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Se trata de un estudio retrospectivo, realizado a 137 pacientes con infección activa por Helicobacter pylori y a 37 no infectados, en el que se ha evaluado la concentración de lípidos y lipoproteínas y su respuesta después del tratamiento erradicador. Los pacientes con infección presentaron una concentración de colesterol total y triglicéridos más elevada que los no infectados (220 frente a 200 mg/dl; p = 0,027 y 98 frente a 71 mg/dl; p = 0,008, respectivamente). La prevalencia de serología positiva a marcadores de mayor virulencia (CagA y VacA) no se asoció con alteraciones más desfavorables en el perfil lipídico. La erradicación de la infección se acompañó de un incremento en la concentración de cHDL (de 52,3 a 56,4 mg/dl; p = 0,001).
Palabras clave:
Helicobacter pylori
Colesterol
Infección
In a retrospective study the lipid profile of 137 patients with active infection and 37 with no infection by Helicobacter pylori was analyzed before and after eradicative therapy. Infected patients presented higher total cholesterol and triglyceride concentrations (220 vs 200 mg/dl, p = 0.027, 98 vs 71 mg/dl, p = 0.008, respectively) than not infected.
The prevalence of positive serological tests showing higher aggressive infection (CagA y VacA) was not associated with changes in lipid profile abnormalities. Eradicative therapy was associated with an increase of HDL-cholesterol concentration (from 52.3 mg/dl to 56.4 mg/dl, p = 0.001).
Key words:
Helicobacter pylori
Cholesterol
Infection
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