Transanal irrigation as a therapeutic option for patients with incontinence and severe chronic constipation refractory to first-line treatment María Valero Soriano; María Milagros Carrasco Prats; Cristóbal Perán Fernández; Purificación Calero García; Pedro López Morales; Clara Giménez Francés; Isabel María Jiménez Moreno; Antonio Albarracín Marín-Blázquez;