmHg &#40;&#60;10&#8201;mmHg&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3</span><p id="par0020" class="elsevierStylePara elsevierViewall">Anatomical abnormalities of the OJG&#46; In patients with hiatal hernia&#44; the function of the crural diaphragm is compromised by its axial displacement and atrophy secondary to dilatation of the diaphragmatic hiatus&#46; In addition&#44; the presence of a hiatal hernia leads to a decrease in the intraluminal pressure of the OJG favouring reflux episodes&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4</span><p id="par0025" class="elsevierStylePara elsevierViewall">Impaired oesophageal clearance&#46; Prolonged exposure of the oesophageal mucosa to gastric juice correlates with the severity of erosive oesophagitis and the presence of Barrett&#39;s oesophagus&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The two main causes of prolonged reflux exposure and impaired oesophageal clearance are defects in oesophageal peristalsis and saliva production&#46; Impaired oesophageal emptying and retrograde flow phenomena of reflux gastric contents are also present in patients with hiatal hernia&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p></li></ul></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Pathophysiological mechanisms of gastro-oesophageal reflux disease in obese patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">In patients with obesity&#44; an increase in intra-abdominal pressure has been identified in patients with obesity&#44; due to the transmission of gravitational force from the adipose tissue to the abdominal cavity favouring reflux episodes through abrupt increases in intragastric pressure&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The gastric volume of obese patients is higher than in the normopese population&#44; which could favour reflux episodes of higher volume&#46; Another theory is that obese patients may have slowed gastric emptying&#44; due to neural and humoral mechanisms&#44; and that this favours the presence of GORD&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Obese patients have a higher incidence of hiatal hernia&#44; with figures of up to 50&#37;&#44; which is also associated with an increased risk for GORD&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> It has been shown that TLOSR is more common in obese patients than in normal weight patients&#44; and in one published series of patients in up to 51&#37; of obese patients manometry revealed dysmotility&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The underlying mechanisms of GORD in obese patients are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">High-resolution oesophageal manometry &#40;HR-OM&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Oesophageal manometry is the technique for studying and quantifying the contractile motor activity of the oesophagus and is therefore the technique of choice for the diagnosis of oesophageal motility disorders &#40;OMD&#41;&#46; HR-OM assesses oesophageal motility patterns by measuring the amplitude of the contractile events of the oesophagus and its sphincters in relation to time by means of pressure sensors located along the catheter&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> HR-OM probes have 36 pressure sensors spaced 1&#8201;cm apart&#46; These sensors collect dynamic information and&#44; using computer software&#44; it is transformed into spatio-temporal graphs called oesophageal pressure topography &#40;OPT&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> A standardised protocol is used to interpret OPT as described in Chicago Classification v 4&#46;0&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The indications for HR-OM are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">HR-OM protocol Chicago v4&#46;0</span><p id="par0040" class="elsevierStylePara elsevierViewall">The study starts with the patient in the supine position&#44; after intubation of the manometry catheter via the transnasal route&#46; Once the catheter is in place&#44; a 60-second stabilisation period is required&#44; followed by 3 deep breaths to confirm placement and the passage of at least 3 sensors from the distal end of the catheter into the gastric chamber&#46; The resting pressure is then recorded for 30&#8201;s to identify anatomical landmarks&#58; the upper oesophageal sphincter &#40;UOS&#41; and lower oesophageal sphincter &#40;LOS&#41;&#44; the respiratory inversion point &#40;RIP&#41; and the baseline OJG pressure&#46; This is followed by 10 swallows of 5&#8201;ml water or saline&#46; The protocol is completed with the patient supine and with the multiple swallow test&#44; by administering 5 liquid swallows of 2&#8201;ml with 2&#8211;3 seconds between each swallow&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The aim of this test is to assess peristaltic reserve&#46; Once this part is completed&#44; the patient is placed upright&#44; and the resting pressure is performed again for 30&#8201;s&#46; Five liquid swallows of 5&#8201;ml are performed with at least 30&#8201;s between each swallow and finished with the 200&#8201;ml liquid overload test&#44; to determine the presence of brief obstructive or hyperpressive patterns in case of impaired motility or relaxation of the LOS&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Manometric study of swallowing</span><p id="par0045" class="elsevierStylePara elsevierViewall">To assess and classify swallowing&#44; certain parameters have to be calculated on the OPT&#58; the integrated relaxation pressure &#40;IRP&#41;&#44; a measure of LOS relaxation of swallowing&#46; Oesophageal contractile function through the distal contractile integral &#40;DCI&#41;&#44; which measures the strength of oesophageal contraction&#44; distal latency &#40;DL&#41;&#44; a measure of time to identify premature or spastic waves&#44; and peristaltic integrity&#44; which describes the presence or absence of fragmented peristaltic waves&#46; The HR-OM allows for the assessment of intra-oesophageal pressurisation patterns&#46; Oesophageal pressurisation occurs when swallowed fluid is trapped between two contracting oesophageal segments&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the classification of OMDs&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Manometric assessment of OGJ</span><p id="par0050" class="elsevierStylePara elsevierViewall">The OGJ has unique characteristics that make manometric assessment challenging&#46; First&#44; the OGJ pressure comprises the pressure of the LOS and the CD&#46; Second&#44; its morphology is influenced by the anatomical integrity of the OGJ&#44; which is affected in the presence of a hiatal hernia&#44; and the arrangement of the LOS and CD is dynamic&#44; one manometric recording can identify from the overlap of both elements to the presence of an overt hiatal hernia&#46; Third&#44; the OGJ shows marked radial and axial asymmetry in pressure morphology&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Finally&#44; when the LOS and CD are separated&#44; the RIP&#44; which is where the pressure change occurs during inspiration from negative intrathoracic pressure to positive intragastric pressure&#44; can be located above the LOS or between the CD and LOS&#46; There is evidence that the relative location of the RIP to the LES is more associated with pathological oesophageal acid reflux exposure than the presence and size of the hiatal hernia&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The Chicago Consensus version 4 classifies the OGJ into three subtypes according to morphology<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Type 1&#44; absence of hiatal hernia&#58; overlapping LOS and CD&#44; separation &#60;1&#8201;cm&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Type 2&#44; hiatal hernia with the RIP proximal to the CD&#58; separation of the LOS and CD&#62;1&#8201;cm and RIP between CD and LOS&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Type 3&#44; hiatal hernia with the IRP proximal to the LOS&#58; separation of the LOS and CD&#62;1&#8201;cm and RIP above the LOS&#46;</p></li></ul></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">HR-OM and impedance</span><p id="par0075" class="elsevierStylePara elsevierViewall">HR-OM and impedance allows simultaneous assessment of oesophageal movements through HR-OM and the transit of the swallowed bolus by means of impedance without the need for radiological studies&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Good correlation has been demonstrated in the measurement of bolus transit and oesophageal clearance measured by impedance versus videofluoroscopy considered the gold standard&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> The basic principle of impedance measurements is to evaluate the resistance to the passage of an alternating current between two electrodes&#46; The resistance to the passage of the current is influenced by the conductive medium&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> During saline swallowing&#44; as it is a good conductor&#44; the impedance decreases as the bolus progresses&#44; returning to its baseline value once the bolus is cleared&#44; allowing assessment of whether the bolus transit is complete or incomplete or whether it is retained&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Manometry in GORD</span><p id="par0080" class="elsevierStylePara elsevierViewall">HR-OM should always be requested for GORD prior to placement of the pH-monitoring probe to locate the LOS and its correct placement&#46; HR-OM allows the identification of GORD-associated OMD and correct differential diagnosis with other oesophageal diseases that may present the same symptoms as GORD&#44; such as achalasia or other primary OMD&#46; In addition&#44; an HR-OM should be requested in all patients who are candidates for surgical and&#47;or endoscopic anti-reflux techniques to confirm the diagnosis and assess peristaltic reserve&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Up to one third of patients classified as refractory GORD do not have GORD and present with other disorders&#44; most commonly functional heartburn&#44; but they sometimes present findings compatible with achalasia or rumination syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">According to the international consensus on the classification of motility disorders in GORD&#44; two motor phenotypes are identified in GORD&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> which are described in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Hypomotility-type oesophageal disorders are the most common of the GORD-associated MODs&#44; although spastic disorders &#40;OH and DOS&#41; have also been associated with pathological exposure of the oesophagus to gastric reflux&#46; Up to 38&#37; of patients diagnosed with DOS have pathological acid exposure according to the largest published series&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> and 43&#37; of patients with OH have typical GORD symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">The international consensus on the classification of motility disorders in GORD proposes a three-step algorithm to characterise oesophageal motility function in the context of GORD study and assessment prior to antireflux surgery&#46; The first step is to assess the integrity of the OGJ&#44; the second step is to assess oesophageal body motility function&#44; and finally to assess the contractile reserve by means of provocative tests&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> The presence of a contractile wave following the multiple swallow test with contractile force&#44; as assessed by DCI &#40;mmHg&#41;&#44; greater than the mean of the 10 liquid swallows indicates the presence of contractile reserve and a lower risk of post-fundoplication dysphagia&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> The solid swallow test is another complementary test used to assess contractile reserve&#46; Contractile reserve is considered present if the strength of the peristaltic wave generated after swallowing the solid &#40;a piece of bread or biscuit&#41; is greater than the average of the 10 liquid swallows&#46; A good correlation has been demonstrated in the assessment of contractile reserve with the multiple swallow test and solid swallows in patients meeting manometric criteria for ineffective oesophageal motility&#46; The increased risk for developing post-fundoplication oesophageal symptoms in patients without contractile reserve in both tests has also been confirmed&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;20</span></a> The solid swallow test is complementary to the multiple swallow test in assessing peristaltic reserve and predicting the risk of developing post-fundoplication dysphagia&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Manometric findings in overweight&#47;obese patients</span><p id="par0100" class="elsevierStylePara elsevierViewall">In patients with obesity&#44; increased abdominal girth plays a key role in the pathophysiological mechanisms of GORD&#46; Obese patients have disruptions in both the barrier effect of the OGJ and oesophageal peristalsis&#46; A negative association between BMI&#44; LOS pressure and the intra-abdominal segment of the LOS has been demonstrated&#46; Overweight and obese patients more frequently present with hypotensive LOS and disrupted OGJ in the form of hiatal hernia&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Obese patients have higher intragastric pressure than non-obese patients<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&#59; and there is a positive correlation between BMI and intragastric pressure&#46; The gastro-oesophageal pressure gradient is also found to be increased in overweight or obese patients compared to normopese patients&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Obese patients have a higher number of TLOSR episodes during the postprandial period &#40;2&#8201;h after a meal&#41;&#44; 7 episodes compared to 2 episodes in the control group&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> In the supine position&#44; patients with obesity often have an IRP above the limit of normal&#44; which&#44; when changing position to upright&#44; becomes within the normal range&#46; In a recent study&#44; 75&#37; of patients with a diagnosis of oesophagogastric junction outflow obstruction &#40;OGJOO&#41; with elevated supine IRP&#44; after evaluation of IRP in both positions&#44; a diagnosis of OGJOO was excluded&#46; The hypothesis for this increase in supine IRP values is that the effect of gravity on abdominal fat increases intra-abdominal pressure and pressure on the OGJ&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> In a cohort of 147 patients with obesity underwent HR-OM and OMD was identified in up to 34&#37;&#44; according to the Chicago classification version 3&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> A total of 18&#46;4&#37; had a manometric diagnosis of OGJOO&#44; 7&#46;5&#37; of HO&#44; 4&#46;1&#37; of DOS&#44; 2&#37; of IOM&#44; and 1&#46;4&#37; of fragmented peristalsis&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Manometry findings in patients undergoing bariatric surgery</span><p id="par0105" class="elsevierStylePara elsevierViewall">Vertical gastrectomy or gastric sleeve is one of the most commonly used surgical techniques in bariatric surgery&#46; Vertical gastrectomy is a restrictive technique that involves a reduction in gastric volume and gastric accommodation&#44; which leads to an increase in intragastric pressure that favours the onset of upper GI symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> In patients undergoing vertical gastrectomy&#44; an increase in intragastric pressure above 30&#8201;mmHg during LOS contraction after single swallows is characteristic on HR-OM&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Hypomotility disorders in oesophageal peristalsis occur after vertical gastrectomy&#44; with a decrease in the mean DCI of the 10 liquid swallows and an increase of more than 30&#37; of de novo diagnosis of ineffective oesophageal motility&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Assessment of gastro-oesophageal reflux in obese patients</span><p id="par0110" class="elsevierStylePara elsevierViewall">In the symptomatic population&#44; gastrointestinal endoscopy detects erosive oesophagitis in 50&#37; of patients&#44; while 24&#8201;h pH-impedance monitoring diagnoses 92&#37; of patients with non-erosive reflux disease &#40;NERD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a> defines the indications for 24&#8201;h pH-impedance monitoring&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Twenty-four-hour oesophageal pH monitoring</span><p id="par0120" class="elsevierStylePara elsevierViewall">Twenty-four-hour oesophageal pH monitoring in off-PPI &#40;without proton pump inhibitor &#91;PPI&#93; treatment&#41; is the diagnostic benchmark and consists of the recording of oesophageal acidity levels using a probe with acid-sensitive receptors and a computer recording the results&#46; <a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a> describes the variables to be measured in pH monitoring&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Normal and pathological findings of 24&#8201;h pH monitoring</span><p id="par0125" class="elsevierStylePara elsevierViewall">To test the pathophysiological relationship between obesity and reflux&#44; objective data have been evaluated with pH monitoring&#44; but these results have been contradictory because patients with obesity are more likely to have OGJ disruption<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> and an increased gastro-oesophageal pressure gradient&#44; which provides a perfect scenario for reflux to occur&#46; There are patients with obesity who do not have reflux and are asymptomatic&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> the pH recording in the distal oesophagus in asymptomatic individuals shows the presence of occasional episodes of reflux&#44; compatible with <span class="elsevierStyleItalic">physiological</span> reflux which is characterised by episodes of reflux of short duration predominantly in the standing position&#46; A pathological reflux is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Twenty-four-hour pH monitoring and impedance study</span><p id="par0130" class="elsevierStylePara elsevierViewall">Multichannel intraluminal impedance-pH-monitoring &#40;pHz&#41; has the advantage of simultaneously detecting both acid and non-acid reflux&#44; as well as its characteristics which can be liquid&#44; gas&#44; or mixed and the direction of the refluxed material which can be either retrograde or antegrade&#46; With pHz monitoring it has been shown that patients with obesity have more gastro-oesophageal reflux&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The indications for pHz are&#58;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">1</span><p id="par0140" class="elsevierStylePara elsevierViewall">To quantify and characterise oesophagogastric reflux&#44; especially in patients with incomplete response or no response to suppressive therapy with proton pump inhibitors and who have previously undergone endoscopic study and show no disruptions&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">2</span><p id="par0145" class="elsevierStylePara elsevierViewall">To evaluate the patient with symptoms of atypical reflux or extra-oesophageal manifestations of reflux&#44; such as pharyngeal globus&#44; cough&#44; and dysphonia&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">3</span><p id="par0150" class="elsevierStylePara elsevierViewall">To evaluate acid and non-acid reflux in patients undergoing bariatric surgery or after second-stage bariatric surgery&#46;</p></li></ul></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">pH impedance monitoring technique</span><p id="par0155" class="elsevierStylePara elsevierViewall">pHz is performed technically in the same way as conventional pH-monitoring&#46; The patient needs to fast for 6&#8201;h&#44; an HR-OM is performed beforehand to determine how many centimetres away the upper edge of the LOS is located and 5&#8201;cm is subtracted from that measurement&#44; because the site where peptidases are inactivated is at that height&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The characteristics to be evaluated are&#58;</p><p id="par0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Composition of reflux&#58;</span> impedance monitoring helps classify reflux episodes as gas&#44; liquid&#44; or mixed&#46; Air is a poor conductor and therefore has a high impedance&#44; whereas liquid&#44; which is a good conductor&#44; has a low impedance&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Proximal reflux&#58;</span> The proximal extent of an episode is defined by the most proximal impedance measurement segment reached by the liquid component of the reflux episode&#46; Gas reflux episodes are not assigned a proximal extent&#44; as they typically enter the upper oesophageal sphincter and are eliminated&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Number of acid and non-acid reflux episodes&#58;</span> the combination of pHz defines the number of reflux episodes with change in impedance monitoring as well as the total number of episodes detected by impedance monitoring alone without pH alteration&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Reflux contact time&#58;</span> this determines the presence of reflux time&#44; which is the total amount of time of refluxed material detected by impedance monitoring from the segment located 5&#8201;cm above the LOS&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Oesophageal clearance time&#58;</span> defined as the mean duration during which reflux is present 5&#8201;cm above the LOS&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Reflux pH</span>&#58; all of the above parameters are classified as acid and non-acid based on the changes recorded at the time when the reflux occurred and are also determined by the patient&#39;s position&#44; either standing or supine&#46; An <span class="elsevierStyleItalic">acid reflux</span> episode is an event with pH falling below 4&#59; a <span class="elsevierStyleItalic">non-acid reflux</span> is defined as the reflux episode in which the pH is above 4&#59; a <span class="elsevierStyleItalic">weakly acid</span> episode defines the episode within a pH&#8201;4&#8211;7&#44; and <span class="elsevierStyleItalic">alkaline reflux</span> when the pH is &#62;7&#46; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows dual-channel pH monitoring&#44; with short refluxes&#44; and preserved oesophageal clearance&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0195" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a> shows the graph of a patient with reflux in both the supine and standing position&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Interpretation of results</span><p id="par0200" class="elsevierStylePara elsevierViewall">Once these characteristics have been determined&#44; we have to evaluate the following parameters in the pHz recording<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;34</span></a>&#58;<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">1</span><p id="par0205" class="elsevierStylePara elsevierViewall">Duration of pHz monitoring&#58; the minimum duration to interpret a study and for it to be valid is 18&#8201;h&#46;</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">2</span><p id="par0210" class="elsevierStylePara elsevierViewall">Acid exposure time &#40;AET&#41; determination&#58; this refers to the time the oesophagus is exposed to a pH&#8201;&#60;&#8201;4 and correlates with the presence of reflux&#46; AET&#8201;&#60;&#8201;4&#37;&#58; physiological reflux&#59; AET &#62;4&#37;&#8211;&#60;6&#37;&#58; grey area&#59; AET&#8201;&#62;&#8201;6&#37;&#58; pathological reflux&#46;</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">3</span><p id="par0215" class="elsevierStylePara elsevierViewall">Assessment of the number of reflux episodes&#58; acid reflux is considered physiological when there are &#60;40 acid reflux episodes&#59; pathological reflux is when there are &#62;80 episodes of acid reflux&#46;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">4</span><p id="par0220" class="elsevierStylePara elsevierViewall">Establishment of the association of symptoms with reflux episodes&#58; the symptomatic index is the ratio of the number of symptoms associated with reflux episodes to the total number of symptomatic episodes&#215;100&#46; The clinical symptom is present at least 3 times in 24&#8201;h monitoring&#44; and is considered pathological when it happens 2&#8201;min&#46; before or after the reflux episode&#59; it is pathological if it is &#62;50&#37;&#44; and the symptom association probability &#40;SAP&#41; is the probability that a patient&#39;s symptoms are related to reflux&#44; it is significant if it is &#62;95&#37;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">5</span><p id="par0225" class="elsevierStylePara elsevierViewall">DeMeester score assessment&#58; this is the best-known measure for assessing pathological reflux&#59; it is considered impaired when the total DeMeester score is &#62;14&#46;72&#59; this measure considers the percentage of total time at pH&#8201;&#60;&#8201;4&#44; the number of reflux episodes&#44; and the position in which reflux episodes occur&#46;</p></li><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">6</span><p id="par0230" class="elsevierStylePara elsevierViewall">Nocturnal baseline impedance&#58; this expresses mucosal integrity and provides evidence of macroscopic and microscopic oesophageal damage after exposure to reflux&#46; It consists of measuring baseline impedance from 3 to 5&#8201;cm above the LOS during sleep in 3 periods of 10&#8201;min&#46; Values &#60;2292&#8201;&#937; suggest the presence of GORD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">7</span><p id="par0235" class="elsevierStylePara elsevierViewall">Post-reflux swallow-induced peristaltic wave&#58; reflects the integrity of oesophageal peristalsis stimulated by reflux episodes and chemical clearance&#46; It is abnormal when present with a 50&#37; anterograde drop in impedance within 30&#8201;s after the reflux event&#46;</p></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">8</span><p id="par0240" class="elsevierStylePara elsevierViewall">Assessment of nocturnal acid leakage&#58; physiologically&#44; during sleep the frequency of reflux episodes decreases&#59; however&#44; there may be a nocturnal leakage phenomenon&#44; with reflux episodes &#62;1&#8201;h in duration during sleep&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a></p></li></ul></p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">pH impedance monitoring in patients with obesity</span><p id="par0245" class="elsevierStylePara elsevierViewall">There are no established normality values for pHz assessment in patients with obesity&#46; In 2016 Doulami et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> were the first group to assess normal values for 24&#8201;h pHz in volunteers with obesity without reflux and reported a higher number of reflux episodes and an equal or&#44; in some cases&#44; slightly increased median acid bolus clearance exposure&#44; hypothesising that specific cohort values should be used in the assessment of pHz for patients with obesity<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#59; however&#44; to date we still use the same parameters as those established for healthy non-obese volunteers&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> The values are shown in <a class="elsevierStyleCrossRef" href="#tbl0035">Table 7</a>&#46;</p><elsevierMultimedia ident="tbl0035"></elsevierMultimedia><p id="par0250" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a> shows a pH impedance monitoring plot&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interests</span><p id="par0255" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Overweight and obesity are a public health problem and in 1997 obesity was recognized as a global epidemic by the World Health Organization &#40;WHO&#41;&#46; Overweight and obesity affect almost 60&#37; of adults and one in three children in Europe according to the most recent WHO report&#46; Objectively&#44; gastroesophageal reflux disease &#40;GERD&#41; is defined as the presence of characteristic esophageal mucosal damage assessed by endoscopy and&#47;or the demonstra-tion of pathological acid exposure by reflux monitoring studies&#46; The prevalence of GERD is increased in obese patients</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">In overweight and obese patients&#44; the clinical symptoms of GERD are especially present in the supine position and this correlates with more frequent episodes of nocturnal reflux in the 24-h pH monitoring&#44; there is also an increase in the number of refluxes with content acid&#46; In the population with symptoms&#44; digestive endoscopy detects data of erosive esophagitis in 50&#37; of patients&#44; while 24-h pH-impedanciometry diagnoses 92&#37; of patients with non-erosive reflux disease &#40;NERD&#41;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">The presence of persistent GERD in the mucosa affects esophageal motility and patients may develop ineffective esophageal motility-type disorders&#44; so we will review the interpre-tation of the functional tests that determine motility&#44; which is esophageal manometry&#44; and those that determine reflux gastroesophageal&#44; acid and non-acid&#44; which is the pH measure-ment with or without 24-h impedanciometry&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">El sobrepeso y la obesidad son un problema de salud p&#250;blica y en 1997 la obesidad fue reconocida como una epidemia global por la Organizacio&#8217;n Mundial de la Salud &#40;OMS&#41;&#46; El sobrepeso y la obesidad afectan a casi un 60&#37; de los adultos y a uno de cada 3 ni&#241;os del territorio europeo seg&#250;n el informe m&#225;s reciente de la OMS&#46; De forma objetiva&#44; la enferme-dad por reflujo gastroesof&#225;gico &#40;ERGE&#41; se define como la presencia de un da&#241;o mucoso esof&#225;gico caracter&#237;stico evaluado por endoscopia y&#47;o la demostraci&#243;n de una exposici&#243;n al &#225;cido patol&#243;gica mediante estudios de monitorizaci&#243;n del reflujo&#46; La prevalencia de la ERGE est&#225; aumentada en los pacientes con obesidad</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">En los pacientes con sobrepeso y obesidad&#44; la sintomatolog&#237;a cl&#237;nica de la ERGE se presenta especialmente en posici&#243;n en supino y esto se correlaciona con episodios m&#225;s frecuentes de reflujo nocturno en la pHmetr&#237;a de 24&#8201;h&#59; existe tambi&#233;n un incremento en el n&#250;mero de reflujos con contenido &#225;cido&#46; En la poblaci&#243;n con sintomatolog&#237;a la endoscopia digestiva detecta datos de esofagitis erosiva en un 50&#37; de los pacientes&#44; mientras que la pH impedanciometr&#237;a de 24&#8201;h diagnostica el 92&#37; de los pacientes con enfermedad por reflujo no erosiva &#40;ERNE&#41;&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">La presencia de ERGE persistente en la mucosa afecta la motilidad esof&#225;gica y los pacientes pueden desarrollar trastornos de tipo motilidad esof&#225;gica ineficaz&#44; por lo que revisaremos la interpretaci&#243;n de las pruebas funcionales que determinan la motilidad&#44; que es la manometr&#237;a esof&#225;gica&#44; y las que determinan el reflujo gastroes&#243;fagico&#44; &#225;cido y no &#225;cido&#44; que es la pHmetr&#237;a con o sin impedanciometr&#237;a de 24&#8201;h&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Barba Orozco E&#44; Ezquerra Duran A&#44; Estudio del reflujo gastroesof&#225;gico&#46; Interpretaci&#243;n de las pruebas funcionales en el paciente obeso&#46; Cir Esp&#46; 2023&#46; <span class="elsevierStyleInterRef" id="intr0005" href="https://doi.org/10.1016/j.ciresp.2023.01.001">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;ciresp&#46;2023&#46;01&#46;001</span></p>"
      ]
    ]
    "multimedia" => array:20 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pathological reflux&#46; The numerical bar on the left shows the pH value from 0 to 8&#59; the red line delimits a pH lower and higher than 4&#44; to determine the episodes of pathological acid reflux with pH&#8201;&#60;&#8201;4&#44; which corresponds to the critical point of the deleterious effect of acid and pepsin&#46; The lower scale shows the hours during which the recording was made&#44; and the yellow bars delimit the times at the beginning and end of meals&#59; the time the patient was in the supine position during sleep can also be measured &#40;green box&#41;&#46; In this graph there is a percentage of time with a pH&#8201;&#60;&#8201;4 of 14&#46;8&#37;&#44; with 100 reflux episodes&#44; of short duration due to correct oesophageal clearance&#46; The longest reflux lasted 3&#8201;min and a DeMeester score of 15&#46;1&#46;</p>"
        ]
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      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
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          0 => array:3 [
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Obese patient with a BMI of 42 and with episodes of regurgitation&#46; Twenty-four-hour pH monitoring&#44; with proximal and distal oesophageal pH sensor&#44; observing physiological reflux&#44; short duration reflux episodes during the day&#44; with adequate clearance&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Fig&#46; 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Obese patient with a BMI of 38&#46; Twenty-four-hour graph&#44; with pathological acid reflux&#44; total percentage of time with a pH&#8201;&#60;&#8201;4 of 23&#46;8&#37;&#44; standing 26&#44;4&#37;&#44; and supine 20&#46;9&#37;&#44; with a DeMeester score of 85&#46;2&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "fig0020"
        "etiqueta" => "Fig&#46; 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
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            "Tamanyo" => 488347
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          0 => array:3 [
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">pH impedance monitoring study of obese patient with BMI of 36&#44; showing &#40;1&#41; prolonged acid reflux episode&#44; &#40;2&#41; with incomplete clearance&#44; &#40;3&#41; with post-swallow peristaltic wave&#46;</p>"
        ]
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      4 => array:9 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "fuente" => "Source&#58; Ricci et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>"
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0290"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anti-reflux barrier incompetence&#58; hypotensive LOS&#44; TLOSR episodes&#44; and presence of hiatal hernia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Abnormal oesophageal clearance&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased intra-abdominal pressure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Altered transdiaphragmatic pressure gradient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dietary habits &#40;high fat&#44; low fibre diet&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3389026.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Underlying mechanisms of GORD in obese patients&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0295"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">The main indications for HR-OM are<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Study of an oesophageal motility disorder in non-organic dysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Study of chest pain of non-cardiological origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Correct placement of pH-monitoring probes by locating the upper edge of the LOS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Preoperative study of anti-reflux surgery&#44; to rule out OMD that contradict it&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>To rule out oesophageal involvement by various systemic diseases &#40;scleroderma&#44; neuropathies&#44; myopathies&#44; or endocrinopathies&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>To assess dysphagia after oesophagogastric surgery &#40;antireflux surgery or achalasia surgery&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3389025.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Indications for high-resolution oesophageal manometry&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0300"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Oesophagogastric junction outflow tract obstruction</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Median IRP above upper limit of normal</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Achalasia type I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; failed peristalsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131941"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Achalasia type II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; failed peristalsis and &#8805;20&#37; of swallows with pan-oesophageal pressurisation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131942"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Achalasia type III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absence of peristalsis and &#8805; 20&#37; swallows with premature waves &#40;distal latency &#60;4&#46;5&#8201;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131943"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Oesophagogastric junction outflow tract obstruction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evidence of oesophageal peristalsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131944"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disordered oesophageal peristalsis</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Median IRP within normal limits</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absent contractility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37; failed peristalsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131945"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ineffective oesophageal motility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805;50&#37; of swallows with failed waves or &#62;70&#37; of swallows with ineffective waves &#40;weak or fragmented&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131946"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Distal oesophageal spasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805;20&#37; of swallows with premature waves &#40;DL&#8201;&#60;&#8201;4&#46;5&#8201;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131947"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypercontractile oesophagus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8805;20&#37; of swallows with hypercontractile waves &#40;DCI&#62;8000mmHg&#42;s&#42;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131948"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normal oesophageal motility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None of the above criteria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202312080923131949"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3389030.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Chicago Classification v4&#46;0 for oesophageal motility disorders&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0305"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal motility function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intact OGJ with normal oesophageal motility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Impaired motility function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disruption of OGJ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypotensive OGJ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hiatal hernia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Defects in oesophageal peristalsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ineffective oesophageal motility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Absent contractility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disruption of OGJ and defects in oesophageal peristalsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">The presence of hiatal hernia is associated with defects in oesophageal peristalsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3389028.png"
              ]
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Motility phenotypes of GORD&#46;</p>"
        ]
      ]
      8 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0310"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients with typical reflux symptoms&#44; who do not respond after 4 weeks of treatment with proton pump inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients with atypical symptoms&#44; who do not respond to 6&#8722;8 weeks of proton pump inhibitor therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients who are going to undergo bariatric surgery&#44; asymptomatic or symptomatic&#44; to decide on surgical technique&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients who have undergone vertical gastrectomy&#44; prior to second-stage surgery to decide on duodenal switch or gastric bypass&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3389029.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Indications for 24-hr pH impedance monitoring&#46;</p>"
        ]
      ]
      9 => array:8 [
        "identificador" => "tbl0030"
        "etiqueta" => "Table 6"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0315"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Number of reflux episodes with reflux below pH&#8201;4&#46;0&#44; normal &#60;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Number of refluxes with duration longer than 5&#8201;min&#44; &#8804;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duration of longest reflux&#44; &#60;9&#46;2&#8201;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total time of mucosal exposure to acid &#40;minutes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Percentage of time of mucosal exposure to acid&#44; &#60;4&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reflux rate &#40;reflux&#47;hour&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mean oesophageal clearance time &#40;minutes&#47;refluxes&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Assessment of symptom correlation &#40;SI&#41; and symptom association probability &#40;SAP&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3389031.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Variables to be measured in pH monitoring&#46;</p>"
        ]
      ]
      10 => array:8 [
        "identificador" => "tbl0035"
        "etiqueta" => "Table 7"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0320"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Values for pH monitoring&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OffPPI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">On PPI twice a day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#37; time with pH &#60;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                        "paginaFinal" => "932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9070474"
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                      "titulo" => "Patterns of esophageal pressure responses to a rapid drink challenge test in patients with esophageal motility disorders"
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                      "titulo" => "Chicago classification update &#40;v4&#46;0&#41;&#58; technical review of high&#8208;resolution manometry metrics for EGJ barrier function"
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                      "titulo" => "Classification for esophagogastric junction &#40;EGJ&#41; complex based on physiology"
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                      "titulo" => "Modern diagnosis of GERD&#58; the Lyon Consensus"
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                        ]
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29437910"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Assessment of bolus transit with intraluminal impedance measurement in patients with esophageal motility disorders"
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                        "link" => array:1 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease"
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                        "paginaFinal" => "56"
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                    0 => array:2 [
                      "titulo" => "Patients with refractory reflux symptoms often do not have GERD"
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                    0 => array:2 [
                      "titulo" => "Classification of esophageal motor findings in gastro-esophageal reflux disease&#58; Conclusions from an international consensus group"
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                    0 => array:2 [
                      "titulo" => "Esophageal spasm&#58; demographic&#44; clinical&#44; radiographic&#44; and manometric features in 108 patients"
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                        "paginaFinal" => "1712"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Waist belt and central obesity cause partial hiatus hernia and short-segment acid reflux in asymptomatic volunteers"
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                0 => array:2 [
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                        "tituloSerie" => "Gastroenterology"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Obesity is associated with increased transient lower esophageal sphincter relaxation"
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              "identificador" => "bib0135"
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                      "titulo" => "High-resolution impedance manometry after sleeve gastrectomy&#58; increased intragastric pressure and reflux are frequent events"
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                          "autores" => array:6 [
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                            2 => "A&#46; Garros"
                            3 => "E&#46; Savarino"
                            4 => "E&#46; Pelascini"
                            5 => "M&#46; Robert"
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                        "numero" => "10"
                        "paginaInicial" => "2449"
                        "paginaFinal" => "2456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26956879"
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                      "titulo" => "Manometric and pH-monitoring changes after laparoscopic sleeve gastrectomy&#58; a systematic review"
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                            4 => "M&#46;C&#46; Sacchi"
                            5 => "E&#46; Ribichini"
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                        "tituloSerie" => "Langenbecks Arch Surg&#46;"
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                        "numero" => "8"
                        "paginaInicial" => "2591"
                        "paginaFinal" => "2609"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33855600"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Role of esophageal function tests in diagnosis of gastroesophageal reflux disease"
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                            3 => "D&#46; Molena"
                            4 => "L&#46;W&#46; Way"
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                        "numero" => "3"
                        "paginaInicial" => "597"
                        "paginaFinal" => "602"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11318538"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Obesity&#58; a challenge to esophagogastric junction integrity"
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                          "autores" => array:6 [
                            0 => "J&#46;E&#46; Pandolfino"
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                            3 => "N&#46; Shah"
                            4 => "S&#46;K&#46; Ghosh"
                            5 => "P&#46;J&#46; Kahrilas"
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                        "tituloSerie" => "Gastroenterology"
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                        "volumen" => "130"
                        "numero" => "3"
                        "paginaInicial" => "639"
                        "paginaFinal" => "649"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16530504"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Obesity is associated with increased transient lower esophageal sphincter relaxation"
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                            4 => "J&#46;J&#46; Sung"
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                        "link" => array:1 [
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                        "paginaFinal" => "1447"
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                            4 => "S&#46; Roman"
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